{"id":"https://openalex.org/W1968648963","doi":"https://doi.org/10.1111/j.1476-5381.1985.tb08919.x","title":"Effect of nonsteroidal anti\u2010inflammatory drugs on glycogenolysis in isolated hepatocytes","display_name":"Effect of nonsteroidal anti\u2010inflammatory drugs on glycogenolysis in isolated hepatocytes","publication_year":1985,"publication_date":"1985-10-01","ids":{"openalex":"https://openalex.org/W1968648963","doi":"https://doi.org/10.1111/j.1476-5381.1985.tb08919.x","mag":"1968648963","pmid":"https://pubmed.ncbi.nlm.nih.gov/3863682","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1916690"},"language":"en","primary_location":{"id":"doi:10.1111/j.1476-5381.1985.tb08919.x","doi":"https://doi.org/10.1111/j.1476-5381.1985.tb08919.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1985.tb08919.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1985.tb08919.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1985.tb08919.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002808291","display_name":"Eric P. Brass","orcid":"https://orcid.org/0009-0009-6260-2414","observed_orcids":["https://orcid.org/0009-0009-6260-2414"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric P. Brass","raw_affiliation_strings":["Departments of Medicine and Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado, U.S.A","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059610135","display_name":"Maureen J. Garrity","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maureen J. Garrity","raw_affiliation_strings":["Departments of Medicine and Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado, U.S.A","institution_ids":["https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002808291"],"corresponding_institution_ids":["https://openalex.org/I921990950"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":1.5758,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.80260672,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"86","issue":"2","first_page":"491","last_page":"496"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9950000047683716},{"id":"https://openalex.org/keywords/glycogenolysis","display_name":"glycogenolysis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.9440000057220459},{"id":"https://openalex.org/keywords/ibuprofen","display_name":"ibuprofen","score":0.9670000076293945},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":1.0},{"id":"https://openalex.org/keywords/meclofenamate","display_name":"meclofenamate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/piroxicam","display_name":"piroxicam","score":0.9779999852180481},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibition","display_name":"cyclooxygenase inhibition","score":0.8830000162124634},{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":0.843999981880188},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9269999861717224},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.9829999804496765},{"id":"https://openalex.org/keywords/intracellular-calcium-homeostasis","display_name":"intracellular calcium homeostasis","score":0.8190000057220459},{"id":"https://openalex.org/keywords/hepatic-glycogen-metabolism","display_name":"hepatic glycogen metabolism","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C2777949327","wikidata":"https://www.wikidata.org/wiki/Q680603","display_name":"Glycogenolysis","level":3,"score":0.988579273223877},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.7218251824378967},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6624414920806885},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6542523503303528},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6527231931686401},{"id":"https://openalex.org/C2779944601","wikidata":"https://www.wikidata.org/wiki/Q186969","display_name":"Ibuprofen","level":2,"score":0.6372271776199341},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5220848917961121},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.5116798877716064},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.4573386013507843},{"id":"https://openalex.org/C2778139025","wikidata":"https://www.wikidata.org/wiki/Q408676","display_name":"Piroxicam","level":3,"score":0.45504844188690186},{"id":"https://openalex.org/C2777198256","wikidata":"https://www.wikidata.org/wiki/Q4860325","display_name":"Prostaglandin E","level":2,"score":0.4381476938724518},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.42327505350112915},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2919681668281555},{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.25125136971473694},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.21294641494750977},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20676323771476746},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15154537558555603},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1418399214744568},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1290082037448883},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06368717551231384},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007052","descriptor_name":"Ibuprofen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008112","descriptor_name":"Liver Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011458","descriptor_name":"Prostaglandins E","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1476-5381.1985.tb08919.x","doi":"https://doi.org/10.1111/j.1476-5381.1985.tb08919.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1985.tb08919.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1985.tb08919.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1916690","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1916690","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},{"id":"pmid:3863682","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3863682","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1476-5381.1985.tb08919.x","doi":"https://doi.org/10.1111/j.1476-5381.1985.tb08919.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1985.tb08919.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1985.tb08919.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5408446109","display_name":null,"funder_award_id":"BRS-G05357","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968648963.pdf","grobid_xml":"https://content.openalex.org/works/W1968648963.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W63181634","https://openalex.org/W1524136845","https://openalex.org/W1923597418","https://openalex.org/W1969518728","https://openalex.org/W1972709192","https://openalex.org/W1987915694","https://openalex.org/W1990540732","https://openalex.org/W2001869217","https://openalex.org/W2008574207","https://openalex.org/W2011273256","https://openalex.org/W2038301236","https://openalex.org/W2061731738","https://openalex.org/W2070092697","https://openalex.org/W2072482644","https://openalex.org/W2076320501","https://openalex.org/W2086049904","https://openalex.org/W2169503005","https://openalex.org/W2285310955","https://openalex.org/W2314395292","https://openalex.org/W2401690367","https://openalex.org/W2409957202","https://openalex.org/W2418556670","https://openalex.org/W2464322821","https://openalex.org/W2734965406"],"related_works":["https://openalex.org/W2062133020","https://openalex.org/W2086049904","https://openalex.org/W191382531","https://openalex.org/W1987915694","https://openalex.org/W1561495590","https://openalex.org/W2099444411","https://openalex.org/W4214544857","https://openalex.org/W1531379526","https://openalex.org/W1906277760","https://openalex.org/W2004813631"],"abstract_inverted_index":{"E-series":[0],"prostaglandins":[1],"have":[2],"previously":[3],"been":[4],"demonstrated":[5],"to":[6,12,189],"inhibit":[7,29],"hormone-stimulated":[8],"glycogenolysis":[9,33,54,69,94,120,133,179,217],"when":[10,55],"added":[11,56],"isolated":[13,181],"hepatocytes":[14],"of":[15,24,53,75,85,98,114,125,140,147,178,186,194,196,201,208,216,225],"the":[16,19,22,37,71,96,112,145,176,192,199,206,214],"rat.":[17],"In":[18,60,161],"present":[20],"study,":[21],"effect":[23,67,92,152,195],"nonsteroidal":[25,167,237],"anti-inflammatory":[26,168,238],"drugs,":[27],"which":[28,170],"cyclo-oxygenase":[30],"activity,":[31],"on":[32,68,93,153],"was":[34,121,134],"examined":[35],"in":[36,70,95,111,180,205],"hepatocyte":[38,72,157],"model.":[39],"Ibuprofen":[40,87,149],"(80":[41,88,142],"microM),":[42],"indomethacin":[43,220],"(50":[44,63],"microM)":[45,49,64,89,143],"and":[46,198,221],"meclofenamate":[47,222],"(60":[48],"all":[50,211],"increased":[51,144],"rates":[52,84,110],"under":[57],"basal":[58,154],"conditions.":[59],"contrast,":[61],"piroxicam":[62],"had":[65,90,150],"no":[66,91,151],"system.":[73],"Concentrations":[74],"ibuprofen":[76,141,204],"below":[77],"80":[78],"microM":[79],"did":[80,107],"not":[81],"significantly":[82],"increase":[83,108,175],"glycogenolysis.":[86,148],"presence":[97,113,207],"10(-5)M":[99],"adrenaline":[100],"or":[101,155],"5":[102,115],"X":[103,116],"10(-7)M":[104],"glucagon,":[105],"but":[106],"glycogenolytic":[109],"10(-8)M":[117],"glucagon.":[118],"Ibuprofen-stimulated":[119],"inhibited":[122,135],"by":[123,136,203,218],"addition":[124,139],"prostaglandin":[126],"E2":[127],"(PGE2).":[128],"Under":[129],"conditions":[130],"where":[131],"glucagon-stimulated":[132,156],"exogenous":[137,209],"PGE2,":[138],"rate":[146,177],"adenylate":[158],"cyclase":[159],"activity.":[160],"conclusion,":[162],"these":[163],"results":[164],"demonstrate":[165],"that":[166,213,234],"drugs":[169,239],"are":[171,230],"carboxylic":[172,235],"acids":[173],"can":[174,240],"hepatocytes.":[182],"The":[183],"high":[184],"concentrations":[185],"drug":[187],"required":[188],"stimulate":[190],"glycogenolysis,":[191],"lack":[193],"piroxicam,":[197],"demonstration":[200],"stimulation":[202,215],"PGE2":[210],"suggest":[212],"ibuprofen,":[219],"is":[223],"independent":[224],"cyclooxygenase":[226],"inhibition.":[227],"These":[228],"observations":[229],"consistent":[231],"with":[232,242],"reports":[233],"acid":[236],"interfere":[241],"hepatic":[243],"intracellular":[244],"calcium":[245],"handling.":[246]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
