{"id":"https://openalex.org/W1968654828","doi":"https://doi.org/10.1016/0029-7844(94)00448-m","title":"Comparison of oral estrogens and estrogens plus androgen on bone mineral density, menopausal symptoms, and lipid-lipoprotein profiles in surgical menopause","display_name":"Comparison of oral estrogens and estrogens plus androgen on bone mineral density, menopausal symptoms, and lipid-lipoprotein profiles in surgical menopause","publication_year":1995,"publication_date":"1995-04-01","ids":{"openalex":"https://openalex.org/W1968654828","doi":"https://doi.org/10.1016/0029-7844(94)00448-m","mag":"1968654828","pmid":"https://pubmed.ncbi.nlm.nih.gov/7898828"},"language":"en","primary_location":{"id":"doi:10.1016/0029-7844(94)00448-m","doi":"https://doi.org/10.1016/0029-7844(94)00448-m","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0029-7844(94)00448-m","pdf_url":null,"source":{"id":"https://openalex.org/S139838620","display_name":"Obstetrics and Gynecology","issn_l":"0029-7844","issn":["0029-7844","1873-233X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obstetrics &amp; Gynecology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1968654828"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009444658","display_name":"N WATTS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N WATTS","raw_affiliation_strings":["Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047161553","display_name":"Morris Notelovitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M NOTELOVITZ","raw_affiliation_strings":["From Emory University School of Medicine, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106826432","display_name":"M CHRYSTIETIMMONS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M CHRYSTIETIMMONS","raw_affiliation_strings":["From Emory University School of Medicine, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106826433","display_name":"W ALLENADDISON","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W ALLENADDISON","raw_affiliation_strings":["From Emory University School of Medicine, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062962860","display_name":"Brinda Wiita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B WIITA","raw_affiliation_strings":["From Emory University School of Medicine, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":null,"display_name":"L DOWNEY","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L DOWNEY","raw_affiliation_strings":["From Emory University School of Medicine, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":null,"apc_paid":null,"fwci":6.6817,"has_fulltext":false,"cited_by_count":268,"citation_normalized_percentile":{"value":0.97565449,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"85","issue":"4","first_page":"529","last_page":"537"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/surgical-menopause","display_name":"surgical menopause","score":0.8489999771118164},{"id":"https://openalex.org/keywords/oral-estrogen","display_name":"oral estrogen","score":0.8029999732971191},{"id":"https://openalex.org/keywords/methyltestosterone","display_name":"methyltestosterone","score":0.8830000162124634},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.9259999990463257},{"id":"https://openalex.org/keywords/menopausal-symptoms","display_name":"menopausal symptoms","score":0.8009999990463257},{"id":"https://openalex.org/keywords/hot-flashes","display_name":"hot flashes","score":0.7860000133514404},{"id":"https://openalex.org/keywords/lipoprotein-profile","display_name":"lipoprotein profile","score":0.7929999828338623},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9120000004768372},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.7120000123977661},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9399999976158142},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.7329999804496765},{"id":"https://openalex.org/keywords/bone-loss-prevention","display_name":"bone loss prevention","score":0.6079999804496765},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8612959384918213},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.7481410503387451},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.7217271327972412},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6891442537307739},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.674593985080719},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.5750253200531006},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.5324013829231262},{"id":"https://openalex.org/C2779329777","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone density","level":3,"score":0.5081217288970947},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.5057313442230225},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.4625501036643982},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4553819000720978},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.44401663541793823},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.25615614652633667}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001053","descriptor_name":"Apolipoproteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001053","descriptor_name":"Apolipoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005269","descriptor_name":"Femur","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007044","descriptor_name":"Hysterectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008593","descriptor_name":"Menopause","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008593","descriptor_name":"Menopause","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008777","descriptor_name":"Methyltestosterone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008777","descriptor_name":"Methyltestosterone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010052","descriptor_name":"Ovariectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011184","descriptor_name":"Postoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013131","descriptor_name":"Spine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015914","descriptor_name":"Estrogen Replacement Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D045166","descriptor_name":"Estradiol Congeners","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0029-7844(94)00448-m","doi":"https://doi.org/10.1016/0029-7844(94)00448-m","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0029-7844(94)00448-m","pdf_url":null,"source":{"id":"https://openalex.org/S139838620","display_name":"Obstetrics and Gynecology","issn_l":"0029-7844","issn":["0029-7844","1873-233X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obstetrics &amp; Gynecology","raw_type":"journal-article"},{"id":"pmid:7898828","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7898828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obstetrics and gynecology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W21914839","https://openalex.org/W1930168886","https://openalex.org/W1969332081","https://openalex.org/W1974831475","https://openalex.org/W1987144846","https://openalex.org/W1989258056","https://openalex.org/W1992502576","https://openalex.org/W1996493031","https://openalex.org/W2008362821","https://openalex.org/W2022705586","https://openalex.org/W2024103219","https://openalex.org/W2032083115","https://openalex.org/W2042505926","https://openalex.org/W2045848177","https://openalex.org/W2046428578","https://openalex.org/W2046983302","https://openalex.org/W2066226218","https://openalex.org/W2070079676","https://openalex.org/W2072627238","https://openalex.org/W2077767519","https://openalex.org/W2078406992","https://openalex.org/W2092295293","https://openalex.org/W2107073242","https://openalex.org/W2116404316","https://openalex.org/W2120955256","https://openalex.org/W2130702804","https://openalex.org/W2148727186","https://openalex.org/W2154519603","https://openalex.org/W2170345838","https://openalex.org/W2262818029","https://openalex.org/W2341922045","https://openalex.org/W2399797509","https://openalex.org/W2416139549","https://openalex.org/W2416653136","https://openalex.org/W2417679673"],"related_works":["https://openalex.org/W105897893","https://openalex.org/W120047217","https://openalex.org/W1971217465","https://openalex.org/W3144506277","https://openalex.org/W2066124773","https://openalex.org/W2416407368","https://openalex.org/W2325307930","https://openalex.org/W2387993077","https://openalex.org/W3036679615","https://openalex.org/W2351552727"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"compare":[2],"an":[3],"oral":[4,25],"estrogen-androgen":[5,83,138,174],"combination":[6,196],"with":[7,87,97,181],"estrogens":[8,27,32],"alone":[9],"on":[10],"bone,":[11],"menopausal":[12,22,52],"symptoms,":[13,53],"and":[14,35,50,56,58,80,123,132,149,184],"lipoprotein":[15,54,118,125,191],"profiles":[16],"in":[17,68,91,136,169],"postmenopausal":[18],"women.":[19],"METHODS:":[20],"Surgically":[21],"women":[23],"received":[24],"esterified":[26,31],"(1.25":[28,33],"mg),":[29],"or":[30,164],"mg)":[34,38],"methyltestosterone":[36],"(2.5":[37],"daily,":[39],"for":[40],"2":[41,202],"years.":[42],"Bone":[43],"mineral":[44,94,178],"density":[45,95,179],"of":[46,142,204],"the":[47,69,78,114,137,195,201],"lumbar":[48],"spine":[49,79],"hip,":[51],"profiles,":[55],"biochemical":[57],"hematologic":[59],"indices":[60],"were":[61,66,151,167],"evaluated.":[62],"RESULTS:":[63],"Sixty-six":[64],"patients":[65],"enrolled":[67],"study.":[70],"Both":[71],"treatment":[72],"regimens":[73],"prevented":[74],"bone":[75,93,177],"loss":[76],"at":[77],"hip;":[81],"combined":[82],"therapy":[84],"was":[85,197],"associated":[86],"a":[88],"significant":[89,162],"increase":[90],"spinal":[92],"compared":[96,180],"baseline":[98],"(n":[99],"=":[100],"24;":[101],"mean":[102],"score":[103],"+/-":[104,108],"standard":[105],"error":[106],"3.4":[107],"1.2%,":[109],"P":[110],"<":[111],".01).":[112],"In":[113],"estrogen":[115],"group,":[116],"high-density":[117],"(HDL)":[119],"cholesterol":[120,126],"increased":[121,175],"significantly":[122,135,153],"low-density":[124],"decreased":[127,134],"significantly.":[128],"Cholesterol,":[129],"HDL":[130],"cholesterol,":[131],"triglycerides":[133],"group.":[139,171],"Menopausal":[140],"symptoms":[141],"somatic":[143,186],"origin":[144],"(hot":[145],"flashes,":[146],"vaginal":[147],"dryness,":[148],"insomnia)":[150],"improved":[152],"by":[154],"both":[155],"treatments.":[156],"Neither":[157],"adverse":[158],"hepatic":[159],"effects":[160],"nor":[161],"safety":[163],"tolerance":[165],"problems":[166],"reported":[168],"either":[170],"CONCLUSION:":[172],"Oral":[173],"vertebral":[176],"pre-treatment":[182],"values":[183],"relieved":[185],"symptoms.":[187],"Safety":[188],"indices,":[189],"including":[190],"levels,":[192],"indicated":[193],"that":[194],"well":[198],"tolerated":[199],"over":[200],"years":[203],"treatment.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}