{"id":"https://openalex.org/W1968464339","doi":"https://doi.org/10.1056/nejm197302152880702","title":"Diurnal Variation in Biliary Lipid Composition","display_name":"Diurnal Variation in Biliary Lipid Composition","publication_year":1973,"publication_date":"1973-02-15","ids":{"openalex":"https://openalex.org/W1968464339","doi":"https://doi.org/10.1056/nejm197302152880702","mag":"1968464339","pmid":"https://pubmed.ncbi.nlm.nih.gov/4682942"},"language":"en","primary_location":{"id":"doi:10.1056/nejm197302152880702","doi":"https://doi.org/10.1056/nejm197302152880702","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm197302152880702","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085647090","display_name":"ALLAN LAWRENCE METZGER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153440","display_name":"Phoenix Indian Medical Center","ror":"https://ror.org/05g4knm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I157850169","https://openalex.org/I4210153440"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allan L. Metzger","raw_affiliation_strings":["Phoenix Clinical Research Section, National Institute of Arthritis, Metabolism and Digestive Diseases, Phoenix Indian Medical Center, 4212 North 16th St., Phoenix, Ariz., where reprint requests should be addressed to Dr. Grundy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phoenix Clinical Research Section, National Institute of Arthritis, Metabolism and Digestive Diseases, Phoenix Indian Medical Center, 4212 North 16th St., Phoenix, Ariz., where reprint requests should be addressed to Dr. Grundy","institution_ids":["https://openalex.org/I4210153440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112056945","display_name":"Ronald D. Adler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153440","display_name":"Phoenix Indian Medical Center","ror":"https://ror.org/05g4knm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I157850169","https://openalex.org/I4210153440"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Adler","raw_affiliation_strings":["Phoenix Clinical Research Section, National Institute of Arthritis, Metabolism and Digestive Diseases, Phoenix Indian Medical Center, 4212 North 16th St., Phoenix, Ariz., where reprint requests should be addressed to Dr. Grundy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phoenix Clinical Research Section, National Institute of Arthritis, Metabolism and Digestive Diseases, Phoenix Indian Medical Center, 4212 North 16th St., Phoenix, Ariz., where reprint requests should be addressed to Dr. Grundy","institution_ids":["https://openalex.org/I4210153440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065818595","display_name":"Steven B. Heymsfield","orcid":"https://orcid.org/0000-0003-1127-9425","observed_orcids":["https://orcid.org/0000-0003-1127-9425"]},"institutions":[{"id":"https://openalex.org/I4210153440","display_name":"Phoenix Indian Medical Center","ror":"https://ror.org/05g4knm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I157850169","https://openalex.org/I4210153440"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Heymsfield","raw_affiliation_strings":["Phoenix Clinical Research Section, National Institute of Arthritis, Metabolism and Digestive Diseases, Phoenix Indian Medical Center, 4212 North 16th St., Phoenix, Ariz., where reprint requests should be addressed to Dr. Grundy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phoenix Clinical Research Section, National Institute of Arthritis, Metabolism and Digestive Diseases, Phoenix Indian Medical Center, 4212 North 16th St., Phoenix, Ariz., where reprint requests should be addressed to Dr. Grundy","institution_ids":["https://openalex.org/I4210153440"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056794714","display_name":"Scott M. Grundy","orcid":"https://orcid.org/0000-0003-2956-7900","observed_orcids":["https://orcid.org/0000-0003-2956-7900"]},"institutions":[{"id":"https://openalex.org/I4210153440","display_name":"Phoenix Indian Medical Center","ror":"https://ror.org/05g4knm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I157850169","https://openalex.org/I4210153440"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott M. Grundy","raw_affiliation_strings":["Phoenix Clinical Research Section, National Institute of Arthritis, Metabolism and Digestive Diseases, Phoenix Indian Medical Center, 4212 North 16th St., Phoenix, Ariz., where reprint requests should be addressed to Dr. Grundy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phoenix Clinical Research Section, National Institute of Arthritis, Metabolism and Digestive Diseases, Phoenix Indian Medical Center, 4212 North 16th St., Phoenix, Ariz., where reprint requests should be addressed to Dr. Grundy","institution_ids":["https://openalex.org/I4210153440"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210153440"],"apc_list":null,"apc_paid":null,"fwci":28.9217,"has_fulltext":false,"cited_by_count":140,"citation_normalized_percentile":{"value":0.99846514,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"288","issue":"7","first_page":"333","last_page":"336"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biliary-lipid-composition","display_name":"biliary lipid composition","score":0.8889999985694885},{"id":"https://openalex.org/keywords/gallstones","display_name":"gallstones","score":0.5699999928474426},{"id":"https://openalex.org/keywords/lithogenic-bile","display_name":"lithogenic bile","score":0.8370000123977661},{"id":"https://openalex.org/keywords/diurnal-variation","display_name":"diurnal variation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/fasting","display_name":"fasting","score":0.6859999895095825},{"id":"https://openalex.org/keywords/feeding","display_name":"feeding","score":0.7020000219345093},{"id":"https://openalex.org/keywords/hepatic-bile","display_name":"hepatic bile","score":0.8399999737739563},{"id":"https://openalex.org/keywords/gallbladder-bile","display_name":"gallbladder bile","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cholesterol-secretion","display_name":"cholesterol secretion","score":0.9100000262260437},{"id":"https://openalex.org/keywords/bile-acids","display_name":"bile acids","score":0.824999988079071},{"id":"https://openalex.org/keywords/cholesterol-gallstone-formation","display_name":"cholesterol gallstone formation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/american-indian-women","display_name":"American Indian women","score":0.7490000128746033},{"id":"https://openalex.org/keywords/white-women","display_name":"white women","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8290421962738037},{"id":"https://openalex.org/C2779388726","wikidata":"https://www.wikidata.org/wiki/Q272714","display_name":"Gallstones","level":2,"score":0.7593705654144287},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6879705190658569},{"id":"https://openalex.org/C2777148285","wikidata":"https://www.wikidata.org/wiki/Q64386","display_name":"Gallbladder","level":2,"score":0.6391960382461548},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5921775102615356},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5495433807373047},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.548390805721283},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4243854284286499}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001646","descriptor_name":"Bile","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002769","descriptor_name":"Cholelithiasis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005704","descriptor_name":"Gallbladder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007198","descriptor_name":"Indians, North American","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejm197302152880702","doi":"https://doi.org/10.1056/nejm197302152880702","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm197302152880702","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:4682942","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4682942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1628383901","https://openalex.org/W1914951297","https://openalex.org/W2024753390","https://openalex.org/W2030010306","https://openalex.org/W2064774121","https://openalex.org/W2085345062","https://openalex.org/W2092713296","https://openalex.org/W2127421402","https://openalex.org/W2137698034","https://openalex.org/W2143618022","https://openalex.org/W2146519712","https://openalex.org/W2280176957","https://openalex.org/W2315045608","https://openalex.org/W2323042506","https://openalex.org/W2324761579","https://openalex.org/W2413733649","https://openalex.org/W2425490811","https://openalex.org/W2615411536","https://openalex.org/W4235633489","https://openalex.org/W4298211688","https://openalex.org/W4301108117","https://openalex.org/W4301203542"],"related_works":["https://openalex.org/W2146519712","https://openalex.org/W7098825148","https://openalex.org/W2022822994","https://openalex.org/W2212971608","https://openalex.org/W2049413823","https://openalex.org/W2067677896","https://openalex.org/W2339340287","https://openalex.org/W1991451699","https://openalex.org/W2068466602","https://openalex.org/W2309615628"],"abstract_inverted_index":{"Biliary":[0],"lipid":[1],"composition":[2],"was":[3,36,51,103],"determined":[4],"on":[5,9],"gallbladder":[6,41,86,138],"bile":[7,11,35,42,45,63,76,80,96,114,125,146],"and":[8,18,24,27,75,116],"hepatic":[10,34,44,124],"during":[12,47,64,87],"the":[13,65,85,137],"diurnal":[14],"cycle":[15],"of":[16,70,73,95,113,123,144],"feeding":[17],"fasting":[19,66,127],"in":[20,28,53,84,106,136],"American":[21],"Indians":[22],"with":[23],"without":[25,31],"gallstones":[26],"Caucasian":[29,56],"women":[30,57],"gallstones.":[32],"Fasting":[33],"consistently":[37],"more":[38,60,104],"lithogenic":[39,62,145],"than":[40],"or":[43],"obtained":[46],"feeding.":[48],"Although":[49,79],"lithogenicity":[50,122],"greater":[52],"Indians,":[54],"even":[55],"regularly":[58],"produce":[59],"highly":[61],"period,":[67],"apparently":[68],"because":[69],"an":[71],"uncoupling":[72],"cholesterol":[74,90,118,131],"acid":[77],"secretion.":[78,119],"acids":[81,115],"were":[82],"sequestered":[83],"late":[88],"fasting,":[89],"secretion":[91],"continued":[92],"somewhat":[93],"independently":[94],"acids,":[97],"thus":[98],"enhancing":[99],"lithogenicity.":[100],"This":[101],"effect":[102],"pronounced":[105],"Indian":[107],"women,":[108],"who":[109],"have":[110],"reduced":[111],"pools":[112],"increased":[117],"An":[120],"increasing":[121],"throughout":[126],"might":[128],"contribute":[129],"to":[130],"gallstone":[132],"formation":[133],"if":[134],"mixing":[135],"is":[139],"incomplete":[140],"so":[141],"that":[142],"levels":[143],"become":[147],"segregated.":[148]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}