{"id":"https://openalex.org/W1968578271","doi":"https://doi.org/10.1074/jbc.272.39.24363","title":"p32 Protein, a Splicing Factor 2-associated Protein, Is Localized in Mitochondrial Matrix and Is Functionally Important in Maintaining Oxidative Phosphorylation","display_name":"p32 Protein, a Splicing Factor 2-associated Protein, Is Localized in Mitochondrial Matrix and Is Functionally Important in Maintaining Oxidative Phosphorylation","publication_year":1997,"publication_date":"1997-09-01","ids":{"openalex":"https://openalex.org/W1968578271","doi":"https://doi.org/10.1074/jbc.272.39.24363","mag":"1968578271","pmid":"https://pubmed.ncbi.nlm.nih.gov/9305894"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.272.39.24363","doi":"https://doi.org/10.1074/jbc.272.39.24363","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.39.24363","pdf_url":"http://www.jbc.org/article/S0021925819636070/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819636070/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020162205","display_name":"Tsuyoshi Muta","orcid":"https://orcid.org/0000-0002-8305-9467","observed_orcids":["https://orcid.org/0000-0002-8305-9467"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Muta","raw_affiliation_strings":["Department of Clinical Chemistry and Laboratory Medicine, Kyushu University, Faculty of Medicine, Fukuoka 812-82, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry and Laboratory Medicine, Kyushu University, Faculty of Medicine, Fukuoka 812-82, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110716341","display_name":"Dongchon Kang","orcid":"https://orcid.org/0009-0009-4607-3380","observed_orcids":["https://orcid.org/0009-0009-4607-3380"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Dongchon Kang","raw_affiliation_strings":["Department of Clinical Chemistry and Laboratory Medicine, Kyushu University, Faculty of Medicine, Fukuoka 812-82, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry and Laboratory Medicine, Kyushu University, Faculty of Medicine, Fukuoka 812-82, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086973360","display_name":"Shigetaka Kitajima","orcid":"https://orcid.org/0000-0003-3959-6107","observed_orcids":["https://orcid.org/0000-0003-3959-6107"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigetaka Kitajima","raw_affiliation_strings":["Department of Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Toshiyuki Fujiwara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Fujiwara","raw_affiliation_strings":["Department of Biochemistry, Fukuoka University School of Medicine, Fukuoka 814-01, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Fukuoka University School of Medicine, Fukuoka 814-01, Japan","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111617725","display_name":"Naotaka Hamasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naotaka Hamasaki","raw_affiliation_strings":["Department of Clinical Chemistry and Laboratory Medicine, Kyushu University, Faculty of Medicine, Fukuoka 812-82, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry and Laboratory Medicine, Kyushu University, Faculty of Medicine, Fukuoka 812-82, Japan","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5110716341"],"corresponding_institution_ids":["https://openalex.org/I135598925"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.786,"has_fulltext":true,"cited_by_count":235,"citation_normalized_percentile":{"value":0.8492299,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"272","issue":"39","first_page":"24363","last_page":"24370"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p32-protein","display_name":"p32 protein","score":0.972000002861023},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/mitochondrial-atp-synthesis","display_name":"mitochondrial ATP production","score":0.9049999713897705},{"id":"https://openalex.org/keywords/hiv-1-tat","display_name":"HIV-1 Tat protein","score":0.5130000114440918},{"id":"https://openalex.org/keywords/c1q","display_name":"C1q","score":0.8730000257492065},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6427077651023865},{"id":"https://openalex.org/C11701378","wikidata":"https://www.wikidata.org/wiki/Q3493378","display_name":"Mitochondrial matrix","level":4,"score":0.6423185467720032},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6342252492904663},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5555319786071777},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.5053313374519348},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.49330225586891174},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4612715244293213},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.44278404116630554},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44196322560310364},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.4174966812133789},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39627805352211},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3720717430114746},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.18650725483894348},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.10551390051841736},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010085","descriptor_name":"Oxidative Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.272.39.24363","doi":"https://doi.org/10.1074/jbc.272.39.24363","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.39.24363","pdf_url":"http://www.jbc.org/article/S0021925819636070/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9305894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9305894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.272.39.24363","doi":"https://doi.org/10.1074/jbc.272.39.24363","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.39.24363","pdf_url":"http://www.jbc.org/article/S0021925819636070/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968578271.pdf","grobid_xml":"https://content.openalex.org/works/W1968578271.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1507851645","https://openalex.org/W1526043578","https://openalex.org/W1536270671","https://openalex.org/W1547269929","https://openalex.org/W1552627359","https://openalex.org/W1567493631","https://openalex.org/W1584574994","https://openalex.org/W1600651336","https://openalex.org/W1609484548","https://openalex.org/W1662981245","https://openalex.org/W1775749144","https://openalex.org/W1931585919","https://openalex.org/W1967406596","https://openalex.org/W1972407993","https://openalex.org/W1973782344","https://openalex.org/W1982629607","https://openalex.org/W1988540925","https://openalex.org/W1993244187","https://openalex.org/W1997561848","https://openalex.org/W1997760969","https://openalex.org/W2003496833","https://openalex.org/W2015149117","https://openalex.org/W2016385127","https://openalex.org/W2019101123","https://openalex.org/W2020268823","https://openalex.org/W2020648113","https://openalex.org/W2023444927","https://openalex.org/W2037314620","https://openalex.org/W2044725367","https://openalex.org/W2059158182","https://openalex.org/W2060657842","https://openalex.org/W2069326021","https://openalex.org/W2069326426","https://openalex.org/W2076990795","https://openalex.org/W2079073757","https://openalex.org/W2080408951","https://openalex.org/W2081422975","https://openalex.org/W2102716555","https://openalex.org/W2117976997","https://openalex.org/W2125562918","https://openalex.org/W2131870749","https://openalex.org/W2150580904","https://openalex.org/W2396964508","https://openalex.org/W3215619572"],"related_works":["https://openalex.org/W2150856613","https://openalex.org/W2008542507","https://openalex.org/W1967493968","https://openalex.org/W2093534373","https://openalex.org/W7217048787","https://openalex.org/W2086056565","https://openalex.org/W1974660961","https://openalex.org/W3120037888","https://openalex.org/W2009312555","https://openalex.org/W2153244115"],"abstract_inverted_index":{"Human":[0],"p32,":[1,72],"originally":[2],"cloned":[3,101],"as":[4],"a":[5,16,63,102,140,146,174],"splicing":[6],"factor":[7],"2-associated":[8],"protein,":[9],"has":[10],"been":[11],"reported":[12],"to":[13,33,61,111],"interact":[14],"with":[15,46],"variety":[17],"of":[18,55,71,78,82,106,128,136,152,165,178],"molecules":[19],"including":[20],"human":[21,47,107,167,179],"immunodeficiency":[22,48],"virus":[23,49],"Tat":[24,50],"and":[25,38,51,86,185,191],"complement":[26],"1q":[27],"(C1q).":[28],"p32":[29,92,108,168,184],"protein":[30,118],"is":[31,59,93,119,173],"supposed":[32],"be":[34],"in":[35,96,122,139,145,188,196],"the":[36,40,44,56,68,75,97,123,129,133,150,153,163,166],"nucleus":[37],"on":[39],"plasma":[41],"membrane":[42],"for":[43],"association":[45],"C1q,":[52],"respectively.":[53],"None":[54],"interactions,":[57],"however,":[58],"proven":[60],"have":[62],"physiological":[64,69],"role.":[65],"To":[66],"investigate":[67],"function":[70],"we":[73],"determined":[74],"intracellular":[76],"localization":[77],"p32.":[79,180],"The":[80,115,126,157],"fractionation":[81],"cells,":[83],"fluorescent":[84],"immunocytochemistry,":[85],"electron":[87],"microscopic":[88],"immunostaining":[89],"show":[90],"that":[91,171],"exclusively":[94],"localized":[95,121],"mitochondrial":[98,124,154,189,198],"matrix.":[99,125],"We":[100],"Saccharomyces":[103],"cerevisiae":[104],"homologue":[105],"gene,":[109],"referred":[110],"yeast":[112,116,137,176],"p30":[113,117,130,172,186],"gene.":[114],"also":[120],"disruption":[127],"gene":[131],"caused":[132],"growth":[134,158],"retardation":[135],"cells":[138],"glycerol":[141],"medium":[142],"but":[143],"not":[144],"glucose":[147],"medium,":[148],"i.e.":[149],"impairment":[151,159],"ATP":[155],"synthesis.":[156],"was":[160],"restored":[161],"by":[162],"introduction":[164],"cDNA,":[169],"indicating":[170],"functional":[175],"counterpart":[177],"Taken":[181],"together,":[182],"both":[183],"reside":[187],"matrix":[190],"play":[192],"an":[193],"important":[194],"role":[195],"maintaining":[197],"oxidative":[199],"phosphorylation.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}