{"id":"https://openalex.org/W1968836067","doi":"https://doi.org/10.1371/journal.pone.0085344","title":"Discovery of Bile Salt Hydrolase Inhibitors Using an Efficient High-Throughput Screening System","display_name":"Discovery of Bile Salt Hydrolase Inhibitors Using an Efficient High-Throughput Screening System","publication_year":2014,"publication_date":"2014-01-14","ids":{"openalex":"https://openalex.org/W1968836067","doi":"https://doi.org/10.1371/journal.pone.0085344","mag":"1968836067","pmid":"https://pubmed.ncbi.nlm.nih.gov/24454844","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3891821"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0085344","doi":"https://doi.org/10.1371/journal.pone.0085344","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0085344","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0085344&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0085344&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075304355","display_name":"Katie Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie Smith","raw_affiliation_strings":["Department of Animal Science, University of Tennessee, Knoxville, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Science, University of Tennessee, Knoxville, Tennessee, United States of America","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060239112","display_name":"Ximin Zeng","orcid":"https://orcid.org/0000-0003-2795-6988","observed_orcids":["https://orcid.org/0000-0003-2795-6988"]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ximin Zeng","raw_affiliation_strings":["Department of Animal Science, University of Tennessee, Knoxville, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Science, University of Tennessee, Knoxville, Tennessee, United States of America","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082435542","display_name":"Jun Lin","orcid":"https://orcid.org/0000-0003-0377-1030","observed_orcids":["https://orcid.org/0000-0003-0377-1030"]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jun Lin","raw_affiliation_strings":["Department of Animal Science, University of Tennessee, Knoxville, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Science, University of Tennessee, Knoxville, Tennessee, United States of America","institution_ids":["https://openalex.org/I75027704"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082435542"],"corresponding_institution_ids":["https://openalex.org/I75027704"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":7.7135,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.97324653,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"e85344","last_page":"e85344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13791","display_name":"Veterinary medicine and infectious diseases","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.8209999799728394},{"id":"https://openalex.org/keywords/antibiotic-growth-promoters","display_name":"antibiotic growth promoters","score":0.8769999742507935},{"id":"https://openalex.org/keywords/antibiotic-alternatives","display_name":"antibiotic alternatives","score":0.8080000281333923},{"id":"https://openalex.org/keywords/ligilactobacillus-salivarius","display_name":"Lactobacillus salivarius","score":0.9520000219345093},{"id":"https://openalex.org/keywords/chickens","display_name":"chickens","score":0.4320000112056732},{"id":"https://openalex.org/keywords/tetracycline-antibiotics","display_name":"tetracycline antibiotics","score":0.7419999837875366},{"id":"https://openalex.org/keywords/roxarsone","display_name":"roxarsone","score":0.996999979019165},{"id":"https://openalex.org/keywords/riboflavin","display_name":"riboflavin","score":0.9570000171661377},{"id":"https://openalex.org/keywords/lipid-digestion","display_name":"lipid digestion","score":0.6610000133514404},{"id":"https://openalex.org/keywords/animal-growth-performance","display_name":"animal growth performance","score":0.7080000042915344},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C51323132","wikidata":"https://www.wikidata.org/wiki/Q626251","display_name":"High-throughput screening","level":2,"score":0.6968652606010437},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5070631504058838},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48291298747062683},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.45532914996147156},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.42833802103996277},{"id":"https://openalex.org/C2779172262","wikidata":"https://www.wikidata.org/wiki/Q422265","display_name":"Spiramycin","level":4,"score":0.41471806168556213},{"id":"https://openalex.org/C2776155809","wikidata":"https://www.wikidata.org/wiki/Q130365","display_name":"Riboflavin","level":2,"score":0.41173070669174194},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3282526433467865},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31137388944625854},{"id":"https://openalex.org/C2780206985","wikidata":"https://www.wikidata.org/wiki/Q213511","display_name":"Erythromycin","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000821","descriptor_name":"Animal Feed","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007778","descriptor_name":"Lactobacillus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007778","descriptor_name":"Lactobacillus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D057075","descriptor_name":"Enzyme Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0085344","doi":"https://doi.org/10.1371/journal.pone.0085344","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0085344","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0085344&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2880955","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3891821","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3891821","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3891821","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24454844","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24454844","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.817.9438","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.817.9438","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/f0/e6/pone.0085344.PMC3891821.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:e5522b882d204947b69055e670c0de92","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e5522b882d204947b69055e670c0de92","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 1, p e85344 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0085344","doi":"https://doi.org/10.1371/journal.pone.0085344","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0085344","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0085344&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6735000014305115},{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320309931","display_name":"AgResearch","ror":"https://ror.org/0124gwh94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968836067.pdf","grobid_xml":"https://content.openalex.org/works/W1968836067.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W76310475","https://openalex.org/W203488689","https://openalex.org/W1535081778","https://openalex.org/W1554889033","https://openalex.org/W1591061891","https://openalex.org/W1905791211","https://openalex.org/W1963536647","https://openalex.org/W1968582726","https://openalex.org/W1969503257","https://openalex.org/W1978272694","https://openalex.org/W1981035379","https://openalex.org/W1996697998","https://openalex.org/W1998676255","https://openalex.org/W2000192783","https://openalex.org/W2007776917","https://openalex.org/W2008804013","https://openalex.org/W2008833979","https://openalex.org/W2015095938","https://openalex.org/W2015129154","https://openalex.org/W2024754142","https://openalex.org/W2035779227","https://openalex.org/W2038868978","https://openalex.org/W2042195600","https://openalex.org/W2042238370","https://openalex.org/W2043616069","https://openalex.org/W2048730287","https://openalex.org/W2055364285","https://openalex.org/W2056408605","https://openalex.org/W2068242678","https://openalex.org/W2071586084","https://openalex.org/W2076999096","https://openalex.org/W2084164305","https://openalex.org/W2090907793","https://openalex.org/W2096595394","https://openalex.org/W2096997867","https://openalex.org/W2099610549","https://openalex.org/W2101571099","https://openalex.org/W2108616928","https://openalex.org/W2112842686","https://openalex.org/W2117398483","https://openalex.org/W2125003824","https://openalex.org/W2125552828","https://openalex.org/W2126979693","https://openalex.org/W2127320820","https://openalex.org/W2129295478","https://openalex.org/W2131157225","https://openalex.org/W2132022155","https://openalex.org/W2132645356","https://openalex.org/W2137448333","https://openalex.org/W2138007699","https://openalex.org/W2149303750","https://openalex.org/W2153568933","https://openalex.org/W2155321813","https://openalex.org/W2166749760","https://openalex.org/W2167179929","https://openalex.org/W2169936978","https://openalex.org/W2323188755","https://openalex.org/W2402876066","https://openalex.org/W3023874569","https://openalex.org/W4401213121"],"related_works":["https://openalex.org/W7096007714","https://openalex.org/W2887672362","https://openalex.org/W2089110886","https://openalex.org/W2584092516","https://openalex.org/W3011444194","https://openalex.org/W2619435213","https://openalex.org/W7100962591","https://openalex.org/W4403209938","https://openalex.org/W7097335822","https://openalex.org/W4410397619"],"abstract_inverted_index":{"The":[0],"global":[1],"trend":[2],"of":[3,7,27,34,68,92,98,153,192,249,251],"restricting":[4],"the":[5,16,64,96,162,186,204,239],"use":[6],"antibiotic":[8],"growth":[9,60],"promoters":[10],"(AGP)":[11],"in":[12,74,197],"animal":[13,59,255],"production":[14],"necessitates":[15],"need":[17],"to":[18,22,57,72,133,211,235],"develop":[19],"valid":[20],"alternatives":[21,71,234],"maintain":[23],"productivity":[24],"and":[25,51,79,87,121,125,127,157,167,173,178,202,226],"sustainability":[26],"food":[28],"animals.":[29],"Previous":[30],"studies":[31],"suggest":[32,245],"inhibition":[33],"bile":[35],"salt":[36],"hydrolase":[37],"(BSH),":[38],"an":[39,222],"intestinal":[40],"bacteria-produced":[41],"enzyme":[42],"that":[43],"exerts":[44],"negative":[45],"impact":[46],"on":[47,216],"host":[48],"fat":[49],"digestion":[50],"utilization,":[52],"is":[53],"a":[54,77,99,103,129,148,190,246],"promising":[55,166],"approach":[56,132],"promote":[58],"performance.":[61],"To":[62],"achieve":[63],"long":[65],"term":[66],"goal":[67],"developing":[69],"novel":[70],"AGPs,":[73],"this":[75,219,242],"study,":[76],"rapid":[78],"convenient":[80],"high-throughput":[81],"screening":[82,111,131],"(HTS)":[83],"system":[84,225],"was":[85,145],"developed":[86,221],"successfully":[88],"used":[89,206],"for":[90,253],"identification":[91],"BSH":[93,101,114,135,169,182,195,229],"inhibitors.":[94],"With":[95],"aid":[97],"high-purity":[100],"from":[102,241],"chicken":[104],"Lactobacillus":[105],"salivarius":[106],"strain,":[107],"we":[108],"optimized":[109],"various":[110,199],"conditions":[112],"(e.g.":[113,171],"concentration,":[115],"reaction":[116],"buffer":[117],"pH,":[118],"incubation":[119],"temperature":[120],"length,":[122],"substrate":[123],"type":[124],"concentration)":[126],"establish":[128],"precipitation-based":[130],"identify":[134],"inhibitors":[136,170,230],"using":[137,147],"96-well":[138],"or":[139],"384-well":[140],"microplates.":[141],"A":[142],"pilot":[143],"HTS":[144,187,224],"performed":[146],"small":[149],"compound":[150],"library":[151],"comprised":[152],"2,240":[154],"biologically":[155],"active":[156],"structurally":[158],"diverse":[159],"compounds.":[160],"Among":[161],"107":[163],"hits,":[164],"several":[165,228],"potent":[168,213],"riboflavin":[172],"phenethyl":[174],"caffeate)":[175],"were":[176],"selected":[177],"validated":[179],"by":[180],"standard":[181],"activity":[183],"assay.":[184],"Interestingly,":[185],"also":[188,244],"identified":[189,227],"panel":[191],"antibiotics":[193,201],"as":[194,233],"inhibitor;":[196],"particular,":[198],"tetracycline":[200],"roxarsone,":[203],"widely":[205],"AGP,":[207],"have":[208],"been":[209],"demonstrated":[210],"display":[212],"inhibitory":[214],"effect":[215],"BSH.":[217],"Together,":[218],"study":[220,243],"efficient":[223],"with":[231],"potential":[232],"AGP.":[236],"In":[237],"addition,":[238],"findings":[240],"new":[247],"mode":[248],"action":[250],"AGP":[252],"promoting":[254],"growth.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}