{"id":"https://openalex.org/W1968650795","doi":"https://doi.org/10.3816/ccc.2006.s.002","title":"The Molecular Pathogenesis of Gastrointestinal Stromal Tumors","display_name":"The Molecular Pathogenesis of Gastrointestinal Stromal Tumors","publication_year":2006,"publication_date":"2006-11-01","ids":{"openalex":"https://openalex.org/W1968650795","doi":"https://doi.org/10.3816/ccc.2006.s.002","mag":"1968650795","pmid":"https://pubmed.ncbi.nlm.nih.gov/17101067"},"language":"en","primary_location":{"id":"doi:10.3816/ccc.2006.s.002","doi":"https://doi.org/10.3816/ccc.2006.s.002","is_oa":false,"landing_page_url":"https://doi.org/10.3816/ccc.2006.s.002","pdf_url":null,"source":{"id":"https://openalex.org/S112974357","display_name":"Clinical Colorectal Cancer","issn_l":"1533-0028","issn":["1533-0028","1938-0674"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Colorectal Cancer","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104066958","display_name":"Chi Tarn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chi Tarn","raw_affiliation_strings":["Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. chi.tarn@fccc.edu","Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. chi.tarn@fccc.edu","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA;","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033625395","display_name":"Andrew K. Godwin","orcid":"https://orcid.org/0000-0002-3987-9580","observed_orcids":["https://orcid.org/0000-0002-3987-9580"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew K. Godwin","raw_affiliation_strings":["Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA","institution_ids":["https://openalex.org/I1289437631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5104066958"],"corresponding_institution_ids":["https://openalex.org/I1289437631"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":null,"fwci":0.3654,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.33240223,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"6","issue":null,"first_page":"S7","last_page":"S17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastrointestinal-stromal-tumor","display_name":"gastrointestinal stromal tumor","score":0.9879999756813049},{"id":"https://openalex.org/keywords/kit-mutations","display_name":"KIT mutations","score":0.8059999942779541},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.718999981880188},{"id":"https://openalex.org/keywords/oncogenic-addiction","display_name":"oncogenic addiction","score":0.8769999742507935},{"id":"https://openalex.org/keywords/gain-of-function-mutations","display_name":"gain-of-function mutations","score":0.7940000295639038},{"id":"https://openalex.org/keywords/genetic-alterations","display_name":"genetic alterations","score":0.7829999923706055},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.7710000276565552},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.8460000157356262},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8389999866485596},{"id":"https://openalex.org/keywords/molecular-pathogenesis","display_name":"molecular pathogenesis","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8060617446899414},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7670708894729614},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5516494512557983},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5360278487205505},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40437400341033936},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3757169842720032},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32641610503196716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3055487871170044},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2674459218978882}],"mesh":[{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017479","descriptor_name":"Receptors, Platelet-Derived Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046152","descriptor_name":"Gastrointestinal Stromal Tumors","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D046152","descriptor_name":"Gastrointestinal Stromal Tumors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3816/ccc.2006.s.002","doi":"https://doi.org/10.3816/ccc.2006.s.002","is_oa":false,"landing_page_url":"https://doi.org/10.3816/ccc.2006.s.002","pdf_url":null,"source":{"id":"https://openalex.org/S112974357","display_name":"Clinical Colorectal Cancer","issn_l":"1533-0028","issn":["1533-0028","1938-0674"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Colorectal Cancer","raw_type":"journal-article"},{"id":"pmid:17101067","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17101067","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical colorectal cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G12238774","display_name":null,"funder_award_id":"CA 106588","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8049163461","display_name":"The Molecular Actions of Imatinib Mesylate in GISTs","funder_award_id":"R01CA106588","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320316008","display_name":"GIST Cancer Research Fund","ror":"https://ror.org/04py4hz40"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":131,"referenced_works":["https://openalex.org/W25562819","https://openalex.org/W65881094","https://openalex.org/W126870657","https://openalex.org/W148052780","https://openalex.org/W1507654024","https://openalex.org/W1516279414","https://openalex.org/W1546148535","https://openalex.org/W1549034776","https://openalex.org/W1570546989","https://openalex.org/W1681341977","https://openalex.org/W1734860714","https://openalex.org/W1752312133","https://openalex.org/W1808106197","https://openalex.org/W1840010921","https://openalex.org/W1858648870","https://openalex.org/W1964822816","https://openalex.org/W1967073729","https://openalex.org/W1968478357","https://openalex.org/W1969038110","https://openalex.org/W1970041112","https://openalex.org/W1970226788","https://openalex.org/W1971212668","https://openalex.org/W1971251991","https://openalex.org/W1971972894","https://openalex.org/W1976768230","https://openalex.org/W1976890484","https://openalex.org/W1977914780","https://openalex.org/W1978095082","https://openalex.org/W1981290785","https://openalex.org/W1981491302","https://openalex.org/W1982434417","https://openalex.org/W1988649165","https://openalex.org/W1992121498","https://openalex.org/W1992632909","https://openalex.org/W1992704301","https://openalex.org/W1998990808","https://openalex.org/W1999856068","https://openalex.org/W2000998080","https://openalex.org/W2002060029","https://openalex.org/W2003544192","https://openalex.org/W2006182505","https://openalex.org/W2006556639","https://openalex.org/W2007328596","https://openalex.org/W2008640800","https://openalex.org/W2014300063","https://openalex.org/W2015313106","https://openalex.org/W2015492609","https://openalex.org/W2016433042","https://openalex.org/W2016654284","https://openalex.org/W2016899343","https://openalex.org/W2018171716","https://openalex.org/W2021680242","https://openalex.org/W2022195787","https://openalex.org/W2023004333","https://openalex.org/W2023193264","https://openalex.org/W2025518732","https://openalex.org/W2025620553","https://openalex.org/W2028367089","https://openalex.org/W2028750359","https://openalex.org/W2032235066","https://openalex.org/W2032359283","https://openalex.org/W2033847195","https://openalex.org/W2035157342","https://openalex.org/W2041609971","https://openalex.org/W2041656488","https://openalex.org/W2041889823","https://openalex.org/W2044422249","https://openalex.org/W2044663728","https://openalex.org/W2046283103","https://openalex.org/W2047116608","https://openalex.org/W2049085719","https://openalex.org/W2051638902","https://openalex.org/W2057319282","https://openalex.org/W2058976091","https://openalex.org/W2062232901","https://openalex.org/W2062296569","https://openalex.org/W2062655114","https://openalex.org/W2065406815","https://openalex.org/W2067848715","https://openalex.org/W2071746901","https://openalex.org/W2074608272","https://openalex.org/W2091066174","https://openalex.org/W2091220038","https://openalex.org/W2091865841","https://openalex.org/W2092462025","https://openalex.org/W2095589221","https://openalex.org/W2095786994","https://openalex.org/W2096419712","https://openalex.org/W2101214437","https://openalex.org/W2101986793","https://openalex.org/W2102769930","https://openalex.org/W2103322585","https://openalex.org/W2105396280","https://openalex.org/W2119649187","https://openalex.org/W2121383540","https://openalex.org/W2122573984","https://openalex.org/W2130089200","https://openalex.org/W2130755604","https://openalex.org/W2134094496","https://openalex.org/W2136277705","https://openalex.org/W2137211135","https://openalex.org/W2137791754","https://openalex.org/W2140626630","https://openalex.org/W2149698450","https://openalex.org/W2149701462","https://openalex.org/W2150766319","https://openalex.org/W2151767797","https://openalex.org/W2155186551","https://openalex.org/W2159360580","https://openalex.org/W2161080750","https://openalex.org/W2165720262","https://openalex.org/W2168506172","https://openalex.org/W2168672282","https://openalex.org/W2169363650","https://openalex.org/W2169569777","https://openalex.org/W2169598152","https://openalex.org/W2171620774","https://openalex.org/W2252961166","https://openalex.org/W2264714702","https://openalex.org/W2320293250","https://openalex.org/W2325670521","https://openalex.org/W2327210468","https://openalex.org/W2409128558","https://openalex.org/W2430016701","https://openalex.org/W4238299672","https://openalex.org/W4249605179","https://openalex.org/W4249792421","https://openalex.org/W6639054525","https://openalex.org/W6680294142","https://openalex.org/W6692946832","https://openalex.org/W6714300070"],"related_works":["https://openalex.org/W2175623346","https://openalex.org/W1521633337","https://openalex.org/W2101214437","https://openalex.org/W2152634746","https://openalex.org/W2784327695","https://openalex.org/W2026386845","https://openalex.org/W2588774125","https://openalex.org/W3103656192","https://openalex.org/W1535973975","https://openalex.org/W2031928350"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}