{"id":"https://openalex.org/W1968754191","doi":"https://doi.org/10.1212/01.wnl.0000142260.61443.7c","title":"Elevated pro-inflammatory CD4 + CD28 \u2212 lymphocytes and stroke recurrence and death","display_name":"Elevated pro-inflammatory CD4 + CD28 \u2212 lymphocytes and stroke recurrence and death","publication_year":2004,"publication_date":"2004-10-26","ids":{"openalex":"https://openalex.org/W1968754191","doi":"https://doi.org/10.1212/01.wnl.0000142260.61443.7c","mag":"1968754191","pmid":"https://pubmed.ncbi.nlm.nih.gov/15505163"},"language":"en","primary_location":{"id":"doi:10.1212/01.wnl.0000142260.61443.7c","doi":"https://doi.org/10.1212/01.wnl.0000142260.61443.7c","is_oa":false,"landing_page_url":"https://doi.org/10.1212/01.wnl.0000142260.61443.7c","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036092823","display_name":"Zurab Nadareishvili","orcid":"https://orcid.org/0000-0002-5526-1342","observed_orcids":["https://orcid.org/0000-0002-5526-1342"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z. G. Nadareishvili","raw_affiliation_strings":["From the Stroke Branch (Drs. Hadareishvili, Li, Wright, Warach, Hallenbeck, and Baird), Stroke Neuroscience Unit (Drs. Li, Wright, and Baird), Laboratory of Neurophysiology (Drs. Maric and Barker), and Biostatistics Branch (Dr. Dambrosia), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Stroke Branch (Drs. Hadareishvili, Li, Wright, Warach, Hallenbeck, and Baird), Stroke Neuroscience Unit (Drs. Li, Wright, and Baird), Laboratory of Neurophysiology (Drs. Maric and Barker), and Biostatistics Branch (Dr. Dambrosia), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008732835","display_name":"Hong\u2010Wu Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Li","raw_affiliation_strings":["From the Stroke Branch (Drs. Hadareishvili, Li, Wright, Warach, Hallenbeck, and Baird), Stroke Neuroscience Unit (Drs. Li, Wright, and Baird), Laboratory of Neurophysiology (Drs. Maric and Barker), and Biostatistics Branch (Dr. Dambrosia), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Stroke Branch (Drs. Hadareishvili, Li, Wright, Warach, Hallenbeck, and Baird), Stroke Neuroscience Unit (Drs. Li, Wright, and Baird), Laboratory of Neurophysiology (Drs. Maric and Barker), and Biostatistics Branch (Dr. Dambrosia), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090251996","display_name":"Violet Wright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Wright","raw_affiliation_strings":["From the Stroke Branch (Drs. Hadareishvili, Li, Wright, Warach, Hallenbeck, and Baird), Stroke Neuroscience Unit (Drs. Li, Wright, and Baird), Laboratory of Neurophysiology (Drs. Maric and Barker), and Biostatistics Branch (Dr. Dambrosia), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Stroke Branch (Drs. Hadareishvili, Li, Wright, Warach, Hallenbeck, and Baird), Stroke Neuroscience Unit (Drs. Li, Wright, and Baird), Laboratory of Neurophysiology (Drs. Maric and Barker), and Biostatistics Branch (Dr. Dambrosia), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080479135","display_name":"Dragan Maric","orcid":"https://orcid.org/0000-0003-2912-7921","observed_orcids":["https://orcid.org/0000-0003-2912-7921"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Maric","raw_affiliation_strings":["From the Stroke Branch (Drs. Hadareishvili, Li, Wright, Warach, Hallenbeck, and Baird), Stroke Neuroscience Unit (Drs. Li, Wright, and Baird), Laboratory of Neurophysiology (Drs. Maric and Barker), and Biostatistics Branch (Dr. Dambrosia), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Stroke Branch (Drs. Hadareishvili, Li, Wright, Warach, Hallenbeck, and Baird), Stroke Neuroscience Unit (Drs. Li, Wright, and Baird), Laboratory of Neurophysiology (Drs. Maric and Barker), and Biostatistics Branch (Dr. Dambrosia), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069989341","display_name":"Steven J. Warach","orcid":"https://orcid.org/0000-0003-3125-7979","observed_orcids":["https://orcid.org/0000-0003-3125-7979"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Warach","raw_affiliation_strings":["From the Stroke Branch (Drs. Hadareishvili, Li, Wright, Warach, Hallenbeck, and Baird), Stroke Neuroscience Unit (Drs. Li, Wright, and Baird), Laboratory of Neurophysiology (Drs. Maric and Barker), and Biostatistics Branch (Dr. Dambrosia), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Stroke Branch (Drs. Hadareishvili, Li, Wright, Warach, Hallenbeck, and Baird), Stroke Neuroscience Unit (Drs. Li, Wright, and Baird), Laboratory of Neurophysiology (Drs. Maric and Barker), and Biostatistics Branch (Dr. Dambrosia), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036008306","display_name":"John M. Hallenbeck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. M. Hallenbeck","raw_affiliation_strings":["From the Stroke Branch (Drs. Hadareishvili, Li, Wright, Warach, Hallenbeck, and Baird), Stroke Neuroscience Unit (Drs. Li, Wright, and Baird), Laboratory of Neurophysiology (Drs. Maric and Barker), and Biostatistics Branch (Dr. Dambrosia), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Stroke Branch (Drs. Hadareishvili, Li, Wright, Warach, Hallenbeck, and Baird), Stroke Neuroscience Unit (Drs. Li, Wright, and Baird), Laboratory of Neurophysiology (Drs. Maric and Barker), and Biostatistics Branch (Dr. Dambrosia), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006169984","display_name":"James Dambrosia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Dambrosia","raw_affiliation_strings":["From the Stroke Branch (Drs. Hadareishvili, Li, Wright, Warach, Hallenbeck, and Baird), Stroke Neuroscience Unit (Drs. Li, Wright, and Baird), Laboratory of Neurophysiology (Drs. Maric and Barker), and Biostatistics Branch (Dr. Dambrosia), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Stroke Branch (Drs. Hadareishvili, Li, Wright, Warach, Hallenbeck, and Baird), Stroke Neuroscience Unit (Drs. Li, Wright, and Baird), Laboratory of Neurophysiology (Drs. Maric and Barker), and Biostatistics Branch (Dr. Dambrosia), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. L. Barker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. L. Barker","raw_affiliation_strings":["From the Stroke Branch (Drs. Hadareishvili, Li, Wright, Warach, Hallenbeck, and Baird), Stroke Neuroscience Unit (Drs. Li, Wright, and Baird), Laboratory of Neurophysiology (Drs. Maric and Barker), and Biostatistics Branch (Dr. Dambrosia), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Stroke Branch (Drs. Hadareishvili, Li, Wright, Warach, Hallenbeck, and Baird), Stroke Neuroscience Unit (Drs. Li, Wright, and Baird), Laboratory of Neurophysiology (Drs. Maric and Barker), and Biostatistics Branch (Dr. Dambrosia), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112760395","display_name":"Alison E. Baird","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. E. Baird","raw_affiliation_strings":["From the Stroke Branch (Drs. Hadareishvili, Li, Wright, Warach, Hallenbeck, and Baird), Stroke Neuroscience Unit (Drs. Li, Wright, and Baird), Laboratory of Neurophysiology (Drs. Maric and Barker), and Biostatistics Branch (Dr. Dambrosia), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Stroke Branch (Drs. Hadareishvili, Li, Wright, Warach, Hallenbeck, and Baird), Stroke Neuroscience Unit (Drs. Li, Wright, and Baird), Laboratory of Neurophysiology (Drs. Maric and Barker), and Biostatistics Branch (Dr. Dambrosia), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4351,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.881462,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"63","issue":"8","first_page":"1446","last_page":"1451"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.08020000159740448,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd4-cd28-t-cells","display_name":"CD4+CD28- T cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.7580000162124634},{"id":"https://openalex.org/keywords/stroke-recurrence","display_name":"stroke recurrence","score":0.8859999775886536},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.675000011920929},{"id":"https://openalex.org/keywords/proinflammatory-t-cells","display_name":"proinflammatory T cells","score":0.8289999961853027},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.47099998593330383},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6520000100135803},{"id":"https://openalex.org/keywords/peripheral-blood-lymphocytes","display_name":"peripheral blood lymphocytes","score":0.5929999947547913},{"id":"https://openalex.org/keywords/history-of-stroke","display_name":"stroke history","score":0.47200000286102295},{"id":"https://openalex.org/keywords/stroke-pathogenesis","display_name":"stroke pathogenesis","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7909991145133972},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.7832099199295044},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.5939653515815735},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5548869371414185},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5499514937400818},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4964185357093811},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36802035570144653},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30466175079345703},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.21861854195594788},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.12446010112762451},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.12440267205238342},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009026","descriptor_name":"Mortality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009026","descriptor_name":"Mortality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009026","descriptor_name":"Mortality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018106","descriptor_name":"CD28 Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018106","descriptor_name":"CD28 Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018106","descriptor_name":"CD28 Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1212/01.wnl.0000142260.61443.7c","doi":"https://doi.org/10.1212/01.wnl.0000142260.61443.7c","is_oa":false,"landing_page_url":"https://doi.org/10.1212/01.wnl.0000142260.61443.7c","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:15505163","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15505163","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1966644533","https://openalex.org/W1975564845","https://openalex.org/W1976292294","https://openalex.org/W1979090235","https://openalex.org/W1979346069","https://openalex.org/W1992145204","https://openalex.org/W2004059400","https://openalex.org/W2014266911","https://openalex.org/W2016114416","https://openalex.org/W2032485049","https://openalex.org/W2041039411","https://openalex.org/W2043909750","https://openalex.org/W2050694917","https://openalex.org/W2050735040","https://openalex.org/W2056769769","https://openalex.org/W2057817955","https://openalex.org/W2058555166","https://openalex.org/W2061950838","https://openalex.org/W2069805041","https://openalex.org/W2094663408","https://openalex.org/W2116884033","https://openalex.org/W2121893515","https://openalex.org/W2127708226","https://openalex.org/W2132657882","https://openalex.org/W2138595885","https://openalex.org/W2140066663","https://openalex.org/W2150470032","https://openalex.org/W2161272496","https://openalex.org/W2320300320","https://openalex.org/W2467358614","https://openalex.org/W2796700885","https://openalex.org/W3023254611","https://openalex.org/W4388324735"],"related_works":["https://openalex.org/W2367453350","https://openalex.org/W4224325733","https://openalex.org/W3080873401","https://openalex.org/W4409746941","https://openalex.org/W3037048642","https://openalex.org/W1996163802","https://openalex.org/W362679014","https://openalex.org/W2060474997","https://openalex.org/W1967978968","https://openalex.org/W4409824877"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"determine":[2],"if":[3],"the":[4,24,41],"CD4+CD28-":[5,53,93,121,129,138,151,181,209],"T-cell":[6,27,234],"subset":[7,22,235],"is":[8],"expanded":[9],"in":[10,126,156,222],"patients":[11,39,80,127,157],"with":[12,119,128,137,158,187,213,228],"recurrent":[13,64,105,247],"stroke":[14,47,65,163,200,218,248],"or":[15,66,202],"death":[16,67,250],"after":[17,251],"acute":[18],"ischemic":[19,46,252],"stroke.":[20,230,253],"This":[21],"of":[23,45,74,131,140,148,161,183,192,207,217,232,246],"peripheral":[25],"blood":[26,52],"lymphocyte":[28],"population":[29],"has":[30],"a":[31,159,188,238,242],"strong":[32],"pro-inflammatory":[33],"and":[34,107,178,220,240,249],"tissue-damaging":[35],"potential.":[36],"METHODS:":[37],"Consecutive":[38],"within":[40],"first":[42],"48":[43],"hours":[44],"were":[48,55,89,116,153,185],"prospectively":[49],"studied.":[50,90],"Peripheral":[51],"cells":[54,210],"quantified":[56],"by":[57],"flow":[58],"cytometry.":[59],"The":[60,91],"study":[61],"endpoint":[62],"was":[63,96],"from":[68,124],"any":[69],"cause":[70],"during":[71,111],"1":[72],"year":[73],"follow-up.":[75,112],"RESULTS:":[76],"One":[77],"hundred":[78],"six":[79],"(mean":[81],"age":[82],"75.0":[83],"+/-":[84],"13.5":[85],"years;":[86],"50":[87],"women)":[88],"median":[92],"cell":[94],"count":[95],"4.5%":[97],"(range":[98],"0.2":[99],"to":[100,133,197,224],"72.2%).":[101],"Twenty-seven":[102],"endpoints":[103],"(10":[104],"strokes":[106],"17":[108],"deaths)":[109],"occurred":[110],"Stroke":[113,173],"recurrence/death":[114],"rates":[115],"significantly":[117],"associated":[118,186,212],"increasing":[120,215],"counts,":[122],"rising":[123],"14.2%":[125],"levels":[130],"<1.0":[132],"48.1%":[134],"for":[135,169,199],"those":[136],"counts":[139,152,182,206],">8.0%":[141,184],"(p":[142,164],"=":[143,165],"0.003,":[144],"Cochran":[145],"linear":[146],"test":[147],"trend).":[149],"Higher":[150],"also":[154],"present":[155],"history":[160],"prior":[162,176,229],"0.03).":[166],"After":[167],"adjustment":[168],"age,":[170],"admission":[171],"NIH":[172],"Scale":[174],"score,":[175],"stroke,":[177],"atrial":[179],"fibrillation,":[180],"cumulative":[189],"hazard":[190],"ratio":[191],"5.81":[193],"(95%":[194],"CI:":[195],"1.58":[196],"21.32)":[198],"recurrence":[201,219],"death.":[203],"CONCLUSIONS:":[204],"Rising":[205],"circulating":[208],"are":[211],"an":[214,225],"risk":[216],"death,":[221],"addition":[223],"observed":[226],"association":[227],"Expansion":[231],"this":[233],"presumably":[236],"represents":[237],"biomarker":[239],"possibly":[241],"contributory":[243],"pathogenic":[244],"mechanism":[245]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}