{"id":"https://openalex.org/W1968875445","doi":"https://doi.org/10.1097/00000542-199106000-00018","title":"Differences in Cerebral Blood Flow between Alpha-stat and pH-stat Management Are Eliminated during Periods of Decreased Systemic Flow and Pressure A Study during Cardiopulmonary Bypass in Rabbits","display_name":"Differences in Cerebral Blood Flow between Alpha-stat and pH-stat Management Are Eliminated during Periods of Decreased Systemic Flow and Pressure A Study during Cardiopulmonary Bypass in Rabbits","publication_year":1991,"publication_date":"1991-06-01","ids":{"openalex":"https://openalex.org/W1968875445","doi":"https://doi.org/10.1097/00000542-199106000-00018","mag":"1968875445","pmid":"https://pubmed.ncbi.nlm.nih.gov/1904205"},"language":"en","primary_location":{"id":"doi:10.1097/00000542-199106000-00018","doi":"https://doi.org/10.1097/00000542-199106000-00018","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-199106000-00018","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/74/6/1096/321659/0000542-199106000-00018.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pubs.asahq.org/anesthesiology/article-pdf/74/6/1096/321659/0000542-199106000-00018.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042976496","display_name":"Bradley J. Hindman","orcid":"https://orcid.org/0000-0003-2242-7980","observed_orcids":["https://orcid.org/0000-0003-2242-7980"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley\u00a0J. Hindman","raw_affiliation_strings":["Assistant Professor of Anesthesia","Department of Anesthesia, College of Medicine, University of Iowa, Iowa City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor of Anesthesia","institution_ids":[]},{"raw_affiliation_string":"Department of Anesthesia, College of Medicine, University of Iowa, Iowa City","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023019898","display_name":"Naohiko Funatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naohiko Funatsu","raw_affiliation_strings":["Research Fellow. Current affiliation: Yamaguchi University School of Medicine, Ube Yamaguchi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Fellow. Current affiliation: Yamaguchi University School of Medicine, Ube Yamaguchi, Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103389910","display_name":"Jeanette Harrington","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeanette Harrington","raw_affiliation_strings":["Research Fellow","University of Iowa, "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Fellow","institution_ids":[]},{"raw_affiliation_string":"University of Iowa, ","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006522457","display_name":"Johann Cutkomp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johann Cutkomp","raw_affiliation_strings":["Research Assistant"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Assistant","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023350278","display_name":"T. A. Miller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tim Miller","raw_affiliation_strings":["Resident in Anesthesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Resident in Anesthesia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020070598","display_name":"Michael M. Todd","orcid":"https://orcid.org/0000-0003-1531-5825","observed_orcids":["https://orcid.org/0000-0003-1531-5825"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael\u00a0M. Todd","raw_affiliation_strings":["Professor","University of Iowa, "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor","institution_ids":[]},{"raw_affiliation_string":"University of Iowa, ","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009361560","display_name":"John H. Tinker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John\u00a0H. Tinker","raw_affiliation_strings":["Professor and Head"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor and Head","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4009,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.87868729,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"74","issue":"6","first_page":"1096","last_page":"1102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cardiopulmonary-bypass","display_name":"cardiopulmonary bypass","score":0.8769999742507935},{"id":"https://openalex.org/keywords/mean-arterial-pressure","display_name":"mean arterial pressure","score":0.8450000286102295},{"id":"https://openalex.org/keywords/paco2","display_name":"PaCO2","score":0.7910000085830688},{"id":"https://openalex.org/keywords/arterial-ph","display_name":"arterial pH","score":0.6029999852180481},{"id":"https://openalex.org/keywords/hypothermic-cardiopulmonary-bypass","display_name":"hypothermic cardiopulmonary bypass","score":0.5049999952316284},{"id":"https://openalex.org/keywords/regional-cerebral-blood-flow","display_name":"regional cerebral blood flow","score":0.6460000276565552},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7870239019393921},{"id":"https://openalex.org/C2778881276","wikidata":"https://www.wikidata.org/wiki/Q552304","display_name":"Cardiopulmonary bypass","level":2,"score":0.6741166710853577},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.6554615497589111},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6271277666091919},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.5936868190765381},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.5311941504478455},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.47501859068870544},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33723294734954834},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.330812931060791},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.22308483719825745}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002315","descriptor_name":"Cardiopulmonary Bypass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002315","descriptor_name":"Cardiopulmonary Bypass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002315","descriptor_name":"Cardiopulmonary Bypass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010313","descriptor_name":"Partial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010313","descriptor_name":"Partial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010313","descriptor_name":"Partial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000542-199106000-00018","doi":"https://doi.org/10.1097/00000542-199106000-00018","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-199106000-00018","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/74/6/1096/321659/0000542-199106000-00018.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:1904205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1904205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1097/00000542-199106000-00018","doi":"https://doi.org/10.1097/00000542-199106000-00018","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-199106000-00018","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/74/6/1096/321659/0000542-199106000-00018.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8100000023841858,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968875445.pdf","grobid_xml":"https://content.openalex.org/works/W1968875445.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4251439755","https://openalex.org/W1971185134","https://openalex.org/W1971084346","https://openalex.org/W2381936772","https://openalex.org/W2034193452","https://openalex.org/W2067270305","https://openalex.org/W2055662173","https://openalex.org/W2041801999","https://openalex.org/W2040083618","https://openalex.org/W2043680123"],"abstract_inverted_index":{"Prior":[0],"reports":[1],"suggest":[2],"cerebral":[3],"blood":[4,26,67],"flow":[5,12,35,114,135,188,223,239],"(CBF)":[6],"responses":[7,31],"to":[8,32,65,104,145,172,186,216],"changing":[9,33],"bypass":[10,51,134,165,187,204,222,232,238],"(systemic)":[11],"rates":[13],"may":[14],"differ":[15],"between":[16,182,253],"alpha-stat":[17,66],"and":[18,36,46,126,148,152,175,243,252],"pH-stat":[19,95],"management.":[20],"To":[21],"compare":[22],"the":[23,105,158,228,244],"effect":[24],"of":[25,58,116,160,163,231,246],"gas":[27,68],"management":[28,69],"upon":[29],"CBF":[30,127,151,234],"systemic":[34],"pressure,":[37,196],"15":[38],"New":[39],"Zealand":[40],"White":[41],"rabbits,":[42],"anesthetized":[43],"with":[44,94,170,184,220,236],"fentanyl":[45],"diazepam,":[47],"underwent":[48],"nonpulsatile":[49],"cardiopulmonary":[50],"at":[52,82,112,142,157,206],"25":[53],"degrees":[54,84],"C.":[55,85],"One":[56],"group":[57,88],"animals":[59],"(n":[60,89],"=":[61,90,225,241],"8)":[62],"was":[63,92,110,137,248],"randomized":[64],"that":[70],"maintained":[71],"arterial":[72,191,199],"carbon":[73],"dioxide":[74],"tension":[75,201],"(PaCO2)":[76],"approximately":[77,99,121,214,217],"40":[78,100],"mmHg":[79,101,219],"when":[80,102],"measured":[81],"37":[83],"A":[86],"second":[87],"7)":[91],"managed":[93],"technique,":[96],"maintaining":[97],"PaCO2":[98],"corrected":[103],"animal's":[106],"actual":[107],"temperature.":[108],"Bypass":[109],"initiated":[111],"a":[113],"rate":[115,136],"100":[117,149],"ml.kg-1.min-1":[118],"and,":[119],"after":[120],"20":[122],"min,":[123],"control":[124],"hemodynamic":[125,153],"measurements":[128,154],"(radioactive":[129],"microspheres)":[130],"were":[131,155,178],"made.":[132],"Thereafter,":[133],"changed":[138],"in":[139],"random":[140],"order":[141],"15-min":[143],"intervals":[144],"50,":[146],"70,":[147],"ml.kg-1.min-1.":[150],"repeated":[156],"end":[159],"each":[161],"period":[162],"altered":[164],"flow.":[166],"Groups":[167],"differed":[168],"significantly":[169],"respect":[171,185],"both":[173],"pHa":[174],"PaCO2.":[176],"There":[177],"no":[179],"significant":[180],"differences":[181],"groups":[183],"rate,":[189],"mean":[190],"pressure":[192],"(MAP),":[193],"central":[194],"venous":[195],"temperature,":[197],"hematocrit,":[198],"oxygen":[200],"(PaCO2),":[202],"or":[203],"duration":[205],"any":[207],"measurement":[208],"point.":[209],"MAP":[210],"decreased":[211,235],"significantly,":[212],"from":[213],"80":[215],"65":[218],"decreasing":[221,237],"(P":[224,240],"0.0001).":[226],"Over":[227],"entire":[229],"range":[230],"flows,":[233],"0.001),":[242],"degree":[245],"change":[247],"equivalent":[249],"among":[250],"regions":[251],"groups.(ABSTRACT":[254],"TRUNCATED":[255],"AT":[256],"250":[257],"WORDS)":[258]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}