{"id":"https://openalex.org/W1968336299","doi":"https://doi.org/10.1097/01.tp.0000188172.26531.6f","title":"Recipient-Specific Tolerance after HLA-Mismatched Umbilical Cord Blood Stem Cell Transplantation","display_name":"Recipient-Specific Tolerance after HLA-Mismatched Umbilical Cord Blood Stem Cell Transplantation","publication_year":2005,"publication_date":"2005-11-01","ids":{"openalex":"https://openalex.org/W1968336299","doi":"https://doi.org/10.1097/01.tp.0000188172.26531.6f","mag":"1968336299","pmid":"https://pubmed.ncbi.nlm.nih.gov/16314801"},"language":"en","primary_location":{"id":"doi:10.1097/01.tp.0000188172.26531.6f","doi":"https://doi.org/10.1097/01.tp.0000188172.26531.6f","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000188172.26531.6f","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043462716","display_name":"Thomas O. Kleen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas O. Kleen","raw_affiliation_strings":["Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106-7284, USA","Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106-7284, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089873983","display_name":"Suzanne Kadereit","orcid":"https://orcid.org/0000-0003-3507-1506","observed_orcids":["https://orcid.org/0000-0003-3507-1506"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne Kadereit","raw_affiliation_strings":["005","Department of Medicine, School of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"005","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, School of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105421632","display_name":"Laura R. Fanning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura R. Fanning","raw_affiliation_strings":["005","Department of Medicine, School of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"005","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, School of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083330958","display_name":"Jennifer Jaroscak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Jaroscak","raw_affiliation_strings":["Department of Pediatrics, School of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, School of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059061070","display_name":"Pingfu Fu","orcid":"https://orcid.org/0000-0002-2334-5218","observed_orcids":["https://orcid.org/0000-0002-2334-5218"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pingfu Fu","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013116738","display_name":"Howard J. Meyerson","orcid":"https://orcid.org/0000-0001-5084-6643","observed_orcids":["https://orcid.org/0000-0001-5084-6643"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard J. Meyerson","raw_affiliation_strings":["Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022202395","display_name":"Lara K. Kulchycki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lara Kulchycki","raw_affiliation_strings":["005","Department of Medicine, School of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"005","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, School of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011643619","display_name":"Laura F. Slivka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura F. Slivka","raw_affiliation_strings":["005","Department of Medicine, School of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"005","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, School of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108617645","display_name":"Margaret M. Kozik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret Kozik","raw_affiliation_strings":["005","Department of Medicine, School of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"005","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, School of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064125084","display_name":"Magdalena Tary\u2010Lehmann","orcid":"https://orcid.org/0000-0002-0709-1609","observed_orcids":["https://orcid.org/0000-0002-0709-1609"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Magdalena Tary-Lehmann","raw_affiliation_strings":["Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113618728","display_name":"Mary J. Laughlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mary J. Laughlin","raw_affiliation_strings":["005","Department of Medicine, School of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH","Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH","Mary J. Laughlin, M.D., Case Western Reserve University, 10900 Euclid Ave., WRB2-129, Cleveland, OH 44106-7284"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"005","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, School of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Mary J. Laughlin, M.D., Case Western Reserve University, 10900 Euclid Ave., WRB2-129, Cleveland, OH 44106-7284","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113618728"],"corresponding_institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":1.969,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.85567503,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"80","issue":"9","first_page":"1316","last_page":"1322"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cord-blood-transplantation","display_name":"cord blood transplantation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hla-mismatch","display_name":"HLA mismatch","score":0.9430000185966492},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.9419999718666077},{"id":"https://openalex.org/keywords/acute-graft-versus-host-disease","display_name":"acute graft-versus-host disease","score":0.5730000138282776},{"id":"https://openalex.org/keywords/th2-cytokine-response","display_name":"Th2 cytokine response","score":0.6779999732971191},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.8939999938011169},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7834892868995667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6298566460609436},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6211576461791992},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.5969036221504211},{"id":"https://openalex.org/C2908824208","wikidata":"https://www.wikidata.org/wiki/Q914952","display_name":"Umbilical Cord Blood Transplantation","level":4,"score":0.5913153886795044},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5674595832824707},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5661450028419495},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.5357308387756348},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5056085586547852},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.49915575981140137},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.4656534790992737},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.4417414367198944},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.43325212597846985},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24102851748466492},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12593302130699158},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001782","descriptor_name":"Blood Donors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001787","descriptor_name":"Blood Group Incompatibility","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007959","descriptor_name":"Lymphocyte Culture Test, Mixed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023001","descriptor_name":"Transplantation Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/01.tp.0000188172.26531.6f","doi":"https://doi.org/10.1097/01.tp.0000188172.26531.6f","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000188172.26531.6f","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:16314801","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16314801","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"},{"id":"pmh:oai:kops.uni-konstanz.de:123456789/7541","doi":null,"is_oa":false,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-123277","pdf_url":null,"source":{"id":"https://openalex.org/S4306401487","display_name":"KOPS (University of Konstanz)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189712700","host_organization_name":"University of Konstanz","host_organization_lineage":["https://openalex.org/I189712700"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Transplantation. 2005, 80(9), S. 1316-1322. ISSN 0041-1337. Verf\u00fcgbar unter: doi: 10.1097/01.tp.0000188172.26531.6f","raw_type":"doc-type:article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7599999904632568}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1754199630","display_name":null,"funder_award_id":"R01-AI47289-01","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2132388686","display_name":null,"funder_award_id":"R01AI47756","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4377351199","display_name":"MECHANISMS UNDERLYING GRAFT-VERSUS-HOST DISEASE","funder_award_id":"R01AI047289","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G766838549","display_name":"SINGLE CELL ANALYSIS OF T CELL IMMUNITY IN HIV","funder_award_id":"R01AI047756","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1485136427","https://openalex.org/W1532778742","https://openalex.org/W1953216172","https://openalex.org/W1965613868","https://openalex.org/W1970529772","https://openalex.org/W1981368156","https://openalex.org/W1993003726","https://openalex.org/W1994657650","https://openalex.org/W1996699644","https://openalex.org/W2000933354","https://openalex.org/W2002855771","https://openalex.org/W2005367603","https://openalex.org/W2020377341","https://openalex.org/W2023341231","https://openalex.org/W2027729283","https://openalex.org/W2031693919","https://openalex.org/W2074507269","https://openalex.org/W2080878594","https://openalex.org/W2081217322","https://openalex.org/W2084147684","https://openalex.org/W2085516849","https://openalex.org/W2092180372","https://openalex.org/W2098795862","https://openalex.org/W2114840643","https://openalex.org/W2127340198","https://openalex.org/W2127677637","https://openalex.org/W2135067231","https://openalex.org/W2147323639","https://openalex.org/W2147416997","https://openalex.org/W2157325100","https://openalex.org/W2164761946","https://openalex.org/W2167125750","https://openalex.org/W2172088850","https://openalex.org/W2304521922","https://openalex.org/W2317259161","https://openalex.org/W2330713242","https://openalex.org/W2333162405","https://openalex.org/W2411385814","https://openalex.org/W4313422306"],"related_works":["https://openalex.org/W2071397002","https://openalex.org/W2005637193","https://openalex.org/W2159787475","https://openalex.org/W1974046751","https://openalex.org/W2065162083","https://openalex.org/W7218270220","https://openalex.org/W2332363829","https://openalex.org/W2073831759","https://openalex.org/W2138883485","https://openalex.org/W2141433705"],"abstract_inverted_index":{"BACKGROUND:":[0],"Lower":[1],"incidence":[2],"and":[3,108,178],"severity":[4],"of":[5,29,61,106,138,153,156,163,193],"acute":[6],"graft":[7,159,174],"versus":[8],"host":[9],"disease":[10],"(GVHD)":[11],"has":[12],"been":[13],"observed":[14,179,187],"in":[15,31,91,197],"leukemia":[16],"patients":[17],"receiving":[18],"HLA-mismatched":[19],"umbilical":[20],"cord":[21],"(UCB)":[22],"transplants.":[23],"However,":[24],"despite":[25,191],"the":[26,35,57,92,186,198],"increased":[27],"use":[28],"UCB":[30,62,81,158,173],"stem":[32],"cell":[33],"transplantation,":[34],"mechanisms":[36],"underlying":[37],"these":[38],"favorable":[39,188],"outcomes":[40],"are":[41],"not":[42,131],"well":[43],"delineated.":[44],"METHODS:":[45],"We":[46],"analyzed":[47],"antigen":[48],"specific":[49],"lymphocyte":[50,68,175],"responses":[51],"after":[52,80,96],"transplant":[53,82,164],"to":[54,66,145,185],"determine":[55],"whether":[56],"decreased":[58],"allogeneic":[59,200],"responsiveness":[60],"lymphocytes":[63,75,102,127,160],"is":[64],"attributable":[65],"pan-unresponsiveness,":[67],"repressive":[69],"or":[70,115],"recipient-specific":[71,165],"tolerance.":[72],"RESULTS:":[73],"Circulating":[74],"collected":[76],"early":[77,151,180],"(3":[78],"months)":[79],"demonstrate":[83],"a":[84,142],"less":[85],"na\u00efve":[86,157],"phenotype":[87],"compared":[88],"with":[89,113,123,161],"that":[90],"infused":[93],"graft.":[94],"Additionally,":[95],"transplant,":[97],"circulating":[98,126],"peripheral":[99],"blood":[100],"UCB-derived":[101],"produced":[103],"normal":[104],"levels":[105],"interferon-gamma":[107],"proliferated":[109],"normally":[110],"when":[111,121],"stimulated":[112,122],"mitogen":[114],"third":[116],"party":[117],"alloantigen.":[118],"In":[119],"contrast,":[120],"recipient":[124,146],"antigen,":[125],"emerging":[128],"posttransplant":[129],"did":[130],"proliferate":[132],"nor":[133],"produce":[134],"interferon-gamma.":[135],"Moreover,":[136],"analysis":[137],"interleukin-4":[139],"production":[140],"revealed":[141],"Th2":[143,169],"response":[144,167],"antigens.":[147],"These":[148],"data":[149],"indicate":[150],"induction":[152,182],"immune":[154,166,176],"tolerance":[155,181],"skewing":[162],"towards":[168],"cytokine":[170],"profile.":[171],"CONCLUSIONS:":[172],"naivety":[177],"may":[183],"contribute":[184],"GVHD":[189],"incidence,":[190],"infusion":[192],"HLA":[194],"mismatch":[195],"grafts":[196],"unrelated":[199],"setting.":[201]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}