{"id":"https://openalex.org/W1968697201","doi":"https://doi.org/10.1016/j.bbamcr.2011.06.008","title":"Molecular and biochemical characterization of nitric oxide synthase isoforms and their intracellular distribution in human peripheral blood mononuclear cells","display_name":"Molecular and biochemical characterization of nitric oxide synthase isoforms and their intracellular distribution in human peripheral blood mononuclear cells","publication_year":2011,"publication_date":"2011-06-27","ids":{"openalex":"https://openalex.org/W1968697201","doi":"https://doi.org/10.1016/j.bbamcr.2011.06.008","mag":"1968697201","pmid":"https://pubmed.ncbi.nlm.nih.gov/21722677"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbamcr.2011.06.008","doi":"https://doi.org/10.1016/j.bbamcr.2011.06.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbamcr.2011.06.008","pdf_url":null,"source":{"id":"https://openalex.org/S4210226410","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","issn_l":"0167-4889","issn":["0167-4889","1879-2596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.bbamcr.2011.06.008","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032403601","display_name":"Rohit Saluja","orcid":"https://orcid.org/0000-0002-8578-198X","observed_orcids":["https://orcid.org/0000-0002-8578-198X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rohit Saluja","raw_affiliation_strings":["Pharmacology Division, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Division, Lucknow, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084013075","display_name":"Anupam Jyoti","orcid":"https://orcid.org/0000-0002-4135-7466","observed_orcids":["https://orcid.org/0000-0002-4135-7466"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anupam Jyoti","raw_affiliation_strings":["Pharmacology Division, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Division, Lucknow, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071436332","display_name":"Madhumita Chatterjee","orcid":"https://orcid.org/0000-0002-3428-4107","observed_orcids":["https://orcid.org/0000-0002-3428-4107"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Madhumita Chatterjee","raw_affiliation_strings":["Pharmacology Division, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Division, Lucknow, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017413200","display_name":"Saman Habib","orcid":"https://orcid.org/0000-0001-9378-7786","observed_orcids":["https://orcid.org/0000-0001-9378-7786"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saman Habib","raw_affiliation_strings":["Division of Structural and Molecular Biology, Central Drug Research Institute (CSIR), Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Structural and Molecular Biology, Central Drug Research Institute (CSIR), Lucknow, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020819633","display_name":"Anupam R. Verma","orcid":"https://orcid.org/0000-0001-6555-7924","observed_orcids":["https://orcid.org/0000-0001-6555-7924"]},"institutions":[{"id":"https://openalex.org/I161370692","display_name":"Sanjay Gandhi Post Graduate Institute of Medical Sciences","ror":"https://ror.org/01rsgrz10","country_code":"IN","type":"facility","lineage":["https://openalex.org/I161370692"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anupam Verma","raw_affiliation_strings":["Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India","institution_ids":["https://openalex.org/I161370692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084618028","display_name":"Kalyan Mitra","orcid":"https://orcid.org/0000-0002-7252-1716","observed_orcids":["https://orcid.org/0000-0002-7252-1716"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kalyan Mitra","raw_affiliation_strings":["Electron Microscopy Unit, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electron Microscopy Unit, Lucknow, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044225349","display_name":"Manoj Kumar Barthwal","orcid":"https://orcid.org/0000-0001-7574-482X","observed_orcids":["https://orcid.org/0000-0001-7574-482X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manoj Kumar Barthwal","raw_affiliation_strings":["Pharmacology Division, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Division, Lucknow, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103394543","display_name":"Virendra Kumar Bajpai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Virendra K. Bajpai","raw_affiliation_strings":["Electron Microscopy Unit, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electron Microscopy Unit, Lucknow, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060712880","display_name":"Madhu Dikshit","orcid":"https://orcid.org/0000-0002-2777-0940","observed_orcids":["https://orcid.org/0000-0002-2777-0940"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Madhu Dikshit","raw_affiliation_strings":["Pharmacology Division, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Division, Lucknow, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060712880"],"corresponding_institution_ids":[],"apc_list":{"value":3930,"currency":"USD","value_usd":3930},"apc_paid":null,"fwci":3.0368,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.89558338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"1813","issue":"10","first_page":"1700","last_page":"1707"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.9760000109672546},{"id":"https://openalex.org/keywords/nos-isoforms","display_name":"NOS isoforms","score":0.8870000243186951},{"id":"https://openalex.org/keywords/neuronal-nitric-oxide-synthase","display_name":"neuronal nitric oxide synthase","score":0.8119999766349792},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":1.0},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":1.0},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9419999718666077},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.8040000200271606},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.996999979019165},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.8429999947547913},{"id":"https://openalex.org/keywords/nitric-oxide-production","display_name":"nitric oxide production","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C30030713","wikidata":"https://www.wikidata.org/wiki/Q17029513","display_name":"Immunogold labelling","level":3,"score":0.812536358833313},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.7709619402885437},{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.7553174495697021},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.6746697425842285},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.6706611514091492},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.6115666031837463},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.5987104773521423},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5765182375907898},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5663514137268066},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5055315494537354},{"id":"https://openalex.org/C2779698670","wikidata":"https://www.wikidata.org/wiki/Q408853","display_name":"Endothelial NOS","level":5,"score":0.45984283089637756},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.438326358795166},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39120516180992126},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2694365382194519},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21726223826408386},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.13429975509643555},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.117974191904068},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07308721542358398},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06781676411628723},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06026846170425415}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbamcr.2011.06.008","doi":"https://doi.org/10.1016/j.bbamcr.2011.06.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbamcr.2011.06.008","pdf_url":null,"source":{"id":"https://openalex.org/S4210226410","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","issn_l":"0167-4889","issn":["0167-4889","1879-2596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","raw_type":"journal-article"},{"id":"pmid:21722677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21722677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.bbamcr.2011.06.008","doi":"https://doi.org/10.1016/j.bbamcr.2011.06.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbamcr.2011.06.008","pdf_url":null,"source":{"id":"https://openalex.org/S4210226410","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","issn_l":"0167-4889","issn":["0167-4889","1879-2596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"},{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W190871061","https://openalex.org/W633514430","https://openalex.org/W1518080160","https://openalex.org/W1550563624","https://openalex.org/W1560571961","https://openalex.org/W1605694747","https://openalex.org/W1966299181","https://openalex.org/W1969853188","https://openalex.org/W1990795329","https://openalex.org/W1994525023","https://openalex.org/W1999625965","https://openalex.org/W2000297780","https://openalex.org/W2004724154","https://openalex.org/W2004940500","https://openalex.org/W2007452107","https://openalex.org/W2015723689","https://openalex.org/W2020310146","https://openalex.org/W2027883616","https://openalex.org/W2032322260","https://openalex.org/W2035691895","https://openalex.org/W2041521858","https://openalex.org/W2054755999","https://openalex.org/W2058520514","https://openalex.org/W2062162125","https://openalex.org/W2062178630","https://openalex.org/W2063680573","https://openalex.org/W2066039419","https://openalex.org/W2066649179","https://openalex.org/W2074277484","https://openalex.org/W2082775864","https://openalex.org/W2090161961","https://openalex.org/W2096725924","https://openalex.org/W2097654356","https://openalex.org/W2105192538","https://openalex.org/W2106319422","https://openalex.org/W2106554511","https://openalex.org/W2107673518","https://openalex.org/W2112084358","https://openalex.org/W2118797909","https://openalex.org/W2120013988","https://openalex.org/W2131474149","https://openalex.org/W2142028027","https://openalex.org/W2158494776","https://openalex.org/W2253648208","https://openalex.org/W2408158381","https://openalex.org/W2467782639"],"related_works":["https://openalex.org/W1990795329","https://openalex.org/W3151068574","https://openalex.org/W2062162125","https://openalex.org/W2106554511","https://openalex.org/W2292339228","https://openalex.org/W3183927978","https://openalex.org/W2183600202","https://openalex.org/W2142028027","https://openalex.org/W2043622514","https://openalex.org/W1974596384"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}