{"id":"https://openalex.org/W1968598690","doi":"https://doi.org/10.3109/15419061.2014.905930","title":"Junctions and Inflammation in the Skin","display_name":"Junctions and Inflammation in the Skin","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W1968598690","doi":"https://doi.org/10.3109/15419061.2014.905930","mag":"1968598690","pmid":"https://pubmed.ncbi.nlm.nih.gov/24787376"},"language":"en","primary_location":{"id":"doi:10.3109/15419061.2014.905930","doi":"https://doi.org/10.3109/15419061.2014.905930","is_oa":true,"landing_page_url":"https://doi.org/10.3109/15419061.2014.905930","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/15419061.2014.905930?download=true","source":{"id":"https://openalex.org/S9145135","display_name":"Cell Communication & Adhesion","issn_l":"1023-7046","issn":["1023-7046","1026-7883","1029-2314","1061-5385","1541-9061","1543-5180","2573-0029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication &amp; Adhesion","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.3109/15419061.2014.905930?download=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001535983","display_name":"Agnieszka Kobielak","orcid":"https://orcid.org/0000-0002-9293-0787","observed_orcids":["https://orcid.org/0000-0002-9293-0787"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Agnieszka Kobielak","raw_affiliation_strings":["Department of Otolaryngology - Head & Neck Surgery, Biochemistry and Molecular Biology, Norris Cancer Center, University of Southern California , Los Angeles, CA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology - Head & Neck Surgery, Biochemistry and Molecular Biology, Norris Cancer Center, University of Southern California , Los Angeles, CA , USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087938795","display_name":"Keerthi Boddupally","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keerthi Boddupally","raw_affiliation_strings":["Department of Otolaryngology - Head & Neck Surgery, Biochemistry and Molecular Biology, Norris Cancer Center, University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology - Head & Neck Surgery, Biochemistry and Molecular Biology, Norris Cancer Center, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001535983"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"],"apc_list":null,"apc_paid":null,"fwci":0.2672,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.19433198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"21","issue":"3","first_page":"141","last_page":"147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.6528000235557556,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.6528000235557556,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.24940000474452972,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.042100001126527786,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skin-barrier-function","display_name":"skin barrier function","score":0.7870000004768372},{"id":"https://openalex.org/keywords/adherens-junctions","display_name":"adherens junctions","score":0.8410000205039978},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.8830000162124634},{"id":"https://openalex.org/keywords/desmosomes","display_name":"desmosomes","score":0.9419999718666077},{"id":"https://openalex.org/keywords/gap-junctions","display_name":"gap junctions","score":0.8190000057220459},{"id":"https://openalex.org/keywords/stratum-corneum","display_name":"stratum corneum","score":0.7609999775886536},{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":1.0},{"id":"https://openalex.org/keywords/filaggrin","display_name":"filaggrin","score":0.8550000190734863},{"id":"https://openalex.org/keywords/p120-catenin","display_name":"p120 catenin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/alpha-catenin","display_name":"alpha-catenin","score":0.9620000123977661},{"id":"https://openalex.org/keywords/barrier-dysfunction","display_name":"barrier dysfunction","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C201508349","wikidata":"https://www.wikidata.org/wiki/Q45173","display_name":"Adherens junction","level":4,"score":0.905463457107544},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.7755621671676636},{"id":"https://openalex.org/C190684412","wikidata":"https://www.wikidata.org/wiki/Q21201832","display_name":"Filaggrin","level":3,"score":0.7728399038314819},{"id":"https://openalex.org/C2778370115","wikidata":"https://www.wikidata.org/wiki/Q2038676","display_name":"Stratum corneum","level":2,"score":0.7564464807510376},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6996719837188721},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.6445102691650391},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.6309518814086914},{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.5916287899017334},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.5205829739570618},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5053480267524719},{"id":"https://openalex.org/C2991981033","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Skin barrier","level":2,"score":0.48048916459083557},{"id":"https://openalex.org/C2778757060","wikidata":"https://www.wikidata.org/wiki/Q846957","display_name":"Desmosome","level":3,"score":0.46983644366264343},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.372677743434906},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3686709403991699},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3238253593444824},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3145296573638916},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3073230981826782},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28798776865005493},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.23780542612075806},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.13866278529167175},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09193000197410583},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000091344","descriptor_name":"Filaggrin Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007381","descriptor_name":"Intermediate Filament Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007381","descriptor_name":"Intermediate Filament Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051177","descriptor_name":"Catenins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/15419061.2014.905930","doi":"https://doi.org/10.3109/15419061.2014.905930","is_oa":true,"landing_page_url":"https://doi.org/10.3109/15419061.2014.905930","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/15419061.2014.905930?download=true","source":{"id":"https://openalex.org/S9145135","display_name":"Cell Communication & Adhesion","issn_l":"1023-7046","issn":["1023-7046","1026-7883","1029-2314","1061-5385","1541-9061","1543-5180","2573-0029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication &amp; Adhesion","raw_type":"journal-article"},{"id":"pmid:24787376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24787376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell communication & adhesion","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3109/15419061.2014.905930","doi":"https://doi.org/10.3109/15419061.2014.905930","is_oa":true,"landing_page_url":"https://doi.org/10.3109/15419061.2014.905930","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/15419061.2014.905930?download=true","source":{"id":"https://openalex.org/S9145135","display_name":"Cell Communication & Adhesion","issn_l":"1023-7046","issn":["1023-7046","1026-7883","1029-2314","1061-5385","1541-9061","1543-5180","2573-0029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication &amp; Adhesion","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5600000023841858,"display_name":"Life on land","id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968598690.pdf","grobid_xml":"https://content.openalex.org/works/W1968598690.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W80775301","https://openalex.org/W1504954000","https://openalex.org/W1518075729","https://openalex.org/W1744742580","https://openalex.org/W1772212485","https://openalex.org/W1964223904","https://openalex.org/W1965642261","https://openalex.org/W1968837172","https://openalex.org/W1969737072","https://openalex.org/W1972693119","https://openalex.org/W1974004014","https://openalex.org/W1977125048","https://openalex.org/W1978477306","https://openalex.org/W1989552966","https://openalex.org/W1993343256","https://openalex.org/W1993653794","https://openalex.org/W1994554109","https://openalex.org/W1999525281","https://openalex.org/W2012919091","https://openalex.org/W2016727199","https://openalex.org/W2034108449","https://openalex.org/W2034654881","https://openalex.org/W2034950600","https://openalex.org/W2035793907","https://openalex.org/W2035950592","https://openalex.org/W2042194530","https://openalex.org/W2044788416","https://openalex.org/W2048616064","https://openalex.org/W2054083814","https://openalex.org/W2054570534","https://openalex.org/W2058497055","https://openalex.org/W2063748338","https://openalex.org/W2067117198","https://openalex.org/W2068176013","https://openalex.org/W2069469763","https://openalex.org/W2074970582","https://openalex.org/W2075645862","https://openalex.org/W2076743940","https://openalex.org/W2077130771","https://openalex.org/W2077796802","https://openalex.org/W2102144390","https://openalex.org/W2109016302","https://openalex.org/W2110916958","https://openalex.org/W2112718635","https://openalex.org/W2114942120","https://openalex.org/W2124076790","https://openalex.org/W2128492601","https://openalex.org/W2135693542","https://openalex.org/W2148294117","https://openalex.org/W2156261247","https://openalex.org/W2165641861","https://openalex.org/W2166589605","https://openalex.org/W2171854519"],"related_works":["https://openalex.org/W2002840861","https://openalex.org/W2509919933","https://openalex.org/W1582703399","https://openalex.org/W2739123501","https://openalex.org/W2769875674","https://openalex.org/W2296086836","https://openalex.org/W2891808755","https://openalex.org/W2070316318","https://openalex.org/W4401244251","https://openalex.org/W2295976626"],"abstract_inverted_index":{"The":[0,12],"skin":[1,16,70,116,134],"forms":[2],"a":[3,107,121],"life-sustaining":[4],"barrier":[5,14,32,61,71,88,111],"between":[6],"the":[7,21,31,69,87,91,114],"organism":[8],"and":[9,36,45,56,119],"physical":[10,13],"environment.":[11],"of":[15,86,123],"is":[17,64,73,99],"mainly":[18],"localized":[19],"in":[20,83,105,133],"stratum":[22],"corneum":[23],"(SC);":[24],"however,":[25],"nucleated":[26],"epidermis":[27],"also":[28],"contributes":[29],"to":[30],"through":[33,43],"tight,":[34],"gap,":[35],"adherens":[37],"junctions":[38],"(AJs),":[39],"as":[40,42,52],"well":[41],"desmosomes":[44],"cytoskeletal":[46],"elements.":[47],"Many":[48],"inflammatory":[49,78,95,115],"diseases,":[50],"such":[51],"atopic":[53],"dermatitis":[54],"(AD)":[55],"psoriasis,":[57],"are":[58],"associated":[59],"with":[60],"dysfunction.":[62],"It":[63],"becoming":[65],"increasingly":[66],"clear":[67],"that":[68,81,103,120],"function":[72],"not":[74],"only":[75],"affected":[76],"by":[77,101],"signals":[79],"but":[80],"defects":[82],"structural":[84,109],"components":[85],"may":[89],"be":[90],"initiating":[92],"event":[93],"for":[94],"diseases.":[96],"This":[97],"view":[98],"supported":[100],"findings":[102],"mutations":[104],"filaggrin,":[106],"key":[108],"epidermal":[110,127],"protein,":[112],"cause":[113],"disease":[117],"AD,":[118],"loss":[122],"AJ":[124],"components,":[125],"namely":[126],"p120":[128],"catenin":[129],"or":[130],"\u03b1-catenin":[131],"results":[132],"inflammation.":[135]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
