{"id":"https://openalex.org/W1968373432","doi":"https://doi.org/10.1074/jbc.m006795200","title":"Analysis of the Binding of p53 to DNAs Containing Mismatched and Bulged Bases","display_name":"Analysis of the Binding of p53 to DNAs Containing Mismatched and Bulged Bases","publication_year":2001,"publication_date":"2001-03-01","ids":{"openalex":"https://openalex.org/W1968373432","doi":"https://doi.org/10.1074/jbc.m006795200","mag":"1968373432","pmid":"https://pubmed.ncbi.nlm.nih.gov/11124254"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m006795200","doi":"https://doi.org/10.1074/jbc.m006795200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m006795200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m006795200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077710427","display_name":"Natalya P. Degtyareva","orcid":"https://orcid.org/0000-0002-7141-6308","observed_orcids":["https://orcid.org/0000-0002-7141-6308"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalya Degtyareva","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center and the Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7295, USA","From the Lineberger Comprehensive Cancer Center and the Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7295"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center and the Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7295, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]},{"raw_affiliation_string":"From the Lineberger Comprehensive Cancer Center and the Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7295","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058282369","display_name":"Deepa Subramanian","orcid":"https://orcid.org/0000-0001-5446-9750","observed_orcids":["https://orcid.org/0000-0001-5446-9750"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepa Subramanian","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center and the Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7295","From the Lineberger Comprehensive Cancer Center and the Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7295"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center and the Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7295","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]},{"raw_affiliation_string":"From the Lineberger Comprehensive Cancer Center and the Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7295","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061660001","display_name":"Jack D. Griffith","orcid":"https://orcid.org/0000-0002-8357-8689","observed_orcids":["https://orcid.org/0000-0002-8357-8689"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jack D. Griffith","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center and the Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7295","From the Lineberger Comprehensive Cancer Center and the Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7295"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center and the Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7295","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]},{"raw_affiliation_string":"From the Lineberger Comprehensive Cancer Center and the Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7295","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061660001"],"corresponding_institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.0947,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.8638075,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"276","issue":"12","first_page":"8778","last_page":"8784"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.4113999903202057,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.031599998474121094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dna-mismatch","display_name":"DNA mismatch","score":0.5299999713897705},{"id":"https://openalex.org/keywords/dna-damage-recognition","display_name":"DNA damage recognition","score":0.49799999594688416},{"id":"https://openalex.org/keywords/protein-dna-binding-affinity","display_name":"protein-DNA binding affinity","score":0.7509999871253967},{"id":"https://openalex.org/keywords/dna-mismatch-repair","display_name":"DNA mismatch repair","score":0.7360000014305115},{"id":"https://openalex.org/keywords/single-base-mismatch","display_name":"single-base mismatch","score":0.6899999976158142},{"id":"https://openalex.org/keywords/tumor-suppressor-proteins","display_name":"tumor suppressor proteins","score":0.6129999756813049},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3769993782043457}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020137","descriptor_name":"Base Pair Mismatch","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051718","descriptor_name":"MutS Homolog 2 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m006795200","doi":"https://doi.org/10.1074/jbc.m006795200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m006795200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11124254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11124254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m006795200","doi":"https://doi.org/10.1074/jbc.m006795200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m006795200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2774293502","display_name":null,"funder_award_id":"GM-31819","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3518478496","display_name":"DNA-Protein Interactions at the Replication Fork","funder_award_id":"R01GM031819","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3654874316","display_name":null,"funder_award_id":"CA70343","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7674067404","display_name":"PRIMARY DNA LESIONS AS SIGNALS FOR P53","funder_award_id":"5r01ca070343-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W165254100","https://openalex.org/W189821932","https://openalex.org/W1556127367","https://openalex.org/W1574139365","https://openalex.org/W1847864430","https://openalex.org/W1849359401","https://openalex.org/W1912742005","https://openalex.org/W1971966311","https://openalex.org/W1980655006","https://openalex.org/W1985999867","https://openalex.org/W1991494214","https://openalex.org/W1994552302","https://openalex.org/W2005065014","https://openalex.org/W2015853472","https://openalex.org/W2016286342","https://openalex.org/W2016544300","https://openalex.org/W2021491682","https://openalex.org/W2033985470","https://openalex.org/W2037670899","https://openalex.org/W2040159897","https://openalex.org/W2054528125","https://openalex.org/W2055993339","https://openalex.org/W2060810889","https://openalex.org/W2062269069","https://openalex.org/W2064795157","https://openalex.org/W2068637634","https://openalex.org/W2068884609","https://openalex.org/W2075158287","https://openalex.org/W2077706229","https://openalex.org/W2081446097","https://openalex.org/W2086321629","https://openalex.org/W2087404852","https://openalex.org/W2090547063","https://openalex.org/W2092722802","https://openalex.org/W2095732342","https://openalex.org/W2095899775","https://openalex.org/W2096079439","https://openalex.org/W2113314034","https://openalex.org/W2137452601","https://openalex.org/W2143778153","https://openalex.org/W2150710841","https://openalex.org/W2152863070","https://openalex.org/W2155740016","https://openalex.org/W2156299289","https://openalex.org/W2170472485","https://openalex.org/W2321602063","https://openalex.org/W2418492732","https://openalex.org/W2471178790"],"related_works":["https://openalex.org/W2046732438","https://openalex.org/W2064795157","https://openalex.org/W2029504073","https://openalex.org/W1999060423","https://openalex.org/W116885976","https://openalex.org/W1995856480","https://openalex.org/W2315471685","https://openalex.org/W2055633579","https://openalex.org/W6958349099","https://openalex.org/W1983704426"],"abstract_inverted_index":{"The":[0,99],"tumor":[1],"suppressor":[2],"protein":[3],"p53":[4,57,105],"modulates":[5],"cellular":[6],"response":[7],"to":[8,66],"DNA":[9,26],"damage":[10],"by":[11,92,97,113],"a":[12,43,59,109],"variety":[13],"of":[14,21,24,56,61,71,102,104],"mechanisms":[15],"that":[16,53,70],"may":[17],"include":[18],"direct":[19],"recognition":[20],"some":[22],"forms":[23],"primary":[25],"damage.":[27],"Linear":[28],"49-base":[29],"pair":[30],"duplex":[31],"DNAs":[32],"were":[33,94],"constructed":[34],"containing":[35],"all":[36,125],"possible":[37],"single-base":[38],"mismatches":[39,85],"as":[40,42],"well":[41],"3-cytosine":[44,110],"bulge.":[45],"Filter":[46],"binding":[47,81],"and":[48,115,120,123],"gel":[49],"retardation":[50],"assays":[51],"revealed":[52],"the":[54,72,79,126],"affinity":[55,103],"for":[58,108],"number":[60],"these":[62],"lesions":[63],"was":[64,106],"equal":[65],"or":[67],"greater":[68],"than":[69],"human":[73],"mismatch":[74],"repair":[75],"complex,":[76],"hMSH2-hMSH6,":[77,93],"under":[78],"same":[80],"conditions.":[82],"However,":[83],"other":[84,127],"including":[86],"G/T,":[87],"which":[88],"is":[89],"bound":[90],"strongly":[91],"poorly":[95],"recognized":[96],"p53.":[98],"general":[100],"order":[101],"greatest":[107],"bulge":[111],"followed":[112],"A/G":[114],"C/C":[116],"mismatches,":[117,122],"then":[118],"C/T":[119],"G/T":[121],"finally":[124],"mismatches.":[128]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}