{"id":"https://openalex.org/W1968550799","doi":"https://doi.org/10.1177/000456328201900303","title":"Precocious Pseudopuberty Due to a Rare Form of Congenital Adrenal Hyperplasia","display_name":"Precocious Pseudopuberty Due to a Rare Form of Congenital Adrenal Hyperplasia","publication_year":1982,"publication_date":"1982-05-01","ids":{"openalex":"https://openalex.org/W1968550799","doi":"https://doi.org/10.1177/000456328201900303","mag":"1968550799","pmid":"https://pubmed.ncbi.nlm.nih.gov/7092138"},"language":"en","primary_location":{"id":"doi:10.1177/000456328201900303","doi":"https://doi.org/10.1177/000456328201900303","is_oa":true,"landing_page_url":"https://doi.org/10.1177/000456328201900303","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/000456328201900303","source":{"id":"https://openalex.org/S175011280","display_name":"Annals of Clinical Biochemistry International Journal of Laboratory Medicine","issn_l":"0004-5632","issn":["0004-5632","1758-1001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical Biochemistry: International Journal of Laboratory Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/000456328201900303","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107446486","display_name":"WENDY A. RATCLIFFE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800666604","display_name":"Glasgow Royal Infirmary","ror":"https://ror.org/00bjck208","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2800666604"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"W A Ratcliffe","raw_affiliation_strings":["Department of Biochemistry, Royal Infirmary, Glasgow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Royal Infirmary, Glasgow","institution_ids":["https://openalex.org/I2800666604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111538497","display_name":"J. P. McCLURE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799573814","display_name":"Seafield Hospital","ror":"https://ror.org/05mg1ma72","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799573814","https://openalex.org/I4210093322"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J P McClure","raw_affiliation_strings":["Department of Paediatrics, Seafield Hospital, Ayr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Seafield Hospital, Ayr","institution_ids":["https://openalex.org/I2799573814"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111430465","display_name":"William Auld","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W H R Auld","raw_affiliation_strings":["Department of Biochemistry, Ballochmyle Hospital, Mauchline, Ayrshire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Ballochmyle Hospital, Mauchline, Ayrshire","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031628994","display_name":"J W Honour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J W Honour","raw_affiliation_strings":["Division of Clinical Chemistry, MRC Clinical Research Centre, Harrow, Middlesex"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Chemistry, MRC Clinical Research Centre, Harrow, Middlesex","institution_ids":["https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032221961","display_name":"R. Fr\u00e4ser","orcid":"https://orcid.org/0000-0002-4865-4631","observed_orcids":["https://orcid.org/0000-0002-4865-4631"]},"institutions":[{"id":"https://openalex.org/I2801120601","display_name":"Western Infirmary","ror":"https://ror.org/02e22bh87","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2801120601"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R Fraser","raw_affiliation_strings":["MRC Blood Pressure Unit, Western Infirmary, Glasgow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Blood Pressure Unit, Western Infirmary, Glasgow","institution_ids":["https://openalex.org/I2801120601"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110880369","display_name":"John G Ratcliffe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800666604","display_name":"Glasgow Royal Infirmary","ror":"https://ror.org/00bjck208","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2800666604"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J G Ratcliffe","raw_affiliation_strings":["Department of Biochemistry, Royal Infirmary, Glasgow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Royal Infirmary, Glasgow","institution_ids":["https://openalex.org/I2800666604"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.06983313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"19","issue":"3","first_page":"145","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/precocious-puberty","display_name":"precocious puberty","score":0.9039999842643738},{"id":"https://openalex.org/keywords/congenital-adrenal-hyperplasia","display_name":"congenital adrenal hyperplasia","score":0.9089999794960022},{"id":"https://openalex.org/keywords/11beta-hydroxylase-deficiency","display_name":"11beta-hydroxylase deficiency","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hyperandrogenism","display_name":"hyperandrogenism","score":0.7179999947547913},{"id":"https://openalex.org/keywords/11-deoxycortisol","display_name":"11-deoxycortisol","score":0.8610000014305115},{"id":"https://openalex.org/keywords/dexamethasone-suppression-test","display_name":"dexamethasone suppression test","score":0.8330000042915344},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C2777767042","wikidata":"https://www.wikidata.org/wiki/Q366868","display_name":"Congenital adrenal hyperplasia","level":2,"score":0.9473722577095032},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8291895389556885},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8075785040855408},{"id":"https://openalex.org/C2910605048","wikidata":"https://www.wikidata.org/wiki/Q10529545","display_name":"Androgen Excess","level":5,"score":0.7632498145103455},{"id":"https://openalex.org/C2776683971","wikidata":"https://www.wikidata.org/wiki/Q411064","display_name":"Androstenedione","level":4,"score":0.685817539691925},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.6803267002105713},{"id":"https://openalex.org/C2778367240","wikidata":"https://www.wikidata.org/wiki/Q224513","display_name":"Precocious puberty","level":3,"score":0.5588428974151611},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5039829611778259},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.48806464672088623},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.48147812485694885},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.4755396842956543},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.4684712290763855},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.46028557419776917},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.34212321043014526},{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.10363277792930603},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000312","descriptor_name":"Adrenal Hyperplasia, Congenital","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000312","descriptor_name":"Adrenal Hyperplasia, Congenital","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011629","descriptor_name":"Puberty, Precocious","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011629","descriptor_name":"Puberty, Precocious","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011629","descriptor_name":"Puberty, Precocious","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/000456328201900303","doi":"https://doi.org/10.1177/000456328201900303","is_oa":true,"landing_page_url":"https://doi.org/10.1177/000456328201900303","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/000456328201900303","source":{"id":"https://openalex.org/S175011280","display_name":"Annals of Clinical Biochemistry International Journal of Laboratory Medicine","issn_l":"0004-5632","issn":["0004-5632","1758-1001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical Biochemistry: International Journal of Laboratory Medicine","raw_type":"journal-article"},{"id":"pmid:7092138","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7092138","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of clinical biochemistry","raw_type":"Case Reports"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:191886","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/191886/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ann Clin Biochem , 19 (3) pp. 145-150. (1982)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1177/000456328201900303","doi":"https://doi.org/10.1177/000456328201900303","is_oa":true,"landing_page_url":"https://doi.org/10.1177/000456328201900303","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/000456328201900303","source":{"id":"https://openalex.org/S175011280","display_name":"Annals of Clinical Biochemistry International Journal of Laboratory Medicine","issn_l":"0004-5632","issn":["0004-5632","1758-1001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical Biochemistry: International Journal of Laboratory Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968550799.pdf","grobid_xml":"https://content.openalex.org/works/W1968550799.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W2000743989","https://openalex.org/W2012431985","https://openalex.org/W2012856076","https://openalex.org/W2013831526","https://openalex.org/W2021179848","https://openalex.org/W2068363267","https://openalex.org/W2069263762","https://openalex.org/W2094460646","https://openalex.org/W2121900547","https://openalex.org/W2166530128"],"related_works":["https://openalex.org/W2044764304","https://openalex.org/W4400962876","https://openalex.org/W2204855587","https://openalex.org/W2557850977","https://openalex.org/W4414442303","https://openalex.org/W1981047654","https://openalex.org/W2059343993","https://openalex.org/W2010517579","https://openalex.org/W4415169338","https://openalex.org/W216855248"],"abstract_inverted_index":{"The":[0,66,152,165],"biochemical":[1],"investigation":[2],"is":[3,184],"described":[4],"of":[5,16,26,98,100,114,126,139,160,167,181],"a":[6,23,171],"boy":[7],"who":[8],"presented":[9],"with":[10],"precocious":[11,182],"puberty":[12,183],"at":[13],"the":[14,101,177],"age":[15],"3":[17],"years":[18],"9":[19],"months":[20],"due":[21,95],"to":[22,86,93,96],"rare":[24],"form":[25],"congenital":[27],"adrenal":[28],"hyperplasia":[29],"(CAH),":[30],"steroid":[31],"11":[32,128],"beta-hydroxylase":[33,129],"deficiency.":[34],"Serum":[35],"androgen":[36,115,144],"levels":[37,111,118],"were":[38,58,62,88],"grossly":[39],"elevated":[40,52],"(17":[41],"hydroxyandrogens":[42],"10":[43],"nmol/l,":[44],"androstenedione":[45],"129":[46],"nmol/l),":[47,54],"17":[48],"hydroxyprogesterone":[49],"was":[50,70,131,154],"modestly":[51],"(21":[53],"while":[55],"serum":[56,78,158],"gonadotrophins":[57],"low":[59],"and":[60,75,79,83,103,112,116,145,163,170,179],"testes":[61],"prepubertal":[63],"in":[64,176],"size.":[65],"major":[67],"differential":[68],"diagnosis":[69,125,153,178],"between":[71],"an":[72,127],"androgen-producing":[73],"tumour":[74],"CAH.":[76,123],"Initial":[77],"urine":[80,140],"corticosteroid":[81],"concentrations":[82],"their":[84,174],"responses":[85],"dexamethasone":[87,120],"diagnostically":[89],"misleading,":[90],"later":[91],"found":[92],"be":[94],"lack":[97],"specificity":[99],"radioimmunoassays":[102],"fluorimetric":[104],"methods":[105],"employed.":[106],"Elevated":[107],"basal":[108],"plasma":[109],"ACTH":[110,117],"suppression":[113],"by":[119,133,156],"strongly":[121],"suggested":[122],"Definitive":[124],"defect":[130],"established":[132],"capillary":[134],"column":[135],"gas":[136],"liquid":[137],"chromatography":[138],"which":[141],"demonstrated":[142],"excess":[143],"11-deoxycortisol":[146],"metabolites":[147],"but":[148],"no":[149],"cortisol":[150],"metabolites.":[151],"confirmed":[155],"specific":[157],"assays":[159,169],"11-deoxycortisol,":[161],"deoxycorticosterone,":[162],"cortisol.":[164],"contribution":[166],"hormone":[168],"protocol":[172],"for":[173],"use":[175],"monitoring":[180],"discussed.":[185]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
