{"id":"https://openalex.org/W1968368552","doi":"https://doi.org/10.1021/ac1032353","title":"Detection of a Foreign Protein in Milk Using Surface-Enhanced Raman Spectroscopy Coupled with Antibody-Modified Silver Dendrites","display_name":"Detection of a Foreign Protein in Milk Using Surface-Enhanced Raman Spectroscopy Coupled with Antibody-Modified Silver Dendrites","publication_year":2011,"publication_date":"2011-02-09","ids":{"openalex":"https://openalex.org/W1968368552","doi":"https://doi.org/10.1021/ac1032353","mag":"1968368552","pmid":"https://pubmed.ncbi.nlm.nih.gov/21306123"},"language":"en","primary_location":{"id":"doi:10.1021/ac1032353","doi":"https://doi.org/10.1021/ac1032353","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac1032353","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065536725","display_name":"Lili He","orcid":"https://orcid.org/0000-0002-5046-9857","observed_orcids":["https://orcid.org/0000-0002-5046-9857"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lili He","raw_affiliation_strings":["Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Avenue, St. Paul, Minnesota 55108, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Avenue, St. Paul, Minnesota 55108, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016203825","display_name":"Tom Rodda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tom Rodda","raw_affiliation_strings":["Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Avenue, St. Paul, Minnesota 55108, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Avenue, St. Paul, Minnesota 55108, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051055962","display_name":"Christy L. Haynes","orcid":"https://orcid.org/0000-0002-5420-5867","observed_orcids":["https://orcid.org/0000-0002-5420-5867"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christy L. Haynes","raw_affiliation_strings":["Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006320687","display_name":"Timothy O. Deschaines","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142480","display_name":"Thermo Fisher Scientific (United States)","ror":"https://ror.org/03x1ewr52","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142480"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Deschaines","raw_affiliation_strings":["Raman Spectroscopy Group, Thermo Fisher Scientific, 5225 Verona Road, Building 4, Madison, Wisconsin 53711, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Raman Spectroscopy Group, Thermo Fisher Scientific, 5225 Verona Road, Building 4, Madison, Wisconsin 53711, United States","institution_ids":["https://openalex.org/I4210142480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082926461","display_name":"Todd Strother","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142480","display_name":"Thermo Fisher Scientific (United States)","ror":"https://ror.org/03x1ewr52","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142480"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Strother","raw_affiliation_strings":["Raman Spectroscopy Group, Thermo Fisher Scientific, 5225 Verona Road, Building 4, Madison, Wisconsin 53711, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Raman Spectroscopy Group, Thermo Fisher Scientific, 5225 Verona Road, Building 4, Madison, Wisconsin 53711, United States","institution_ids":["https://openalex.org/I4210142480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037548522","display_name":"Francisco Diez\u2010Gonzalez","orcid":"https://orcid.org/0000-0002-8644-1397","observed_orcids":["https://orcid.org/0000-0002-8644-1397"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francisco Diez-Gonzalez","raw_affiliation_strings":["Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Avenue, St. Paul, Minnesota 55108, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Avenue, St. Paul, Minnesota 55108, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049440368","display_name":"Theodore P. Labuza","orcid":"https://orcid.org/0000-0002-3892-997X","observed_orcids":["https://orcid.org/0000-0002-3892-997X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Theodore P. Labuza","raw_affiliation_strings":["Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Avenue, St. Paul, Minnesota 55108, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Avenue, St. Paul, Minnesota 55108, United States","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049440368"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":5.1007,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.96175637,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"83","issue":"5","first_page":"1510","last_page":"1513"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/milk-adulteration","display_name":"milk adulteration","score":0.8500000238418579},{"id":"https://openalex.org/keywords/surface-enhanced-raman-spectroscopy","display_name":"surface-enhanced Raman spectroscopy","score":0.9409999847412109},{"id":"https://openalex.org/keywords/silver-dendrites","display_name":"silver dendrites","score":0.9010000228881836},{"id":"https://openalex.org/keywords/bioterrorism-detection","display_name":"bioterrorism detection","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9261245727539062},{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.850797712802887},{"id":"https://openalex.org/C40003534","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman spectroscopy","level":2,"score":0.8326644897460938},{"id":"https://openalex.org/C2777790068","wikidata":"https://www.wikidata.org/wiki/Q2736291","display_name":"Surface-enhanced Raman spectroscopy","level":4,"score":0.6560884714126587},{"id":"https://openalex.org/C96616956","wikidata":"https://www.wikidata.org/wiki/Q285100","display_name":"Phosphate buffered saline","level":2,"score":0.551170825958252},{"id":"https://openalex.org/C2778484053","wikidata":"https://www.wikidata.org/wiki/Q796758","display_name":"Egg white","level":2,"score":0.5483570098876953},{"id":"https://openalex.org/C31499863","wikidata":"https://www.wikidata.org/wiki/Q905762","display_name":"Silver nanoparticle","level":3,"score":0.47542527318000793},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.42909878492355347},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4214904308319092},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.19918975234031677},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.1968420445919037},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15416398644447327},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.1373252272605896},{"id":"https://openalex.org/C169573571","wikidata":"https://www.wikidata.org/wiki/Q466824","display_name":"Raman scattering","level":3,"score":0.07468521595001221},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.060283511877059937},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008892","descriptor_name":"Milk","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012834","descriptor_name":"Silver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013059","descriptor_name":"Spectrum Analysis, Raman","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ac1032353","doi":"https://doi.org/10.1021/ac1032353","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac1032353","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:21306123","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21306123","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Letter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1546843241","https://openalex.org/W1967212062","https://openalex.org/W1974544543","https://openalex.org/W1996106015","https://openalex.org/W2001372079","https://openalex.org/W2007558063","https://openalex.org/W2009746313","https://openalex.org/W2013869469","https://openalex.org/W2017880027","https://openalex.org/W2022492778","https://openalex.org/W2036939524","https://openalex.org/W2078982177","https://openalex.org/W2086597332","https://openalex.org/W2091273808","https://openalex.org/W2112824422","https://openalex.org/W2130758886","https://openalex.org/W2135003971","https://openalex.org/W2148428997","https://openalex.org/W2168524561"],"related_works":["https://openalex.org/W2108759176","https://openalex.org/W1562902293","https://openalex.org/W2110881928","https://openalex.org/W2567400350","https://openalex.org/W2361245202","https://openalex.org/W3174600236","https://openalex.org/W2038364440","https://openalex.org/W1511312940","https://openalex.org/W2086004633","https://openalex.org/W1942035568"],"abstract_inverted_index":{"Herein":[0],"we":[1],"developed":[2],"a":[3],"rapid":[4],"and":[5,44,73,102],"simple":[6],"method":[7,59,88],"which":[8],"used":[9],"surface-enhanced":[10],"Raman":[11,53],"spectroscopy":[12],"(SERS)":[13],"coupled":[14],"with":[15],"antibody-modified":[16,41],"silver":[17,42,50],"dendrites":[18,43,51],"to":[19],"detect":[20],"ovalbumin":[21],"(OVA),":[22],"the":[23,49,83,90],"egg":[24],"white":[25],"protein,":[26],"introduced":[27],"into":[28],"whole":[29],"milk.":[30],"OVA":[31,64],"was":[32],"first":[33],"captured":[34],"out":[35],"of":[36,40,62],"milk":[37,77],"by":[38,52],"use":[39,94],"then":[45],"directly":[46],"measured":[47],"on":[48,82],"spectroscopy.":[54],"Results":[55],"show":[56],"that":[57],"this":[58],"is":[60],"capable":[61],"detecting":[63],"at":[65],"0.1":[66],"\u03bcg/mL":[67,75],"in":[68,76,95,106],"phosphate":[69],"buffered":[70],"saline":[71],"(PBS)":[72],"5":[74],"within":[78],"30":[79],"min":[80],"based":[81],"principal":[84],"component":[85],"analysis.":[86],"This":[87],"has":[89],"potential":[91],"for":[92],"wide":[93],"areas":[96],"such":[97],"as":[98],"allergenic":[99],"protein":[100],"detection":[101,105],"bioterrorism":[103],"agent":[104],"complex":[107],"matrixes.":[108]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}