{"id":"https://openalex.org/W1968579158","doi":"https://doi.org/10.1021/ol402023c","title":"Practical Silyl Protection of Ribonucleosides","display_name":"Practical Silyl Protection of Ribonucleosides","publication_year":2013,"publication_date":"2013-09-03","ids":{"openalex":"https://openalex.org/W1968579158","doi":"https://doi.org/10.1021/ol402023c","mag":"1968579158","pmid":"https://pubmed.ncbi.nlm.nih.gov/24000770","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3857215"},"language":"en","primary_location":{"id":"doi:10.1021/ol402023c","doi":"https://doi.org/10.1021/ol402023c","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ol402023c","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3857215/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066496633","display_name":"Thomas P. Blaisdell","orcid":"https://orcid.org/0000-0002-6079-1997","observed_orcids":["https://orcid.org/0000-0002-6079-1997"]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]},{"id":"https://openalex.org/I4210088955","display_name":"Institut Catal\u00e0 d'Investigaci\u00f3 Qu\u00edmica","ror":"https://ror.org/013j2zh96","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210088955","https://openalex.org/I4210132884","https://openalex.org/I4387153040"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Thomas P. Blaisdell","raw_affiliation_strings":["Institute of Chemical Research of Catalonia, Av. Paisos Catalans 16, 43007 Tarragona, Spain, and Boston College, 2609 Beacon Street, Chestnut Hill, Massachusetts 02467-3860, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical Research of Catalonia, Av. Paisos Catalans 16, 43007 Tarragona, Spain, and Boston College, 2609 Beacon Street, Chestnut Hill, Massachusetts 02467-3860, United States","institution_ids":["https://openalex.org/I103531236","https://openalex.org/I4210088955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070455001","display_name":"Sunggi Lee","orcid":"https://orcid.org/0000-0002-8817-8465","observed_orcids":["https://orcid.org/0000-0002-8817-8465"]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]},{"id":"https://openalex.org/I4210088955","display_name":"Institut Catal\u00e0 d'Investigaci\u00f3 Qu\u00edmica","ror":"https://ror.org/013j2zh96","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210088955","https://openalex.org/I4210132884","https://openalex.org/I4387153040"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Sunggi Lee","raw_affiliation_strings":["Institute of Chemical Research of Catalonia, Av. Paisos Catalans 16, 43007 Tarragona, Spain, and Boston College, 2609 Beacon Street, Chestnut Hill, Massachusetts 02467-3860, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical Research of Catalonia, Av. Paisos Catalans 16, 43007 Tarragona, Spain, and Boston College, 2609 Beacon Street, Chestnut Hill, Massachusetts 02467-3860, United States","institution_ids":["https://openalex.org/I103531236","https://openalex.org/I4210088955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065834539","display_name":"P\u0131nar Kasaplar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]},{"id":"https://openalex.org/I4210088955","display_name":"Institut Catal\u00e0 d'Investigaci\u00f3 Qu\u00edmica","ror":"https://ror.org/013j2zh96","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210088955","https://openalex.org/I4210132884","https://openalex.org/I4387153040"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Pinar Kasaplar","raw_affiliation_strings":["Institute of Chemical Research of Catalonia, Av. Paisos Catalans 16, 43007 Tarragona, Spain, and Boston College, 2609 Beacon Street, Chestnut Hill, Massachusetts 02467-3860, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical Research of Catalonia, Av. Paisos Catalans 16, 43007 Tarragona, Spain, and Boston College, 2609 Beacon Street, Chestnut Hill, Massachusetts 02467-3860, United States","institution_ids":["https://openalex.org/I103531236","https://openalex.org/I4210088955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109604834","display_name":"Xixi Sun","orcid":"https://orcid.org/0000-0002-5344-8023","observed_orcids":["https://orcid.org/0000-0002-5344-8023"]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]},{"id":"https://openalex.org/I4210088955","display_name":"Institut Catal\u00e0 d'Investigaci\u00f3 Qu\u00edmica","ror":"https://ror.org/013j2zh96","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210088955","https://openalex.org/I4210132884","https://openalex.org/I4387153040"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Xixi Sun","raw_affiliation_strings":["Institute of Chemical Research of Catalonia, Av. Paisos Catalans 16, 43007 Tarragona, Spain, and Boston College, 2609 Beacon Street, Chestnut Hill, Massachusetts 02467-3860, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical Research of Catalonia, Av. Paisos Catalans 16, 43007 Tarragona, Spain, and Boston College, 2609 Beacon Street, Chestnut Hill, Massachusetts 02467-3860, United States","institution_ids":["https://openalex.org/I103531236","https://openalex.org/I4210088955"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045276745","display_name":"Kian L. Tan","orcid":"https://orcid.org/0000-0001-8243-1223","observed_orcids":["https://orcid.org/0000-0001-8243-1223"]},"institutions":[{"id":"https://openalex.org/I103531236","display_name":"Boston College","ror":"https://ror.org/02n2fzt79","country_code":"US","type":"education","lineage":["https://openalex.org/I103531236"]},{"id":"https://openalex.org/I4210088955","display_name":"Institut Catal\u00e0 d'Investigaci\u00f3 Qu\u00edmica","ror":"https://ror.org/013j2zh96","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210088955","https://openalex.org/I4210132884","https://openalex.org/I4387153040"]}],"countries":["ES","US"],"is_corresponding":true,"raw_author_name":"Kian L. Tan","raw_affiliation_strings":["Institute of Chemical Research of Catalonia, Av. Paisos Catalans 16, 43007 Tarragona, Spain, and Boston College, 2609 Beacon Street, Chestnut Hill, Massachusetts 02467-3860, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical Research of Catalonia, Av. Paisos Catalans 16, 43007 Tarragona, Spain, and Boston College, 2609 Beacon Street, Chestnut Hill, Massachusetts 02467-3860, United States","institution_ids":["https://openalex.org/I103531236","https://openalex.org/I4210088955"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045276745"],"corresponding_institution_ids":["https://openalex.org/I103531236","https://openalex.org/I4210088955"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.5396,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.81606589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"15","issue":"18","first_page":"4710","last_page":"4713"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.5073000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.5073000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.23669999837875366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.09470000118017197,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribonucleosides","display_name":"ribonucleosides","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ribonucleoside-analogs","display_name":"ribonucleoside analogs","score":0.9150000214576721},{"id":"https://openalex.org/keywords/ribavirin","display_name":"ribavirin","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9096903800964355},{"id":"https://openalex.org/C5304478","wikidata":"https://www.wikidata.org/wiki/Q502457","display_name":"Silylation","level":3,"score":0.8922666311264038},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.44861900806427},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3043694794178009},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.18213525414466858}],"mesh":[{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012254","descriptor_name":"Ribavirin","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D012254","descriptor_name":"Ribavirin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012254","descriptor_name":"Ribavirin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D012821","descriptor_name":"Silanes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017665","descriptor_name":"Hydroxyl Radical","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/ol402023c","doi":"https://doi.org/10.1021/ol402023c","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ol402023c","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},{"id":"pmid:24000770","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24000770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic letters","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3857215","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3857215/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Org Lett","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3857215","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3857215/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Org Lett","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5102557511","display_name":"Practical Strategies for Controlling Selectivity in Organic Reactions","funder_award_id":"R01GM087581","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337393","display_name":"Division of Chemistry","ror":"https://ror.org/01ar8dr59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1972376076","https://openalex.org/W1976060898","https://openalex.org/W1989947911","https://openalex.org/W1993195920","https://openalex.org/W1995223265","https://openalex.org/W1999251780","https://openalex.org/W2002007474","https://openalex.org/W2012419095","https://openalex.org/W2017985758","https://openalex.org/W2018928003","https://openalex.org/W2021999506","https://openalex.org/W2022358234","https://openalex.org/W2024072661","https://openalex.org/W2029908281","https://openalex.org/W2031486049","https://openalex.org/W2032462727","https://openalex.org/W2033817758","https://openalex.org/W2040286050","https://openalex.org/W2042874864","https://openalex.org/W2043072360","https://openalex.org/W2048247933","https://openalex.org/W2050068721","https://openalex.org/W2050538096","https://openalex.org/W2050754435","https://openalex.org/W2055802029","https://openalex.org/W2061603412","https://openalex.org/W2065129705","https://openalex.org/W2066074720","https://openalex.org/W2067258168","https://openalex.org/W2072660673","https://openalex.org/W2076655264","https://openalex.org/W2078277171","https://openalex.org/W2082675068","https://openalex.org/W2085747135","https://openalex.org/W2091015700","https://openalex.org/W2099302658","https://openalex.org/W2105718579","https://openalex.org/W2117565096","https://openalex.org/W2118490513","https://openalex.org/W2130695178","https://openalex.org/W2134722321","https://openalex.org/W2136737504","https://openalex.org/W2137710375","https://openalex.org/W2149165220","https://openalex.org/W2159955926","https://openalex.org/W2162047917","https://openalex.org/W2166706290","https://openalex.org/W2171472249","https://openalex.org/W2323147230","https://openalex.org/W2328495845","https://openalex.org/W2329327582","https://openalex.org/W2330843301","https://openalex.org/W2335382679","https://openalex.org/W2951326560","https://openalex.org/W3023427459","https://openalex.org/W3023869259"],"related_works":["https://openalex.org/W2952349903","https://openalex.org/W2085747135","https://openalex.org/W1997821915","https://openalex.org/W4313645068","https://openalex.org/W4244898356","https://openalex.org/W1510909753","https://openalex.org/W2079967105","https://openalex.org/W2081510243","https://openalex.org/W2091015700","https://openalex.org/W2171472249"],"abstract_inverted_index":{"Herein":[0],"we":[1],"report":[2],"the":[3,7,28,32,36,40,47,54,59],"site-selective":[4],"silylation":[5,38],"of":[6,31,39,49,56],"ribonucelosides.":[8,57],"The":[9],"method":[10],"enables":[11],"a":[12,65],"simple":[13],"and":[14],"efficient":[15],"procedure":[16,60],"for":[17,22,35,53],"accessing":[18],"suitably":[19],"protected":[20],"monomers":[21],"automated":[23],"RNA":[24,51],"synthesis.":[25],"Switching":[26],"to":[27,63],"opposite":[29],"enantiomer":[30],"catalyst":[33],"allows":[34],"selective":[37],"3'-hydroxyl,":[41],"which":[42],"could":[43],"be":[44],"used":[45],"in":[46],"synthesis":[48],"unnatural":[50],"or":[52],"analoging":[55],"Lastly,":[58],"was":[61],"extended":[62],"ribavirin":[64],"potent":[66],"antiviral":[67],"therapeutic.":[68]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
