{"id":"https://openalex.org/W1968800204","doi":"https://doi.org/10.1016/j.neuroscience.2012.11.061","title":"Acute antidepressant treatment differently modulates ERK/MAPK activation in neurons and astrocytes of the adult mouse prefrontal cortex","display_name":"Acute antidepressant treatment differently modulates ERK/MAPK activation in neurons and astrocytes of the adult mouse prefrontal cortex","publication_year":2012,"publication_date":"2012-12-10","ids":{"openalex":"https://openalex.org/W1968800204","doi":"https://doi.org/10.1016/j.neuroscience.2012.11.061","mag":"1968800204","pmid":"https://pubmed.ncbi.nlm.nih.gov/23238574"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroscience.2012.11.061","doi":"https://doi.org/10.1016/j.neuroscience.2012.11.061","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuroscience.2012.11.061","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002727796","display_name":"Barbara Di Benedetto","orcid":"https://orcid.org/0000-0001-6537-9072","observed_orcids":["https://orcid.org/0000-0001-6537-9072"]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. Di Benedetto","raw_affiliation_strings":["Max Planck Institute of Psychiatry, 80804 Munich, Germany; Department of Psychiatry and Psychotherapy, University of Regensburg, 93053 Regensburg, Germany. Electronic address: barbara@mpipsykl.mpg.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute of Psychiatry, 80804 Munich, Germany; Department of Psychiatry and Psychotherapy, University of Regensburg, 93053 Regensburg, Germany. Electronic address: barbara@mpipsykl.mpg.de","institution_ids":["https://openalex.org/I4210145969","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002689780","display_name":"Julika Radecke","orcid":"https://orcid.org/0000-0002-5815-5537","observed_orcids":["https://orcid.org/0000-0002-5815-5537"]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Radecke","raw_affiliation_strings":["Max Planck Institute of Psychiatry, 80804 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute of Psychiatry, 80804 Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058281761","display_name":"Mathias V. Schmidt","orcid":"https://orcid.org/0000-0002-3788-2268","observed_orcids":["https://orcid.org/0000-0002-3788-2268"]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M.V. Schmidt","raw_affiliation_strings":["Max Planck Institute of Psychiatry, 80804 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute of Psychiatry, 80804 Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048419237","display_name":"Rainer Rupprecht","orcid":"https://orcid.org/0000-0003-2939-9062","observed_orcids":["https://orcid.org/0000-0003-2939-9062"]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R. Rupprecht","raw_affiliation_strings":["Max Planck Institute of Psychiatry, 80804 Munich, Germany; Department of Psychiatry and Psychotherapy, University of Regensburg, 93053 Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute of Psychiatry, 80804 Munich, Germany; Department of Psychiatry and Psychotherapy, University of Regensburg, 93053 Regensburg, Germany","institution_ids":["https://openalex.org/I4210145969","https://openalex.org/I60668342"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":2.5861,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.87395219,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"232","issue":null,"first_page":"161","last_page":"168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.7820000052452087},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.972000002861023},{"id":"https://openalex.org/keywords/extracellular-signal-regulated-kinase-1-2","display_name":"ERK1/ERK2","score":0.7630000114440918},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.9039999842643738},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.9800000190734863},{"id":"https://openalex.org/keywords/fluoxetine","display_name":"fluoxetine","score":0.9549999833106995},{"id":"https://openalex.org/keywords/desipramine","display_name":"desipramine","score":1.0},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.847000002861023},{"id":"https://openalex.org/keywords/chronic-stress","display_name":"chronic stress","score":0.5509999990463257},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.5649999976158142},{"id":"https://openalex.org/keywords/acute-drug-effects","display_name":"acute drug effects","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.8926640748977661},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.7239394187927246},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.6070104241371155},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.587958574295044},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5569533705711365},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.5371817350387573},{"id":"https://openalex.org/C2780250439","wikidata":"https://www.wikidata.org/wiki/Q423288","display_name":"Desipramine","level":4,"score":0.5124667286872864},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.46052178740501404},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4588388502597809},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.4434530735015869},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4292244613170624},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4155743420124054},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.40108081698417664},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32305362820625305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30513957142829895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2706661820411682},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2541886568069458},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.23319286108016968},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003891","descriptor_name":"Desipramine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005473","descriptor_name":"Fluoxetine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.neuroscience.2012.11.061","doi":"https://doi.org/10.1016/j.neuroscience.2012.11.061","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuroscience.2012.11.061","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},{"id":"pmid:23238574","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23238574","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:epub.uni-regensburg.de:62740","doi":null,"is_oa":false,"landing_page_url":"http://orcid.org/0000-0001-6537-9072>,","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.mpg.de:item_1836406","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11858/00-001M-0000-0014-F4D4-0","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuroscience","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W72199885","https://openalex.org/W1503716530","https://openalex.org/W1524934458","https://openalex.org/W1595912406","https://openalex.org/W1710423957","https://openalex.org/W1928141651","https://openalex.org/W1970537792","https://openalex.org/W1970836600","https://openalex.org/W1973642840","https://openalex.org/W1975760153","https://openalex.org/W1980153635","https://openalex.org/W1981874044","https://openalex.org/W1983617759","https://openalex.org/W1986287415","https://openalex.org/W1989505370","https://openalex.org/W1996447644","https://openalex.org/W1997270590","https://openalex.org/W1997632825","https://openalex.org/W1997656209","https://openalex.org/W1999157161","https://openalex.org/W2000975356","https://openalex.org/W2012714268","https://openalex.org/W2017727557","https://openalex.org/W2021872048","https://openalex.org/W2046342486","https://openalex.org/W2050452462","https://openalex.org/W2051113383","https://openalex.org/W2053823852","https://openalex.org/W2060035717","https://openalex.org/W2083875726","https://openalex.org/W2090760765","https://openalex.org/W2097155763","https://openalex.org/W2098815266","https://openalex.org/W2100482653","https://openalex.org/W2101626807","https://openalex.org/W2110831253","https://openalex.org/W2116762319","https://openalex.org/W2117560547","https://openalex.org/W2127087678","https://openalex.org/W2140017673","https://openalex.org/W2146918064","https://openalex.org/W2158656250","https://openalex.org/W2160369817","https://openalex.org/W2166070786","https://openalex.org/W2170318731","https://openalex.org/W2948665150"],"related_works":["https://openalex.org/W2914649743","https://openalex.org/W2030935953","https://openalex.org/W1524934458","https://openalex.org/W2103478749","https://openalex.org/W2002669733","https://openalex.org/W2509828714","https://openalex.org/W1996567906","https://openalex.org/W1984109779","https://openalex.org/W2563088286","https://openalex.org/W1996447644"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}