{"id":"https://openalex.org/W1968674035","doi":"https://doi.org/10.1016/0223-5234(96)88278-x","title":"New pyridazinone derivatives as inhibitors of platelet aggregation","display_name":"New pyridazinone derivatives as inhibitors of platelet aggregation","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W1968674035","doi":"https://doi.org/10.1016/0223-5234(96)88278-x","mag":"1968674035"},"language":"en","primary_location":{"id":"doi:10.1016/0223-5234(96)88278-x","doi":"https://doi.org/10.1016/0223-5234(96)88278-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0223-5234(96)88278-x","pdf_url":null,"source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025487312","display_name":"Stefano Corsano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S Corsano","raw_affiliation_strings":["Institute of Pharmaceutical Chemistry, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Chemistry, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113296341","display_name":"R Vezza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R Vezza","raw_affiliation_strings":["Institute of Internal and Vascular Medicine, University of Perugia, Via E del Pozzo 1, 06126 Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Internal and Vascular Medicine, University of Perugia, Via E del Pozzo 1, 06126 Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001602336","display_name":"Rossana Scapicchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R Scapicchi","raw_affiliation_strings":["Institute of Pharmaceutical Chemistry, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Chemistry, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031218336","display_name":"S Foresi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S Foresi","raw_affiliation_strings":["Institute of Internal and Vascular Medicine, University of Perugia, Via E del Pozzo 1, 06126 Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Internal and Vascular Medicine, University of Perugia, Via E del Pozzo 1, 06126 Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003473752","display_name":"Giovannella Strappaghetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Strappaghetti","raw_affiliation_strings":["Institute of Pharmaceutical Chemistry, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Chemistry, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113763889","display_name":"GG Nenci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"GG Nenci","raw_affiliation_strings":["Institute of Internal and Vascular Medicine, University of Perugia, Via E del Pozzo 1, 06126 Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Internal and Vascular Medicine, University of Perugia, Via E del Pozzo 1, 06126 Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003292078","display_name":"Paolo Gresele","orcid":"https://orcid.org/0000-0001-5365-8445","observed_orcids":["https://orcid.org/0000-0001-5365-8445"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P Gresele","raw_affiliation_strings":["Institute of Internal and Vascular Medicine, University of Perugia, Via E del Pozzo 1, 06126 Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Internal and Vascular Medicine, University of Perugia, Via E del Pozzo 1, 06126 Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27483092"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"30","issue":"7-8","first_page":"627","last_page":"631"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.486299991607666,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.486299991607666,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.3978999853134155,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.03920000046491623,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyridazinone-derivatives","display_name":"pyridazinone derivatives","score":0.9850000143051147},{"id":"https://openalex.org/keywords/antiplatelet-drugs","display_name":"antiplatelet agents","score":0.9629999995231628},{"id":"https://openalex.org/keywords/thromboxane-synthase-inhibitor","display_name":"thromboxane synthetase inhibitor","score":0.9449999928474426},{"id":"https://openalex.org/keywords/thromboxane-a2","display_name":"thromboxane A2","score":0.9729999899864197},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":1.0},{"id":"https://openalex.org/keywords/human-platelets","display_name":"human platelets","score":0.7699999809265137},{"id":"https://openalex.org/keywords/adp-induced-platelet-aggregation","display_name":"ADP-induced aggregation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/collagen-induced-platelet-aggregation","display_name":"collagen-induced aggregation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.9049999713897705},{"id":"https://openalex.org/keywords/u46619","display_name":"U46619","score":0.9229999780654907},{"id":"https://openalex.org/keywords/phosphodiesterase-inhibition","display_name":"phosphodiesterase inhibition","score":0.8820000290870667},{"id":"https://openalex.org/keywords/imidazole-derivatives","display_name":"imidazole derivatives","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9612563252449036},{"id":"https://openalex.org/C2993802102","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet aggregation","level":3,"score":0.6870300769805908},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4385167956352234},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4194732904434204},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.392440527677536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1536765992641449},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/0223-5234(96)88278-x","doi":"https://doi.org/10.1016/0223-5234(96)88278-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0223-5234(96)88278-x","pdf_url":null,"source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W223025435","https://openalex.org/W1945490092","https://openalex.org/W1948702918","https://openalex.org/W1966682207","https://openalex.org/W2002150211","https://openalex.org/W2022335174","https://openalex.org/W2025476403","https://openalex.org/W2039330939","https://openalex.org/W2047854358","https://openalex.org/W2051720100","https://openalex.org/W2054262691","https://openalex.org/W2076696870","https://openalex.org/W2077459776","https://openalex.org/W2083261523","https://openalex.org/W2087652536","https://openalex.org/W2404343508","https://openalex.org/W2414644411","https://openalex.org/W2417667988"],"related_works":["https://openalex.org/W2012628265","https://openalex.org/W2015109710","https://openalex.org/W2471140937","https://openalex.org/W2349062553","https://openalex.org/W1977672646","https://openalex.org/W2348887111","https://openalex.org/W2312579544","https://openalex.org/W1985484014","https://openalex.org/W2382557783","https://openalex.org/W2418965256"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}