{"id":"https://openalex.org/W1968405603","doi":"https://doi.org/10.1002/cmdc.200700038","title":"Design and Synthesis of 2,3,5\u2010Substituted Imidazolidin\u20104\u2010one Inhibitors of BACE\u20101","display_name":"Design and Synthesis of 2,3,5\u2010Substituted Imidazolidin\u20104\u2010one Inhibitors of BACE\u20101","publication_year":2007,"publication_date":"2007-04-25","ids":{"openalex":"https://openalex.org/W1968405603","doi":"https://doi.org/10.1002/cmdc.200700038","mag":"1968405603","pmid":"https://pubmed.ncbi.nlm.nih.gov/17458843"},"language":"en","primary_location":{"id":"doi:10.1002/cmdc.200700038","doi":"https://doi.org/10.1002/cmdc.200700038","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.200700038","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074794226","display_name":"James C. Barrow","orcid":"https://orcid.org/0000-0001-5115-9300","observed_orcids":["https://orcid.org/0000-0001-5115-9300"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James\u2005C. Barrow","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA. james_barrow@merck.com","Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA, Fax: (+1)\u2009215-652-6345"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA. james_barrow@merck.com","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA, Fax: (+1)\u2009215-652-6345","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020633551","display_name":"Kenneth E. Rittle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth\u2005E. Rittle","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA,","Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA, Fax: (+1)\u2009215-652-6345"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA,","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA, Fax: (+1)\u2009215-652-6345","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063877379","display_name":"Phung L. Ngo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phung\u2005L. Ngo","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA,","Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA, Fax: (+1)\u2009215-652-6345"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA,","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA, Fax: (+1)\u2009215-652-6345","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033999151","display_name":"Harold G. Selnick","orcid":"https://orcid.org/0000-0002-7986-9627","observed_orcids":["https://orcid.org/0000-0002-7986-9627"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harold\u2005G. Selnick","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA,","Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA, Fax: (+1)\u2009215-652-6345"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA,","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA, Fax: (+1)\u2009215-652-6345","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039403990","display_name":"Samuel Lindsay Graham","orcid":"https://orcid.org/0000-0002-1299-1636","observed_orcids":["https://orcid.org/0000-0002-1299-1636"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel\u2005L. Graham","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA,","Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA, Fax: (+1)\u2009215-652-6345"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA,","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA, Fax: (+1)\u2009215-652-6345","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111640683","display_name":"Steven M. Pitzenberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven\u2005M. Pitzenberger","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA,","Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA, Fax: (+1)\u2009215-652-6345"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA,","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA, Fax: (+1)\u2009215-652-6345","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029909734","display_name":"Georgia B. McGaughey","orcid":"https://orcid.org/0000-0002-3586-965X","observed_orcids":["https://orcid.org/0000-0002-3586-965X"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Georgia\u2005B. McGaughey","raw_affiliation_strings":["Department of Molecular Systems, Merck Research Laboratories, West Point, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Systems, Merck Research Laboratories, West Point, PA, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025174661","display_name":"Dennis J. Colussi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis Colussi","raw_affiliation_strings":["Department of Alzheimer's Research, Merck Research Laboratories, West Point, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Alzheimer's Research, Merck Research Laboratories, West Point, PA, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103466467","display_name":"Ming\u2010Tain Lai","orcid":"https://orcid.org/0000-0002-9829-7943","observed_orcids":["https://orcid.org/0000-0002-9829-7943"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming\u2010Tain Lai","raw_affiliation_strings":["Department of Alzheimer's Research, Merck Research Laboratories, West Point, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Alzheimer's Research, Merck Research Laboratories, West Point, PA, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068229772","display_name":"Qian Huang","orcid":"https://orcid.org/0000-0002-5502-1023","observed_orcids":["https://orcid.org/0000-0002-5502-1023"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian Huang","raw_affiliation_strings":["Department of Alzheimer's Research, Merck Research Laboratories, West Point, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Alzheimer's Research, Merck Research Laboratories, West Point, PA, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070744153","display_name":"Katherine Tugusheva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Tugusheva","raw_affiliation_strings":["Department of Alzheimer's Research, Merck Research Laboratories, West Point, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Alzheimer's Research, Merck Research Laboratories, West Point, PA, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040740420","display_name":"Amy S. Espeseth","orcid":"https://orcid.org/0000-0003-2213-909X","observed_orcids":["https://orcid.org/0000-0003-2213-909X"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy\u2005S. Espeseth","raw_affiliation_strings":["Department of Alzheimer's Research, Merck Research Laboratories, West Point, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Alzheimer's Research, Merck Research Laboratories, West Point, PA, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103413243","display_name":"Adam J. Simon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam\u2005J. Simon","raw_affiliation_strings":["Department of Alzheimer's Research, Merck Research Laboratories, West Point, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Alzheimer's Research, Merck Research Laboratories, West Point, PA, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103477226","display_name":"Sanjeev\u2005K. Munshi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanjeev\u2005K. Munshi","raw_affiliation_strings":["Department of Structural Biology, Merck Research Laboratories, West Point, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Structural Biology, Merck Research Laboratories, West Point, PA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112471086","display_name":"Joseph P. Vacca","orcid":"https://orcid.org/0000-0003-0794-1527","observed_orcids":["https://orcid.org/0000-0003-0794-1527"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph\u2005P. Vacca","raw_affiliation_strings":["Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA,","Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA, Fax: (+1)\u2009215-652-6345"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA,","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Merck Research Laboratories, P.O Box 4, WP14-1, West Point, PA 19486, USA, Fax: (+1)\u2009215-652-6345","institution_ids":["https://openalex.org/I1285764155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5074794226"],"corresponding_institution_ids":["https://openalex.org/I1285764155"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":3.3388,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.90987527,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2","issue":"7","first_page":"995","last_page":"999"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5723000168800354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5723000168800354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.41429999470710754,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bace1-inhibitors","display_name":"BACE1 inhibitors","score":0.890999972820282},{"id":"https://openalex.org/keywords/imidazolidin-4-ones","display_name":"imidazolidin-4-ones","score":0.8989999890327454},{"id":"https://openalex.org/keywords/aspartyl-protease-inhibitors","display_name":"aspartyl protease inhibitors","score":0.796999990940094},{"id":"https://openalex.org/keywords/structure-based-drug-design","display_name":"structure-based drug design","score":0.8980000019073486},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7188388109207153},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.5995171666145325},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5289181470870972},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5263327956199646},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4985177516937256},{"id":"https://openalex.org/C131779359","wikidata":"https://www.wikidata.org/wiki/Q471875","display_name":"Amine gas treating","level":2,"score":0.49445438385009766},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4790724217891693},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47470560669898987},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.46288368105888367},{"id":"https://openalex.org/C2781143361","wikidata":"https://www.wikidata.org/wiki/Q55761529","display_name":"Protease inhibitor (pharmacology)","level":5,"score":0.43414053320884705},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.41906487941741943},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3500261902809143},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.23811861872673035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18082758784294128},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.14565518498420715},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.0},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.0},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048289","descriptor_name":"Imidazolidines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D048289","descriptor_name":"Imidazolidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D048289","descriptor_name":"Imidazolidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cmdc.200700038","doi":"https://doi.org/10.1002/cmdc.200700038","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.200700038","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},{"id":"pmid:17458843","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17458843","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6499999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1964408458","https://openalex.org/W1984832858","https://openalex.org/W1989607398","https://openalex.org/W1993859868","https://openalex.org/W2009979602","https://openalex.org/W2016628338","https://openalex.org/W2035406947","https://openalex.org/W2039069312","https://openalex.org/W2047149363","https://openalex.org/W2047186114","https://openalex.org/W2071982010","https://openalex.org/W2080274663","https://openalex.org/W2096801261","https://openalex.org/W2124161058","https://openalex.org/W2129233012","https://openalex.org/W2149522871","https://openalex.org/W2159340348","https://openalex.org/W2166230233","https://openalex.org/W2912432751","https://openalex.org/W2949716762","https://openalex.org/W2952022690","https://openalex.org/W2953011238","https://openalex.org/W4234060991"],"related_works":["https://openalex.org/W2019828545","https://openalex.org/W2323742727","https://openalex.org/W2096883126","https://openalex.org/W2640779316","https://openalex.org/W2095461786","https://openalex.org/W2060190169","https://openalex.org/W2058651322","https://openalex.org/W2128896408","https://openalex.org/W1976003675","https://openalex.org/W2910695252"],"abstract_inverted_index":{"Structure-based":[0],"drug":[1,30],"design":[2],"was":[3],"used":[4],"to":[5,41],"incorporate":[6],"the":[7,42],"traditional":[8],"hydroxyethyl":[9],"amine":[10],"aspartyl":[11],"protease":[12],"inhibitor":[13],"motif":[14],"into":[15],"2,3,5-substituted":[16],"imidazolidin-4-one":[17],"structures":[18],"with":[19],"good":[20],"BACE-1":[21],"enzyme":[22],"inhibitory":[23],"potency.":[24],"These":[25],"compounds":[26],"represent":[27],"a":[28],"promising":[29],"target":[31],"for":[32],"Alzheimer\u2032s":[33],"disease-modifying":[34],"therapy":[35],"and":[36],"are":[37],"therefore":[38],"of":[39],"interest":[40],"medicinal":[43],"chemistry":[44],"community.":[45]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}