{"id":"https://openalex.org/W1968559016","doi":"https://doi.org/10.1172/jci116684","title":"Human neuroblastoma cells express alpha and beta platelet-derived growth factor receptors coupling with neurotrophic and chemotactic signaling.","display_name":"Human neuroblastoma cells express alpha and beta platelet-derived growth factor receptors coupling with neurotrophic and chemotactic signaling.","publication_year":1993,"publication_date":"1993-09-01","ids":{"openalex":"https://openalex.org/W1968559016","doi":"https://doi.org/10.1172/jci116684","mag":"1968559016","pmid":"https://pubmed.ncbi.nlm.nih.gov/8376577","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/288252"},"language":"en","primary_location":{"id":"doi:10.1172/jci116684","doi":"https://doi.org/10.1172/jci116684","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci116684","pdf_url":"http://www.jci.org/articles/view/116684/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/116684/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101711253","display_name":"Toshimitsu Matsui","orcid":"https://orcid.org/0000-0002-2536-7584","observed_orcids":["https://orcid.org/0000-0002-2536-7584"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Matsui","raw_affiliation_strings":["Department of Medicine, Kobe University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Kobe University School of Medicine, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090747020","display_name":"Ken\u2010Ichi Sano","orcid":"https://orcid.org/0000-0003-0715-5040","observed_orcids":["https://orcid.org/0000-0003-0715-5040"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Sano","raw_affiliation_strings":["Third Division, Department of *Medicine, and Departments of*tPediatrics and \u00a7Gerontology, Kobe University School ofMedicine, Kobe 650, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Division, Department of *Medicine, and Departments of*tPediatrics and \u00a7Gerontology, Kobe University School ofMedicine, Kobe 650, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076893733","display_name":"Tatsuo Tsukamoto","orcid":"https://orcid.org/0000-0003-2896-5595","observed_orcids":["https://orcid.org/0000-0003-2896-5595"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Tsukamoto","raw_affiliation_strings":["Third Division, Department of *Medicine, and Departments of*tPediatrics and \u00a7Gerontology, Kobe University School ofMedicine, Kobe 650, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Division, Department of *Medicine, and Departments of*tPediatrics and \u00a7Gerontology, Kobe University School ofMedicine, Kobe 650, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083566457","display_name":"Mitsuhiro Ito","orcid":"https://orcid.org/0000-0001-9505-2441","observed_orcids":["https://orcid.org/0000-0001-9505-2441","https://orcid.org/0009-0002-8035-5014"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Ito","raw_affiliation_strings":["Third Division, Department of *Medicine, and Departments of*tPediatrics and \u00a7Gerontology, Kobe University School ofMedicine, Kobe 650, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Division, Department of *Medicine, and Departments of*tPediatrics and \u00a7Gerontology, Kobe University School ofMedicine, Kobe 650, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110158748","display_name":"Tomoaki Takaishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Takaishi","raw_affiliation_strings":["Third Division, Department of *Medicine, and Departments of*tPediatrics and \u00a7Gerontology, Kobe University School ofMedicine, Kobe 650, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Division, Department of *Medicine, and Departments of*tPediatrics and \u00a7Gerontology, Kobe University School ofMedicine, Kobe 650, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H Nakata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Nakata","raw_affiliation_strings":["Third Division, Department of *Medicine, and Departments of*tPediatrics and \u00a7Gerontology, Kobe University School ofMedicine, Kobe 650, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Division, Department of *Medicine, and Departments of*tPediatrics and \u00a7Gerontology, Kobe University School ofMedicine, Kobe 650, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101649079","display_name":"Hiroyuki Nakamura","orcid":"https://orcid.org/0000-0003-2149-7573","observed_orcids":["https://orcid.org/0000-0003-2149-7573"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Nakamura","raw_affiliation_strings":["Third Division, Department of *Medicine, and Departments of*tPediatrics and \u00a7Gerontology, Kobe University School ofMedicine, Kobe 650, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Division, Department of *Medicine, and Departments of*tPediatrics and \u00a7Gerontology, Kobe University School ofMedicine, Kobe 650, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113653169","display_name":"Kazuo Chihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Chihara","raw_affiliation_strings":["Third Division, Department of *Medicine, and Departments of*tPediatrics and \u00a7Gerontology, Kobe University School ofMedicine, Kobe 650, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Division, Department of *Medicine, and Departments of*tPediatrics and \u00a7Gerontology, Kobe University School ofMedicine, Kobe 650, Japan","institution_ids":["https://openalex.org/I65837984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I65837984"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":1.0646,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.78673521,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"92","issue":"3","first_page":"1153","last_page":"1160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.8413000106811523,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.8413000106811523,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.025800000876188278,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.9649999737739563},{"id":"https://openalex.org/keywords/pdgf-receptor","display_name":"PDGF receptor","score":0.7139999866485596},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9620000123977661},{"id":"https://openalex.org/keywords/primitive-neuroectodermal-tumor","display_name":"primitive neuroectodermal tumor","score":0.8569999933242798},{"id":"https://openalex.org/keywords/ewing-sarcoma","display_name":"Ewing sarcoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/neural-crest-derived-tumors","display_name":"neural crest-derived tumors","score":0.7630000114440918},{"id":"https://openalex.org/keywords/pdgf-aa","display_name":"PDGF-AA","score":0.7210000157356262},{"id":"https://openalex.org/keywords/pdgf-bb","display_name":"PDGF-BB","score":1.0},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.7360000014305115},{"id":"https://openalex.org/keywords/mitogenic-activity","display_name":"mitogenic activity","score":0.7440000176429749},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.8600000143051147},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.7814503312110901},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6561097502708435},{"id":"https://openalex.org/C2781294074","wikidata":"https://www.wikidata.org/wiki/Q22327352","display_name":"Platelet-derived growth factor","level":5,"score":0.5874476432800293},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.5765200853347778},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5592427849769592},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5057551860809326},{"id":"https://openalex.org/C126749454","wikidata":"https://www.wikidata.org/wiki/Q1348455","display_name":"Neural crest","level":3,"score":0.4783608317375183},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.448879212141037},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41879603266716003},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4179564118385315},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3991953134536743},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3766992688179016},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3657004237174988},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3335937559604645},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10178729891777039},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08294796943664551},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009432","descriptor_name":"Neural Crest","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016900","descriptor_name":"Neurofilament Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017479","descriptor_name":"Receptors, Platelet-Derived Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020574","descriptor_name":"Proto-Oncogene Proteins c-sis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci116684","doi":"https://doi.org/10.1172/jci116684","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci116684","pdf_url":"http://www.jci.org/articles/view/116684/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:8376577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8376577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:288252","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC288252/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1172/jci116684","doi":"https://doi.org/10.1172/jci116684","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci116684","pdf_url":"http://www.jci.org/articles/view/116684/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968559016.pdf","grobid_xml":"https://content.openalex.org/works/W1968559016.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W169938888","https://openalex.org/W1534154320","https://openalex.org/W1574923688","https://openalex.org/W1638994578","https://openalex.org/W1703816965","https://openalex.org/W1708468382","https://openalex.org/W1781314548","https://openalex.org/W1817058513","https://openalex.org/W1864905496","https://openalex.org/W1894765306","https://openalex.org/W1902133227","https://openalex.org/W1964822816","https://openalex.org/W1974933885","https://openalex.org/W1974967725","https://openalex.org/W1978271705","https://openalex.org/W1979286083","https://openalex.org/W1981012177","https://openalex.org/W1995477422","https://openalex.org/W1996728737","https://openalex.org/W2003196630","https://openalex.org/W2003921130","https://openalex.org/W2004684799","https://openalex.org/W2009210914","https://openalex.org/W2009416998","https://openalex.org/W2011557383","https://openalex.org/W2011957331","https://openalex.org/W2013371970","https://openalex.org/W2013986489","https://openalex.org/W2014456898","https://openalex.org/W2015296842","https://openalex.org/W2020292310","https://openalex.org/W2032359283","https://openalex.org/W2045956897","https://openalex.org/W2046066271","https://openalex.org/W2047258893","https://openalex.org/W2049503539","https://openalex.org/W2050601632","https://openalex.org/W2056557043","https://openalex.org/W2057409901","https://openalex.org/W2059810045","https://openalex.org/W2075703553","https://openalex.org/W2076300616","https://openalex.org/W2081491684","https://openalex.org/W2086862958","https://openalex.org/W2089083607","https://openalex.org/W2091806269","https://openalex.org/W2127197419","https://openalex.org/W2133267068","https://openalex.org/W2137260277","https://openalex.org/W2139397808","https://openalex.org/W2147631014","https://openalex.org/W2148371225","https://openalex.org/W2149967388","https://openalex.org/W2171500262","https://openalex.org/W2399565810","https://openalex.org/W2413168335","https://openalex.org/W2416874932","https://openalex.org/W2416884573","https://openalex.org/W4240372962","https://openalex.org/W6618349395"],"related_works":["https://openalex.org/W2137889226","https://openalex.org/W7095828123","https://openalex.org/W1978271705","https://openalex.org/W2409349087","https://openalex.org/W1996728737","https://openalex.org/W2003689429","https://openalex.org/W1534154320","https://openalex.org/W653103396","https://openalex.org/W1920519850","https://openalex.org/W2021949056"],"abstract_inverted_index":{"Both":[0],"platelet-derived":[1],"growth":[2,120],"factor":[3,121],"(PDGF)":[4],"A-":[5,153],"and":[6,71,78,101,154,181],"B-chains":[7],"are":[8,162],"expressed":[9,148],"in":[10,35,54,111,166,176,183],"mammalian":[11],"neurons,":[12],"but":[13,174],"their":[14],"precise":[15],"roles":[16],"still":[17],"remain":[18],"to":[19],"be":[20],"clarified.":[21],"In":[22],"the":[23,28,91,133,136,139,149,167,170],"present":[24],"studies,":[25],"we":[26],"examined":[27],"expression":[29,45],"of":[30,46,58,135,138,151,169],"two":[31],"PDGF":[32,50,88,114,130,152,160],"receptor":[33],"genes":[34],"human":[36,61,92,184],"tumor":[37,62],"cell":[38,63,94,127,145,172,178],"lines":[39,64,95,146],"derived":[40],"from":[41],"neural":[42,59],"crest.":[43],"The":[44,143],"alpha":[47],"and/or":[48],"beta":[49],"receptors":[51,89],"was":[52],"detected":[53],"a":[55],"wide":[56],"variety":[57],"crest-derived":[60],"such":[65],"as":[66,116,118],"neuroblastoma,":[67],"primitive":[68],"neuroectodermal":[69],"tumor,":[70],"Ewing's":[72],"sarcoma":[73],"by":[74,80,106],"RNA":[75],"blot":[76],"analysis,":[77],"confirmed":[79],"immunoblot":[81],"analysis.":[82],"We":[83],"have":[84],"also":[85,147,175],"demonstrated":[86],"that":[87,159],"on":[90],"neuroblastoma":[93,144,171],"were":[96,104],"biologically":[97],"functional.":[98],"Accordingly,":[99],"chemotactic":[100],"mitogenic":[102],"activities":[103],"induced":[105,122],"either":[107],"PDGF-AA":[108],"or":[109],"PDGF-BB":[110],"serum-free":[112],"medium.":[113],"isoforms":[115,161],"well":[117],"nerve":[119],"morphological":[123],"changes":[124],"showing":[125],"neuronal":[126,177],"maturation.":[128],"Moreover,":[129],"coordinately":[131],"increased":[132],"levels":[134],"transcript":[137],"midsize":[140],"neurofilament":[141],"gene.":[142],"transcripts":[150],"B-chains.":[155],"These":[156],"findings":[157],"suggest":[158],"involved":[163],"not":[164],"only":[165],"promotion":[168],"growth,":[173,180],"migration,":[179],"differentiation":[182],"brain":[185],"development.":[186]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}