{"id":"https://openalex.org/W1968832830","doi":"https://doi.org/10.1074/jbc.m109.087171","title":"Vinculin Facilitates Cell Invasion into Three-dimensional Collagen Matrices","display_name":"Vinculin Facilitates Cell Invasion into Three-dimensional Collagen Matrices","publication_year":2010,"publication_date":"2010-02-25","ids":{"openalex":"https://openalex.org/W1968832830","doi":"https://doi.org/10.1074/jbc.m109.087171","mag":"1968832830","pmid":"https://pubmed.ncbi.nlm.nih.gov/20181946","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2857131"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m109.087171","doi":"https://doi.org/10.1074/jbc.m109.087171","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.087171","pdf_url":"http://www.jbc.org/article/S0021925820550904/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820550904/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029509930","display_name":"Claudia Tanja Mierke","orcid":"https://orcid.org/0000-0002-6622-335X","observed_orcids":["https://orcid.org/0000-0002-6622-335X"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Claudia T. Mierke","raw_affiliation_strings":["Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, 91052 Erlangen, Germany. claudia.mierke@t-online.de","Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, 91052 Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, 91052 Erlangen, Germany. claudia.mierke@t-online.de","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, 91052 Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005495276","display_name":"Philip Kollmannsberger","orcid":"https://orcid.org/0000-0002-8049-6186","observed_orcids":["https://orcid.org/0000-0002-8049-6186"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philip Kollmannsberger","raw_affiliation_strings":["Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, 91052 Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, 91052 Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008169626","display_name":"Daniel Paranhos Zitterbart","orcid":"https://orcid.org/0000-0001-9429-4350","observed_orcids":["https://orcid.org/0000-0001-9429-4350"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Paranhos Zitterbart","raw_affiliation_strings":["Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, 91052 Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, 91052 Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048623987","display_name":"Gerold Diez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerold Diez","raw_affiliation_strings":["Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, 91052 Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, 91052 Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108446785","display_name":"Thorsten M. Koch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thorsten M. Koch","raw_affiliation_strings":["Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, 91052 Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, 91052 Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007266894","display_name":"Susanna Marg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Susanna Marg","raw_affiliation_strings":["Interdisziplin\u00e4res Zentrum f\u00fcr Klinische Forschung Leipzig, Faculty of Medicine, University of Leipzig, 404103 Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisziplin\u00e4res Zentrum f\u00fcr Klinische Forschung Leipzig, Faculty of Medicine, University of Leipzig, 404103 Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081296506","display_name":"Wolfgang H. Ziegler","orcid":"https://orcid.org/0000-0003-4529-1916","observed_orcids":["https://orcid.org/0000-0003-4529-1916"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang H. Ziegler","raw_affiliation_strings":["Interdisziplin\u00e4res Zentrum f\u00fcr Klinische Forschung Leipzig, Faculty of Medicine, University of Leipzig, 404103 Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisziplin\u00e4res Zentrum f\u00fcr Klinische Forschung Leipzig, Faculty of Medicine, University of Leipzig, 404103 Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015345229","display_name":"Wolfgang H. Goldmann","orcid":"https://orcid.org/0000-0003-0738-2665","observed_orcids":["https://orcid.org/0000-0003-0738-2665"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang H. Goldmann","raw_affiliation_strings":["Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, 91052 Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, 91052 Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012141730","display_name":"Ben Fabry","orcid":"https://orcid.org/0000-0003-1737-0465","observed_orcids":["https://orcid.org/0000-0003-1737-0465"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ben Fabry","raw_affiliation_strings":["Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, 91052 Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, 91052 Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029509930"],"corresponding_institution_ids":["https://openalex.org/I181369854"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.3872,"has_fulltext":true,"cited_by_count":199,"citation_normalized_percentile":{"value":0.95515067,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"285","issue":"17","first_page":"13121","last_page":"13130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vinculin","display_name":"vinculin","score":1.0},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cell-motility","display_name":"cell motility","score":0.796999990940094},{"id":"https://openalex.org/keywords/traction-force","display_name":"traction force","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.7329999804496765},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.5640000104904175},{"id":"https://openalex.org/keywords/actomyosin-cytoskeleton","display_name":"actomyosin cytoskeleton","score":0.8539999723434448},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.6290000081062317},{"id":"https://openalex.org/keywords/cytoskeletal-remodeling","display_name":"cytoskeletal remodeling","score":0.6650000214576721},{"id":"https://openalex.org/keywords/mouse-embryonic-fibroblasts","display_name":"mouse embryonic fibroblasts","score":0.878000020980835}],"concepts":[{"id":"https://openalex.org/C2777979848","wikidata":"https://www.wikidata.org/wiki/Q424042","display_name":"Vinculin","level":4,"score":0.9915468692779541},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7524590492248535},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.6875631809234619},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.6769617795944214},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.6762685775756836},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.674882173538208},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.45593327283859253},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.4221463203430176},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41558730602264404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31819936633110046},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28697919845581055},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.17167383432388306},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14186277985572815}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016596","descriptor_name":"Vinculin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016596","descriptor_name":"Vinculin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1074/jbc.m109.087171","doi":"https://doi.org/10.1074/jbc.m109.087171","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.087171","pdf_url":"http://www.jbc.org/article/S0021925820550904/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2857131","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2857131","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:20181946","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20181946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:epic.awi.de:22593","doi":null,"is_oa":false,"landing_page_url":"https://epic.awi.de/id/eprint/22593/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400378","display_name":"Helmholtz-Zentrum f\u00fcr Polar-und Meeresforschung (Alfred-Wegener-Institut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799732068","host_organization_name":"Royal Prince Alfred Hospital","host_organization_lineage":["https://openalex.org/I2799732068"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"mag:2183540852","doi":null,"is_oa":false,"landing_page_url":"http://lpmt.biomed.uni-erlangen.de/mediafiles/publications/Mierke%20JBC%202010.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1074/jbc.m109.087171","doi":"https://doi.org/10.1074/jbc.m109.087171","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.087171","pdf_url":"http://www.jbc.org/article/S0021925820550904/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4864762343","display_name":"Micromechanics of the airway smooth muscle cell","funder_award_id":"R01HL065960","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968832830.pdf","grobid_xml":"https://content.openalex.org/works/W1968832830.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W54165365","https://openalex.org/W1594278877","https://openalex.org/W1964106556","https://openalex.org/W1967265143","https://openalex.org/W1969359529","https://openalex.org/W1971114436","https://openalex.org/W1973089587","https://openalex.org/W1977676064","https://openalex.org/W1978222826","https://openalex.org/W1978992840","https://openalex.org/W1991370659","https://openalex.org/W1999582860","https://openalex.org/W2000304973","https://openalex.org/W2002208582","https://openalex.org/W2006073003","https://openalex.org/W2044545243","https://openalex.org/W2048172586","https://openalex.org/W2049162816","https://openalex.org/W2053742656","https://openalex.org/W2054792338","https://openalex.org/W2059532010","https://openalex.org/W2086641174","https://openalex.org/W2098518658","https://openalex.org/W2098918253","https://openalex.org/W2100491916","https://openalex.org/W2106374411","https://openalex.org/W2110834542","https://openalex.org/W2112346252","https://openalex.org/W2129926378","https://openalex.org/W2149828650","https://openalex.org/W2159325467","https://openalex.org/W2185271266"],"related_works":["https://openalex.org/W2183540852","https://openalex.org/W1965277696","https://openalex.org/W1649770923","https://openalex.org/W2082071249","https://openalex.org/W2038476759","https://openalex.org/W1588280167","https://openalex.org/W7206360290","https://openalex.org/W7207364588","https://openalex.org/W2128445829","https://openalex.org/W2170330839"],"abstract_inverted_index":{"The":[0,42],"cytoskeletal":[1],"protein":[2],"vinculin":[3,24,45,60,74,77,151,172,179],"contributes":[4],"to":[5,14,141,159,195],"the":[6,10,15,26,197],"mechanical":[7],"link":[8],"of":[9,28,44,189,200],"contractile":[11],"actomyosin":[12],"cytoskeleton":[13,116],"extracellular":[16],"matrix":[17,182],"(ECM)":[18],"through":[19,49,184],"integrin":[20],"receptors.":[21],"In":[22],"addition,":[23],"modulates":[25],"dynamics":[27],"cell":[29,36,47,63],"adhesions":[30],"and":[31,76,113,143],"is":[32,54,120],"associated":[33],"with":[34,95,122,150],"decreased":[35],"motility":[37,70,126],"on":[38,46,90],"two-dimensional":[39,91,125],"ECM":[40,52],"substrates.":[41],"effect":[43],"invasion":[48,64,183],"dense":[50,162],"three-dimensional":[51,66,105,133,165,181],"gels":[53],"unknown.":[55],"Here,":[56],"we":[57],"report":[58],"how":[59],"expression":[61],"affects":[62],"into":[65,161],"collagen":[67,106,142,166],"matrices.":[68,107],"Cell":[69],"was":[71],"investigated":[72],"in":[73,102],"knockout":[75,84,109,152,173],"expressing":[78],"wild-type":[79,96],"mouse":[80],"embryonic":[81],"fibroblasts.":[82],"Vinculin":[83,108],"cells":[85,110,137,156],"were":[86,111,157,169],"2-fold":[87],"more":[88,117,139],"motile":[89],"collagen-coated":[92],"substrates":[93],"compared":[94,149],"cells,":[97],"but":[98,127],"3-fold":[99,145],"less":[100],"invasive":[101],"2.4":[103],"mg/ml":[104],"softer":[112],"remodeled":[114],"their":[115,123,131],"dynamically,":[118],"which":[119],"consistent":[121],"enhanced":[124,187],"does":[128],"not":[129],"explain":[130],"reduced":[132],"invasiveness.":[134],"Importantly,":[135],"vinculin-expressing":[136,155],"adhered":[138],"strongly":[140],"generated":[144],"higher":[146],"traction":[147,190],"forces":[148,191],"cells.":[153,174],"Moreover,":[154],"able":[158],"migrate":[160],"(5.8":[163],"mg/ml)":[164],"matrices":[167],"that":[168,178,192],"impenetrable":[170],"for":[171],"These":[175],"findings":[176],"suggest":[177],"facilitates":[180],"up-regulation":[185],"or":[186],"transmission":[188],"are":[193],"needed":[194],"overcome":[196],"steric":[198],"hindrance":[199],"ECMs.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}