{"id":"https://openalex.org/W1968636735","doi":"https://doi.org/10.1038/gt.2015.27","title":"Potential treatments for genetic hearing loss in humans: current conundrums","display_name":"Potential treatments for genetic hearing loss in humans: current conundrums","publication_year":2015,"publication_date":"2015-03-17","ids":{"openalex":"https://openalex.org/W1968636735","doi":"https://doi.org/10.1038/gt.2015.27","mag":"1968636735","pmid":"https://pubmed.ncbi.nlm.nih.gov/25781649"},"language":"en","primary_location":{"id":"doi:10.1038/gt.2015.27","doi":"https://doi.org/10.1038/gt.2015.27","is_oa":false,"landing_page_url":"https://doi.org/10.1038/gt.2015.27","pdf_url":null,"source":{"id":"https://openalex.org/S65405509","display_name":"Gene Therapy","issn_l":"0969-7128","issn":["0969-7128","1476-5462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074363425","display_name":"Ryosei Minoda","orcid":"https://orcid.org/0000-0002-3830-2018","observed_orcids":["https://orcid.org/0000-0002-3830-2018"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"R Minoda","raw_affiliation_strings":["Departments of Otolaryngology-Head and Neck Surgery, Kumamoto University, Graduate School of Medicine, Kumamoto City, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otolaryngology-Head and Neck Surgery, Kumamoto University, Graduate School of Medicine, Kumamoto City, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040067120","display_name":"Toru Miwa","orcid":"https://orcid.org/0000-0002-5977-0056","observed_orcids":["https://orcid.org/0000-0002-5977-0056"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Miwa","raw_affiliation_strings":["Departments of Otolaryngology-Head and Neck Surgery, Kumamoto University, Graduate School of Medicine, Kumamoto City, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otolaryngology-Head and Neck Surgery, Kumamoto University, Graduate School of Medicine, Kumamoto City, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112743611","display_name":"Momoko Ise","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Ise","raw_affiliation_strings":["Departments of Otolaryngology-Head and Neck Surgery, Kumamoto University, Graduate School of Medicine, Kumamoto City, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otolaryngology-Head and Neck Surgery, Kumamoto University, Graduate School of Medicine, Kumamoto City, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078618329","display_name":"Hiroyuki Takeda","orcid":"https://orcid.org/0000-0003-1677-8127","observed_orcids":["https://orcid.org/0000-0003-1677-8127"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Takeda","raw_affiliation_strings":["Departments of Otolaryngology-Head and Neck Surgery, Kumamoto University, Graduate School of Medicine, Kumamoto City, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Otolaryngology-Head and Neck Surgery, Kumamoto University, Graduate School of Medicine, Kumamoto City, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I96036126"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":0.3308,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.1884984,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"22","issue":"8","first_page":"603","last_page":"609"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hereditary-hearing-loss","display_name":"hereditary hearing loss","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neonatal-gene-therapy","display_name":"neonatal gene therapy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antisense-therapy","display_name":"antisense therapy","score":0.9399999976158142},{"id":"https://openalex.org/keywords/causative-genes","display_name":"causal genes","score":0.6779999732971191},{"id":"https://openalex.org/keywords/curative-treatment","display_name":"curative treatment","score":0.6050000190734863},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.5799999833106995},{"id":"https://openalex.org/keywords/newborns","display_name":"neonates","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.8931376338005066},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.6257715821266174},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5940210223197937},{"id":"https://openalex.org/C2781371907","wikidata":"https://www.wikidata.org/wiki/Q5160434","display_name":"Congenital hearing loss","level":4,"score":0.4820502698421478},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43988341093063354},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.36226367950439453},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3420783579349518},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28553086519241333},{"id":"https://openalex.org/C2780607864","wikidata":"https://www.wikidata.org/wiki/Q928697","display_name":"Sensorineural hearing loss","level":3,"score":0.19472062587738037}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007758","descriptor_name":"Ear, Inner","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D007758","descriptor_name":"Ear, Inner","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D030342","descriptor_name":"Genetic Diseases, Inborn","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030342","descriptor_name":"Genetic Diseases, Inborn","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D034381","descriptor_name":"Hearing Loss","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034381","descriptor_name":"Hearing Loss","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/gt.2015.27","doi":"https://doi.org/10.1038/gt.2015.27","is_oa":false,"landing_page_url":"https://doi.org/10.1038/gt.2015.27","pdf_url":null,"source":{"id":"https://openalex.org/S65405509","display_name":"Gene Therapy","issn_l":"0969-7128","issn":["0969-7128","1476-5462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Therapy","raw_type":"journal-article"},{"id":"pmid:25781649","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25781649","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene therapy","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:00953:0006828745","doi":null,"is_oa":false,"landing_page_url":"https://pure.teikyo.jp/en/publications/7992d237-08e9-49c9-814f-9284b4607cea","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gene Therapy","raw_type":"review article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W79238280","https://openalex.org/W1480384350","https://openalex.org/W1534454035","https://openalex.org/W1558285756","https://openalex.org/W1652268047","https://openalex.org/W1839812923","https://openalex.org/W1847597758","https://openalex.org/W1890207703","https://openalex.org/W1965581612","https://openalex.org/W1969382880","https://openalex.org/W1970847877","https://openalex.org/W1977427979","https://openalex.org/W1978272861","https://openalex.org/W1981750477","https://openalex.org/W1987762534","https://openalex.org/W1989894205","https://openalex.org/W1995408124","https://openalex.org/W2000747235","https://openalex.org/W2009257155","https://openalex.org/W2011355532","https://openalex.org/W2012189889","https://openalex.org/W2013475033","https://openalex.org/W2016662726","https://openalex.org/W2023471002","https://openalex.org/W2024299195","https://openalex.org/W2024385388","https://openalex.org/W2027318031","https://openalex.org/W2030383952","https://openalex.org/W2033347933","https://openalex.org/W2034060287","https://openalex.org/W2054771268","https://openalex.org/W2056204692","https://openalex.org/W2059424037","https://openalex.org/W2069274845","https://openalex.org/W2071446274","https://openalex.org/W2082476939","https://openalex.org/W2088523571","https://openalex.org/W2092472216","https://openalex.org/W2092890929","https://openalex.org/W2102326129","https://openalex.org/W2104453327","https://openalex.org/W2104988801","https://openalex.org/W2109053894","https://openalex.org/W2128768698","https://openalex.org/W2142840122","https://openalex.org/W2143347708","https://openalex.org/W2162903822","https://openalex.org/W2165431561","https://openalex.org/W2182822985","https://openalex.org/W4298298418"],"related_works":["https://openalex.org/W3045355399","https://openalex.org/W2078198995","https://openalex.org/W4380682569","https://openalex.org/W3093716528","https://openalex.org/W2978515961","https://openalex.org/W2959029580","https://openalex.org/W4389299861","https://openalex.org/W2317520310","https://openalex.org/W4404940997","https://openalex.org/W3010499025"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
