{"id":"https://openalex.org/W1968572959","doi":"https://doi.org/10.1093/gerona/56.2.b72","title":"Array-Based Expression Analysis of Mouse Liver Genes: Effect of Age and of the Longevity Mutant Prop1df","display_name":"Array-Based Expression Analysis of Mouse Liver Genes: Effect of Age and of the Longevity Mutant Prop1df","publication_year":2001,"publication_date":"2001-02-01","ids":{"openalex":"https://openalex.org/W1968572959","doi":"https://doi.org/10.1093/gerona/56.2.b72","mag":"1968572959","pmid":"https://pubmed.ncbi.nlm.nih.gov/11213270"},"language":"en","primary_location":{"id":"doi:10.1093/gerona/56.2.b72","doi":"https://doi.org/10.1093/gerona/56.2.b72","is_oa":false,"landing_page_url":"https://doi.org/10.1093/gerona/56.2.b72","pdf_url":null,"source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046941357","display_name":"Igor M. Dozmorov","orcid":"https://orcid.org/0000-0001-6517-8406","observed_orcids":["https://orcid.org/0000-0001-6517-8406"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. Dozmorov","raw_affiliation_strings":["Department of Pathology, Institute of Gerontology, and Geriatrics Center, University of Michigan, Ann Arbor 48109-0940, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Institute of Gerontology, and Geriatrics Center, University of Michigan, Ann Arbor 48109-0940, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018886262","display_name":"Andrzej Bartke","orcid":"https://orcid.org/0000-0002-2569-557X","observed_orcids":["https://orcid.org/0000-0002-2569-557X"]},"institutions":[{"id":"https://openalex.org/I110378019","display_name":"Southern Illinois University Carbondale","ror":"https://ror.org/049kefs16","country_code":"US","type":"education","lineage":["https://openalex.org/I110378019","https://openalex.org/I2801502357"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Bartke","raw_affiliation_strings":["Department of Physiology , Southern Illinois University , Carbondale ","University of Michigan , Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology , Southern Illinois University , Carbondale ","institution_ids":["https://openalex.org/I110378019"]},{"raw_affiliation_string":"University of Michigan , Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066597539","display_name":"Richard A. Miller","orcid":"https://orcid.org/0000-0001-9266-9649","observed_orcids":["https://orcid.org/0000-0001-9266-9649","https://orcid.org/0009-0004-5252-505X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210122509","display_name":"Ann Arbor VA Medical Center","ror":"https://ror.org/039n0s143","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210102099","https://openalex.org/I4210122509","https://openalex.org/I4210127612"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. A. Miller","raw_affiliation_strings":["Ann Arbor DVA Medical Center , Michigan","Department of Pathology , Institute of Gerontology, and Geriatrics Center , University of Michigan , Ann Arbor","University of Michigan , Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ann Arbor DVA Medical Center , Michigan","institution_ids":["https://openalex.org/I4210122509"]},{"raw_affiliation_string":"Department of Pathology , Institute of Gerontology, and Geriatrics Center , University of Michigan , Ann Arbor","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"University of Michigan , Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4408,"currency":"USD","value_usd":4408},"apc_paid":null,"fwci":2.9482,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.92448513,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"56","issue":"2","first_page":"B72","last_page":"B80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ames-dwarf-mice","display_name":"Ames dwarf mice","score":0.8339999914169312},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.7559999823570251},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.43700000643730164},{"id":"https://openalex.org/keywords/hepatic-gene-expression","display_name":"hepatic gene expression","score":0.8930000066757202},{"id":"https://openalex.org/keywords/age-related-gene-expression","display_name":"age-related gene expression","score":0.7620000243186951},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9359999895095825},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-binding-proteins","display_name":"IGF binding proteins","score":0.984000027179718}],"concepts":[{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.7342555522918701},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7168200612068176},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6208348870277405},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.595879077911377},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5324225425720215},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5191935300827026},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.4931451678276062},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.44845953583717346},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3567602038383484},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34236666560173035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11977502703666687}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004392","descriptor_name":"Dwarfism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/gerona/56.2.b72","doi":"https://doi.org/10.1093/gerona/56.2.b72","is_oa":false,"landing_page_url":"https://doi.org/10.1093/gerona/56.2.b72","pdf_url":null,"source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","raw_type":"journal-article"},{"id":"pmid:11213270","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11213270","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journals of gerontology. Series A, Biological sciences and medical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.942.9832","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.942.9832","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://biomedgerontology.oxfordjournals.org/content/56/2/B72.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G534597933","display_name":null,"funder_award_id":"AG-08808","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7513854281","display_name":"Cellular and Molecular Biology of Aging","funder_award_id":"P30AG013283","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320309652","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W191597460","https://openalex.org/W1583148430","https://openalex.org/W1965532984","https://openalex.org/W1966645907","https://openalex.org/W2060135155","https://openalex.org/W2066519654","https://openalex.org/W2078589625","https://openalex.org/W2111063091","https://openalex.org/W2135676923","https://openalex.org/W2136385316","https://openalex.org/W2144355145","https://openalex.org/W2160819759"],"related_works":["https://openalex.org/W7095704866","https://openalex.org/W1495650262","https://openalex.org/W2030241727","https://openalex.org/W2111041983","https://openalex.org/W1999166828","https://openalex.org/W2142820087","https://openalex.org/W2038054416","https://openalex.org/W2008288896","https://openalex.org/W2002018977","https://openalex.org/W7097260332"],"abstract_inverted_index":{"Ames":[0,44],"dwarf":[1,45,109,312],"mice,":[2,61,110,180],"homozygous":[3],"for":[4,39,52,146,151,307,335,343],"the":[5,9,22,37,40,43,90,125,175,183,194,242,267,301,308,311,321,333,357],"df":[6],"allele":[7],"at":[8,69,128],"Prop1":[10],"locus,":[11],"live":[12],"40%":[13],"to":[14,63,248,292,315],"70%":[15],"longer":[16],"than":[17,191],"nonmutant":[18],"siblings":[19],"and":[20,73,76,80,101,149,165,196,262,286,345,351],"represent":[21],"first":[23],"single-gene":[24],"mutant":[25],"that":[26,188,201,310,338],"extends":[27],"life":[28],"span":[29],"in":[30,55,77,98,108,229,326],"a":[31,56,155,157,197,264],"mammal.":[32],"To":[33],"gain":[34],"insight":[35],"into":[36],"basis":[38],"longevity":[41],"of":[42,58,92,113,124,133,182,193,206,245,266,278,295,320,323,360,363],"mouse,":[46],"we":[47],"measured":[48],"liver":[49],"mRNA":[50],"levels":[51],"265":[53],"genes":[54,88,120,150,185,202,228,250,268,279],"group":[57],"11":[59],"df/df":[60,126,302],"(three":[62],"four":[64],"mice":[65,100],"per":[66],"age":[67,93,106],"group),":[68],"ages":[70],"5,":[71],"13,":[72],"22":[74,293],"months,":[75,288],"13":[78,287,291],"age-":[79,344],"sex-matched":[81],"control":[82,179],"mice.":[83],"The":[84,276],"analysis":[85],"showed":[86,121,186,200,233],"seven":[87],"where":[89,251],"effects":[91,107,123,347],"reach":[94],"p":[95,129,273],"<":[96,130,274],".01":[97],"normal":[99],"six":[102],"others":[103],"with":[104,203,269],"possible":[105,122],"but":[111,241],"none":[112],"these":[114,246],"met":[115],"Bonferroni-adjusted":[116],"significance":[117,225],"thresholds.":[118],"Thirteen":[119],"genotype":[127],".01.":[131],"One":[132],"these,":[134],"insulin-like":[135],"growth":[136],"factor":[137],"1":[138],"(IGF-1),":[139],"was":[140,297],"statistically":[141],"significant":[142],"even":[143],"after":[144],"adjustment":[145],"multiple":[147],"comparisons;":[148],"two":[152],"IGF-binding":[153],"proteins,":[154],"cyclin,":[156],"heat":[158],"shock":[159],"protein,":[160],"p38":[161],"mitogen-activated":[162],"protein":[163],"kinase,":[164],"an":[166],"inducible":[167],"cytochrome":[168],"P450":[169],"were":[170,189,216],"among":[171,356],"those":[172],"implicated":[173],"by":[174,259,300],"survey.":[176],"In":[177],"young":[178],"half":[181],"expressed":[184],"SDs":[187],"more":[190],"58%":[192],"mean,":[195],"simulation":[198],"study":[199],"this":[204],"degree":[205],"interanimal":[207,253],"variation":[208,254],"would":[209],"often":[210],"produce":[211],"false-positive":[212],"findings":[213],"when":[214],"conclusions":[215],"based":[217],"on":[218,348],"ratio":[219],"calculations":[220],"alone":[221],"(i.e.,":[222],"without":[223],"formal":[224],"testing).":[226],"Many":[227],"our":[230],"data":[231,331],"set":[232],"apparent":[234],"young-to-old":[235],"or":[236,289,318],"normal-to-dwarf":[237],"ratios":[238,258,271],"above":[239],"2,":[240],"large":[243,270,282],"majority":[244],"proved":[247],"be":[249],"high":[252,257],"could":[255],"create":[256],"chance":[260],"alone,":[261],"only":[263],"few":[265],"achieved":[272],".05.":[275],"proportion":[277],"showing":[280],"relatively":[281],"changes":[283,325],"between":[284],"5":[285],"from":[290],"months":[294],"age,":[296],"not":[298],"diminished":[299],"genotype,":[303],"providing":[304],"no":[305],"support":[306],"idea":[309],"mutation":[313],"leads":[314],"global":[316],"delay":[317],"deceleration":[319],"pace":[322],"age-dependent":[324],"gene":[327,349],"expression.":[328],"These":[329],"survey":[330],"provide":[332,340],"foundation":[334],"replication":[336],"studies":[337],"should":[339],"convincing":[341],"proof":[342],"genotype-specific":[346],"expression":[350],"thus":[352],"reveal":[353],"key":[354],"similarities":[355],"growing":[358],"number":[359],"mouse":[361],"models":[362],"decelerated":[364],"aging.":[365]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}