{"id":"https://openalex.org/W1968554582","doi":"https://doi.org/10.1001/archotol.1981.00790400039009","title":"Chemotherapy for Advanced Carcinoma of the Head and Neck: A Clinical Update","display_name":"Chemotherapy for Advanced Carcinoma of the Head and Neck: A Clinical Update","publication_year":1981,"publication_date":"1981-04-01","ids":{"openalex":"https://openalex.org/W1968554582","doi":"https://doi.org/10.1001/archotol.1981.00790400039009","mag":"1968554582","pmid":"https://pubmed.ncbi.nlm.nih.gov/6971090"},"language":"en","primary_location":{"id":"doi:10.1001/archotol.1981.00790400039009","doi":"https://doi.org/10.1001/archotol.1981.00790400039009","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archotol.1981.00790400039009","pdf_url":null,"source":{"id":"https://openalex.org/S101791497","display_name":"Archives of Otolaryngology - Head and Neck Surgery","issn_l":"0886-4470","issn":["0886-4470","1538-361X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Otolaryngology - Head and Neck Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055209325","display_name":"Thomas J. Ervin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. J. Ervin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065165604","display_name":"D. Miller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Miller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109925894","display_name":"R. Weichselbaum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Weichselbaum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109230292","display_name":"Richard L. Fabian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. L. Fabian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5042717041","display_name":"Michael W. Meshad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Meshad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.0599,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.96906188,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":92},"biblio":{"volume":"107","issue":"4","first_page":"237","last_page":"241"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11669","display_name":"Head and Neck Surgical Oncology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9700000286102295},{"id":"https://openalex.org/keywords/advanced-head-and-neck-cancer","display_name":"advanced head and neck cancer","score":0.7879999876022339},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.9129999876022339},{"id":"https://openalex.org/keywords/induction-chemotherapy","display_name":"induction chemotherapy","score":0.7459999918937683},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.8370000123977661},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7870000004768372},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.7279999852180481},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.6669999957084656},{"id":"https://openalex.org/keywords/definitive-local-therapy","display_name":"definitive local therapy","score":0.5580000281333923},{"id":"https://openalex.org/keywords/stage-iii-iv-disease","display_name":"stage III and IV disease","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8187726140022278},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7587828636169434},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.6890569925308228},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6464203000068665},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.598914623260498},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5757408142089844},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5586639642715454},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.5385206341743469},{"id":"https://openalex.org/C2776611710","wikidata":"https://www.wikidata.org/wiki/Q16888295","display_name":"Induction chemotherapy","level":3,"score":0.5002772808074951},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4863205850124359},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.44791093468666077},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4129642844200134},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35324037075042725},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1001/archotol.1981.00790400039009","doi":"https://doi.org/10.1001/archotol.1981.00790400039009","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archotol.1981.00790400039009","pdf_url":null,"source":{"id":"https://openalex.org/S101791497","display_name":"Archives of Otolaryngology - Head and Neck Surgery","issn_l":"0886-4470","issn":["0886-4470","1538-361X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Otolaryngology - Head and Neck Surgery","raw_type":"journal-article"},{"id":"pmid:6971090","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6971090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of otolaryngology (Chicago, Ill. : 1960)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W63592576","https://openalex.org/W252692730","https://openalex.org/W1514703007","https://openalex.org/W1974024453","https://openalex.org/W1980009493","https://openalex.org/W1986317743","https://openalex.org/W1995100569","https://openalex.org/W1995489749","https://openalex.org/W1996101068","https://openalex.org/W1996173407","https://openalex.org/W2010768898","https://openalex.org/W2019812991","https://openalex.org/W2021603922","https://openalex.org/W2031209163","https://openalex.org/W2032138272","https://openalex.org/W2050891642","https://openalex.org/W2052512461","https://openalex.org/W2053205787","https://openalex.org/W2055400330","https://openalex.org/W2058043732","https://openalex.org/W2074802650","https://openalex.org/W2082284579","https://openalex.org/W2159433441","https://openalex.org/W2278059523","https://openalex.org/W2403460091","https://openalex.org/W2409942922","https://openalex.org/W2412412042","https://openalex.org/W2417719362","https://openalex.org/W2418480388","https://openalex.org/W2419072773","https://openalex.org/W2472731248"],"related_works":["https://openalex.org/W2002801728","https://openalex.org/W2917263375","https://openalex.org/W186252289","https://openalex.org/W2024319054","https://openalex.org/W2070034126","https://openalex.org/W1990799920","https://openalex.org/W2416421618","https://openalex.org/W2039683606","https://openalex.org/W16034276","https://openalex.org/W2117955175"],"abstract_inverted_index":{"Optimal":[0],"therapy":[1,125],"for":[2,130,146],"stage":[3,6,117,120],"III":[4,118],"and":[5,14,28,55,119,153],"IV":[7,121],"squamous":[8,148],"carcinoma":[9,149],"arising":[10],"in":[11,37,116],"the":[12,48,56,86,141,151],"head":[13,152],"neck":[15],"requires":[16],"a":[17],"multidisciplinary":[18],"approach,":[19],"including":[20],"chemotherapy.":[21],"Advances":[22],"have":[23,65],"identified":[24],"several":[25],"chemotherapeutic":[26],"agents":[27,31],"combinations":[29],"of":[30,50,70,85,93,98,114,143,150],"that":[32,112],"show":[33],"substantial":[34],"antitumor":[35,41,51],"activity":[36,42],"this":[38],"disease.":[39,132],"While":[40],"can":[43],"be":[44],"documented,":[45],"experience":[46],"indicates":[47],"duration":[49],"effect":[52],"is":[53],"short,":[54],"toxicity":[57],"may":[58,126],"limit":[59],"further":[60],"therapy.":[61],"To":[62],"date,":[63],"studies":[64],"not":[66],"shown":[67],"an":[68],"advantage":[69],"combination":[71,77,144],"chemotherapy":[72,78,106,145],"over":[73],"single":[74],"agents.":[75],"Theoretically,":[76],"should":[79],"increase":[80,127],"patient":[81],"survival":[82],"through":[83],"regression":[84,113],"primary":[87],"tumor":[88,115],"as":[89,91],"well":[90],"ablation":[92],"distant":[94],"metastases.":[95],"An":[96],"analysis":[97],"recent":[99],"trials":[100,134],"with":[101],"patients":[102],"who":[103],"received":[104],"induction":[105],"before":[107,123],"definitive":[108,124],"local":[109,128],"treatment":[110,129],"suggests":[111],"lesions":[122],"regional":[131],"Randomized":[133],"are":[135],"needed":[136],"to":[137],"confirm":[138],"or":[139],"disprove":[140],"efficacy":[142],"advanced":[147],"neck.":[154]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
