{"id":"https://openalex.org/W1968659783","doi":"https://doi.org/10.3748/wjg.14.1630","title":"Protein-loosing enteropathy associated with rotavirus infection in an infant","display_name":"Protein-loosing enteropathy associated with rotavirus infection in an infant","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W1968659783","doi":"https://doi.org/10.3748/wjg.14.1630","mag":"1968659783","pmid":"https://pubmed.ncbi.nlm.nih.gov/18330961","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2693765"},"language":"en","primary_location":{"id":"doi:10.3748/wjg.14.1630","doi":"https://doi.org/10.3748/wjg.14.1630","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.14.1630","pdf_url":"https://www.wjgnet.com/1007-9327/full/v14/i10/1630.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.wjgnet.com/1007-9327/full/v14/i10/1630.htm","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021635509","display_name":"Tadashi Iwasa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Iwasa","raw_affiliation_strings":["Department of Pediatrics, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu City, Mie Prefecture, 514-8507, Japan. masaru@clin.medic.mie-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu City, Mie Prefecture, 514-8507, Japan. masaru@clin.medic.mie-u.ac.jp","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"last","author":{"id":null,"display_name":"Nobuyuki Matsubayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]},{"id":"https://openalex.org/I191420491","display_name":"Universidad de Ja\u00e9n","ror":"https://ror.org/0122p5f64","country_code":"ES","type":"education","lineage":["https://openalex.org/I191420491"]},{"id":"https://openalex.org/I4405255730","display_name":"Mie Prefectural Shima Hospital","ror":"https://ror.org/03bsybc69","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405255730"]}],"countries":["ES","JP"],"is_corresponding":false,"raw_author_name":"Nobuyuki Matsubayashi","raw_affiliation_strings":["Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Mie, Japan","Department of Pediatrics, Shima Prefectural Hospital, Shima, Mie, Japan","Department of Pediatrics, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu City, Mie Prefecture, 514-8507, Japan","Experimental Biology, University of Jaen, araje de las Lagunillas s/n, Ja\u00e9n 23071, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]},{"raw_affiliation_string":"Department of Pediatrics, Shima Prefectural Hospital, Shima, Mie, Japan","institution_ids":["https://openalex.org/I4405255730"]},{"raw_affiliation_string":"Department of Pediatrics, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu City, Mie Prefecture, 514-8507, Japan","institution_ids":["https://openalex.org/I178574317"]},{"raw_affiliation_string":"Experimental Biology, University of Jaen, araje de las Lagunillas s/n, Ja\u00e9n 23071, Spain","institution_ids":["https://openalex.org/I191420491"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.444,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.66751668,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"14","issue":"10","first_page":"1630","last_page":"1630"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rotavirus-infection","display_name":"rotavirus infection","score":0.9010000228881836},{"id":"https://openalex.org/keywords/rotavirus-gastroenteritis","display_name":"rotavirus gastroenteritis","score":0.9179999828338623},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.8309999704360962},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.902999997138977},{"id":"https://openalex.org/keywords/hypogammaglobulinemia","display_name":"hypogammaglobulinemia","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cd4-cd8-ratio","display_name":"CD4/CD8 ratio","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cd4-positive-lymphocytes","display_name":"CD4-positive lymphocytes","score":0.6269999742507935},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8519999980926514},{"id":"https://openalex.org/keywords/alpha-1-antitrypsin-clearance","display_name":"alpha-1-antitrypsin clearance","score":0.9210000038146973},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.7080000042915344},{"id":"https://openalex.org/keywords/immune-activation","display_name":"immune activation","score":0.3370000123977661}],"concepts":[{"id":"https://openalex.org/C2777805810","wikidata":"https://www.wikidata.org/wiki/Q1047559","display_name":"Hypogammaglobulinemia","level":3,"score":0.844586193561554},{"id":"https://openalex.org/C2781367151","wikidata":"https://www.wikidata.org/wiki/Q164778","display_name":"Rotavirus","level":3,"score":0.7853349447250366},{"id":"https://openalex.org/C2778426112","wikidata":"https://www.wikidata.org/wiki/Q3055380","display_name":"Enteropathy","level":3,"score":0.7661417722702026},{"id":"https://openalex.org/C2776924286","wikidata":"https://www.wikidata.org/wiki/Q284070","display_name":"Protein losing enteropathy","level":4,"score":0.6747201681137085},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6491434574127197},{"id":"https://openalex.org/C2776009029","wikidata":"https://www.wikidata.org/wiki/Q1640780","display_name":"Hypoalbuminemia","level":2,"score":0.6111668944358826},{"id":"https://openalex.org/C2777140744","wikidata":"https://www.wikidata.org/wiki/Q1036403","display_name":"Hypoproteinemia","level":2,"score":0.4928569793701172},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4540666937828064},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41630807518959045},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4155206084251404},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.4141913056373596},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3730778396129608},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2299257218837738},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.19671058654785156},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.10111531615257263},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D005759","descriptor_name":"Gastroenteritis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D005759","descriptor_name":"Gastroenteritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011504","descriptor_name":"Protein-Losing Enteropathies","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011504","descriptor_name":"Protein-Losing Enteropathies","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011504","descriptor_name":"Protein-Losing Enteropathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012400","descriptor_name":"Rotavirus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D012400","descriptor_name":"Rotavirus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016516","descriptor_name":"CD4-CD8 Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3748/wjg.14.1630","doi":"https://doi.org/10.3748/wjg.14.1630","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.14.1630","pdf_url":"https://www.wjgnet.com/1007-9327/full/v14/i10/1630.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmid:18330961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18330961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of gastroenterology","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:2693765","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2693765/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World J Gastroenterol","raw_type":"Text"},{"id":"mag:3152064652","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/84123X/200810/26728418.html","pdf_url":null,"source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e16\u754c\u80c3\u80a0\u75c5\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248\uff08\u7535\u5b50\u7248\uff09","raw_type":null}],"best_oa_location":{"id":"doi:10.3748/wjg.14.1630","doi":"https://doi.org/10.3748/wjg.14.1630","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.14.1630","pdf_url":"https://www.wjgnet.com/1007-9327/full/v14/i10/1630.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968659783.pdf","grobid_xml":"https://content.openalex.org/works/W1968659783.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1966788203","https://openalex.org/W1970062415","https://openalex.org/W1980444612","https://openalex.org/W2002719238","https://openalex.org/W2029023214","https://openalex.org/W2029772807","https://openalex.org/W2034682597","https://openalex.org/W2040802565","https://openalex.org/W2047019642","https://openalex.org/W2058931989","https://openalex.org/W2062166436","https://openalex.org/W2077816011","https://openalex.org/W2084734424","https://openalex.org/W2087309369","https://openalex.org/W2160799172","https://openalex.org/W2392976664"],"related_works":["https://openalex.org/W2593438823","https://openalex.org/W2084734424","https://openalex.org/W2996236328","https://openalex.org/W2587410552","https://openalex.org/W2187385897","https://openalex.org/W7219922859","https://openalex.org/W2912085575","https://openalex.org/W2129309802","https://openalex.org/W2347788036","https://openalex.org/W2147442531"],"abstract_inverted_index":{"Rotavirus":[0],"is":[1],"an":[2,79],"acute":[3],"enteric":[4],"pathogen":[5],"in":[6,32,82,111],"infants":[7],"and":[8,27,43,102],"children.":[9],"We":[10],"reported":[11],"a":[12,16,108],"rare":[13],"case":[14],"of":[15,45,55,62,69,93],"6-mo-old":[17],"infant":[18],"with":[19,58],"protein-loosing":[20,112],"enteropathy":[21],"(PLE)":[22],"caused":[23],"by":[24,96],"rotavirus":[25,97],"gastroenteritis,":[26],"evaluated":[28],"the":[29,53,59,66,83],"immunological":[30],"profile":[31],"peripheral":[33],"blood":[34],"lymphocytes.":[35,64],"Laboratory":[36],"examinations":[37],"showed":[38],"lymphopenia,":[39],"hypoproteinemia,":[40],"hypoalbuminemia,":[41],"hypogammaglobulinemia,":[42],"elevation":[44],"alpha-1-antitrypsin":[46],"(alpha1-AT)":[47],"clearance.":[48],"Lymphocytes":[49],"subpopulation":[50],"study":[51],"revealed":[52],"reversal":[54],"CD4+/CD8+":[56],"ratio":[57],"selective":[60],"decrease":[61],"CD4-positive":[63],"Moreover,":[65],"excessive":[67],"increase":[68],"T":[70],"cells":[71],"producing":[72],"IFN-gamma":[73],"(IFN-gamma)":[74],"was":[75],"found,":[76],"which":[77,105],"plays":[78],"important":[80],"role":[81,110],"protection":[84],"against":[85],"viral":[86],"infection.":[87],"The":[88],"primary":[89],"or":[90],"secondary":[91],"activation":[92],"immune":[94],"system":[95],"may":[98,106],"influence":[99],"structural":[100],"integrity":[101],"vascular":[103],"permeability,":[104],"play":[107],"triggering":[109],"enteropathy.":[113]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}