{"id":"https://openalex.org/W1968715085","doi":"https://doi.org/10.1007/s11064-013-1082-4","title":"Neuronal Autophagy: Self-eating or Self-cannibalism in Alzheimer\u2019s Disease","display_name":"Neuronal Autophagy: Self-eating or Self-cannibalism in Alzheimer\u2019s Disease","publication_year":2013,"publication_date":"2013-06-04","ids":{"openalex":"https://openalex.org/W1968715085","doi":"https://doi.org/10.1007/s11064-013-1082-4","mag":"1968715085","pmid":"https://pubmed.ncbi.nlm.nih.gov/23737325","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3732752"},"language":"en","primary_location":{"id":"doi:10.1007/s11064-013-1082-4","doi":"https://doi.org/10.1007/s11064-013-1082-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11064-013-1082-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11064-013-1082-4.pdf","source":{"id":"https://openalex.org/S174790897","display_name":"Neurochemical Research","issn_l":"0364-3190","issn":["0364-3190","1573-6903"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s11064-013-1082-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109454491","display_name":"Marzena U\u0142amek-Kozio\u0142","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157213","display_name":"Mossakowski Medical Research Institute,  Polish Academy of Sciences","ror":"https://ror.org/05d3ntb42","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marzena U\u0142amek-Kozio\u0142","raw_affiliation_strings":["Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawi\u0144skiego 5 Str, 02-106, Warsaw, Poland","Laboratory of Ischemic & Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawi\u0144skiego 5 Str, 02-106, Warsaw, Poland","institution_ids":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]},{"raw_affiliation_string":"Laboratory of Ischemic & Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063120999","display_name":"Wanda Furmaga-Jab\u0142o\u0144ska","orcid":"https://orcid.org/0000-0002-6006-7683","observed_orcids":["https://orcid.org/0000-0002-6006-7683"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Wanda Furmaga-Jab\u0142o\u0144ska","raw_affiliation_strings":["Department of Neonate and Infant Pathology, Medical University of Lublin, Chodzki 2 Str, 20-093, Lublin, Poland","Department of Neonate and Infant Pathology, Medical University of Lublin, Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neonate and Infant Pathology, Medical University of Lublin, Chodzki 2 Str, 20-093, Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]},{"raw_affiliation_string":"Department of Neonate and Infant Pathology, Medical University of Lublin, Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110576921","display_name":"S\u0142awomir Januszewski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157213","display_name":"Mossakowski Medical Research Institute,  Polish Academy of Sciences","ror":"https://ror.org/05d3ntb42","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"S\u0142awomir Januszewski","raw_affiliation_strings":["Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawi\u0144skiego 5 Str, 02-106, Warsaw, Poland","Laboratory of Ischemic & Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawi\u0144skiego 5 Str, 02-106, Warsaw, Poland","institution_ids":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]},{"raw_affiliation_string":"Laboratory of Ischemic & Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020079445","display_name":"Judyta Brzozowska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Judyta Brzozowska","raw_affiliation_strings":["Department of Clinical Psychology, Medical University of Lublin, Chodzki 6, 20-093, Lublin, Poland","Department of Clinical Psychology, Medical University of Lublin, Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Psychology, Medical University of Lublin, Chodzki 6, 20-093, Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]},{"raw_affiliation_string":"Department of Clinical Psychology, Medical University of Lublin, Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079869326","display_name":"Ma\u0142gorzata \u015aci\u015blewska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157213","display_name":"Mossakowski Medical Research Institute,  Polish Academy of Sciences","ror":"https://ror.org/05d3ntb42","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Ma\u0142gorzata \u015aci\u015blewska","raw_affiliation_strings":["Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawi\u0144skiego 5 Str, 02-106, Warsaw, Poland","Laboratory of Ischemic & Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawi\u0144skiego 5 Str, 02-106, Warsaw, Poland","institution_ids":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]},{"raw_affiliation_string":"Laboratory of Ischemic & Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003931221","display_name":"Miros\u0142aw Jab\u0142o\u0144ski","orcid":"https://orcid.org/0000-0002-7490-4745","observed_orcids":["https://orcid.org/0000-0002-7490-4745"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Miros\u0142aw Jab\u0142o\u0144ski","raw_affiliation_strings":["Department of Orthopaedic and Rehabilitation, Medical University of Lublin, Jaczewskiego 8 Str, 20-954, Lublin, Poland","Department of Orthopaedic and Rehabilitation, Medical University of Lublin, Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic and Rehabilitation, Medical University of Lublin, Jaczewskiego 8 Str, 20-954, Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]},{"raw_affiliation_string":"Department of Orthopaedic and Rehabilitation, Medical University of Lublin, Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019175663","display_name":"Ryszard M. Pluta","orcid":"https://orcid.org/0000-0003-0764-1356","observed_orcids":["https://orcid.org/0000-0003-0764-1356"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]},{"id":"https://openalex.org/I4210157213","display_name":"Mossakowski Medical Research Institute,  Polish Academy of Sciences","ror":"https://ror.org/05d3ntb42","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Ryszard Pluta","raw_affiliation_strings":["Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawi\u0144skiego 5 Str, 02-106, Warsaw, Poland","Medical University of Lublin","Mossakowski Medical Research Centre, Polish Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawi\u0144skiego 5 Str, 02-106, Warsaw, Poland","institution_ids":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]},{"raw_affiliation_string":"Medical University of Lublin","institution_ids":["https://openalex.org/I121032520"]},{"raw_affiliation_string":"Mossakowski Medical Research Centre, Polish Academy of Sciences","institution_ids":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019175663"],"corresponding_institution_ids":["https://openalex.org/I121032520","https://openalex.org/I4210157213","https://openalex.org/I99542240"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":{"value":4590,"currency":"USD","value_usd":4590},"fwci":0.5174,"has_fulltext":true,"cited_by_count":74,"citation_normalized_percentile":{"value":0.43706294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"38","issue":"9","first_page":"1769","last_page":"1773"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.36079999804496765,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuronal-autophagy","display_name":"neuronal autophagy","score":0.9509999752044678},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/autophagosomes","display_name":"autophagosomes","score":0.6809999942779541},{"id":"https://openalex.org/keywords/autophagosome-clearance","display_name":"autophagosome clearance","score":0.6570000052452087},{"id":"https://openalex.org/keywords/retrograde-transport","display_name":"retrograde transport","score":0.6679999828338623},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.6830000281333923},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":0.6859999895095825},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.8370000123977661},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8450000286102295},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.9580000042915344},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6769999861717224},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.6600000262260437},{"id":"https://openalex.org/keywords/autophagy-regulation","display_name":"autophagy regulation","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9049656987190247},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6629496812820435},{"id":"https://openalex.org/C177907266","wikidata":"https://www.wikidata.org/wiki/Q17155455","display_name":"P3 peptide","level":5,"score":0.5284587740898132},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.5269240736961365},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.49625712633132935},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4956275224685669},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4711277186870575},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.46502968668937683},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.4485814869403839},{"id":"https://openalex.org/C70192387","wikidata":"https://www.wikidata.org/wiki/Q792602","display_name":"Axoplasmic transport","level":2,"score":0.4444110095500946},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4438210129737854},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.4387408196926117},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.42267894744873047},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2625826597213745},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2346312403678894},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18005934357643127},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16568341851234436},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.15236681699752808},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1007/s11064-013-1082-4","doi":"https://doi.org/10.1007/s11064-013-1082-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11064-013-1082-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11064-013-1082-4.pdf","source":{"id":"https://openalex.org/S174790897","display_name":"Neurochemical Research","issn_l":"0364-3190","issn":["0364-3190","1573-6903"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2726451","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3732752","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3732752","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3732752","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochem Res","raw_type":"Text"},{"id":"pmid:23737325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23737325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.796.2328","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.796.2328","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/b4/08/11064_2013_Article_1082.PMC3732752.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1007/s11064-013-1082-4","doi":"https://doi.org/10.1007/s11064-013-1082-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11064-013-1082-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11064-013-1082-4.pdf","source":{"id":"https://openalex.org/S174790897","display_name":"Neurochemical Research","issn_l":"0364-3190","issn":["0364-3190","1573-6903"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326535","display_name":"Uniwersytet Medyczny w Lublinie","ror":"https://ror.org/016f61126"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968715085.pdf","grobid_xml":"https://content.openalex.org/works/W1968715085.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1919353","https://openalex.org/W1491147801","https://openalex.org/W1747142739","https://openalex.org/W1971616282","https://openalex.org/W1973276273","https://openalex.org/W1987695408","https://openalex.org/W1994823455","https://openalex.org/W1994903603","https://openalex.org/W2000552348","https://openalex.org/W2004984841","https://openalex.org/W2005997790","https://openalex.org/W2013705864","https://openalex.org/W2022380909","https://openalex.org/W2041466151","https://openalex.org/W2052144997","https://openalex.org/W2053215139","https://openalex.org/W2056872519","https://openalex.org/W2062585755","https://openalex.org/W2067042124","https://openalex.org/W2072435649","https://openalex.org/W2082637970","https://openalex.org/W2085522360","https://openalex.org/W2085939493","https://openalex.org/W2089936534","https://openalex.org/W2092310066","https://openalex.org/W2097631517","https://openalex.org/W2107493006","https://openalex.org/W2108326484","https://openalex.org/W2110796758","https://openalex.org/W2124975942","https://openalex.org/W2129321855","https://openalex.org/W2133548029","https://openalex.org/W2138311396","https://openalex.org/W2149388384","https://openalex.org/W2164136371","https://openalex.org/W2167115031","https://openalex.org/W2171155178","https://openalex.org/W2313342767","https://openalex.org/W4243278606"],"related_works":["https://openalex.org/W7098964464","https://openalex.org/W2000552348","https://openalex.org/W835318696","https://openalex.org/W2097631517","https://openalex.org/W2374712162","https://openalex.org/W2325378616","https://openalex.org/W6927245983","https://openalex.org/W2371785606","https://openalex.org/W2152199897","https://openalex.org/W3194364132"],"abstract_inverted_index":{"Autophagy":[0],"is":[1,36,54,95,126,171,235],"a":[2,96,115,250,284],"major":[3,97],"intracellular":[4],"degeneration":[5],"pathway":[6],"involved":[7],"in":[8,43,78,110,131,152,173,222,231,256,280,286,310],"the":[9,23,32,48,90,141,153,226,263,296,305,311],"elimination":[10],"and":[11,16,63,77,104,189,205,220,262,304],"recycling":[12],"of":[13,22,83,99,102,118,143,147,156,161,178,181,201,208,229,242,252,288,307,313],"damaged":[14],"organelles":[15,188],"long-lived":[17],"proteins":[18],"by":[19,56],"lysosomes.":[20,100],"Many":[21],"pathological":[24],"factors,":[25],"which":[26,35,113,183],"trigger":[27],"neurodegenerative":[28,50],"diseases,":[29],"can":[30,158],"perturb":[31],"autophagy":[33,119,170,203,230,247,300],"activity,":[34],"associated":[37],"with":[38],"misfolded":[39],"protein":[40],"aggregates":[41],"accumulation":[42,221],"these":[44,84],"disorders.":[45],"Alzheimer's":[46,67,111,132,174,223,232,289,302,315],"disease,":[47,112],"first":[49],"disorder":[51],"between":[52],"dementias,":[53],"characterized":[55],"two":[57],"aggregating":[58],"proteins,":[59],"\u03b2-amyloid":[60,193,209,217,260],"peptide":[61,218,261],"(plaques)":[62],"\u03c4-protein":[64,135,148,157],"(tangles).":[65],"In":[66,291],"disease":[68,133,175,233,303],"autophagosomes":[69],"dynamically":[70],"form":[71],"along":[72,121,128],"neurites":[73],"within":[74],"neuronal":[75,91,162],"cells":[76,163],"synapses":[79],"but":[80],"effective":[81],"clearance":[82,207,276],"structures":[85],"needs":[86],"retrograde":[87,106],"transportation":[88],"towards":[89],"soma":[92],"where":[93],"there":[94],"concentration":[98,117,251],"Maturation":[101],"autophago-lysosomes":[103],"their":[105],"trafficking":[107],"are":[108],"perturbed":[109],"causes":[114,249],"massive":[116],"elements":[120,264],"degenerating":[122],"neurites.":[123],"Transportation":[124],"system":[125],"disturbed":[127],"defected":[129],"microtubules":[130],"brains.":[134],"has":[136,167],"been":[137],"found":[138],"to":[139,273,301],"control":[140],"stability":[142],"microtubules,":[144],"however,":[145],"phosphorylation":[146],"or":[149,277],"an":[150],"increase":[151],"total":[154],"level":[155],"cause":[159],"dysfunction":[160],"microtubules.":[164],"Current":[165],"evidence":[166,298],"shown":[168],"that":[169,245],"developing":[172],"brains":[176],"because":[177],"ineffective":[179],"degradation":[180],"autophagosomes,":[182],"hold":[184],"amyloid":[185,197,257],"precursor":[186,258],"protein-rich":[187],"secretases":[190],"important":[191],"for":[192,216,266],"peptides":[194],"generation":[195],"from":[196],"precursor.":[198],"The":[199],"combination":[200],"raised":[202],"induction":[204,248],"abnormal":[206,246],"peptide-generating":[210],"autophagic":[211,253,275,281,308],"vacuoles":[212,254],"creates":[213],"circumstances":[214],"helpful":[215],"aggregation":[219],"disease.":[224,290,316],"However,":[225],"key":[227],"role":[228,285,306],"development":[234,312],"still":[236],"under":[237],"consideration":[238],"today.":[239],"One":[240],"point":[241],"view":[243],"suggests":[244],"rich":[255],"protein,":[259],"crucial":[265],"its":[267],"formation,":[268],"whereas":[269],"other":[270],"hypothesis":[271],"points":[272],"marred":[274],"even":[278],"decrease":[279],"effectiveness":[282],"playing":[283],"maturation":[287],"this":[292],"review":[293],"we":[294],"present":[295],"recent":[297],"linking":[299],"regulation":[309],"full-blown":[314]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}