{"id":"https://openalex.org/W1968649972","doi":"https://doi.org/10.1111/j.1346-8138.1992.tb03758.x","title":"The Role of Growth Factor in Wound Healing","display_name":"The Role of Growth Factor in Wound Healing","publication_year":1992,"publication_date":"1992-11-01","ids":{"openalex":"https://openalex.org/W1968649972","doi":"https://doi.org/10.1111/j.1346-8138.1992.tb03758.x","mag":"1968649972","pmid":"https://pubmed.ncbi.nlm.nih.gov/1293154"},"language":"en","primary_location":{"id":"doi:10.1111/j.1346-8138.1992.tb03758.x","doi":"https://doi.org/10.1111/j.1346-8138.1992.tb03758.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1346-8138.1992.tb03758.x","pdf_url":null,"source":{"id":"https://openalex.org/S143887118","display_name":"The Journal of Dermatology","issn_l":"0385-2407","issn":["0385-2407","1346-8138"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090982887","display_name":"Mari Higashiyama","orcid":"https://orcid.org/0000-0001-5742-1146","observed_orcids":["https://orcid.org/0000-0001-5742-1146"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Mari Higashiyama","raw_affiliation_strings":["Department of Dermatology, Osaka University School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Osaka University School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004889536","display_name":"Koji Hashimoto","orcid":"https://orcid.org/0000-0001-8024-0060","observed_orcids":["https://orcid.org/0000-0001-8024-0060"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Hashimoto","raw_affiliation_strings":["Department of Dermatology, Osaka University School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Osaka University School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110184709","display_name":"Akiyoshi Takada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiyoshi Takada","raw_affiliation_strings":["Department of Dermatology, Osaka University School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Osaka University School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kazuhiko Fujita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114030911","display_name":"Otsuka (Japan)","ror":"https://ror.org/013k5y296","country_code":"JP","type":"company","lineage":["https://openalex.org/I114030911"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiko Fujita","raw_affiliation_strings":["Ako Res. Inst. Division of Dermatologicals & Ophthalmologicals Otsuka Pharmaceutical Co., Ltd. Hyogo Japan","Department of Dermatology, Osaka University School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ako Res. Inst. Division of Dermatologicals & Ophthalmologicals Otsuka Pharmaceutical Co., Ltd. Hyogo Japan","institution_ids":["https://openalex.org/I114030911"]},{"raw_affiliation_string":"Department of Dermatology, Osaka University School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048018438","display_name":"Katsunobu Kido","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114030911","display_name":"Otsuka (Japan)","ror":"https://ror.org/013k5y296","country_code":"JP","type":"company","lineage":["https://openalex.org/I114030911"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsunobu Kido","raw_affiliation_strings":["Ako Res. Inst. Division of Dermatologicals & Ophthalmologicals Otsuka Pharmaceutical Co., Ltd. Hyogo Japan","Department of Dermatology, Osaka University School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ako Res. Inst. Division of Dermatologicals & Ophthalmologicals Otsuka Pharmaceutical Co., Ltd. Hyogo Japan","institution_ids":["https://openalex.org/I114030911"]},{"raw_affiliation_string":"Department of Dermatology, Osaka University School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109810777","display_name":"Kunihiko Yoshikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunihiko Yoshikawa","raw_affiliation_strings":["Department of Dermatology, Osaka University School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Osaka University School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090982887"],"corresponding_institution_ids":["https://openalex.org/I98285908"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"19","issue":"11","first_page":"676","last_page":"679"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9909999966621399},{"id":"https://openalex.org/keywords/transforming-growth-factor-alpha","display_name":"transforming growth factor-alpha","score":0.8759999871253967},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.859000027179718},{"id":"https://openalex.org/keywords/incisional-wounds","display_name":"incisional wounds","score":0.8769999742507935},{"id":"https://openalex.org/keywords/excisional-wounds","display_name":"excision wound","score":1.0},{"id":"https://openalex.org/keywords/epidermal-regeneration","display_name":"epidermal regeneration","score":0.9649999737739563},{"id":"https://openalex.org/keywords/keratinocyte-migration","display_name":"keratinocyte migration","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tensile-strength","display_name":"tensile strength","score":0.7770000100135803},{"id":"https://openalex.org/keywords/pig-model","display_name":"porcine model","score":0.49300000071525574},{"id":"https://openalex.org/keywords/immunolocalization","display_name":"immunolocalization","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.8753975629806519},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.853008508682251},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7047855257987976},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5763987898826599},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4796643555164337},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47823041677474976},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3876548111438751},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3107959032058716},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2537497282028198},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25046491622924805}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1346-8138.1992.tb03758.x","doi":"https://doi.org/10.1111/j.1346-8138.1992.tb03758.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1346-8138.1992.tb03758.x","pdf_url":null,"source":{"id":"https://openalex.org/S143887118","display_name":"The Journal of Dermatology","issn_l":"0385-2407","issn":["0385-2407","1346-8138"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Dermatology","raw_type":"journal-article"},{"id":"pmid:1293154","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1293154","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of dermatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W140459365","https://openalex.org/W1970516412","https://openalex.org/W2095549623","https://openalex.org/W2155958456","https://openalex.org/W2160720138","https://openalex.org/W2418221852"],"related_works":["https://openalex.org/W1970794616","https://openalex.org/W1977310782","https://openalex.org/W2078009668","https://openalex.org/W2095549623","https://openalex.org/W2432363979","https://openalex.org/W2418221852","https://openalex.org/W2010218983","https://openalex.org/W2098250766","https://openalex.org/W41069773","https://openalex.org/W2284440429"],"abstract_inverted_index":{"A":[0],"pig":[1],"wound":[2,17,25,63,74,89,122],"healing":[3,123],"model":[4,64,75],"was":[5,97],"developed":[6],"to":[7,109],"study":[8,83],"the":[9,19,28,61,72,101,106,110,121],"morphological":[10],"processes":[11],"involved":[12],"in":[13,24,56,100],"incisional":[14,32,62],"and":[15,27,116],"excisional":[16,57,73],"healing,":[18,26],"immunohistochemical":[20],"localization":[21],"of":[22,37,49,105],"TGF-alpha":[23,92,96],"latter's":[29],"relevance.":[30],"In":[31,45,59],"wounds,":[33],"a":[34],"few":[35],"layers":[36,48,104],"epidermis":[38,50,107,115],"were":[39,51],"regenerated":[40,52],"after":[41],"only":[42],"32":[43],"hours.":[44],"contrast,":[46],"several":[47,103],"on":[53],"day":[54],"7":[55],"wounds.":[58],"general,":[60],"is":[65,76],"useful":[66],"for":[67,78],"evaluating":[68,79],"tensile":[69],"strength,":[70],"while":[71,95],"suitable":[77],"epidermal":[80],"regeneration.":[81],"Immunohistochemical":[82],"showed":[84,117],"that":[85],"keratinocytes":[86],"migrating":[87],"from":[88],"edges":[90],"expressed":[91],"very":[93],"faintly,":[94],"present":[98],"prominently":[99],"upper":[102],"adjacent":[108],"wound,":[111],"which":[112],"resembled":[113],"normal":[114],"no":[118],"changes":[119],"during":[120],"process.":[124]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}