{"id":"https://openalex.org/W1968894752","doi":"https://doi.org/10.1164/ajrccm/147.6_pt_1.1465","title":"Increased Airway Inflammation with Segmental versus Aerosol Antigen Challenge","display_name":"Increased Airway Inflammation with Segmental versus Aerosol Antigen Challenge","publication_year":1993,"publication_date":"1993-06-01","ids":{"openalex":"https://openalex.org/W1968894752","doi":"https://doi.org/10.1164/ajrccm/147.6_pt_1.1465","mag":"1968894752","pmid":"https://pubmed.ncbi.nlm.nih.gov/8389107"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm/147.6_pt_1.1465","doi":"https://doi.org/10.1164/ajrccm/147.6_pt_1.1465","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm/147.6_pt_1.1465","pdf_url":null,"source":{"id":"https://openalex.org/S2751726451","display_name":"American Review of Respiratory Disease","issn_l":"0003-0805","issn":["0003-0805","2376-3752"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Review of Respiratory Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035570881","display_name":"William J. Calhoun","orcid":"https://orcid.org/0000-0001-7075-712X","observed_orcids":["https://orcid.org/0000-0001-7075-712X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William J. Calhoun","raw_affiliation_strings":["Section of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, Department of Medicine, University of Wisconsin, Madison, Wisconsin, and Department of Immunology, Mayo Clinic, Rochester, Minnesota","University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, Department of Medicine, University of Wisconsin, Madison, Wisconsin, and Department of Immunology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005205857","display_name":"Nizar N. Jarjour","orcid":"https://orcid.org/0000-0003-0170-8927","observed_orcids":["https://orcid.org/0000-0003-0170-8927"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nizar N. Jarjour","raw_affiliation_strings":["Section of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, Department of Medicine, University of Wisconsin, Madison, Wisconsin, and Department of Immunology, Mayo Clinic, Rochester, Minnesota","University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, Department of Medicine, University of Wisconsin, Madison, Wisconsin, and Department of Immunology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089757484","display_name":"Gerald J. Gleich","orcid":"https://orcid.org/0000-0002-6317-0811","observed_orcids":["https://orcid.org/0000-0002-6317-0811"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald J. Gleich","raw_affiliation_strings":["Section of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, Department of Medicine, University of Wisconsin, Madison, Wisconsin, and Department of Immunology, Mayo Clinic, Rochester, Minnesota","University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, Department of Medicine, University of Wisconsin, Madison, Wisconsin, and Department of Immunology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006402449","display_name":"Carol A. Stevens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol A. Stevens","raw_affiliation_strings":["Section of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, Department of Medicine, University of Wisconsin, Madison, Wisconsin, and Department of Immunology, Mayo Clinic, Rochester, Minnesota","University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, Department of Medicine, University of Wisconsin, Madison, Wisconsin, and Department of Immunology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044980958","display_name":"William W. Busse","orcid":"https://orcid.org/0000-0003-2591-4696","observed_orcids":["https://orcid.org/0000-0003-2591-4696"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William W. Busse","raw_affiliation_strings":["Section of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, Department of Medicine, University of Wisconsin, Madison, Wisconsin, and Department of Immunology, Mayo Clinic, Rochester, Minnesota","University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, Department of Medicine, University of Wisconsin, Madison, Wisconsin, and Department of Immunology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035570881"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I135310074","https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":3.9852,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.93446284,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"147","issue":"6_Part_1","first_page":"1465","last_page":"1471"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.8669999837875366},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.921999990940094},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.9169999957084656},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.9350000023841858},{"id":"https://openalex.org/keywords/allergen-challenge","display_name":"allergen challenge","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6319499611854553},{"id":"https://openalex.org/C2779345167","wikidata":"https://www.wikidata.org/wiki/Q104541","display_name":"Aerosol","level":2,"score":0.5630272030830383},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.557500422000885},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.4936557710170746},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4846818745136261},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.42277786135673523},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.11884540319442749},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.08400005102157593},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.05761873722076416}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001985","descriptor_name":"Bronchial Provocation Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001991","descriptor_name":"Bronchitis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001999","descriptor_name":"Bronchoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013147","descriptor_name":"Spirometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016676","descriptor_name":"Macrophages, Alveolar","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1164/ajrccm/147.6_pt_1.1465","doi":"https://doi.org/10.1164/ajrccm/147.6_pt_1.1465","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm/147.6_pt_1.1465","pdf_url":null,"source":{"id":"https://openalex.org/S2751726451","display_name":"American Review of Respiratory Disease","issn_l":"0003-0805","issn":["0003-0805","2376-3752"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Review of Respiratory Disease","raw_type":"journal-article"},{"id":"pmid:8389107","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8389107","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American review of respiratory disease","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3836063003","display_name":null,"funder_award_id":"K08-01828","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G699214384","display_name":null,"funder_award_id":"AI15231","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8758245913","display_name":"AIRWAY BIOLOGY OF RHINOVIRUS 16 INFECTION AND ASTHMA","funder_award_id":"R01AI026609","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W29304431","https://openalex.org/W1963678276","https://openalex.org/W1983221612","https://openalex.org/W2022762527","https://openalex.org/W2047163318","https://openalex.org/W2065719831","https://openalex.org/W2085991478","https://openalex.org/W2109709469","https://openalex.org/W2124894851","https://openalex.org/W2126365788","https://openalex.org/W2146050924","https://openalex.org/W2166899892","https://openalex.org/W2315018741","https://openalex.org/W2331980604","https://openalex.org/W2398919530","https://openalex.org/W2410419920","https://openalex.org/W4251942731","https://openalex.org/W7122567731"],"related_works":["https://openalex.org/W1999917626","https://openalex.org/W2166318346","https://openalex.org/W1966518794","https://openalex.org/W2060670626","https://openalex.org/W1992142029","https://openalex.org/W29304431","https://openalex.org/W1936491616","https://openalex.org/W2152939884","https://openalex.org/W2157832975","https://openalex.org/W2336531231"],"abstract_inverted_index":{"Airway":[0],"inflammation":[1,17,171],"is":[2],"increasingly":[3],"recognized":[4],"as":[5,26,80,164],"a":[6,27,143],"pivotal":[7],"component":[8],"of":[9,100],"asthma.":[10],"Because":[11],"allergens":[12],"provoke":[13],"bronchial":[14,21],"constriction":[15],"and":[16,57,67,86,97,120,131,182],"in":[18,34,51,83,93,127,147,152,172,178,186],"allergic":[19,173],"subjects,":[20,56,174],"antigen":[22,44,71],"challenge":[23,45,74],"has":[24],"emerged":[25],"powerful":[28],"technique":[29],"for":[30],"evaluating":[31],"mechanisms":[32],"involved":[33],"this":[35,38],"process.":[36],"In":[37],"study,":[39],"we":[40],"compare":[41],"whole":[42],"lung":[43],"(WLAC)":[46],"with":[47,116,142],"segmental":[48],"bronchoprovocation":[49],"(SBP)":[50],"eight":[52],"allergic,":[53],"non-asthmatic,":[54],"non-smoking":[55],"evaluated":[58],"the":[59],"response":[60],"by":[61,89,103],"bronchoalveolar":[62],"lavage":[63],"(BAL)":[64],"prior":[65],"to,":[66],"48":[68,158],"h":[69,159],"after":[70],"challenge.":[72],"Both":[73],"techniques":[75,139],"evoked":[76,123],"airway":[77,170,180,189],"inflammation,":[78],"manifest":[79],"an":[81,91],"increase":[82,92],"total":[84,94],"cells":[85],"eosinophils":[87],"recovered":[88],"BAL,":[90],"protein":[95,134],"concentration,":[96],"enhanced":[98],"production":[99],"superoxide":[101],"anion":[102],"airspace":[104],"cells.":[105],"The":[106],"degree":[107],"to":[108],"which":[109],"these":[110],"changes":[111,157],"occurred":[112],"was":[113],"significantly":[114],"greater":[115],"SBP":[117,122,166],"than":[118],"WLAC,":[119],"only":[121,149],"persistent":[124,155],"measurable":[125],"change":[126],"alveolar":[128],"macrophage":[129],"density":[130],"eosinophil":[132],"granule":[133],"concentrations.":[135],"Moreover,":[136],"although":[137],"both":[138],"were":[140],"associated":[141],"comparable":[144],"immediate":[145],"fall":[146],"FEV1,":[148],"WLAC":[150],"resulted":[151],"statistically":[153],"significant":[154],"physiologic":[156],"afterwards.":[160],"We":[161],"conclude":[162],"that,":[163],"anticipated,":[165],"produces":[167],"more":[168],"intense":[169],"does":[175],"not":[176],"result":[177],"late":[179],"obstruction,":[181],"offers":[183],"specific":[184],"advantages":[185],"studying":[187],"allergen-driven":[188],"inflammation.":[190]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}