{"id":"https://openalex.org/W1968791237","doi":"https://doi.org/10.1093/molbev/msm037","title":"The Evolution of Spliceosomal Introns in Alveolates","display_name":"The Evolution of Spliceosomal Introns in Alveolates","publication_year":2007,"publication_date":"2007-03-01","ids":{"openalex":"https://openalex.org/W1968791237","doi":"https://doi.org/10.1093/molbev/msm037","mag":"1968791237","pmid":"https://pubmed.ncbi.nlm.nih.gov/17331959"},"language":"en","primary_location":{"id":"doi:10.1093/molbev/msm037","doi":"https://doi.org/10.1093/molbev/msm037","is_oa":false,"landing_page_url":"https://doi.org/10.1093/molbev/msm037","pdf_url":null,"source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028188200","display_name":"Hung Dinh Nguyen","orcid":"https://orcid.org/0009-0002-2649-2552","observed_orcids":["https://orcid.org/0009-0002-2649-2552"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hung D. Nguyen","raw_affiliation_strings":["Frontier Science Research Center, University of Miyazaki, Kiyotake, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frontier Science Research Center, University of Miyazaki, Kiyotake, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013971355","display_name":"Maki Yoshihama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Maki Yoshihama","raw_affiliation_strings":["Frontier Science Research Center, University of Miyazaki, Kiyotake, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frontier Science Research Center, University of Miyazaki, Kiyotake, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054216631","display_name":"Naoya Kenmochi","orcid":"https://orcid.org/0000-0001-5178-0658","observed_orcids":["https://orcid.org/0000-0001-5178-0658"]},"institutions":[{"id":"https://openalex.org/I118574687","display_name":"University of Miyazaki","ror":"https://ror.org/0447kww10","country_code":"JP","type":"education","lineage":["https://openalex.org/I118574687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoya Kenmochi","raw_affiliation_strings":["Frontier Science Research Center, University of Miyazaki, Kiyotake, Miyazaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frontier Science Research Center, University of Miyazaki, Kiyotake, Miyazaki, Japan","institution_ids":["https://openalex.org/I118574687"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I118574687"],"apc_list":{"value":3418,"currency":"USD","value_usd":3418},"apc_paid":null,"fwci":0.8317,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.70851049,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"24","issue":"5","first_page":"1093","last_page":"1096"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.6786999702453613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.6786999702453613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11879","display_name":"Protist diversity and phylogeny","score":0.14270000159740448,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0892999991774559,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spliceosomal-introns","display_name":"spliceosomal introns","score":0.9100000262260437},{"id":"https://openalex.org/keywords/intron-evolution","display_name":"intron evolution","score":0.9160000085830688},{"id":"https://openalex.org/keywords/alveolates","display_name":"alveolates","score":0.8960000276565552},{"id":"https://openalex.org/keywords/intron-gain-and-loss","display_name":"intron gain and loss","score":0.9309999942779541},{"id":"https://openalex.org/keywords/theileria","display_name":"Theileria","score":0.753000020980835},{"id":"https://openalex.org/keywords/plasmodium","display_name":"Plasmodium","score":1.0},{"id":"https://openalex.org/keywords/orthologs","display_name":"orthologs","score":0.6499999761581421},{"id":"https://openalex.org/keywords/eukaryotic-evolution","display_name":"eukaryotic evolution","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9100359678268433},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.8624668717384338},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.582984983921051},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.5693249702453613},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5418189167976379},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4075058698654175}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016054","descriptor_name":"DNA, Protozoan","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017381","descriptor_name":"Spliceosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019020","descriptor_name":"Directed Molecular Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056890","descriptor_name":"Eukaryota","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/molbev/msm037","doi":"https://doi.org/10.1093/molbev/msm037","is_oa":false,"landing_page_url":"https://doi.org/10.1093/molbev/msm037","pdf_url":null,"source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},{"id":"pmid:17331959","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17331959","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology and evolution","raw_type":"Letter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1868142405","https://openalex.org/W1968733465","https://openalex.org/W1988714210","https://openalex.org/W2026152754","https://openalex.org/W2030895290","https://openalex.org/W2032603300","https://openalex.org/W2033718810","https://openalex.org/W2047459061","https://openalex.org/W2048761171","https://openalex.org/W2059383371","https://openalex.org/W2070027232","https://openalex.org/W2074785145","https://openalex.org/W2091777602","https://openalex.org/W2105487208","https://openalex.org/W2113922914","https://openalex.org/W2123438212","https://openalex.org/W2124999206","https://openalex.org/W2132926880","https://openalex.org/W2141880260","https://openalex.org/W2156521045","https://openalex.org/W2158714788","https://openalex.org/W2235442146"],"related_works":["https://openalex.org/W2013277487","https://openalex.org/W2093597710","https://openalex.org/W7099837846","https://openalex.org/W2051348369","https://openalex.org/W2737991121","https://openalex.org/W2086853339","https://openalex.org/W2118606616","https://openalex.org/W7096665213","https://openalex.org/W2167353703","https://openalex.org/W2113956516"],"abstract_inverted_index":{"Many":[0],"issues":[1],"concerning":[2],"the":[3,14,17,37,84,89,110],"evolution":[4,18,39,85],"of":[5,16,19,29,86,91],"spliceosomal":[6],"introns":[7,20],"remain":[8],"poorly":[9],"understood.":[10],"In":[11,32],"this":[12,33],"respect,":[13],"reconstruction":[15],"in":[21,40,46,71,83,96],"deep":[22],"branching":[23],"species":[24,51],"such":[25],"as":[26],"alveolates":[27,41,53,97],"is":[28],"special":[30],"significance.":[31],"study,":[34],"we":[35],"inferred":[36],"intron":[38,44,65,77,92,114],"using":[42],"3,368":[43],"positions":[45],"162":[47],"orthologs":[48],"from":[49],"10":[50],"(9":[52],"and":[54,67,73,79,94,103,116],"1":[55],"outgroup,":[56],"Homo":[57],"sapiens).":[58],"We":[59],"found":[60],"that":[61,112],"although":[62],"very":[63],"few":[64],"gains":[66,78,115],"losses":[68,80,117],"have":[69,81,98,118],"occurred":[70,82,119],"Theileria":[72],"Plasmodium":[74],"recently,":[75],"many":[76],"alveolates.":[87],"Thus,":[88],"rates":[90],"gain":[93],"loss":[95],"varied":[99],"greatly":[100],"across":[101],"time":[102],"lineage.":[104],"Our":[105],"results":[106],"seem":[107],"to":[108],"support":[109],"notion":[111],"massive":[113],"during":[120],"short":[121],"episodes,":[122],"perhaps":[123],"coinciding":[124],"with":[125],"major":[126],"evolutionary":[127],"events.":[128]},"counts_by_year":[{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}