{"id":"https://openalex.org/W1968633158","doi":"https://doi.org/10.1177/153303460600500601","title":"Dissection of Signaling Pathways in Fourteen Breast Cancer Cell Lines Using Reverse-Phase Protein Lysate Microarray","display_name":"Dissection of Signaling Pathways in Fourteen Breast Cancer Cell Lines Using Reverse-Phase Protein Lysate Microarray","publication_year":2006,"publication_date":"2006-12-01","ids":{"openalex":"https://openalex.org/W1968633158","doi":"https://doi.org/10.1177/153303460600500601","mag":"1968633158","pmid":"https://pubmed.ncbi.nlm.nih.gov/17121430"},"language":"en","primary_location":{"id":"doi:10.1177/153303460600500601","doi":"https://doi.org/10.1177/153303460600500601","is_oa":false,"landing_page_url":"https://doi.org/10.1177/153303460600500601","pdf_url":null,"source":{"id":"https://openalex.org/S2955411","display_name":"Technology in Cancer Research & Treatment","issn_l":"1533-0338","issn":["1533-0338","1533-0346"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Technology in Cancer Research &amp; Treatment","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11424/89278","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005202578","display_name":"Mustafa Akk\u0456pr\u0456k","orcid":"https://orcid.org/0000-0002-1100-765X","observed_orcids":["https://orcid.org/0000-0002-1100-765X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR","US"],"is_corresponding":false,"raw_author_name":"Mustafa Akkiprik","raw_affiliation_strings":["Department of Medical Biology Marmara University School of Medicine Istanbul, Turkey","Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA","#N# 1 Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA","#N# 2 Department of Medical Biology Marmara University School of Medicine Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology Marmara University School of Medicine Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]},{"raw_affiliation_string":"Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"#N# 1 Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"#N# 2 Department of Medical Biology Marmara University School of Medicine Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063658514","display_name":"Daniel Nicorici","orcid":"https://orcid.org/0000-0002-0278-8263","observed_orcids":["https://orcid.org/0000-0002-0278-8263"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I4387152565","display_name":"Tampere University of Technology","ror":"https://ror.org/02ba3pt07","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849","https://openalex.org/I4387152565"]}],"countries":["FI","US"],"is_corresponding":false,"raw_author_name":"Daniel Nicorici","raw_affiliation_strings":["Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA","Institute of Signal Processing Tampere University of Technology Tampere, Finland","#N# 1 Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA","#N# 3 Institute of Signal Processing Tampere University of Technology Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Institute of Signal Processing Tampere University of Technology Tampere, Finland","institution_ids":["https://openalex.org/I4387152565"]},{"raw_affiliation_string":"#N# 1 Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"#N# 3 Institute of Signal Processing Tampere University of Technology Tampere, Finland","institution_ids":["https://openalex.org/I4387152565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089524304","display_name":"David E. Cogdell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Cogdell","raw_affiliation_strings":["Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA","#N# 1 Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"#N# 1 Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112691501","display_name":"Yu Jia","orcid":"https://orcid.org/0009-0009-1096-9054","observed_orcids":["https://orcid.org/0009-0009-1096-9054"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Jack Jia","raw_affiliation_strings":["Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA","#N# 1 Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"#N# 1 Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075123343","display_name":"Andrea Hategan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152565","display_name":"Tampere University of Technology","ror":"https://ror.org/02ba3pt07","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849","https://openalex.org/I4387152565"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Andrea Hategan","raw_affiliation_strings":["Institute of Signal Processing Tampere University of Technology Tampere, Finland","#N# 3 Institute of Signal Processing Tampere University of Technology Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Signal Processing Tampere University of Technology Tampere, Finland","institution_ids":["https://openalex.org/I4387152565"]},{"raw_affiliation_string":"#N# 3 Institute of Signal Processing Tampere University of Technology Tampere, Finland","institution_ids":["https://openalex.org/I4387152565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008130391","display_name":"Ioan T\u0103bu\u015f","orcid":"https://orcid.org/0000-0003-3131-9551","observed_orcids":["https://orcid.org/0000-0003-3131-9551"]},"institutions":[{"id":"https://openalex.org/I4387152565","display_name":"Tampere University of Technology","ror":"https://ror.org/02ba3pt07","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849","https://openalex.org/I4387152565"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Ioan Tabus","raw_affiliation_strings":["Institute of Signal Processing Tampere University of Technology Tampere, Finland","#N# 3 Institute of Signal Processing Tampere University of Technology Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Signal Processing Tampere University of Technology Tampere, Finland","institution_ids":["https://openalex.org/I4387152565"]},{"raw_affiliation_string":"#N# 3 Institute of Signal Processing Tampere University of Technology Tampere, Finland","institution_ids":["https://openalex.org/I4387152565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026230936","display_name":"Olli P. Yli-Harja","orcid":"https://orcid.org/0000-0001-8581-4414","observed_orcids":["https://orcid.org/0000-0001-8581-4414","https://orcid.org/0009-0009-4818-448X"]},"institutions":[{"id":"https://openalex.org/I4387152565","display_name":"Tampere University of Technology","ror":"https://ror.org/02ba3pt07","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849","https://openalex.org/I4387152565"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Olli Yli-Harja","raw_affiliation_strings":["Institute of Signal Processing Tampere University of Technology Tampere, Finland","#N# 3 Institute of Signal Processing Tampere University of Technology Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Signal Processing Tampere University of Technology Tampere, Finland","institution_ids":["https://openalex.org/I4387152565"]},{"raw_affiliation_string":"#N# 3 Institute of Signal Processing Tampere University of Technology Tampere, Finland","institution_ids":["https://openalex.org/I4387152565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040450464","display_name":"Dihua Yu","orcid":"https://orcid.org/0000-0001-6231-9381","observed_orcids":["https://orcid.org/0000-0001-6231-9381"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dihua Yu","raw_affiliation_strings":["Dept. of Surgical Oncology, Unit 107 The University of Texas M. D. Anderson Cancer Center Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Surgical Oncology, Unit 107 The University of Texas M. D. Anderson Cancer Center Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041098535","display_name":"Ay\u015feg\u00fcl A. \u015eahin","orcid":"https://orcid.org/0000-0001-8259-9624","observed_orcids":["https://orcid.org/0000-0001-8259-9624"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aysegul Sahin","raw_affiliation_strings":["Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA","#N# 1 Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"#N# 1 Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":null,"display_name":"Wei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA","#N# 1 Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"#N# 1 Department of Pathology, Unit 85 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":null,"fwci":1.2723,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.78418941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"5","issue":"6","first_page":"543","last_page":"551"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8022000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8022000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.17710000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-cell-lines","display_name":"breast cancer cell lines","score":0.9819999933242798},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.8259999752044678},{"id":"https://openalex.org/keywords/pdgfrbeta","display_name":"PDGFR\u03b2","score":0.8989999890327454},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.5320000052452087},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.8019999861717224},{"id":"https://openalex.org/keywords/igfbp-5","display_name":"IGFBP-5","score":0.7419999837875366},{"id":"https://openalex.org/keywords/igfbp-2","display_name":"IGFBP-2","score":0.9200000166893005},{"id":"https://openalex.org/keywords/igfbp-3","display_name":"IGFBP-3","score":0.9039999842643738},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/c-kit","display_name":"CD117","score":0.6990000009536743},{"id":"https://openalex.org/keywords/hexokinase-1","display_name":"hexokinase 1","score":0.7509999871253967},{"id":"https://openalex.org/keywords/nd2","display_name":"ND2","score":0.4740000069141388},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.670235276222229},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6086714863777161},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5425416231155396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5407336950302124},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5272801518440247},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5238161683082581},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4975943863391876},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.4940679371356964},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39477047324180603},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.26866644620895386},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1177/153303460600500601","doi":"https://doi.org/10.1177/153303460600500601","is_oa":false,"landing_page_url":"https://doi.org/10.1177/153303460600500601","pdf_url":null,"source":{"id":"https://openalex.org/S2955411","display_name":"Technology in Cancer Research & Treatment","issn_l":"1533-0338","issn":["1533-0338","1533-0346"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Technology in Cancer Research &amp; Treatment","raw_type":"journal-article"},{"id":"pmid:17121430","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17121430","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Technology in cancer research & treatment","raw_type":"Journal Article"},{"id":"pmh:oai:openaccess.marmara.edu.tr:11424/116895","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11424/116895","pdf_url":null,"source":{"id":"https://openalex.org/S4306401380","display_name":"Dspace Repository (Marmara \u00dcniversitesi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74897591","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/I74897591"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:openaccess.marmara.edu.tr:11424/228406","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11424/228406","pdf_url":null,"source":{"id":"https://openalex.org/S4306401380","display_name":"Dspace Repository (Marmara \u00dcniversitesi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74897591","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/I74897591"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:openaccess.marmara.edu.tr:11424/89278","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11424/89278","pdf_url":null,"source":{"id":"https://openalex.org/S4306401380","display_name":"Dspace Repository (Marmara \u00dcniversitesi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74897591","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/I74897591"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:openaccess.marmara.edu.tr:11424/89278","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11424/89278","pdf_url":null,"source":{"id":"https://openalex.org/S4306401380","display_name":"Dspace Repository (Marmara \u00dcniversitesi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74897591","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/I74897591"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320329814","display_name":"Kadoorie Charitable Foundation","ror":"https://ror.org/03r5nvr96"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1488039334","https://openalex.org/W1591497216","https://openalex.org/W1813571362","https://openalex.org/W1904552623","https://openalex.org/W1933105316","https://openalex.org/W1951471355","https://openalex.org/W1964231749","https://openalex.org/W1964895626","https://openalex.org/W1966701961","https://openalex.org/W1981986845","https://openalex.org/W1991371485","https://openalex.org/W1992271736","https://openalex.org/W2001506328","https://openalex.org/W2023843856","https://openalex.org/W2024654932","https://openalex.org/W2027953312","https://openalex.org/W2048131754","https://openalex.org/W2049475256","https://openalex.org/W2055269994","https://openalex.org/W2071250342","https://openalex.org/W2078802143","https://openalex.org/W2093298277","https://openalex.org/W2098619516","https://openalex.org/W2102011014","https://openalex.org/W2102037457","https://openalex.org/W2109033574","https://openalex.org/W2110065044","https://openalex.org/W2112228953","https://openalex.org/W2113579151","https://openalex.org/W2119700369","https://openalex.org/W2120018526","https://openalex.org/W2120865735","https://openalex.org/W2121456510","https://openalex.org/W2123179063","https://openalex.org/W2128985829","https://openalex.org/W2133171697","https://openalex.org/W2140272347","https://openalex.org/W2142105072","https://openalex.org/W2145025818","https://openalex.org/W2163376094","https://openalex.org/W2321112275"],"related_works":["https://openalex.org/W2058119644","https://openalex.org/W2114901348","https://openalex.org/W2621936089","https://openalex.org/W2330839320","https://openalex.org/W6940133581","https://openalex.org/W6977276763","https://openalex.org/W1983340023","https://openalex.org/W1997859608","https://openalex.org/W2168037598","https://openalex.org/W2168047396"],"abstract_inverted_index":{"Signal":[0],"transduction":[1],"pathways":[2,43,62],"play":[3],"a":[4,59,115],"crucial":[5],"role":[6],"in":[7,20,36,70,148,207,225],"breast":[8,21,50,71,93,167,210,230],"cancer":[9,22,51,72,94,211,231],"development,":[10,73],"progression,":[11],"and":[12,31,54,63,67,80,101,141,161,163,165,189,201,217,227,241],"response":[13],"to":[14],"different":[15,28,106],"therapies.":[16],"A":[17],"major":[18,245],"problem":[19],"therapy":[23],"is":[24],"the":[25,41,47,56,99,122,151,220],"heterogeneity":[26],"among":[27,58],"tumor":[29],"types":[30],"cell":[32,52,95,107,152],"lines":[33,53,96],"commonly":[34,48],"used":[35,49],"preclinical":[37],"studies.":[38],"To":[39],"characterize":[40],"signaling":[42,108,250],"of":[44,46,61,91,104,121,131,137,150],"some":[45,64],"dissect":[55],"relationship":[57],"number":[60],"key":[65],"genetic":[66],"molecular":[68],"events":[69],"such":[74,194],"as":[75,195],"p53":[76,242],"mutation,":[77],"ErbB2":[78,239],"expression,":[79,240],"estrogen":[81],"receptor":[82,84,145],"(ER)/progesterone":[83],"(PR)":[85],"status,":[86,238],"we":[87],"performed":[88],"pathway":[89],"profiling":[90],"14":[92],"by":[97],"measuring":[98],"expression":[100,123],"phosphorylation":[102],"status":[103,243],"40":[105],"proteins":[109,158,224],"with":[110],"53":[111],"specific":[112],"antibodies":[113],"using":[114],"protein":[116,182],"lysate":[117],"array.":[118],"Cluster":[119],"analysis":[120],"data":[124],"showed":[125],"that":[126,236,247],"there":[127],"was":[128],"close":[129],"clustering":[130],"phosphatidylinositol":[132],"3-kinase,":[133],"Akt,":[134],"mammalian":[135],"target":[136],"rapamycin":[138],"(mTOR),":[139],"Src,":[140],"platelet-derived":[142],"growth":[143,180],"factor":[144],"beta":[146],"(PDGFRbeta)":[147],"all":[149],"lines.":[153],"The":[154],"most":[155,221],"differentially":[156,222],"expressed":[157,223],"between":[159],"ER-":[160,164],"PR-positive":[162],"PR-negative":[166],"cells":[168],"were":[169,205,219],"mTOR,":[170],"Akt":[171,177],"(pThr308),":[172],"PDGFRbeta,":[173],"PDGFRbeta":[174],"(pTyr751),":[175],"panSrc,":[176],"(pSer473),":[178],"insulin-like":[179],"factor-binding":[181],"5":[183],"(IGFBP5),":[184],"Src":[185],"(pTyr418),":[186],"mTOR":[187],"(pSer2448),":[188],"IGFBP2.":[190],"Many":[191],"apoptotic":[192],"proteins,":[193],"apoptosis-inducing":[196],"factor,":[197],"IGFBP3,":[198],"bad,":[199],"bax,":[200],"cleaved":[202],"caspase":[203],"9,":[204],"overexpressed":[206],"mutant":[208],"p53-carrying":[209],"cells.":[212,232],"Hexokinase":[213],"isoenzyme":[214],"1,":[215],"ND2,":[216],"c-kit":[218],"high":[226],"low":[228],"ErbB2-expressing":[229],"This":[233],"study":[234],"demonstrated":[235],"ER/PR":[237],"are":[244],"molecules":[246],"impact":[248],"downstream":[249],"pathways.":[251]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
