{"id":"https://openalex.org/W1968709125","doi":"https://doi.org/10.1021/bi00564a044","title":"Mechanism of the stimulation of calcium ion dependent ATPase of cardiac sarcoplasmic reticulum by adenosine 3',5'-monophosphate dependent protein kinase","display_name":"Mechanism of the stimulation of calcium ion dependent ATPase of cardiac sarcoplasmic reticulum by adenosine 3',5'-monophosphate dependent protein kinase","publication_year":1980,"publication_date":"1980-11-11","ids":{"openalex":"https://openalex.org/W1968709125","doi":"https://doi.org/10.1021/bi00564a044","mag":"1968709125","pmid":"https://pubmed.ncbi.nlm.nih.gov/6255993"},"language":"en","primary_location":{"id":"doi:10.1021/bi00564a044","doi":"https://doi.org/10.1021/bi00564a044","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00564a044","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080329479","display_name":"Evangelia Galani Kranias","orcid":"https://orcid.org/0000-0002-4621-6179","observed_orcids":["https://orcid.org/0000-0002-4621-6179"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Evangelia Galani Kranias","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064386338","display_name":"Frederic Mandel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frederic Mandel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Taitzer Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taitzer Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109835887","display_name":"Arnold Schwartz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arnold Schwartz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":5.9332,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.96004391,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"19","issue":"23","first_page":"5434","last_page":"5439"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.4634000062942505,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.4634000062942505,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.2890999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.11349999904632568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-sarcoplasmic-reticulum","display_name":"cardiac sarcoplasmic reticulum","score":0.9319999814033508},{"id":"https://openalex.org/keywords/ca2-atpase","display_name":"Ca2+-ATPase","score":0.6769999861717224},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9700000286102295},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/calcium-pump-regulation","display_name":"calcium pump regulation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/enzyme-activation-mechanism","display_name":"enzyme activation mechanism","score":0.49000000953674316},{"id":"https://openalex.org/keywords/atp-hydrolysis","display_name":"ATP hydrolysis","score":0.6150000095367432},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.3160000145435333}],"concepts":[{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.7213250994682312},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.720172643661499},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6941481828689575},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.5917510986328125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5713151693344116},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.5545689463615417},{"id":"https://openalex.org/C2779564974","wikidata":"https://www.wikidata.org/wiki/Q80863","display_name":"Adenosine triphosphate","level":2,"score":0.5530392527580261},{"id":"https://openalex.org/C101571972","wikidata":"https://www.wikidata.org/wiki/Q3396061","display_name":"Calcium ATPase","level":4,"score":0.5313236117362976},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5213035941123962},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.4562796354293823},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4344083368778229},{"id":"https://openalex.org/C74998103","wikidata":"https://www.wikidata.org/wiki/Q898254","display_name":"Dissociation constant","level":3,"score":0.4235376715660095},{"id":"https://openalex.org/C2779876172","wikidata":"https://www.wikidata.org/wiki/Q318369","display_name":"Adenosine monophosphate","level":3,"score":0.4201822578907013},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4156396687030792},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37753060460090637},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3413277566432953},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.32581502199172974},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30841904878616333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28181886672973633},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.04277786612510681},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.041070908308029175},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00564a044","doi":"https://doi.org/10.1021/bi00564a044","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00564a044","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:6255993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6255993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7798019519","display_name":"MOLECULAR MECHANISMS OF HEART FAILURE","funder_award_id":"P01HL022619","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W146070021","https://openalex.org/W1496473446","https://openalex.org/W1511168112","https://openalex.org/W1520266592","https://openalex.org/W1577394370","https://openalex.org/W1593848800","https://openalex.org/W1596658458","https://openalex.org/W1606431894","https://openalex.org/W1976302077","https://openalex.org/W2003946902","https://openalex.org/W2021697019","https://openalex.org/W2044390013","https://openalex.org/W2050912327","https://openalex.org/W2056414260","https://openalex.org/W2100837269","https://openalex.org/W2109366031"],"related_works":["https://openalex.org/W2088935634","https://openalex.org/W2053022687","https://openalex.org/W1672493958","https://openalex.org/W2029853313","https://openalex.org/W1969904523","https://openalex.org/W2021697019","https://openalex.org/W1976302077","https://openalex.org/W1596658458","https://openalex.org/W2402459374","https://openalex.org/W1517770822"],"abstract_inverted_index":{"Canine":[0],"cardiac":[1,223],"sarcoplasmic":[2,65],"reticulum":[3,66],"(SR)":[4],"is":[5],"known":[6],"to":[7,148,164],"be":[8],"phosphorylated":[9,89,105],"by":[10,38,204,225],"adenosine":[11,84],"3',5'-monophosphate":[12],"(cAMP)":[13],"dependent":[14],"protein":[15,53,73,227],"kinase":[16,54,228],"on":[17,55],"a":[18,172,182],"22":[19],"000-dalton":[20],"protein.":[21],"Phosphorylation":[22,206],"enhances":[23],"the":[24,35,42,49,56,60,76,103,152,175,209,233,244],"initial":[25,131,210],"rate":[26,190,211],"of":[27,51,59,83,102,110,124,130,135,197,212,222,243],"Ca2+":[28,159,179,186],"uptake":[29],"and":[30,71,80,88,98,118,133,181],"Ca2+-ATPase":[31,61,111,234],"activity.":[32],"To":[33],"determine":[34],"molecular":[36],"mechanism":[37],"which":[39,237],"phosphorylation":[40,123,221],"regulates":[41,229],"calcium":[43,245],"pump":[44,246],"in":[45,75,112,127,174,185,232,239],"SR,":[46],"we":[47],"examined":[48],"effect":[50,153],"cAMP-dependent":[52,72,122,226],"individual":[57],"steps":[58,231],"reaction":[62,235],"sequence.":[63],"Cardiac":[64],"was":[67,154,169,200],"preincubated":[68],"with":[69,171],"cAMP":[70],"kinse":[74],"presence":[77],"(phosphorylated":[78],"SR)":[79],"absence":[81],"(control)":[82],"5'-triphosphate":[85],"(ATP).":[86],"Control":[87],"SR":[90,125,199,224],"were":[91],"subsequently":[92],"assayed":[93],"for":[94,178,192],"formation":[95,196],"(4-200":[96],"ms)":[97,101],"decomposition":[99],"(0-73":[100],"acid-stable":[104],"enzyme":[106],"(E":[107],"approximately":[108,137,194,214],"P)":[109],"media":[113],"containing":[114],"100":[115],"microM":[116],"[ATP]":[117],"various":[119],"free":[120,142,158],"[Ca2+].":[121],"resulted":[126],"pronounced":[128],"stimulation":[129,168,242],"rates":[132],"levels":[134],"E":[136,193,213],"P":[138,195,215],"formed":[139],"at":[140,156,248],"low":[141],"[Ca2+]":[143],"(less":[144],"than":[145,161],"or":[146,162],"equal":[147,163],"7":[149],"microM),":[150],"but":[151],"less":[155],"high":[157],"(greater":[160],"10":[165],"microM).":[166],"This":[167],"associated":[170],"decrease":[173],"dissociation":[176],"constant":[177,191],"binding":[180],"possible":[183],"increase":[184],"sites.":[187],"The":[188],"observed":[189,247],"calcium-preincubated":[198],"not":[201],"significantly":[202],"altered":[203],"phosphorylation.":[205],"also":[207],"increased":[208],"decomposition.":[216],"These":[217],"findings":[218],"indicate":[219],"that":[220],"several":[230],"sequence":[236],"result":[238],"an":[240],"overall":[241],"steady":[249],"state.":[250]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}