{"id":"https://openalex.org/W1968779137","doi":"https://doi.org/10.1074/jbc.m207872200","title":"Human Fibroblast Growth Factor-23 Mutants Suppress Na+-dependent Phosphate Co-transport Activity and 1\u03b1,25-Dihydroxyvitamin D3 Production","display_name":"Human Fibroblast Growth Factor-23 Mutants Suppress Na+-dependent Phosphate Co-transport Activity and 1\u03b1,25-Dihydroxyvitamin D3 Production","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W1968779137","doi":"https://doi.org/10.1074/jbc.m207872200","mag":"1968779137","pmid":"https://pubmed.ncbi.nlm.nih.gov/12419819"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m207872200","doi":"https://doi.org/10.1074/jbc.m207872200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m207872200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m207872200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006884303","display_name":"Hitoshi Sait\u00f4","orcid":"https://orcid.org/0000-0002-5973-1364","observed_orcids":["https://orcid.org/0000-0002-5973-1364"]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]},{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hitoshi Saito","raw_affiliation_strings":["Pharmaceutical Laboratory II, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513, Japan. saitohts@chugai-pharm.co.jp","From the #N#\u2021Pharmaceutical Laboratory II and#N##N#\u00b6Technology Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513 and the #N##N#\u2016Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Laboratory II, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513, Japan. saitohts@chugai-pharm.co.jp","institution_ids":["https://openalex.org/I4405254473"]},{"raw_affiliation_string":"From the #N#\u2021Pharmaceutical Laboratory II and#N##N#\u00b6Technology Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513 and the #N##N#\u2016Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan#N#","institution_ids":["https://openalex.org/I4405254473","https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110221867","display_name":"Kenichiro Kusano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]},{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichiro Kusano","raw_affiliation_strings":["Pharmaceutical Laboratory II, Shizuoka 412-8513","From the #N#\u2021Pharmaceutical Laboratory II and#N##N#\u00b6Technology Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513 and the #N##N#\u2016Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Laboratory II, Shizuoka 412-8513","institution_ids":[]},{"raw_affiliation_string":"From the #N#\u2021Pharmaceutical Laboratory II and#N##N#\u00b6Technology Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513 and the #N##N#\u2016Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan#N#","institution_ids":["https://openalex.org/I4405254473","https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063577523","display_name":"Masahiko Kinosaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]},{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiko Kinosaki","raw_affiliation_strings":["Technology Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513","From the #N#\u2021Pharmaceutical Laboratory II and#N##N#\u00b6Technology Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513 and the #N##N#\u2016Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513","institution_ids":["https://openalex.org/I4405254473"]},{"raw_affiliation_string":"From the #N#\u2021Pharmaceutical Laboratory II and#N##N#\u00b6Technology Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513 and the #N##N#\u2016Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan#N#","institution_ids":["https://openalex.org/I4405254473","https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101937834","display_name":"Hirotaka Ito","orcid":"https://orcid.org/0000-0002-6446-5195","observed_orcids":["https://orcid.org/0000-0002-6446-5195"]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]},{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotaka Ito","raw_affiliation_strings":["Technology Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513","From the #N#\u2021Pharmaceutical Laboratory II and#N##N#\u00b6Technology Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513 and the #N##N#\u2016Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513","institution_ids":["https://openalex.org/I4405254473"]},{"raw_affiliation_string":"From the #N#\u2021Pharmaceutical Laboratory II and#N##N#\u00b6Technology Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513 and the #N##N#\u2016Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan#N#","institution_ids":["https://openalex.org/I4405254473","https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036280254","display_name":"Michinori Hirata","orcid":"https://orcid.org/0000-0001-7367-4012","observed_orcids":["https://orcid.org/0000-0001-7367-4012"]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]},{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michinori Hirata","raw_affiliation_strings":["Pharmaceutical Laboratory II, Shizuoka 412-8513","From the #N#\u2021Pharmaceutical Laboratory II and#N##N#\u00b6Technology Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513 and the #N##N#\u2016Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Laboratory II, Shizuoka 412-8513","institution_ids":[]},{"raw_affiliation_string":"From the #N#\u2021Pharmaceutical Laboratory II and#N##N#\u00b6Technology Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513 and the #N##N#\u2016Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan#N#","institution_ids":["https://openalex.org/I4405254473","https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069476050","display_name":"Hiroko Segawa","orcid":"https://orcid.org/0000-0002-0905-246X","observed_orcids":["https://orcid.org/0000-0002-0905-246X"]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]},{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroko Segawa","raw_affiliation_strings":["Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan","From the #N#\u2021Pharmaceutical Laboratory II and#N##N#\u00b6Technology Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513 and the #N##N#\u2016Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"From the #N#\u2021Pharmaceutical Laboratory II and#N##N#\u00b6Technology Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513 and the #N##N#\u2016Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan#N#","institution_ids":["https://openalex.org/I4405254473","https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102715056","display_name":"Ken\u2010ichi Miyamoto","orcid":"https://orcid.org/0000-0002-8714-3009","observed_orcids":["https://orcid.org/0000-0002-8714-3009"]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]},{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken-ichi Miyamoto","raw_affiliation_strings":["Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan","From the #N#\u2021Pharmaceutical Laboratory II and#N##N#\u00b6Technology Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513 and the #N##N#\u2016Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"From the #N#\u2021Pharmaceutical Laboratory II and#N##N#\u00b6Technology Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513 and the #N##N#\u2016Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan#N#","institution_ids":["https://openalex.org/I4405254473","https://openalex.org/I922474255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077032764","display_name":"Naoshi Fukushima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]},{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoshi Fukushima","raw_affiliation_strings":["Pharmaceutical Laboratory II, Shizuoka 412-8513","From the #N#\u2021Pharmaceutical Laboratory II and#N##N#\u00b6Technology Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513 and the #N##N#\u2016Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Laboratory II, Shizuoka 412-8513","institution_ids":[]},{"raw_affiliation_string":"From the #N#\u2021Pharmaceutical Laboratory II and#N##N#\u00b6Technology Laboratory, Chugai Pharmaceutical Co., Ltd., Shizuoka 412-8513 and the #N##N#\u2016Nutritional Science, Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan#N#","institution_ids":["https://openalex.org/I4405254473","https://openalex.org/I922474255"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006884303"],"corresponding_institution_ids":["https://openalex.org/I4405254473","https://openalex.org/I922474255"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":15.5026,"has_fulltext":false,"cited_by_count":411,"citation_normalized_percentile":{"value":0.99323639,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"278","issue":"4","first_page":"2206","last_page":"2211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgf23","display_name":"fibroblast growth factor 23","score":0.9879999756813049},{"id":"https://openalex.org/keywords/autosomal-dominant-hypophosphatemic-rickets","display_name":"autosomal dominant hypophosphatemic rickets","score":0.9729999899864197},{"id":"https://openalex.org/keywords/phosphate-homeostasis","display_name":"phosphate homeostasis","score":0.875},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.9120000004768372},{"id":"https://openalex.org/keywords/vitamin-d-synthesis","display_name":"vitamin D synthesis","score":0.5360000133514404},{"id":"https://openalex.org/keywords/serum-phosphorus","display_name":"serum phosphorus","score":0.7149999737739563},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.8149999976158142},{"id":"https://openalex.org/keywords/proteolytic-processing","display_name":"proteolytic processing","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.5971642732620239},{"id":"https://openalex.org/C2911197707","wikidata":"https://www.wikidata.org/wiki/Q1779987","display_name":"Hypophosphatemic Rickets","level":4,"score":0.5936550498008728},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.581813395023346},{"id":"https://openalex.org/C114276007","wikidata":"https://www.wikidata.org/wiki/Q14897899","display_name":"Fibroblast growth factor 23","level":4,"score":0.5781800150871277},{"id":"https://openalex.org/C2778573388","wikidata":"https://www.wikidata.org/wiki/Q1641384","display_name":"Hypophosphatemia","level":2,"score":0.5769847631454468},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5604897141456604},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5104045271873474},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.5057966709136963},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4642038941383362},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.4535738229751587},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4053924083709717},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4024255871772766},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.40068432688713074},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33619481325149536},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3303648829460144},{"id":"https://openalex.org/C2776489590","wikidata":"https://www.wikidata.org/wiki/Q183392","display_name":"Rickets","level":3,"score":0.244716078042984},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.131818950176239},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13137853145599365},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09116676449775696}],"mesh":[{"descriptor_ui":"D000089703","descriptor_name":"Fibroblast Growth Factor-23","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002762","descriptor_name":"Cholecalciferol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009393","descriptor_name":"Nephritis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m207872200","doi":"https://doi.org/10.1074/jbc.m207872200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m207872200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:12419819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12419819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m207872200","doi":"https://doi.org/10.1074/jbc.m207872200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m207872200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1563425273","https://openalex.org/W1585985640","https://openalex.org/W1948548825","https://openalex.org/W1976870188","https://openalex.org/W1977771802","https://openalex.org/W1987998131","https://openalex.org/W1998100845","https://openalex.org/W2000004275","https://openalex.org/W2021589464","https://openalex.org/W2026991428","https://openalex.org/W2031948766","https://openalex.org/W2044154722","https://openalex.org/W2045129957","https://openalex.org/W2062435336","https://openalex.org/W2063291578","https://openalex.org/W2063765502","https://openalex.org/W2066761745","https://openalex.org/W2068226571","https://openalex.org/W2070517674","https://openalex.org/W2086656837","https://openalex.org/W2100545183","https://openalex.org/W2135192550","https://openalex.org/W2140099557","https://openalex.org/W2167120768","https://openalex.org/W2170351820"],"related_works":["https://openalex.org/W2133492406","https://openalex.org/W2004168425","https://openalex.org/W2161413069","https://openalex.org/W1998100845","https://openalex.org/W2007546762","https://openalex.org/W2139989191","https://openalex.org/W2003963660","https://openalex.org/W2068226571","https://openalex.org/W1970305413","https://openalex.org/W2109539957"],"abstract_inverted_index":{"The":[0,33,130],"human":[1],"fibroblast":[2],"growth":[3],"factor":[4],"23":[5],"(hFGF23)":[6],"and":[7,38,65,139,145,194],"its":[8],"autosomal":[9],"dominant":[10],"hypophosphatemic":[11],"rickets":[12],"(ADHR)":[13],"mutant":[14,98],"genes":[15],"were":[16,68],"incorporated":[17],"into":[18],"animals":[19,94],"by":[20,143],"naked":[21],"DNA":[22],"injection":[23],"to":[24,126,154],"investigate":[25],"the":[26,48,74,81,90,115,121,185],"action":[27],"on":[28,164],"phosphate":[29,190,195],"homeostasis":[30],"in":[31,73,89,114,137,140,176,192,197],"vivo.":[32],"hFGF23":[34,55,64,85,107],"mutants":[35,187],"(R176Q,":[36],"R179Q,":[37],"R179W)":[39],"markedly":[40],"reduced":[41],"serum":[42,59,91,151,165,174,181],"phosphorus":[43,60,175],"(6.2-6.9":[44],"mg/dl)":[45],"compared":[46],"with":[47],"plasmid":[49],"MOCK":[50],"(8.5":[51],"mg/dl).":[52,62],"However,":[53,159],"native":[54,106],"did":[56],"not":[57],"affect":[58],"(8.6":[61],"Both":[63],"hFGF23R179Q":[66,97,122,131,171],"mRNAs":[67],"expressed":[69],"more":[70],"than":[71,156],"100-fold":[72],"liver":[75],"4":[76],"days":[77],"after":[78],"injection,":[79],"however,":[80],"C-terminal":[82],"portion":[83],"of":[84,170,200],"was":[86,99,108],"detected":[87,109],"only":[88],"from":[92],"hFGF23R179Q-injected":[93],"(1109":[95],"pg/ml).":[96],"secreted":[100],"as":[101,110,148,150],"a":[102,111],"32-kDa":[103],"protein,":[104],"whereas,":[105],"20-kDa":[112],"protein":[113,123,172],"cell-conditioned":[116],"media.":[117],"These":[118],"results":[119],"suggest":[120],"is":[124],"resistant":[125],"intracellular":[127],"proteolytic":[128],"processing.":[129],"suppressed":[132],"Na/P(i)":[133],"co-transport":[134],"activities":[135],"both":[136,189],"kidney":[138],"small":[141],"intestine":[142,193],"45":[144],"30%,":[146],"respectively,":[147],"well":[149],"1alpha,25-dihydroxyvitamin":[152],"D(3)":[153],"less":[155],"15":[157],"pg/ml.":[158],"it":[160],"had":[161],"little":[162],"effect":[163],"parathyroid":[166],"hormone":[167],"(PTH).":[168],"Infusion":[169],"normalized":[173],"thyroparathyroidectomized":[177],"rats":[178],"without":[179],"affecting":[180],"calcium.":[182],"Taken":[183],"together,":[184],"FGF23":[186],"reduce":[188],"uptake":[191],"reabsorption":[196],"kidney,":[198],"independent":[199],"PTH":[201],"action.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":30},{"year":2012,"cited_by_count":31}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}