{"id":"https://openalex.org/W1968705390","doi":"https://doi.org/10.1007/s10535-007-0008-x","title":"Production of asiaticoside and madecassoside in Centella asiatica in vitro and in vivo","display_name":"Production of asiaticoside and madecassoside in Centella asiatica in vitro and in vivo","publication_year":2007,"publication_date":"2007-03-01","ids":{"openalex":"https://openalex.org/W1968705390","doi":"https://doi.org/10.1007/s10535-007-0008-x","mag":"1968705390"},"language":"en","primary_location":{"id":"doi:10.1007/s10535-007-0008-x","doi":"https://doi.org/10.1007/s10535-007-0008-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10535-007-0008-x","pdf_url":"http://bp.ueb.cas.cz/doi/10.1007/s10535-007-0008-x.pdf","source":{"id":"https://openalex.org/S56909845","display_name":"Biologia Plantarum","issn_l":"0006-3134","issn":["0006-3134","1573-8264"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310314217","host_organization_name":"Institute of Experimental Botany of the Czech Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310314217","https://openalex.org/P4310314171"],"host_organization_lineage_names":["Institute of Experimental Botany of the Czech Academy of Sciences","Czech Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biologia plantarum","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://bp.ueb.cas.cz/doi/10.1007/s10535-007-0008-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032344225","display_name":"Zaleha Abdul Aziz","orcid":"https://orcid.org/0000-0002-1971-1254","observed_orcids":["https://orcid.org/0000-0002-1971-1254"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Z. A. Aziz","raw_affiliation_strings":["Plant Sciences Division, School of Biosciences, University of Nottingham, Loughborough, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Sciences Division, School of Biosciences, University of Nottingham, Loughborough, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110088682","display_name":"M.R. Davey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. R. Davey","raw_affiliation_strings":["Plant Sciences Division, School of Biosciences, University of Nottingham, Loughborough, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Sciences Division, School of Biosciences, University of Nottingham, Loughborough, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051751081","display_name":"J. Brian Power","orcid":"https://orcid.org/0009-0008-0834-5384","observed_orcids":["https://orcid.org/0009-0008-0834-5384"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. B. Power","raw_affiliation_strings":["Plant Sciences Division, School of Biosciences, University of Nottingham, Loughborough, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Sciences Division, School of Biosciences, University of Nottingham, Loughborough, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108156317","display_name":"Paul Anthony","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. Anthony","raw_affiliation_strings":["Plant Sciences Division, School of Biosciences, University of Nottingham, Loughborough, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Sciences Division, School of Biosciences, University of Nottingham, Loughborough, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057271826","display_name":"Roger M. Smith","orcid":"https://orcid.org/0000-0002-5252-9649","observed_orcids":["https://orcid.org/0000-0002-5252-9649"]},"institutions":[{"id":"https://openalex.org/I143804889","display_name":"Loughborough University","ror":"https://ror.org/04vg4w365","country_code":"GB","type":"education","lineage":["https://openalex.org/I143804889"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. M. Smith","raw_affiliation_strings":["Department of Chemistry, Loughborough University, Loughborough, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Loughborough University, Loughborough, UK","institution_ids":["https://openalex.org/I143804889"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108402707","display_name":"K. C. Lowe","orcid":"https://orcid.org/0009-0004-0713-2935","observed_orcids":["https://orcid.org/0009-0004-0713-2935"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K. C. Lowe","raw_affiliation_strings":["School of Biology, University of Nottingham, University Park, Nottingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biology, University of Nottingham, University Park, Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3140,"currency":"USD","value_usd":3140},"apc_paid":null,"fwci":3.7059,"has_fulltext":true,"cited_by_count":102,"citation_normalized_percentile":{"value":0.91891068,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"51","issue":"1","first_page":"34","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10240","display_name":"Plant tissue culture and regeneration","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10240","display_name":"Plant tissue culture and regeneration","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/centella-asiatica","display_name":"Centella asiatica","score":0.9539999961853027},{"id":"https://openalex.org/keywords/asiaticoside","display_name":"asiaticoside","score":1.0},{"id":"https://openalex.org/keywords/madecassoside","display_name":"madecassoside","score":1.0},{"id":"https://openalex.org/keywords/triterpenoids","display_name":"triterpenoids","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tissue-specific-distribution","display_name":"tissue-specific distribution","score":0.640999972820282},{"id":"https://openalex.org/keywords/leaf-phenotype","display_name":"leaf phenotype","score":0.8109999895095825},{"id":"https://openalex.org/keywords/transformed-roots","display_name":"transformed roots","score":0.703000009059906},{"id":"https://openalex.org/keywords/agrobacterium-rhizogenes","display_name":"Agrobacterium rhizogenes","score":0.9319999814033508},{"id":"https://openalex.org/keywords/callus","display_name":"callus","score":0.6489999890327454},{"id":"https://openalex.org/keywords/in-vitro-production","display_name":"in vitro production","score":0.5320000052452087},{"id":"https://openalex.org/keywords/plant-secondary-metabolites","display_name":"plant secondary metabolites","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C2779077069","wikidata":"https://www.wikidata.org/wiki/Q1348880","display_name":"Centella","level":2,"score":0.9927459955215454},{"id":"https://openalex.org/C9549007","wikidata":"https://www.wikidata.org/wiki/Q1072909","display_name":"Callus","level":2,"score":0.6770986318588257},{"id":"https://openalex.org/C206103511","wikidata":"https://www.wikidata.org/wiki/Q426694","display_name":"Terpenoid","level":2,"score":0.6749809384346008},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.49504008889198303},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.4649798572063446},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46002617478370667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44797343015670776},{"id":"https://openalex.org/C144027150","wikidata":"https://www.wikidata.org/wiki/Q48803","display_name":"Horticulture","level":1,"score":0.42306646704673767},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3338397145271301},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s10535-007-0008-x","doi":"https://doi.org/10.1007/s10535-007-0008-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10535-007-0008-x","pdf_url":"http://bp.ueb.cas.cz/doi/10.1007/s10535-007-0008-x.pdf","source":{"id":"https://openalex.org/S56909845","display_name":"Biologia Plantarum","issn_l":"0006-3134","issn":["0006-3134","1573-8264"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310314217","host_organization_name":"Institute of Experimental Botany of the Czech Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310314217","https://openalex.org/P4310314171"],"host_organization_lineage_names":["Institute of Experimental Botany of the Czech Academy of Sciences","Czech Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biologia plantarum","raw_type":"journal-article"},{"id":"pmh:oai:eprints.ums.edu.my:33403","doi":null,"is_oa":true,"landing_page_url":"https://eprints.ums.edu.my/id/eprint/33403/1/Production%20of%20asiaticoside%20and%20madecasosside%20in%20Centella%20asiatica%20in%20vitro%20and%20in%20vivo.pdf","pdf_url":"https://eprints.ums.edu.my/id/eprint/33403/3/Production%20of%20asiaticoside%20and%20madecasosside%20in%20Centella%20asiatica%20in%20vitro%20and%20in%20vivo%20_ABSTRACT.pdf","source":{"id":"https://openalex.org/S4306400331","display_name":"UMS Institutional Repository (Universiti Malaysia Sabah)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161371597","host_organization_name":"Universiti of Malaysia Sabah","host_organization_lineage":["https://openalex.org/I161371597"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1007/s10535-007-0008-x","doi":"https://doi.org/10.1007/s10535-007-0008-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10535-007-0008-x","pdf_url":"http://bp.ueb.cas.cz/doi/10.1007/s10535-007-0008-x.pdf","source":{"id":"https://openalex.org/S56909845","display_name":"Biologia Plantarum","issn_l":"0006-3134","issn":["0006-3134","1573-8264"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310314217","host_organization_name":"Institute of Experimental Botany of the Czech Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310314217","https://openalex.org/P4310314171"],"host_organization_lineage_names":["Institute of Experimental Botany of the Czech Academy of Sciences","Czech Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biologia plantarum","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968705390.pdf","grobid_xml":"https://content.openalex.org/works/W1968705390.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W167580448","https://openalex.org/W612532208","https://openalex.org/W1482106182","https://openalex.org/W1559919694","https://openalex.org/W1580875586","https://openalex.org/W1968388053","https://openalex.org/W1980918529","https://openalex.org/W1995205851","https://openalex.org/W1999546069","https://openalex.org/W2001762131","https://openalex.org/W2003020635","https://openalex.org/W2004569967","https://openalex.org/W2013344241","https://openalex.org/W2018004737","https://openalex.org/W2019673870","https://openalex.org/W2024556021","https://openalex.org/W2033129896","https://openalex.org/W2045569819","https://openalex.org/W2057856305","https://openalex.org/W2074605281","https://openalex.org/W2075736397","https://openalex.org/W2086434990","https://openalex.org/W2120478361","https://openalex.org/W2125933976","https://openalex.org/W2144634347","https://openalex.org/W2346397980","https://openalex.org/W2481847842","https://openalex.org/W2502009607","https://openalex.org/W2521738389","https://openalex.org/W4251050500","https://openalex.org/W4285719527","https://openalex.org/W4294911073","https://openalex.org/W6724445612"],"related_works":["https://openalex.org/W7200042203","https://openalex.org/W4206616511","https://openalex.org/W2064941501","https://openalex.org/W2086744270","https://openalex.org/W2037248352","https://openalex.org/W2612753988","https://openalex.org/W2069758483","https://openalex.org/W1981874160","https://openalex.org/W2331475986","https://openalex.org/W4245290151"],"abstract_inverted_index":{"The":[0,45],"localization":[1],"was":[2,71,153],"determined":[3],"of":[4,13,22,25,30,35,48,85,109,116,124,131],"the":[5,99,110,113,128],"triterpenoids,":[6],"asiaticoside":[7,36,76,117,132,168],"and":[8,16,37,60,65,80,88,93,102,137,150,157,169,176],"madecassoside,":[9],"in":[10,53,73,98,173],"different":[11],"organs":[12],"glasshouse-grown":[14,63],"plants":[15,64,126],"cultured":[17],"material,":[18],"including":[19],"transformed":[20,174],"roots,":[21],"two":[23,46],"phenotypes":[24,47],"Centella":[26],"asiatica":[27,50],"(L.)":[28],"Urban":[29],"Malaysian":[31],"origin.":[32],"Methanolic":[33],"extracts":[34],"madecassoside":[38,89,138,170],"were":[39,57,145,171],"prepared":[40],"for":[41],"gradient":[42],"HPLC":[43],"analysis.":[44],"C.":[49],"exhibited":[51],"differences":[52],"terpenoid":[54],"content":[55,70,115,130],"that":[56],"tissue":[58,66],"specific":[59],"varied":[61],"between":[62],"culture-derived":[67],"material.":[68],"Terpenoid":[69],"highest":[72],"leaves,":[74],"with":[75,162],"(0.79":[77],"\u00b1":[78,82,91,95,119,134,140],"0.03":[79],"1.15":[81],"0.10":[83],"%":[84],"dry":[86],"mass)":[87],"[0.97":[90],"0.06":[92],"1.65":[94],"0.01":[96,120,135],"%(d.m.)]":[97,136],"fringed":[100],"(F)":[101],"smooth":[103],"leaf":[104],"(S)":[105],"phenotypes,":[106],"respectively.":[107],"Roots":[108],"F-phenotype":[111],"contained":[112,127],"lowest":[114,129],"[0.12":[118],"%(d.m.)],":[121],"whereas":[122],"petioles":[123],"S-phenotype":[125],"[0.16":[133],"[0.18":[139],"0.14":[141],"%(d.m.)].":[142],"Transformed":[143],"roots":[144,175],"induced":[146],"using":[147],"Agrobacterium":[148],"rhizogens":[149],"their":[151],"growth":[152],"maximal":[154],"on":[155],"Murashige":[156],"Skoog":[158],"basal":[159],"medium":[160],"supplemented":[161],"60":[163],"g":[164],"dm-3":[165],"sucrose.":[166],"However,":[167],"undetectable":[172],"undifferentiated":[177],"callus.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}