{"id":"https://openalex.org/W1968779080","doi":"https://doi.org/10.1136/sti.69.3.196","title":"Effectiveness of norfloxacin and ofloxacin for treatment of gonorrhoea and decrease of in vitro susceptibility to quinolones over time in Rwanda.","display_name":"Effectiveness of norfloxacin and ofloxacin for treatment of gonorrhoea and decrease of in vitro susceptibility to quinolones over time in Rwanda.","publication_year":1993,"publication_date":"1993-06-01","ids":{"openalex":"https://openalex.org/W1968779080","doi":"https://doi.org/10.1136/sti.69.3.196","mag":"1968779080","pmid":"https://pubmed.ncbi.nlm.nih.gov/8335312","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1195062"},"language":"en","primary_location":{"id":"doi:10.1136/sti.69.3.196","doi":"https://doi.org/10.1136/sti.69.3.196","is_oa":true,"landing_page_url":"https://doi.org/10.1136/sti.69.3.196","pdf_url":"https://sti.bmj.com/content/sextrans/69/3/196.full.pdf","source":{"id":"https://openalex.org/S112197712","display_name":"Sexually Transmitted Infections","issn_l":"0007-134X","issn":["0007-134X","0266-4348","1368-4973","1472-3263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sexually Transmitted Infections","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://sti.bmj.com/content/sextrans/69/3/196.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113626133","display_name":"Joseph Bogaerts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128173","display_name":"Centre Hospitalier Universitaire de Kigali","ror":"https://ror.org/038vngd42","country_code":"RW","type":"healthcare","lineage":["https://openalex.org/I4210128173","https://openalex.org/I4210165170"]}],"countries":["RW"],"is_corresponding":false,"raw_author_name":"J Bogaerts","raw_affiliation_strings":["Centre Hospitalier De Kigali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier De Kigali","institution_ids":["https://openalex.org/I4210128173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067267784","display_name":"W Martinez Tello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128173","display_name":"Centre Hospitalier Universitaire de Kigali","ror":"https://ror.org/038vngd42","country_code":"RW","type":"healthcare","lineage":["https://openalex.org/I4210128173","https://openalex.org/I4210165170"]}],"countries":["RW"],"is_corresponding":false,"raw_author_name":"W M Tello","raw_affiliation_strings":["Centre Hospitalier De Kigali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier De Kigali","institution_ids":["https://openalex.org/I4210128173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009646058","display_name":"J Akingeneye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128173","display_name":"Centre Hospitalier Universitaire de Kigali","ror":"https://ror.org/038vngd42","country_code":"RW","type":"healthcare","lineage":["https://openalex.org/I4210128173","https://openalex.org/I4210165170"]}],"countries":["RW"],"is_corresponding":false,"raw_author_name":"J Akingeneye","raw_affiliation_strings":["Centre Hospitalier De Kigali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier De Kigali","institution_ids":["https://openalex.org/I4210128173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060376413","display_name":"V Mukantabana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128173","display_name":"Centre Hospitalier Universitaire de Kigali","ror":"https://ror.org/038vngd42","country_code":"RW","type":"healthcare","lineage":["https://openalex.org/I4210128173","https://openalex.org/I4210165170"]}],"countries":["RW"],"is_corresponding":false,"raw_author_name":"V Mukantabana","raw_affiliation_strings":["Centre Hospitalier De Kigali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier De Kigali","institution_ids":["https://openalex.org/I4210128173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058084507","display_name":"Eric Van Dyck","orcid":"https://orcid.org/0000-0001-8614-2402","observed_orcids":["https://orcid.org/0000-0001-8614-2402"]},"institutions":[{"id":"https://openalex.org/I4210128173","display_name":"Centre Hospitalier Universitaire de Kigali","ror":"https://ror.org/038vngd42","country_code":"RW","type":"healthcare","lineage":["https://openalex.org/I4210128173","https://openalex.org/I4210165170"]}],"countries":["RW"],"is_corresponding":false,"raw_author_name":"E Van Dyck","raw_affiliation_strings":["Centre Hospitalier De Kigali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier De Kigali","institution_ids":["https://openalex.org/I4210128173"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027320613","display_name":"Peter Piot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128173","display_name":"Centre Hospitalier Universitaire de Kigali","ror":"https://ror.org/038vngd42","country_code":"RW","type":"healthcare","lineage":["https://openalex.org/I4210128173","https://openalex.org/I4210165170"]}],"countries":["RW"],"is_corresponding":false,"raw_author_name":"P Piot","raw_affiliation_strings":["Centre Hospitalier De Kigali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier De Kigali","institution_ids":["https://openalex.org/I4210128173"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210128173"],"apc_list":null,"apc_paid":null,"fwci":4.8629,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.9539778,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"69","issue":"3","first_page":"196","last_page":"200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.049400001764297485,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gonorrhea","display_name":"gonorrhea","score":0.9860000014305115},{"id":"https://openalex.org/keywords/neisseria-gonorrhoeae","display_name":"Neisseria gonorrhoeae","score":0.9580000042915344},{"id":"https://openalex.org/keywords/norfloxacin","display_name":"norfloxacin","score":0.9269999861717224},{"id":"https://openalex.org/keywords/ofloxacin","display_name":"ofloxacin","score":1.0},{"id":"https://openalex.org/keywords/quinolone-resistance","display_name":"quinolone resistance","score":0.875},{"id":"https://openalex.org/keywords/antimicrobial-resistance-surveillance","display_name":"antimicrobial resistance surveillance","score":0.7379999756813049},{"id":"https://openalex.org/keywords/gonococcal-urethritis","display_name":"gonococcal urethritis","score":0.871999979019165},{"id":"https://openalex.org/keywords/penicillinase-production","display_name":"penicillinase production","score":0.734000027179718},{"id":"https://openalex.org/keywords/penicillin-resistance","display_name":"penicillin resistance","score":0.8500000238418579},{"id":"https://openalex.org/keywords/tetracycline-resistance","display_name":"tetracycline resistance","score":0.9639999866485596},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.8199999928474426},{"id":"https://openalex.org/keywords/rwanda","display_name":"Rwanda","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2778049240","wikidata":"https://www.wikidata.org/wiki/Q411447","display_name":"Ofloxacin","level":4,"score":0.9532829523086548},{"id":"https://openalex.org/C2778746504","wikidata":"https://www.wikidata.org/wiki/Q417897","display_name":"Norfloxacin","level":4,"score":0.9287116527557373},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7587521076202393},{"id":"https://openalex.org/C2778416477","wikidata":"https://www.wikidata.org/wiki/Q1122485","display_name":"Urethritis","level":2,"score":0.7462968230247498},{"id":"https://openalex.org/C2779166590","wikidata":"https://www.wikidata.org/wiki/Q131129","display_name":"Neisseria gonorrhoeae","level":2,"score":0.7053475975990295},{"id":"https://openalex.org/C2778063948","wikidata":"https://www.wikidata.org/wiki/Q416154","display_name":"Spectinomycin","level":4,"score":0.6594783663749695},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.6566423177719116},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.51674884557724},{"id":"https://openalex.org/C2779922871","wikidata":"https://www.wikidata.org/wiki/Q426549","display_name":"Quinolone","level":3,"score":0.5107290744781494},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.48855599761009216},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.48294204473495483},{"id":"https://openalex.org/C2777728207","wikidata":"https://www.wikidata.org/wiki/Q425015","display_name":"Thiamphenicol","level":4,"score":0.4318041205406189},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.41224753856658936},{"id":"https://openalex.org/C174802600","wikidata":"https://www.wikidata.org/wiki/Q12190","display_name":"Penicillin","level":3,"score":0.41043341159820557},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3956238925457001},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32418757677078247},{"id":"https://openalex.org/C2778473333","wikidata":"https://www.wikidata.org/wiki/Q274515","display_name":"Chloramphenicol","level":3,"score":0.21323028206825256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12942123413085938}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006069","descriptor_name":"Gonorrhea","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006069","descriptor_name":"Gonorrhea","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009344","descriptor_name":"Neisseria gonorrhoeae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009344","descriptor_name":"Neisseria gonorrhoeae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D009643","descriptor_name":"Norfloxacin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009643","descriptor_name":"Norfloxacin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012432","descriptor_name":"Rwanda","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015242","descriptor_name":"Ofloxacin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015242","descriptor_name":"Ofloxacin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1136/sti.69.3.196","doi":"https://doi.org/10.1136/sti.69.3.196","is_oa":true,"landing_page_url":"https://doi.org/10.1136/sti.69.3.196","pdf_url":"https://sti.bmj.com/content/sextrans/69/3/196.full.pdf","source":{"id":"https://openalex.org/S112197712","display_name":"Sexually Transmitted Infections","issn_l":"0007-134X","issn":["0007-134X","0266-4348","1368-4973","1472-3263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sexually Transmitted Infections","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1195062","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1195062","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genitourin Med","raw_type":"Text"},{"id":"pmid:8335312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8335312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genitourinary medicine","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:sextrans:69/3/196","doi":null,"is_oa":false,"landing_page_url":"http://sti.bmj.com/cgi/content/short/69/3/196","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1136/sti.69.3.196","doi":"https://doi.org/10.1136/sti.69.3.196","is_oa":true,"landing_page_url":"https://doi.org/10.1136/sti.69.3.196","pdf_url":"https://sti.bmj.com/content/sextrans/69/3/196.full.pdf","source":{"id":"https://openalex.org/S112197712","display_name":"Sexually Transmitted Infections","issn_l":"0007-134X","issn":["0007-134X","0266-4348","1368-4973","1472-3263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sexually Transmitted Infections","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968779080.pdf","grobid_xml":"https://content.openalex.org/works/W1968779080.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1971491910","https://openalex.org/W1972116696","https://openalex.org/W1974098957","https://openalex.org/W1983386021","https://openalex.org/W1992755596","https://openalex.org/W2003740787","https://openalex.org/W2018809289","https://openalex.org/W2022868998","https://openalex.org/W2024841861","https://openalex.org/W2026778684","https://openalex.org/W2032446305","https://openalex.org/W2048617342","https://openalex.org/W2052637357","https://openalex.org/W2063410322","https://openalex.org/W2077973995","https://openalex.org/W2149726733","https://openalex.org/W2258241138","https://openalex.org/W4243639396"],"related_works":["https://openalex.org/W2094849622","https://openalex.org/W1976001726","https://openalex.org/W2461388927","https://openalex.org/W2022868998","https://openalex.org/W15558693","https://openalex.org/W78696063","https://openalex.org/W2088664468","https://openalex.org/W2418040454","https://openalex.org/W3029125542","https://openalex.org/W7099368597"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"study":[2],"the":[3,11,45,87,106,117,174,241,250,258,262],"effectiveness":[4,260],"of":[5,13,47,52,105,116,165,193,200,214,227,234,249,254,261],"single-dose":[6],"norfloxacin":[7,65,99,194],"and":[8,18,70,72,92,100,113,135,142,144,159,246,257],"ofloxacin":[9,76,158],"in":[10,16,21,40,68,79,139,147,168,181,229,251],"treatment":[12,46,63,74,226],"gonococcal":[14,58],"urethritis":[15,59],"men,":[17],"to":[19,25,124,133,153,173,207,240],"monitor":[20],"vitro":[22,252],"antimicrobial":[23,235,238],"susceptibility":[24,172,239,253],"these":[26],"antibiotics":[27,218,263],"over":[28],"time.":[29],"SETTING:":[30],"Centre":[31],"M\u00e9dico-Social":[32],"de":[33],"Bilyogo,":[34],"Kigali,":[35],"Rwanda.":[36],"The":[37],"only":[38],"clinic":[39],"Rwanda":[41],"using":[42],"quinolones":[43,242],"for":[44],"gonorrhoea.":[48],"METHODS:":[49],"As":[50],"part":[51],"a":[53,162,223,232],"monitoring":[54,248],"programme,":[55],"men":[56,96],"with":[57,64,75,98,183,231],"were":[60,121,151],"evaluated":[61],"after":[62,73],"(800":[66],"mg)":[67,78],"1986":[69],"1987,":[71],"(400":[77],"1989.":[80,148],"RESULTS:":[81],"Neisseria":[82],"gonorrhoeae":[83,256],"was":[84,137],"eradicated":[85],"from":[86,89,93],"urethra":[88],"96.0%":[90],"(189/197)":[91],"97.1%":[94],"(166/171)":[95],"treated":[97],"ofloxacin,":[101],"respectively.":[102],"Overall":[103],"38.2%":[104],"pretreatment":[107],"isolates":[108,120,150,166,184],"produced":[109],"penicillinase":[110],"(PPNG":[111],"isolates)":[112],"20.4%":[114],"(44/216)":[115],"tested":[118],"non-PPNG":[119,143],"chromosomally":[122],"resistant":[123],"penicillin":[125],"(MIC":[126],">":[127,188],"or":[128,189],"=":[129,190,196],"2.0":[130],"mg/l).":[131],"Resistance":[132],"tetracycline":[134],"thiamphenicol":[136],"common":[138],"both":[140],"PPNG":[141],"increased":[145],"considerably":[146],"All":[149],"susceptible":[152],"kanamycin,":[154],"spectinomycin,":[155],"ceftiaxone,":[156],"norfloxacin,":[157],"ciprofloxacin.":[160],"However,":[161,237],"higher":[163],"number":[164],"recovered":[167],"1989":[169],"showed":[170],"decreased":[171],"quinolones.":[175],"Treatment":[176],"failure":[177],"occurred":[178],"more":[179],"often":[180],"subjects":[182],"having":[185],"MIC":[186],"values":[187],"0.06":[191],"mg/L":[192],"(p":[195],"0.006).":[197],"Seven":[198],"out":[199],"13":[201],"patients":[202],"who":[203],"did":[204],"not":[205],"respond":[206],"therapy":[208],"had":[209],"no":[210],"signs":[211],"nor":[212],"symptoms":[213],"urethritis.":[215],"CONCLUSION:":[216],"Quinolone":[217],"are":[219],"now":[220],"indicated":[221],"as":[222],"first":[224],"line":[225],"gonorrhoea":[228],"countries":[230],"problem":[233],"multiresistance.":[236],"may":[243],"decrease":[244],"rapidly,":[245],"close":[247],"N":[255],"clinical":[259],"is":[264],"imperative.":[265]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}