{"id":"https://openalex.org/W1968762000","doi":"https://doi.org/10.1073/pnas.0611660104","title":"Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-\u03b2 signaling","display_name":"Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-\u03b2 signaling","publication_year":2007,"publication_date":"2007-02-16","ids":{"openalex":"https://openalex.org/W1968762000","doi":"https://doi.org/10.1073/pnas.0611660104","mag":"1968762000","pmid":"https://pubmed.ncbi.nlm.nih.gov/17307870"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0611660104","doi":"https://doi.org/10.1073/pnas.0611660104","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0611660104","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1800736","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091050414","display_name":"Mitsunobu R. Kano","orcid":"https://orcid.org/0000-0003-1593-1855","observed_orcids":["https://orcid.org/0000-0003-1593-1855"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsunobu R. Kano","raw_affiliation_strings":["Center for Nano-Bio Integration, University of Tokyo, Tokyo 113-0033 Japan; and","Departments of *Molecular Pathology,","Geriatrics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Nano-Bio Integration, University of Tokyo, Tokyo 113-0033 Japan; and","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Departments of *Molecular Pathology,","institution_ids":[]},{"raw_affiliation_string":"Geriatrics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055884988","display_name":"Younsoo Bae","orcid":"https://orcid.org/0000-0003-1360-3524","observed_orcids":["https://orcid.org/0000-0003-1360-3524"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Younsoo Bae","raw_affiliation_strings":["Center for Disease Biology and Integrative Medicine, Graduate School of Medicine;","Center for Nano-Bio Integration, University of Tokyo, Tokyo 113-0033 Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Disease Biology and Integrative Medicine, Graduate School of Medicine;","institution_ids":[]},{"raw_affiliation_string":"Center for Nano-Bio Integration, University of Tokyo, Tokyo 113-0033 Japan; and","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007485914","display_name":"Caname Iwata","orcid":"https://orcid.org/0000-0003-1957-711X","observed_orcids":["https://orcid.org/0000-0003-1957-711X"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Caname Iwata","raw_affiliation_strings":["Departments of *Molecular Pathology,","Gastrointestinal Surgery, and","university of Tokyo;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Molecular Pathology,","institution_ids":[]},{"raw_affiliation_string":"Gastrointestinal Surgery, and","institution_ids":[]},{"raw_affiliation_string":"university of Tokyo;","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109492014","display_name":"Yasuyuki Morishita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuyuki Morishita","raw_affiliation_strings":["Departments of *Molecular Pathology,","university of Tokyo;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Molecular Pathology,","institution_ids":[]},{"raw_affiliation_string":"university of Tokyo;","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089607790","display_name":"Masakazu Yashiro","orcid":"https://orcid.org/0000-0001-5743-7228","observed_orcids":["https://orcid.org/0000-0001-5743-7228"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masakazu Yashiro","raw_affiliation_strings":["Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan","OSAKA-CITY UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"OSAKA-CITY UNIVERSITY","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086423380","display_name":"Masako Oka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masako Oka","raw_affiliation_strings":["Departments of *Molecular Pathology,","university of Tokyo;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Molecular Pathology,","institution_ids":[]},{"raw_affiliation_string":"university of Tokyo;","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091508879","display_name":"Tomoko Fujii","orcid":"https://orcid.org/0000-0003-3854-4081","observed_orcids":["https://orcid.org/0000-0003-3854-4081"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoko Fujii","raw_affiliation_strings":["Departments of *Molecular Pathology,","university of Tokyo;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Molecular Pathology,","institution_ids":[]},{"raw_affiliation_string":"university of Tokyo;","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017769235","display_name":"Akiyoshi Komuro","orcid":"https://orcid.org/0000-0003-0571-6377","observed_orcids":["https://orcid.org/0000-0003-0571-6377"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiyoshi Komuro","raw_affiliation_strings":["Departments of *Molecular Pathology,","university of Tokyo;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Molecular Pathology,","institution_ids":[]},{"raw_affiliation_string":"university of Tokyo;","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032172273","display_name":"Kunihiko Kiyono","orcid":"https://orcid.org/0009-0008-2004-2036","observed_orcids":["https://orcid.org/0009-0008-2004-2036"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunihiko Kiyono","raw_affiliation_strings":["Departments of *Molecular Pathology,","university of Tokyo;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Molecular Pathology,","institution_ids":[]},{"raw_affiliation_string":"university of Tokyo;","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060305761","display_name":"Michio Kaminishi","orcid":"https://orcid.org/0000-0002-7010-058X","observed_orcids":["https://orcid.org/0000-0002-7010-058X"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michio Kaminishi","raw_affiliation_strings":["Gastrointestinal Surgery, and","university of Tokyo;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Surgery, and","institution_ids":[]},{"raw_affiliation_string":"university of Tokyo;","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032903747","display_name":"Kosei Hirakawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kosei Hirakawa","raw_affiliation_strings":["Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan","OSAKA-CITY UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"OSAKA-CITY UNIVERSITY","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034271311","display_name":"Yasuyoshi Ouchi","orcid":"https://orcid.org/0000-0002-8178-6994","observed_orcids":["https://orcid.org/0000-0002-8178-6994"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuyoshi Ouchi","raw_affiliation_strings":["Geriatrics,","university of Tokyo;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geriatrics,","institution_ids":[]},{"raw_affiliation_string":"university of Tokyo;","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086040518","display_name":"Nobuhiro Nishiyama","orcid":"https://orcid.org/0000-0002-6886-9357","observed_orcids":["https://orcid.org/0000-0002-6886-9357"]},"institutions":[{"id":"https://openalex.org/I2802505300","display_name":"\u00c9cole Sup\u00e9rieure d'Ing\u00e9nieurs en G\u00e9nie \u00c9lectrique","ror":"https://ror.org/01apwkd48","country_code":"FR","type":"education","lineage":["https://openalex.org/I2802505300"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nobuhiro Nishiyama","raw_affiliation_strings":["**Department of Materials Engineering, Graduate School of Engineering; and","Center for Disease Biology and Integrative Medicine, Graduate School of Medicine;","Polymer Chemistry Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"**Department of Materials Engineering, Graduate School of Engineering; and","institution_ids":["https://openalex.org/I2802505300"]},{"raw_affiliation_string":"Center for Disease Biology and Integrative Medicine, Graduate School of Medicine;","institution_ids":[]},{"raw_affiliation_string":"Polymer Chemistry Division","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015097923","display_name":"Kazunori Kataoka","orcid":"https://orcid.org/0000-0002-8591-413X","observed_orcids":["https://orcid.org/0000-0002-8591-413X"]},"institutions":[{"id":"https://openalex.org/I2802505300","display_name":"\u00c9cole Sup\u00e9rieure d'Ing\u00e9nieurs en G\u00e9nie \u00c9lectrique","ror":"https://ror.org/01apwkd48","country_code":"FR","type":"education","lineage":["https://openalex.org/I2802505300"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["FR","JP"],"is_corresponding":false,"raw_author_name":"Kazunori Kataoka","raw_affiliation_strings":["**Department of Materials Engineering, Graduate School of Engineering; and","Center for Disease Biology and Integrative Medicine, Graduate School of Medicine;","Center for Nano-Bio Integration, University of Tokyo, Tokyo 113-0033 Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"**Department of Materials Engineering, Graduate School of Engineering; and","institution_ids":["https://openalex.org/I2802505300"]},{"raw_affiliation_string":"Center for Disease Biology and Integrative Medicine, Graduate School of Medicine;","institution_ids":[]},{"raw_affiliation_string":"Center for Nano-Bio Integration, University of Tokyo, Tokyo 113-0033 Japan; and","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051009186","display_name":"Kohei Miyazono","orcid":"https://orcid.org/0000-0001-7341-0172","observed_orcids":["https://orcid.org/0000-0001-7341-0172"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohei Miyazono","raw_affiliation_strings":["Departments of *Molecular Pathology,","university of Tokyo;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Molecular Pathology,","institution_ids":[]},{"raw_affiliation_string":"university of Tokyo;","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.7145,"has_fulltext":false,"cited_by_count":410,"citation_normalized_percentile":{"value":0.97957231,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"104","issue":"9","first_page":"3460","last_page":"3465"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.5557000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.5557000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.3716000020503998,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta-inhibition","display_name":"TGF-beta inhibition","score":0.8999999761581421},{"id":"https://openalex.org/keywords/nanocarriers","display_name":"nanocarriers","score":0.7570000290870667},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9660000205039978},{"id":"https://openalex.org/keywords/diffuse-type-gastric-cancer","display_name":"diffuse-type gastric cancer","score":0.9570000171661377},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tumor-fibrosis","display_name":"tumor fibrosis","score":0.6949999928474426},{"id":"https://openalex.org/keywords/pericyte-coverage","display_name":"pericyte coverage","score":0.9350000023841858},{"id":"https://openalex.org/keywords/tumor-neovasculature","display_name":"tumor neovasculature","score":0.9729999899864197},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5270000100135803},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7239975333213806},{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.6635371446609497},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.6069694757461548},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5496000051498413},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.49525633454322815},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.49265056848526},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.48438841104507446},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4606160819530487},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4519753158092499},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4388981759548187},{"id":"https://openalex.org/C111001777","wikidata":"https://www.wikidata.org/wiki/Q3562192","display_name":"TGF beta signaling pathway","level":3,"score":0.42575305700302124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3155727982521057},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.30673426389694214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2794513702392578},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15961650013923645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14737936854362488},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.08046829700469971},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.0664975643157959}],"mesh":[{"descriptor_ui":"D000077293","descriptor_name":"Receptor, Transforming Growth Factor-beta Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077293","descriptor_name":"Receptor, Transforming Growth Factor-beta Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077293","descriptor_name":"Receptor, Transforming Growth Factor-beta Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0611660104","doi":"https://doi.org/10.1073/pnas.0611660104","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0611660104","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:17307870","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17307870","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:1800736","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1800736","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1800736","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1800736","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7599999904632568}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1497490920","https://openalex.org/W1576609386","https://openalex.org/W1871308790","https://openalex.org/W1931508686","https://openalex.org/W1964513396","https://openalex.org/W1967156938","https://openalex.org/W1975522586","https://openalex.org/W1980842095","https://openalex.org/W1985968411","https://openalex.org/W1989195046","https://openalex.org/W1993490822","https://openalex.org/W2002606648","https://openalex.org/W2015959969","https://openalex.org/W2024787650","https://openalex.org/W2030662016","https://openalex.org/W2037111838","https://openalex.org/W2039275948","https://openalex.org/W2065977830","https://openalex.org/W2067747597","https://openalex.org/W2074238578","https://openalex.org/W2080916834","https://openalex.org/W2082587127","https://openalex.org/W2094280155","https://openalex.org/W2099580743","https://openalex.org/W2110405971","https://openalex.org/W2112927879","https://openalex.org/W2117200840","https://openalex.org/W2152643817","https://openalex.org/W2156606731","https://openalex.org/W2162472165","https://openalex.org/W2163504684","https://openalex.org/W2166736202","https://openalex.org/W2169187623","https://openalex.org/W2171227711","https://openalex.org/W2209147002","https://openalex.org/W4253344709"],"related_works":["https://openalex.org/W4240130371","https://openalex.org/W2355360993","https://openalex.org/W2308616550","https://openalex.org/W2155558762","https://openalex.org/W2366835330","https://openalex.org/W2147273545","https://openalex.org/W3029292979","https://openalex.org/W2016510087","https://openalex.org/W2088343538","https://openalex.org/W2016318437"],"abstract_inverted_index":{"Transforming":[0],"growth":[1,34,61],"factor":[2],"(TGF)-beta":[3],"plays":[4],"a":[5,69,79],"pivotal":[6],"role":[7],"in":[8,82,102,112,134,145,164,187],"regulation":[9],"of":[10,12,37,54,59,68,118,126,140,152,167,172,181],"progression":[11],"cancer":[13,23,113],"through":[14],"effects":[15,45,160],"on":[16,22,161],"tumor":[17,103,135],"microenvironment":[18],"as":[19,21],"well":[20],"cells.":[24],"TGF-beta":[25,48,72,110],"inhibitors":[26],"have":[27],"recently":[28],"been":[29],"shown":[30],"to":[31],"prevent":[32],"the":[33,52,57,116,127,146,150,165],"and":[35,92,99,137,184],"metastasis":[36],"certain":[38],"cancers.":[39,191],"However,":[40,121],"there":[41],"may":[42,178],"be":[43,180],"adverse":[44],"caused":[46],"by":[47,56,97],"signaling":[49,111],"inhibition,":[50],"including":[51,89,142],"induction":[53],"cancers":[55,163],"repression":[58],"TGF-beta-mediated":[60],"inhibition.":[62],"Here,":[63],"we":[64],"present":[65],"an":[66],"application":[67],"short-acting,":[70],"small-molecule":[71],"type":[73],"I":[74],"receptor":[75],"(TbetaR-I)":[76],"inhibitor":[77,107,174],"at":[78],"low":[80],"dose":[81],"treating":[83,188],"several":[84],"experimental":[85],"intractable":[86,189],"solid":[87,190],"tumors,":[88],"pancreatic":[90],"adenocarcinoma":[91],"diffuse-type":[93],"gastric":[94],"cancer,":[95],"characterized":[96],"hypovascularity":[98],"thick":[100],"fibrosis":[101],"microenvironments.":[104],"Low-dose":[105],"TbetaR-I":[106,153,168,173],"altered":[108],"neither":[109],"cells":[114],"nor":[115],"amount":[117],"fibrotic":[119],"components.":[120],"it":[122],"decreased":[123],"pericyte":[124],"coverage":[125],"endothelium":[128],"without":[129],"reducing":[130],"endothelial":[131],"area":[132],"specifically":[133],"neovasculature":[136],"promoted":[138],"accumulation":[139],"macromolecules,":[141],"anticancer":[143,155],"nanocarriers,":[144],"tumors.":[147],"Compared":[148],"with":[149,176],"absence":[151],"inhibitor,":[154],"nanocarriers":[156,177],"exhibited":[157],"potent":[158],"growth-inhibitory":[159],"these":[162],"presence":[166],"inhibitor.":[169],"The":[170],"use":[171],"combined":[175],"thus":[179],"significant":[182],"clinical":[183],"practical":[185],"importance":[186]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":31},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":22},{"year":2017,"cited_by_count":31},{"year":2016,"cited_by_count":30},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":37},{"year":2013,"cited_by_count":39},{"year":2012,"cited_by_count":36}],"updated_date":"2026-10-05T09:50:58.205359","created_date":"2025-10-10T00:00:00"}
