{"id":"https://openalex.org/W1968877547","doi":"https://doi.org/10.1016/j.ajpath.2013.08.017","title":"Bacterial Infection Increases Periodontal Bone Loss in Diabetic Rats through Enhanced Apoptosis","display_name":"Bacterial Infection Increases Periodontal Bone Loss in Diabetic Rats through Enhanced Apoptosis","publication_year":2013,"publication_date":"2013-10-08","ids":{"openalex":"https://openalex.org/W1968877547","doi":"https://doi.org/10.1016/j.ajpath.2013.08.017","mag":"1968877547","pmid":"https://pubmed.ncbi.nlm.nih.gov/24113454","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5745547"},"language":"en","primary_location":{"id":"doi:10.1016/j.ajpath.2013.08.017","doi":"https://doi.org/10.1016/j.ajpath.2013.08.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpath.2013.08.017","pdf_url":"http://ajp.amjpathol.org/article/S0002944013006032/pdf","source":{"id":"https://openalex.org/S145577119","display_name":"American Journal Of Pathology","issn_l":"0002-9440","issn":["0002-9440","1525-2191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://ajp.amjpathol.org/article/S0002944013006032/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020390969","display_name":"Sandra Pacios","orcid":"https://orcid.org/0000-0001-5977-6610","observed_orcids":["https://orcid.org/0000-0001-5977-6610"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Pacios","raw_affiliation_strings":["Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038364857","display_name":"Oelisoa Mireille Andriankaja","orcid":"https://orcid.org/0000-0002-0917-7633","observed_orcids":["https://orcid.org/0000-0002-0917-7633"]},"institutions":[{"id":"https://openalex.org/I158818660","display_name":"University of Puerto Rico, Medical Sciences Campus","ror":"https://ror.org/00h25w961","country_code":"PR","type":"education","lineage":["https://openalex.org/I158818660","https://openalex.org/I200399037"]},{"id":"https://openalex.org/I200399037","display_name":"University of Puerto Rico System","ror":"https://ror.org/02yg0nm07","country_code":"PR","type":"education","lineage":["https://openalex.org/I200399037"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["PR","US"],"is_corresponding":false,"raw_author_name":"Oelisoa Andriankaja","raw_affiliation_strings":["Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Center for Clinical Research and Health Promotion, School of Dental Medicine, University of Puerto Rico, San Juan, Puerto Rico","Center for Clinical Research and Health Promotion, School of Dental Medicine, University of Puerto Rico, San Juan, Puerto Rico","Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Center for Clinical Research and Health Promotion, School of Dental Medicine, University of Puerto Rico, San Juan, Puerto Rico","institution_ids":["https://openalex.org/I158818660","https://openalex.org/I200399037","https://openalex.org/I79576946"]},{"raw_affiliation_string":"Center for Clinical Research and Health Promotion, School of Dental Medicine, University of Puerto Rico, San Juan, Puerto Rico","institution_ids":["https://openalex.org/I158818660","https://openalex.org/I200399037"]},{"raw_affiliation_string":"Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078970092","display_name":"Jun Kang","orcid":"https://orcid.org/0000-0001-6692-1230","observed_orcids":["https://orcid.org/0000-0001-6692-1230"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Kang","raw_affiliation_strings":["Department of Periodontology, School and Hospital of Stomatology, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, School and Hospital of Stomatology, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073592324","display_name":"Maher Alnammary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maher Alnammary","raw_affiliation_strings":["Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113439040","display_name":"Jason Bae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Bae","raw_affiliation_strings":["Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066917905","display_name":"Beatriz de Brito Bezerra","orcid":"https://orcid.org/0000-0003-1686-6450","observed_orcids":["https://orcid.org/0000-0003-1686-6450"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Beatriz de Brito Bezerra","raw_affiliation_strings":["Prosthodontics and Periodontics Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prosthodontics and Periodontics Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038617092","display_name":"Helen C. Schreiner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen Schreiner","raw_affiliation_strings":["Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey","institution_ids":["https://openalex.org/I4405286694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042440777","display_name":"Daniel H. Fine","orcid":"https://orcid.org/0000-0001-6242-6451","observed_orcids":["https://orcid.org/0000-0001-6242-6451"]},"institutions":[{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel H. Fine","raw_affiliation_strings":["Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey","institution_ids":["https://openalex.org/I4405286694"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056774287","display_name":"Dana T. Graves","orcid":"https://orcid.org/0000-0002-4664-8529","observed_orcids":["https://orcid.org/0000-0002-4664-8529"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dana T. Graves","raw_affiliation_strings":["Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: dtgraves@dental.upenn.edu","Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: dtgraves@dental.upenn.edu","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5056774287"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":2800,"currency":"USD","value_usd":2800},"fwci":6.876,"has_fulltext":true,"cited_by_count":75,"citation_normalized_percentile":{"value":0.97101955,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"183","issue":"6","first_page":"1928","last_page":"1935"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.7422000169754028,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.7422000169754028,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.25459998846054077,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13328","display_name":"Osteomyelitis and Bone Disorders Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/periodontal-bone-loss","display_name":"periodontal bone loss","score":0.9049999713897705},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9300000071525574},{"id":"https://openalex.org/keywords/aggregatibacter-actinomycetemcomitans","display_name":"Aggregatibacter actinomycetemcomitans","score":0.9810000061988831},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.9679999947547913},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9660000205039978},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.8209999799728394},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8320000171661377},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.5879999995231628},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7003424763679504},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45620936155319214},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.3838048279285431},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35674750804901123},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34715619683265686},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07075297832489014}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016301","descriptor_name":"Alveolar Bone Loss","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016301","descriptor_name":"Alveolar Bone Loss","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D016301","descriptor_name":"Alveolar Bone Loss","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016871","descriptor_name":"Pasteurellaceae Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016871","descriptor_name":"Pasteurellaceae Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D016871","descriptor_name":"Pasteurellaceae Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016976","descriptor_name":"Aggregatibacter actinomycetemcomitans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.ajpath.2013.08.017","doi":"https://doi.org/10.1016/j.ajpath.2013.08.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpath.2013.08.017","pdf_url":"http://ajp.amjpathol.org/article/S0002944013006032/pdf","source":{"id":"https://openalex.org/S145577119","display_name":"American Journal Of Pathology","issn_l":"0002-9440","issn":["0002-9440","1525-2191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Pathology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5745547","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5745547","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:24113454","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24113454","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:repository.upenn.edu:20.500.14332/9372","doi":null,"is_oa":true,"landing_page_url":"https://repository.upenn.edu/handle/20.500.14332/9372","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"183","raw_type":"Article"},{"id":"pmh:oai:repository.upenn.edu:dental_papers-1064","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=1064&context=dental_papers","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Departmental Papers (Dental)","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1016/j.ajpath.2013.08.017","doi":"https://doi.org/10.1016/j.ajpath.2013.08.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpath.2013.08.017","pdf_url":"http://ajp.amjpathol.org/article/S0002944013006032/pdf","source":{"id":"https://openalex.org/S145577119","display_name":"American Journal Of Pathology","issn_l":"0002-9440","issn":["0002-9440","1525-2191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1845378498","display_name":null,"funder_award_id":"DE-017732","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G5909585136","display_name":"Core Center for Musculoskeletal Disorders","funder_award_id":"P30AR050950","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6397202843","display_name":"Diabetic Fracture Healing","funder_award_id":"R01AR060055","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000910291","display_name":"Diabetes-enhanced Experimental Periodontitis","funder_award_id":"R01DE017732","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"},{"id":"https://openalex.org/F4320337897","display_name":"Penn Center for Musculoskeletal Disorders","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968877547.pdf","grobid_xml":"https://content.openalex.org/works/W1968877547.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W29748414","https://openalex.org/W1577834403","https://openalex.org/W1593195558","https://openalex.org/W1925706324","https://openalex.org/W1964922032","https://openalex.org/W1971206408","https://openalex.org/W1973722411","https://openalex.org/W1980682706","https://openalex.org/W1985576422","https://openalex.org/W1988533223","https://openalex.org/W1990974422","https://openalex.org/W2002070061","https://openalex.org/W2002727339","https://openalex.org/W2017937067","https://openalex.org/W2018480371","https://openalex.org/W2026988411","https://openalex.org/W2027111854","https://openalex.org/W2029861410","https://openalex.org/W2033425579","https://openalex.org/W2035326606","https://openalex.org/W2037235015","https://openalex.org/W2038241080","https://openalex.org/W2039015646","https://openalex.org/W2043671725","https://openalex.org/W2050445378","https://openalex.org/W2062080406","https://openalex.org/W2067791442","https://openalex.org/W2070572867","https://openalex.org/W2078419961","https://openalex.org/W2078594613","https://openalex.org/W2078882998","https://openalex.org/W2084092378","https://openalex.org/W2093630253","https://openalex.org/W2093930780","https://openalex.org/W2098581073","https://openalex.org/W2100069737","https://openalex.org/W2115341402","https://openalex.org/W2120741277","https://openalex.org/W2134937110","https://openalex.org/W2135885268","https://openalex.org/W2143528121","https://openalex.org/W2144957471","https://openalex.org/W2145551978","https://openalex.org/W2153092921","https://openalex.org/W2159386785","https://openalex.org/W2170640959","https://openalex.org/W2171627084"],"related_works":["https://openalex.org/W2098581073","https://openalex.org/W2487591307","https://openalex.org/W2128697411","https://openalex.org/W2349867260","https://openalex.org/W2356553414","https://openalex.org/W2393963099","https://openalex.org/W2134937110","https://openalex.org/W1978783778","https://openalex.org/W2080327736","https://openalex.org/W2774098164"],"abstract_inverted_index":{"Periodontal":[0],"disease":[1,7],"is":[2,11],"the":[3,19,115,140],"most":[4],"common":[5],"osteolytic":[6],"in":[8,27,68,156,166,175,181,186],"humans":[9],"and":[10,46,63,81,91,122,144,172],"significantly":[12,157],"increased":[13,123,139],"by":[14,76,82,97],"diabetes":[15],"mellitus.":[16],"We":[17],"tested":[18],"hypothesis":[20],"that":[21,33,194],"bacterial":[22,179],"infection":[23,113,180],"induces":[24],"bone":[25,64,72,89,93,128,146,160,168,176],"loss":[26],"diabetic":[28,39,182],"animals":[29],"through":[30,188,198],"a":[31,49,199],"mechanism":[32],"involves":[34],"enhanced":[35,189],"apoptosis.":[36],"Type":[37],"II":[38],"rats":[40,183],"were":[41,58,66,95],"inoculated":[42],"with":[43,48,60,78,105,134],"Aggregatibacter":[44],"actinomycetemcomitans":[45],"treated":[47],"caspase-3":[50],"inhibitor,":[51],"ZDEVD-FMK,":[52],"or":[53],"vehicle":[54],"alone.":[55],"Apoptotic":[56],"cells":[57,121,125,193],"measured":[59,67,96],"TUNEL;":[61],"osteoblasts":[62],"area":[65,161],"H&E":[69],"sections.":[70],"New":[71],"formation":[73,94],"was":[74,103],"assessed":[75],"labeling":[77],"fluorescent":[79],"dyes":[80],"osteocalcin":[83],"mRNA":[84],"levels.":[85],"Osteoclast":[86],"number,":[87],"eroded":[88,145],"surface,":[90],"new":[92,167],"tartrate-resistant":[98],"acid":[99],"phosphatase":[100],"staining.":[101],"Immunohistochemistry":[102],"performed":[104],"an":[106,164,173],"antibody":[107],"against":[108],"tumor":[109,118],"necrosis":[110,119],"factor-\u03b1.":[111],"Bacterial":[112],"doubled":[114],"number":[116,141],"of":[117,142,153,163,191],"factor-\u03b1-expressing":[120],"apoptotic":[124],"adjacent":[126],"to":[127],"10-fold":[129],"(P":[130,148],"<":[131,149],"0.05).":[132],"Treatment":[133],"caspase":[135],"inhibitor":[136],"blocked":[137],"apoptosis,":[138],"osteoclasts,":[143],"surface":[147],"0.05);":[150],"yet,":[151],"inhibition":[152],"apoptosis":[154,190],"resulted":[155],"greater":[158],"net":[159],"because":[162],"increase":[165,174],"formation,":[169],"osteoblast":[170],"numbers,":[171],"coupling.":[177],"Thus,":[178],"stimulates":[184],"periodontitis,":[185],"part":[187],"osteoblastic":[192],"reduces":[195],"osseous":[196],"coupling":[197],"caspase-3-dependent":[200],"mechanism.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}