{"id":"https://openalex.org/W1968470326","doi":"https://doi.org/10.1113/jphysiol.2010.199380","title":"Muscle spindle afferents and the mystery of the \u03b13isoform of Na+,K+-ATPase","display_name":"Muscle spindle afferents and the mystery of the \u03b13isoform of Na+,K+-ATPase","publication_year":2010,"publication_date":"2010-10-29","ids":{"openalex":"https://openalex.org/W1968470326","doi":"https://doi.org/10.1113/jphysiol.2010.199380","mag":"1968470326","pmid":"https://pubmed.ncbi.nlm.nih.gov/21037311","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3002435"},"language":"en","primary_location":{"id":"doi:10.1113/jphysiol.2010.199380","doi":"https://doi.org/10.1113/jphysiol.2010.199380","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.2010.199380","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3002435","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083200304","display_name":"Maxim G. Dobretsov","orcid":"https://orcid.org/0000-0001-6007-9775","observed_orcids":["https://orcid.org/0000-0001-6007-9775"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maxim Dobretsov","raw_affiliation_strings":["Department of Anesthesiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. dobretsovmaxim@uams.edu","Departments of Anesthesiology","Neurobiology and Developmental Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. dobretsovmaxim@uams.edu","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Departments of Anesthesiology","institution_ids":[]},{"raw_affiliation_string":"Neurobiology and Developmental Sciences","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109829731","display_name":"Joseph R. Stimers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph R. Stimers","raw_affiliation_strings":["Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5083200304"],"corresponding_institution_ids":["https://openalex.org/I79620101"],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.07684339,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"588","issue":"21","first_page":"4061","last_page":"4061"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.2912999987602234,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/na-k-atpase","display_name":"Na+/K+-ATPase","score":0.9490000009536743},{"id":"https://openalex.org/keywords/alpha3-isoform","display_name":"alpha3 isoform","score":0.8370000123977661},{"id":"https://openalex.org/keywords/muscle-spindle-afferents","display_name":"muscle spindle afferents","score":0.9300000071525574},{"id":"https://openalex.org/keywords/sensory-neurons","display_name":"sensory neurons","score":0.4009999930858612},{"id":"https://openalex.org/keywords/ion-transport","display_name":"ion transport","score":0.4020000100135803},{"id":"https://openalex.org/keywords/neuronal-excitability","display_name":"neuronal excitability","score":0.5910000205039978},{"id":"https://openalex.org/keywords/potassium-accumulation","display_name":"potassium accumulation","score":0.3190000057220459},{"id":"https://openalex.org/keywords/hyperpolarization","display_name":"hyperpolarization","score":0.5519999861717224},{"id":"https://openalex.org/keywords/dystonia","display_name":"dystonia","score":0.4779999852180481},{"id":"https://openalex.org/keywords/motor-impairment","display_name":"motor impairment","score":0.5389999747276306},{"id":"https://openalex.org/keywords/atp-hydrolysis","display_name":"ATP hydrolysis","score":0.4740000069141388},{"id":"https://openalex.org/keywords/na-k-exchange","display_name":"Na+/K+ exchange","score":0.492000013589859},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.33500000834465027},{"id":"https://openalex.org/keywords/neuronal-network-activity","display_name":"neuronal network activity","score":0.3140000104904175}],"concepts":[{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.7105115652084351},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.6123689413070679},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.5749304294586182},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.5393130779266357},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5006771087646484},{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.4969055950641632},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.49559152126312256},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4396221339702606},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43674615025520325},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43550926446914673},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41873496770858765},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40666061639785767},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2812064588069916},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.24565768241882324},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10435530543327332}],"mesh":[{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009470","descriptor_name":"Muscle Spindles","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D009475","descriptor_name":"Neurons, Afferent","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012026","descriptor_name":"Reflex, Stretch","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1113/jphysiol.2010.199380","doi":"https://doi.org/10.1113/jphysiol.2010.199380","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.2010.199380","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3002435","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3002435","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},{"id":"pmid:21037311","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21037311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3002435","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3002435","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1530855917","https://openalex.org/W1540591510","https://openalex.org/W1925234459","https://openalex.org/W2051736421","https://openalex.org/W2088689487","https://openalex.org/W2161888572"],"related_works":["https://openalex.org/W1966970502","https://openalex.org/W2346595516","https://openalex.org/W1530855917","https://openalex.org/W7165886719","https://openalex.org/W1596424589","https://openalex.org/W2179055415","https://openalex.org/W155351022","https://openalex.org/W2904907785","https://openalex.org/W2010105327","https://openalex.org/W3085313397"],"abstract_inverted_index":{"Normal":[0],"nervous":[1,106,118,171,215,262,364],"system":[2,119,172,365],"function":[3,583],"is":[4,58,83,173,193,553,628],"critically":[5],"dependent":[6],"upon":[7],"Na+,K+-ATPase":[8,57,82,115,135,148,224,248,266,305,352,406,485,597,627,687,754],"activity.":[9],"The":[10,81,315,357,432,443,502,739],"functional":[11,246,360,530],"Na+,K+-ATPase,":[12,180,649],"a":[13,197,242,268,307,327,382,522,554,655,748],"complex":[14],"of":[15,50,53,67,78,90,95,110,129,133,146,162,169,200,213,231,245,251,281,284,293,298,302,326,336,339,349,351,362,387,427,442,445,490,504,512,528,532,535,556,587,589,596,613,621,624,634,639,661,672,681,685,695,697,706,712,720,722,731,733,741,750,761],"\u03b1,":[16],"\u03b2":[17],"and":[18,35,38,46,76,92,98,143,186,202,270,346,359,401,467,479,498,551,565,611,667,669,700,724,757],"\u03b3":[19],"protein":[20],"subunits,":[21],"hydrolyses":[22],"ATP":[23,668],"to":[24,64,177,495,547,561,664],"exchange":[25,52],"intracellular":[26],"Na+":[27,37],"for":[28,55,278,483,515,525,579,647,658,703,770],"extracellular":[29,88],"K+.":[30],"Thus,":[31,259],"the":[32,42,65,74,84,117,130,134,147,152,163,170,190,214,222,261,264,285,296,303,320,324,334,337,344,363,374,385,395,412,451,471,487,529,544,585,590,593,632,704],"transporter":[33],"sets":[34],"maintains":[36],"K+":[39,54,91,666],"gradients":[40],"controlling":[41],"resting":[43],"membrane":[44,489],"potential":[45],"neuronal":[47,79,96,533,582,625],"excitability.":[48],"Because":[49],"unequal":[51],"Na+,":[56,665],"an":[59,689,717,728],"electrogenic":[60],"mechanism":[61,86],"that":[62,273,331,373,418,475,492,539,572],"adds":[63],"generation":[66],"hyperpolarizing":[68],"afterpotentials":[69],"when":[70],"activated,":[71],"thus":[72],"modulating":[73],"frequency":[75],"duration":[77],"discharges.":[80],"major":[85,141,316],"preventing":[87],"accumulation":[89],"associated":[93,701],"hyperactivity":[94],"networks":[97],"centres.":[99],"Despite":[100],"such":[101,367,381],"profound":[102],"involvement":[103],"in":[104,175,221,227,260,318,439,450,464,476,675,692,752,755],"basic":[105],"function,":[107],"many":[108],"aspects":[109],"active":[111],"ion":[112],"transport":[113,144],"by":[114,151,195,206,279,354,434,454,602,608],"within":[116],"are":[120,149,158,511,542,598],"poorly":[121],"understood.":[122],"One":[123],"unresolved":[124],"matter":[125],"concerns":[126],"neuron-specific":[127],"expression":[128,534,684],"\u03b13":[131,187,191,223,247,265,304,405,428,484,536,626,648,686,753],"isoform":[132],"(Dobretsov":[136,407],"&":[137,312],"Stimers,":[138,313],"2005).":[139,314],"All":[140],"catalytic":[142],"properties":[145,348,595,623],"determined":[150,599],"\u03b1":[153,164],"subunit.":[154,165],"In":[155,217],"mammals":[156],"there":[157,552],"four":[159],"known":[160],"isoforms":[161,283,350,588],"An":[166],"exceptional":[167],"feature":[168],"that,":[174],"addition":[176,230],"ubiquitous":[178],"\u03b11":[179,400],"cells":[181,211,646],"may":[182,379,745],"also":[183,607,653,746],"express":[184,391,399],"\u03b12":[185],"isozymes.":[188],"Furthermore,":[189],"isozyme":[192],"expressed":[194,353],"only":[196,394,404,601],"small":[198],"subset":[199],"neurons,":[201],"not":[203,423,600],"at":[204,289],"all":[205],"glia":[207],"or":[208,403],"any":[209],"other":[210,282],"outside":[212],"system.":[216],"humans,":[218],"missense":[219],"mutations":[220],"gene":[225],"result":[226],"dystonia":[228,723],"with":[229,241,343,414,559,584],"some":[232],"Parkinsonian":[233],"symptoms":[234],"(de":[235],"Carvalho":[236],"et":[237,256,408,436,508,743],"al.":[238,257,409,437,509,744],"2004).":[239],"Mice":[240],"genetic":[243],"deficiency":[244],"display":[249],"signs":[250],"severe":[252],"motor":[253],"impairment":[254],"(Clapcote":[255],"2009).":[258],"system,":[263],"plays":[267],"unique":[269,300],"critical":[271],"role":[272,301,749],"apparently":[274],"cannot":[275],"be":[276,570,576,727,768],"compensated":[277],"up-regulation":[280],"Na+,K+-ATPase.":[286,537,591],"However,":[287,411],"despite":[288],"least":[290],"two":[291],"decades":[292],"research":[294],"already,":[295],"essence":[297],"this":[299,440,448,505],"remains":[306],"mystery":[308],"(Lingrel,":[309],"1992;":[310],"Dobretsov":[311],"obstacle":[317],"answering":[319],"question":[321],"above":[322],"was":[323,417],"lack":[325],"preparation":[328,383,657],"allowing":[329],"studies":[330,416,453,527,580,660,766],"directly":[332],"compare":[333],"characteristics":[335,612],"discharge":[338],"functionally":[340,455],"identified":[341],"neurons":[342,390,398,458,491,541,574,652],"type":[345],"biophysical":[347,594,622],"these":[355,415,457,573,651,773],"neurons.":[356,431],"structural":[358],"complexity":[361],"complicates":[366],"comparisons.":[368],"Recent":[369],"immunohistochemical":[370],"experiments":[371],"suggested":[372,420],"dorsal":[375],"root":[376],"ganglion":[377],"(DRG)":[378],"provide":[380],"because":[384],"majority":[386],"primary":[388],"afferent":[389],"\u03b11,":[392],"while":[393],"largest":[396],"myelinated":[397],"\u03b13,":[402],"2003).":[410],"problem":[413],"they":[419],"but":[421,606],"did":[422],"allow":[424],"definite":[425],"classification":[426],"Na+,K+-ATPase-expressing":[429],"DRG":[430,540],"report":[433],"Parekh":[435,742],"(2010)":[438],"issue":[441],"Journal":[444],"Physiology":[446],"closes":[447],"gap":[449],"previous":[452],"identifying":[456],"as":[459,643,654,737],"muscle":[460,496,640,682],"spindle":[461,641],"afferents.":[462],"Using":[463],"vivo":[465],"recordings":[466],"various":[468,548],"peripheral":[469,713],"stimuli":[470,500],"authors":[472],"have":[473],"shown":[474],"both":[477],"rat":[478],"guinea":[480],"pig,":[481],"antibodies":[482],"label":[486],"plasma":[488],"were":[493],"responding":[494],"stretch":[497,698],"vibratory":[499],"only.":[501],"findings":[503,740],"work":[506],"(Parekh":[507],"2010)":[510],"special":[513],"importance":[514],"three":[516],"main":[517],"reasons.":[518],"First,":[519],"it":[520,568,725],"opens":[521],"new":[523],"avenue":[524],"general":[526],"significance":[531],"Considering":[538],"among":[543],"most":[545],"accessible":[546],"experimental":[549],"approaches":[550],"wealth":[555],"background":[557],"information":[558,715],"respect":[560],"their":[562],"development,":[563],"physiological":[564],"biochemical":[566],"characteristics,":[567],"should":[569],"expected":[571],"would":[575],"especially":[577],"suited":[578],"linking":[581],"activity":[586],"Second,":[592],"its":[603,662,673,676],"molecular":[604],"structure":[605],"cellular":[609],"factors":[610],"lipid":[614],"bilayer.":[615],"Thus":[616],"far,":[617],"however,":[618],"our":[619,693],"knowledge":[620],"based":[629],"mostly":[630],"on":[631,772],"results":[633],"cell":[635],"transfection":[636],"experiments.":[637],"Identification":[638],"afferents":[642],"natural":[644,656],"host":[645],"identifies":[650],"patch-clamp":[659],"affinity":[663],"voltage":[670],"dependence":[671],"cycle":[674],"native":[677],"cell.":[678],"Finally,":[679],"confirmation":[680],"spindle-associated":[683],"constitutes":[688],"important":[690,718,774],"step":[691],"understanding":[694],"physiology":[696],"reflexes":[699],"circuits":[702],"control":[705],"movement.":[707],"Abnormal":[708],"inflow":[709],"and/or":[710],"processing":[711],"proprioceptive":[714],"constitute":[716],"component":[719],"pathogenesis":[721,732],"could":[726],"essential":[729,769],"part":[730],"rapid-onset":[734],"dystonia-Parkinsonism":[735],"syndrome":[736],"well.":[738],"suggest":[747],"abnormalities":[751],"age-":[756],"neurodegenerative":[758],"disease-associated":[759],"loss":[760],"deep":[762],"tendon":[763],"reflexes.":[764],"Future":[765],"will":[767],"expanding":[771],"areas.":[775]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}