{"id":"https://openalex.org/W1968652295","doi":"https://doi.org/10.1002/ajh.20142","title":"Follow\u2010up of sickle cell disease patients with priapism treated by hydroxyurea","display_name":"Follow\u2010up of sickle cell disease patients with priapism treated by hydroxyurea","publication_year":2004,"publication_date":"2004-08-11","ids":{"openalex":"https://openalex.org/W1968652295","doi":"https://doi.org/10.1002/ajh.20142","mag":"1968652295","pmid":"https://pubmed.ncbi.nlm.nih.gov/15307105"},"language":"en","primary_location":{"id":"doi:10.1002/ajh.20142","doi":"https://doi.org/10.1002/ajh.20142","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajh.20142","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajh.20142","source":{"id":"https://openalex.org/S199810014","display_name":"American Journal of Hematology","issn_l":"0361-8609","issn":["0361-8609","1096-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajh.20142","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109135656","display_name":"Sara T. Olalla Saad","orcid":"https://orcid.org/0000-0003-0809-8068","observed_orcids":["https://orcid.org/0000-0003-0809-8068"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Sara T.O. Saad","raw_affiliation_strings":["Hematology and Hemotherapy Center of the State University of Campinas, Campinas, S\u00e3o Paulo, Brazil. sara@unicamp.br","Hematology and Hemotherapy Center of the State University of Campinas, Campinas, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Hemotherapy Center of the State University of Campinas, Campinas, S\u00e3o Paulo, Brazil. sara@unicamp.br","institution_ids":["https://openalex.org/I181391015"]},{"raw_affiliation_string":"Hematology and Hemotherapy Center of the State University of Campinas, Campinas, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103732399","display_name":"Camila Philbert Lajolo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Camila Lajolo","raw_affiliation_strings":["Hematology and Hemotherapy Center of the State University of Campinas, Campinas, Sa\u0303o Paulo, Brazil","Hematology and Hemotherapy Center of the State University of Campinas, Campinas, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Hemotherapy Center of the State University of Campinas, Campinas, Sa\u0303o Paulo, Brazil","institution_ids":["https://openalex.org/I181391015"]},{"raw_affiliation_string":"Hematology and Hemotherapy Center of the State University of Campinas, Campinas, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111985878","display_name":"Simone Cristina Olenscki Gilli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Simone Gilli","raw_affiliation_strings":["Hematology and Hemotherapy Center of the State University of Campinas, Campinas, Sa\u0303o Paulo, Brazil","Hematology and Hemotherapy Center of the State University of Campinas, Campinas, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Hemotherapy Center of the State University of Campinas, Campinas, Sa\u0303o Paulo, Brazil","institution_ids":["https://openalex.org/I181391015"]},{"raw_affiliation_string":"Hematology and Hemotherapy Center of the State University of Campinas, Campinas, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039927875","display_name":"Jos\u00e9 Francisco Comenalli Marques","orcid":"https://orcid.org/0000-0003-0334-2180","observed_orcids":["https://orcid.org/0000-0003-0334-2180"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Francisco C. Marques","raw_affiliation_strings":["Hematology and Hemotherapy Center of the State University of Campinas, Campinas, Sa\u0303o Paulo, Brazil","Hematology and Hemotherapy Center of the State University of Campinas, Campinas, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Hemotherapy Center of the State University of Campinas, Campinas, Sa\u0303o Paulo, Brazil","institution_ids":["https://openalex.org/I181391015"]},{"raw_affiliation_string":"Hematology and Hemotherapy Center of the State University of Campinas, Campinas, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029695191","display_name":"Carmen S\u00edlvia Passos Lima","orcid":"https://orcid.org/0000-0002-1314-2345","observed_orcids":["https://orcid.org/0000-0002-1314-2345"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carmen S. Lima","raw_affiliation_strings":["Hematology and Hemotherapy Center of the State University of Campinas, Campinas, Sa\u0303o Paulo, Brazil","Hematology and Hemotherapy Center of the State University of Campinas, Campinas, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Hemotherapy Center of the State University of Campinas, Campinas, Sa\u0303o Paulo, Brazil","institution_ids":["https://openalex.org/I181391015"]},{"raw_affiliation_string":"Hematology and Hemotherapy Center of the State University of Campinas, Campinas, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067713063","display_name":"Fernando Ferreira Costa","orcid":"https://orcid.org/0000-0002-4632-572X","observed_orcids":["https://orcid.org/0000-0002-4632-572X","https://orcid.org/0009-0002-1844-2870"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fernando F. Costa","raw_affiliation_strings":["Hematology and Hemotherapy Center of the State University of Campinas, Campinas, Sa\u0303o Paulo, Brazil","Hematology and Hemotherapy Center of the State University of Campinas, Campinas, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Hemotherapy Center of the State University of Campinas, Campinas, Sa\u0303o Paulo, Brazil","institution_ids":["https://openalex.org/I181391015"]},{"raw_affiliation_string":"Hematology and Hemotherapy Center of the State University of Campinas, Campinas, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083658192","display_name":"Valder R. Arruda","orcid":"https://orcid.org/0000-0002-8100-5481","observed_orcids":["https://orcid.org/0000-0002-8100-5481"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Valder R. Arruda","raw_affiliation_strings":["Hematology and Hemotherapy Center of the State University of Campinas, Campinas, Sa\u0303o Paulo, Brazil","Hematology and Hemotherapy Center of the State University of Campinas, Campinas, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Hemotherapy Center of the State University of Campinas, Campinas, Sa\u0303o Paulo, Brazil","institution_ids":["https://openalex.org/I181391015"]},{"raw_affiliation_string":"Hematology and Hemotherapy Center of the State University of Campinas, Campinas, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I181391015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109135656"],"corresponding_institution_ids":["https://openalex.org/I181391015"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":1.1037,"has_fulltext":true,"cited_by_count":79,"citation_normalized_percentile":{"value":0.79855177,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"77","issue":"1","first_page":"45","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9559999704360962},{"id":"https://openalex.org/keywords/priapism","display_name":"priapism","score":0.9679999947547913},{"id":"https://openalex.org/keywords/stuttering-priapism","display_name":"stuttering priapism","score":0.968999981880188},{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.996999979019165},{"id":"https://openalex.org/keywords/erectile-dysfunction","display_name":"erectile dysfunction","score":0.8429999947547913},{"id":"https://openalex.org/keywords/follow-up","display_name":"follow-up","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C2780345856","wikidata":"https://www.wikidata.org/wiki/Q156590","display_name":"Priapism","level":2,"score":0.9919500946998596},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8661823272705078},{"id":"https://openalex.org/C2779316324","wikidata":"https://www.wikidata.org/wiki/Q212272","display_name":"Hydroxycarbamide","level":3,"score":0.5076779127120972},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4256436824798584},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42558005452156067},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3999800980091095},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3211509585380554}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011317","descriptor_name":"Priapism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011317","descriptor_name":"Priapism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011317","descriptor_name":"Priapism","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D012725","descriptor_name":"Sexual Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ajh.20142","doi":"https://doi.org/10.1002/ajh.20142","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajh.20142","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajh.20142","source":{"id":"https://openalex.org/S199810014","display_name":"American Journal of Hematology","issn_l":"0361-8609","issn":["0361-8609","1096-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hematology","raw_type":"journal-article"},{"id":"pmid:15307105","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15307105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of hematology","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1002/ajh.20142","doi":"https://doi.org/10.1002/ajh.20142","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajh.20142","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajh.20142","source":{"id":"https://openalex.org/S199810014","display_name":"American Journal of Hematology","issn_l":"0361-8609","issn":["0361-8609","1096-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968652295.pdf","grobid_xml":"https://content.openalex.org/works/W1968652295.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W7055056","https://openalex.org/W29610599","https://openalex.org/W33002337","https://openalex.org/W170541499","https://openalex.org/W1559833729","https://openalex.org/W1601711829","https://openalex.org/W1835121324","https://openalex.org/W1972716918","https://openalex.org/W1981818777","https://openalex.org/W2000770399","https://openalex.org/W2015337008","https://openalex.org/W2027446314","https://openalex.org/W2027789486","https://openalex.org/W2030040458","https://openalex.org/W2039806480","https://openalex.org/W2045392613","https://openalex.org/W2046299714","https://openalex.org/W2046500825","https://openalex.org/W2049354191","https://openalex.org/W2056291788","https://openalex.org/W2061972670","https://openalex.org/W2062117176","https://openalex.org/W2070434673","https://openalex.org/W2075706580","https://openalex.org/W2076832075","https://openalex.org/W2126233568","https://openalex.org/W2137322303","https://openalex.org/W2137742501","https://openalex.org/W2145724610","https://openalex.org/W2159085792","https://openalex.org/W2195280390","https://openalex.org/W2258655905","https://openalex.org/W2313541759","https://openalex.org/W2319125068","https://openalex.org/W2416056112","https://openalex.org/W2465415502","https://openalex.org/W2731935530","https://openalex.org/W3135637599","https://openalex.org/W4242029354","https://openalex.org/W4253130889","https://openalex.org/W4293765499"],"related_works":["https://openalex.org/W2555515840","https://openalex.org/W2137742501","https://openalex.org/W4409412673","https://openalex.org/W4408356876","https://openalex.org/W2141759236","https://openalex.org/W4411673746","https://openalex.org/W2339115736","https://openalex.org/W4405657592","https://openalex.org/W4243525936","https://openalex.org/W4409832076"],"abstract_inverted_index":{"Hydroxyurea":[0,109,179,189],"is":[1,33],"one":[2,34],"of":[3,14,35,76,117,130,206],"the":[4,36,50,86,96,100,114,122,126,139,146,163,237],"most":[5],"successfully":[6],"used":[7,58],"therapies":[8],"for":[9,22,62,99,259],"sickle":[10,249],"cell":[11,250],"disease.":[12],"Results":[13],"many":[15],"clinical":[16],"trials":[17],"point":[18],"to":[19,135,155,161,224],"hydroxyurea":[20,55,123,209,243],"administration":[21],"patients":[23,66,82,105,174],"with":[24,67],"frequent":[25],"painful":[26,260],"crises":[27],"and":[28,88,120,193],"acute":[29,101],"chest":[30],"syndrome.":[31],"Priapism":[32],"complications":[37],"that":[38,222,227,242],"could":[39],"be":[40],"prevented":[41],"by":[42,92],"hydroxyurea,":[43],"but":[44,185],"there":[45],"are":[46,73],"few":[47],"reports":[48],"demonstrating":[49],"results.":[51],"Since":[52],"November":[53],"1993,":[54],"has":[56],"been":[57],"in":[59,65,85,166,182,248],"our":[60],"clinic":[61],"preventing":[63],"priapism":[64,131,187,194,207,246],"stuttering":[68,107,186,214],"or":[69,128],"major":[70,220],"attacks":[71,247],"who":[72],"still":[74],"capable":[75],"achieving":[77],"intercourse":[78],"on":[79],"demand.":[80],"Five":[81],"were":[83,153],"enrolled":[84],"study,":[87],"4":[89],"cases":[90],"benefited":[91],"this":[93],"treatment.":[94],"After":[95],"initial":[97,115],"treatment":[98],"attack,":[102,221],"all":[103],"five":[104],"developed":[106],"priapism.":[108],"was":[110,144,171,180,190],"then":[111,191],"introduced":[112],"at":[113,253],"dose":[116,141],"10":[118],"mg/kg,":[119],"as":[121],"dosage":[124],"increased,":[125],"number":[127],"length":[129],"episodes":[132,147],"decreased.":[133],"One":[134,196],"two":[136,150,183],"months":[137],"after":[138,208],"maximal":[140],"(20-35":[142],"mg/kg)":[143],"introduced,":[145],"disappeared.":[148,195],"In":[149,235],"patients,":[151,184],"we":[152],"forced":[154],"administer":[156],"over":[157],"30":[158],"mg":[159,200],"hydroxyurea/kg":[160],"abort":[162],"episodes,":[164],"and,":[165],"another":[167],"patient,":[168,197],"25":[169],"mg/kg":[170],"necessary.":[172],"All":[173],"present":[175],"normal":[176],"sexual":[177],"activity.":[178],"discontinued":[181],"reappeared.":[188],"re-introduced,":[192],"using":[198],"20":[199],"hydroxyurea/kg,":[201],"had":[202],"a":[203,219],"6-year":[204],"remission":[205],"administration;":[210],"however,":[211],"he":[212,229],"experienced":[213],"priapism,":[215],"1":[216],"month":[217],"before":[218],"progressed":[223],"impotence.":[225],"During":[226],"month,":[228],"did":[230],"not":[231],"seek":[232],"medical":[233],"attention.":[234],"conclusion,":[236],"data":[238],"here":[239],"presented":[240],"suggests":[241],"may":[244],"prevent":[245],"disease,":[251],"probably":[252],"higher":[254],"doses":[255],"than":[256],"usually":[257],"prescribed":[258],"crisis":[261],"prevention.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}