{"id":"https://openalex.org/W1968447365","doi":"https://doi.org/10.2307/3579411","title":"Radiation-Induced Chromosomal Instability in BALB/c and C57BL/6 Mice: The Difference Is as Clear as Black and White","display_name":"Radiation-Induced Chromosomal Instability in BALB/c and C57BL/6 Mice: The Difference Is as Clear as Black and White","publication_year":1997,"publication_date":"1997-02-01","ids":{"openalex":"https://openalex.org/W1968447365","doi":"https://doi.org/10.2307/3579411","mag":"1968447365","pmid":"https://pubmed.ncbi.nlm.nih.gov/9008202"},"language":"en","primary_location":{"id":"doi:10.2307/3579411","doi":"https://doi.org/10.2307/3579411","is_oa":false,"landing_page_url":"https://doi.org/10.2307/3579411","pdf_url":null,"source":{"id":"https://openalex.org/S152208300","display_name":"Radiation Research","issn_l":"0033-7587","issn":["0033-7587","1938-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315745","host_organization_name":"Radiation Research Society","host_organization_lineage":["https://openalex.org/P4310315745"],"host_organization_lineage_names":["Radiation Research Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041934870","display_name":"Brian Ponnaiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Ponnaiya","raw_affiliation_strings":["University of Texas Medical Branch at Galveston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch at Galveston","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048752550","display_name":"Michael N. Cornforth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. N. Cornforth","raw_affiliation_strings":["Radiation Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058892925","display_name":"Robert L. Ullrich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. L. Ullrich","raw_affiliation_strings":["Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.1631,"has_fulltext":false,"cited_by_count":200,"citation_normalized_percentile":{"value":0.99202393,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"147","issue":"2","first_page":"121","last_page":"121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiation-induced-chromosomal-instability","display_name":"radiation-induced chromosomal instability","score":0.8560000061988831},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.9279999732971191},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.8949999809265137},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":1.0},{"id":"https://openalex.org/keywords/mammary-epithelial-cells","display_name":"mammary epithelial cells","score":0.871999979019165},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.8220000267028809},{"id":"https://openalex.org/keywords/chromatid-breaks","display_name":"chromatid breaks","score":0.8259999752044678},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.7352269291877747},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7321168184280396},{"id":"https://openalex.org/C73397532","wikidata":"https://www.wikidata.org/wiki/Q623749","display_name":"Chromatid","level":4,"score":0.7295098304748535},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.6950616240501404},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6404373645782471},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6320670247077942},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43891578912734985},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4267067313194275},{"id":"https://openalex.org/C8502773","wikidata":"https://www.wikidata.org/wiki/Q2066168","display_name":"Sister chromatids","level":4,"score":0.42250603437423706},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33511602878570557},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.3071984648704529},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2863851487636566},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.25079864263534546},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2081795334815979},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17541345953941345},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12550032138824463},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002842","descriptor_name":"Chromatids","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D002842","descriptor_name":"Chromatids","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005720","descriptor_name":"Gamma Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009381","descriptor_name":"Neoplasms, Radiation-Induced","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2307/3579411","doi":"https://doi.org/10.2307/3579411","is_oa":false,"landing_page_url":"https://doi.org/10.2307/3579411","pdf_url":null,"source":{"id":"https://openalex.org/S152208300","display_name":"Radiation Research","issn_l":"0033-7587","issn":["0033-7587","1938-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315745","host_organization_name":"Radiation Research Society","host_organization_lineage":["https://openalex.org/P4310315745"],"host_organization_lineage_names":["Radiation Research Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Research","raw_type":"journal-article"},{"id":"pmid:9008202","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9008202","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6558661458","display_name":"Carcinogenic Interactions of Radiation and Chemicals","funder_award_id":"R01CA043322","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W45648795","https://openalex.org/W1537420881","https://openalex.org/W1675678105","https://openalex.org/W1782413320","https://openalex.org/W1964550158","https://openalex.org/W1971408707","https://openalex.org/W1976966995","https://openalex.org/W2017816297","https://openalex.org/W2037621441","https://openalex.org/W2043856334","https://openalex.org/W2050345547","https://openalex.org/W2062198345","https://openalex.org/W2067469467","https://openalex.org/W2072596846","https://openalex.org/W2114024672","https://openalex.org/W2118574139","https://openalex.org/W2335144766","https://openalex.org/W4302361206"],"related_works":["https://openalex.org/W2087741421","https://openalex.org/W7036770600","https://openalex.org/W1587592647","https://openalex.org/W2325907269","https://openalex.org/W2001359134","https://openalex.org/W2128230063","https://openalex.org/W2120570439","https://openalex.org/W2091326316","https://openalex.org/W4235840235","https://openalex.org/W2605447949"],"abstract_inverted_index":{"Genomic":[0],"instability":[1,198],"has":[2],"been":[3],"proposed":[4],"to":[5,22,40,71],"be":[6],"the":[7,63,115,126,130,140,146,152,158,175,193,200],"earliest":[8],"step":[9],"in":[10,114,157,181,199],"radiation-induced":[11,31,41,79,197],"tumorigenesis.":[12,203],"It":[13],"follows":[14],"from":[15,56,87,107],"this":[16,49],"hypothesis":[17],"that":[18],"individuals":[19],"highly":[20],"susceptible":[21],"induction":[23],"of":[24,66,78,94,117,129,142,149,154,166,178,196,202],"tumors":[25],"by":[26],"radiation":[27],"should":[28],"exhibit":[29],"enhanced":[30],"instability.":[32,81],"BALB/c":[33,108],"white":[34],"mice":[35,109],"are":[36],"considerably":[37],"more":[38],"sensitive":[39],"mammary":[42,52,186],"cancer":[43],"than":[44],"C57BL/6":[45,143],"black":[46],"mice.":[47],"In":[48],"study,":[50],"primary":[51],"epithelial":[53],"cell":[54],"cultures":[55,86],"these":[57],"two":[58],"strains":[59,89],"were":[60],"examined":[61],"for":[62,139,185,192],"\"delayed\"":[64],"appearance":[65],"chromosomal":[67,179],"aberrations":[68,97,156],"after":[69,102,145],"exposure":[70],"137Cs":[72],"gamma":[73],"radiation,":[74],"as":[75],"a":[76,91,111,172],"measure":[77],"genomic":[80],"As":[82],"expected,":[83],"actively":[84],"dividing":[85],"both":[88],"showed":[90],"rapid":[92,147],"decline":[93],"initial":[95,150],"asymmetrical":[96],"with":[98],"time":[99,127],"postirradiation.":[100],"However,":[101],"16":[103],"population":[104,160],"doublings,":[105],"cells":[106,141],"exhibited":[110],"marked":[112],"increase":[113],"frequency":[116,153],"chromatid-type":[118,155],"breaks":[119],"and":[120,183,188],"gaps":[121],"which":[122],"remained":[123,161],"elevated":[124],"throughout":[125],"course":[128],"experiment":[131],"(28":[132],"doublings).":[133],"No":[134],"such":[135],"effect":[136],"was":[137],"observed":[138],"mice;":[144],"clearance":[148],"aberrations,":[151],"irradiated":[159],"at":[162],"or":[163],"near":[164],"those":[165],"nonirradiated":[167],"controls.":[168],"These":[169],"results":[170],"demonstrate":[171],"correlation":[173],"between":[174],"latent":[176],"expression":[177],"damage":[180],"vitro":[182],"susceptibility":[184],"tumors,":[187],"provide":[189],"further":[190],"support":[191],"central":[194],"role":[195],"process":[201]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
