{"id":"https://openalex.org/W1968810322","doi":"https://doi.org/10.1182/blood-2006-06-030841","title":"Mad2 is required for optimal hematopoiesis: Mad2 associates with c-Kit in MO7e cells","display_name":"Mad2 is required for optimal hematopoiesis: Mad2 associates with c-Kit in MO7e cells","publication_year":2006,"publication_date":"2006-10-12","ids":{"openalex":"https://openalex.org/W1968810322","doi":"https://doi.org/10.1182/blood-2006-06-030841","mag":"1968810322","pmid":"https://pubmed.ncbi.nlm.nih.gov/17038523","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1801064"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2006-06-030841","doi":"https://doi.org/10.1182/blood-2006-06-030841","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2006-06-030841","pdf_url":"https://ashpublications.org/blood/article-pdf/109/5/1923/1478988/zh800507001923.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/109/5/1923/1478988/zh800507001923.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021620288","display_name":"Shigeki Ito","orcid":"https://orcid.org/0000-0002-3899-6603","observed_orcids":["https://orcid.org/0000-0002-3899-6603"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shigeki Ito","raw_affiliation_strings":["Department of Microbiology and Immunology and","Walther Oncology Center, Indiana University School of Medicine, Indianapolis; the Walther Cancer Institute, Indianapolis, IN; and","the Walther Cancer Institute, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology and","institution_ids":[]},{"raw_affiliation_string":"Walther Oncology Center, Indiana University School of Medicine, Indianapolis; the Walther Cancer Institute, Indianapolis, IN; and","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"the Walther Cancer Institute, Indianapolis, IN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031468426","display_name":"Charlie Mantel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlie R. Mantel","raw_affiliation_strings":["Department of Microbiology and Immunology and","Walther Oncology Center, Indiana University School of Medicine, Indianapolis; the Walther Cancer Institute, Indianapolis, IN; and","the Walther Cancer Institute, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology and","institution_ids":[]},{"raw_affiliation_string":"Walther Oncology Center, Indiana University School of Medicine, Indianapolis; the Walther Cancer Institute, Indianapolis, IN; and","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"the Walther Cancer Institute, Indianapolis, IN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017921394","display_name":"Myung\u2010Kwan Han","orcid":"https://orcid.org/0000-0003-1931-8898","observed_orcids":["https://orcid.org/0000-0003-1931-8898","https://orcid.org/0000-0001-5536-9778"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Myung-Kwan Han","raw_affiliation_strings":["Department of Microbiology and Immunology and","Department of Microbiology and Immunology, Chonbuk National University Medical School, Jeonju, South Korea","Walther Oncology Center, Indiana University School of Medicine, Indianapolis; the Walther Cancer Institute, Indianapolis, IN; and","the Walther Cancer Institute, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology and","institution_ids":[]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Chonbuk National University Medical School, Jeonju, South Korea","institution_ids":["https://openalex.org/I80611190"]},{"raw_affiliation_string":"Walther Oncology Center, Indiana University School of Medicine, Indianapolis; the Walther Cancer Institute, Indianapolis, IN; and","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"the Walther Cancer Institute, Indianapolis, IN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065816840","display_name":"Sunanda Basu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunanda Basu","raw_affiliation_strings":["Department of Microbiology and Immunology and","Walther Oncology Center, Indiana University School of Medicine, Indianapolis; the Walther Cancer Institute, Indianapolis, IN; and","the Walther Cancer Institute, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology and","institution_ids":[]},{"raw_affiliation_string":"Walther Oncology Center, Indiana University School of Medicine, Indianapolis; the Walther Cancer Institute, Indianapolis, IN; and","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"the Walther Cancer Institute, Indianapolis, IN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001045007","display_name":"Seiji Fukuda","orcid":"https://orcid.org/0000-0003-2397-3326","observed_orcids":["https://orcid.org/0000-0003-2397-3326"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seiji Fukuda","raw_affiliation_strings":["Department of Microbiology and Immunology and","Walther Oncology Center, Indiana University School of Medicine, Indianapolis; the Walther Cancer Institute, Indianapolis, IN; and","the Walther Cancer Institute, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology and","institution_ids":[]},{"raw_affiliation_string":"Walther Oncology Center, Indiana University School of Medicine, Indianapolis; the Walther Cancer Institute, Indianapolis, IN; and","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"the Walther Cancer Institute, Indianapolis, IN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034118912","display_name":"Scott H. Cooper","orcid":"https://orcid.org/0000-0001-9091-8269","observed_orcids":["https://orcid.org/0000-0001-9091-8269"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Cooper","raw_affiliation_strings":["Department of Microbiology and Immunology and","Walther Oncology Center, Indiana University School of Medicine, Indianapolis; the Walther Cancer Institute, Indianapolis, IN; and","the Walther Cancer Institute, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology and","institution_ids":[]},{"raw_affiliation_string":"Walther Oncology Center, Indiana University School of Medicine, Indianapolis; the Walther Cancer Institute, Indianapolis, IN; and","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"the Walther Cancer Institute, Indianapolis, IN","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038161052","display_name":"Hal E. Broxmeyer","orcid":"https://orcid.org/0000-0001-6575-0476","observed_orcids":["https://orcid.org/0000-0001-6575-0476"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hal E. Broxmeyer","raw_affiliation_strings":["Department of Microbiology and Immunology and","Walther Oncology Center, Indiana University School of Medicine, Indianapolis; the Walther Cancer Institute, Indianapolis, IN; and","the Walther Cancer Institute, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology and","institution_ids":[]},{"raw_affiliation_string":"Walther Oncology Center, Indiana University School of Medicine, Indianapolis; the Walther Cancer Institute, Indianapolis, IN; and","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"the Walther Cancer Institute, Indianapolis, IN","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.9664,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.76357886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"109","issue":"5","first_page":"1923","last_page":"1930"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mad2","display_name":"Mad2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitotic-spindle-assembly-checkpoint","display_name":"mitotic spindle checkpoint","score":0.8240000009536743},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/c-kit","display_name":"CD117","score":0.8730000257492065},{"id":"https://openalex.org/keywords/hematopoietic-progenitor-cells","display_name":"hematopoietic progenitor cells","score":0.9779999852180481},{"id":"https://openalex.org/keywords/stem-cell-factor","display_name":"stem cell factor","score":0.8240000009536743},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cfu-gm","display_name":"CFU-GM","score":0.8059999942779541},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7039999961853027},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/mo7e-cells","display_name":"MO7e cells","score":0.875}],"concepts":[{"id":"https://openalex.org/C2777563682","wikidata":"https://www.wikidata.org/wiki/Q24721471","display_name":"Mad2","level":5,"score":0.9608904123306274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.592917263507843},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5510943531990051},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.49183201789855957},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.37437134981155396},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36140790581703186},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.19406378269195557},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1451617181301117},{"id":"https://openalex.org/C47432576","wikidata":"https://www.wikidata.org/wiki/Q918594","display_name":"Spindle apparatus","level":4,"score":0.13657528162002563},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11333322525024414}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019089","descriptor_name":"Stem Cell Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064246","descriptor_name":"Mad2 Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1182/blood-2006-06-030841","doi":"https://doi.org/10.1182/blood-2006-06-030841","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2006-06-030841","pdf_url":"https://ashpublications.org/blood/article-pdf/109/5/1923/1478988/zh800507001923.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1801064","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1801064","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Text"},{"id":"pmid:17038523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17038523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.327.6343","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.6343","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://bloodjournal.hematologylibrary.org/content/109/5/1923.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1182/blood-2006-06-030841","doi":"https://doi.org/10.1182/blood-2006-06-030841","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2006-06-030841","pdf_url":"https://ashpublications.org/blood/article-pdf/109/5/1923/1478988/zh800507001923.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1093411735","display_name":"Mechanisms of Synergistic Regulation of Stem/Progenitors","funder_award_id":"R01HL056416","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1202359724","display_name":"Chemokines/Cytokines and Receptors in Stem Cell Homing","funder_award_id":"R01DK053674","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2546977291","display_name":null,"funder_award_id":"DK53674","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3565741846","display_name":null,"funder_award_id":"HL67384","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3747627319","display_name":"Cytokine Enhancement of Myeloid Progenitor Cell Survival","funder_award_id":"R01HL067384","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4647722578","display_name":null,"funder_award_id":"HL 56416","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968810322.pdf","grobid_xml":"https://content.openalex.org/works/W1968810322.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W18739752","https://openalex.org/W193851687","https://openalex.org/W593384367","https://openalex.org/W1488719611","https://openalex.org/W1490555452","https://openalex.org/W1552274890","https://openalex.org/W1556017388","https://openalex.org/W1591540697","https://openalex.org/W1858315965","https://openalex.org/W1963750681","https://openalex.org/W1966773208","https://openalex.org/W1967657989","https://openalex.org/W1973544072","https://openalex.org/W1973916918","https://openalex.org/W1991116680","https://openalex.org/W2000551045","https://openalex.org/W2000929253","https://openalex.org/W2006389406","https://openalex.org/W2011722739","https://openalex.org/W2012810528","https://openalex.org/W2014776078","https://openalex.org/W2021312110","https://openalex.org/W2025713007","https://openalex.org/W2039426604","https://openalex.org/W2053423170","https://openalex.org/W2057490312","https://openalex.org/W2077278757","https://openalex.org/W2078358000","https://openalex.org/W2084314276","https://openalex.org/W2084567406","https://openalex.org/W2089588210","https://openalex.org/W2091458058","https://openalex.org/W2097973787","https://openalex.org/W2099257384","https://openalex.org/W2100495944","https://openalex.org/W2102653975","https://openalex.org/W2106285650","https://openalex.org/W2123154779","https://openalex.org/W2128150699","https://openalex.org/W2136896400","https://openalex.org/W2139524845","https://openalex.org/W2157452670","https://openalex.org/W2164812741","https://openalex.org/W2228095215","https://openalex.org/W2266255187","https://openalex.org/W2375468400","https://openalex.org/W2410131683","https://openalex.org/W2410687897","https://openalex.org/W2474600807","https://openalex.org/W4297671284","https://openalex.org/W4388117542"],"related_works":["https://openalex.org/W2565664480","https://openalex.org/W2495780533","https://openalex.org/W7098137288","https://openalex.org/W2594064310","https://openalex.org/W79461703","https://openalex.org/W2069681027","https://openalex.org/W1593116832","https://openalex.org/W2411595601","https://openalex.org/W2102653975","https://openalex.org/W6978314911"],"abstract_inverted_index":{"Mitotic":[0],"arrest":[1],"deficiency":[2],"2":[3],"(Mad2)":[4],"is":[5,14,163],"a":[6,22],"component":[7],"of":[8,45,75,98,127,140,155,168,187],"mitotic":[9],"spindle":[10],"checkpoint":[11],"proteins":[12],"and":[13,36,42,90,105,111],"essential":[15],"for":[16,24],"accurate":[17],"chromosome":[18],"segregation.":[19],"We":[20],"investigated":[21],"role":[23],"Mad2":[25,141,148,162,188],"in":[26,64,81,96,120,152,165,173],"hematopoiesis":[27],"using":[28],"Mad2-haploinsufficient":[29],"(Mad2+/-)":[30],"mice.":[31],"Mad2+/-":[32,53,82,110],"bone":[33],"marrow":[34],"(BM)":[35],"spleen":[37],"manifested":[38],"decreased":[39],"absolute":[40],"numbers":[41],"cycling":[43],"status":[44],"immature,":[46],"but":[47],"not":[48,60],"mature,":[49],"hematopoietic":[50,170],"progenitor":[51,171],"cells.":[52,157],"BM":[54,85],"granulocyte-macrophage":[55],"colony-forming":[56],"units":[57],"(CFU-GMs)":[58],"did":[59],"manifest":[61],"synergistic":[62,166],"proliferation":[63],"response":[65,174],"to":[66,138,175],"stem":[67],"cell":[68],"factor":[69],"(SCF)":[70],"plus":[71,135,177],"GM-CSF.":[72,91],"The":[73],"percentage":[74],"annexin":[76],"V+":[77],"cells":[78,114,123,172],"was":[79,115],"higher":[80],"than":[83],"Mad2+/+c-Kit+lin-":[84],"after":[86],"culture":[87],"with":[88,129,133,150,189],"SCF":[89,134,176],"However,":[92],"no":[93],"significant":[94],"difference":[95],"phosphorylation":[97],"extracellular":[99],"signal-related":[100],"kinase":[101],"(Erk1/2)":[102],"at":[103,107],"Thr202/Tyr204":[104],"Akt":[106],"Ser473":[108],"between":[109],"Mad2+/+BM":[112],"c-Kit+lin-":[113],"observed.":[116],"Immunoprecipitation":[117],"assays":[118],"performed":[119],"human":[121],"MO7e":[122,156],"demonstrated":[124,146],"physical":[125,185],"association":[126,186],"c-Kit":[128,151],"Mad2.":[130],"Moreover,":[131],"stimulation":[132],"GM-CSF":[136],"led":[137],"dissociation":[139],"from":[142],"c-Kit.":[143,190],"Confocal":[144],"microscopy":[145],"that":[147,161,180],"colocalized":[149],"the":[153],"cytoplasm":[154],"These":[158],"results":[159],"suggest":[160],"involved":[164],"growth":[167],"immature":[169],"GM-CSF,":[178],"effects":[179],"may":[181],"be":[182],"mediated":[183],"via":[184]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
