{"id":"https://openalex.org/W1968331107","doi":"https://doi.org/10.1158/0008-5472.can-14-1246","title":"PLK1 Phosphorylates PAX3-FOXO1, the Inhibition of Which Triggers Regression of Alveolar Rhabdomyosarcoma","display_name":"PLK1 Phosphorylates PAX3-FOXO1, the Inhibition of Which Triggers Regression of Alveolar Rhabdomyosarcoma","publication_year":2014,"publication_date":"2014-11-15","ids":{"openalex":"https://openalex.org/W1968331107","doi":"https://doi.org/10.1158/0008-5472.can-14-1246","mag":"1968331107","pmid":"https://pubmed.ncbi.nlm.nih.gov/25398439"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-14-1246","doi":"https://doi.org/10.1158/0008-5472.can-14-1246","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-14-1246","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.zora.uzh.ch/id/eprint/101251/7/PLK1_rev2_merged.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064105123","display_name":"Verena Thalhammer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128593","display_name":"University Children's Hospital Zurich","ror":"https://ror.org/035vb3h42","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210128593"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Verena Thalhammer","raw_affiliation_strings":["1Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210128593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010050202","display_name":"Laura A. Lopez-Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128593","display_name":"University Children's Hospital Zurich","ror":"https://ror.org/035vb3h42","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210128593"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Laura A. Lopez-Garcia","raw_affiliation_strings":["1Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210128593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054566975","display_name":"David Herrero\u2010Mart\u00edn","orcid":"https://orcid.org/0000-0001-6548-6812","observed_orcids":["https://orcid.org/0000-0001-6548-6812"]},"institutions":[{"id":"https://openalex.org/I4210128593","display_name":"University Children's Hospital Zurich","ror":"https://ror.org/035vb3h42","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210128593"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"David Herrero-Martin","raw_affiliation_strings":["1Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210128593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029508427","display_name":"Regina Hecker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128593","display_name":"University Children's Hospital Zurich","ror":"https://ror.org/035vb3h42","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210128593"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Regina Hecker","raw_affiliation_strings":["1Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210128593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076912977","display_name":"Dominik Laubscher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128593","display_name":"University Children's Hospital Zurich","ror":"https://ror.org/035vb3h42","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210128593"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Dominik Laubscher","raw_affiliation_strings":["1Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210128593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074325335","display_name":"Maria E. Gierisch","orcid":"https://orcid.org/0000-0002-8053-4402","observed_orcids":["https://orcid.org/0000-0002-8053-4402"]},"institutions":[{"id":"https://openalex.org/I4210128593","display_name":"University Children's Hospital Zurich","ror":"https://ror.org/035vb3h42","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210128593"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Maria E. Gierisch","raw_affiliation_strings":["1Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210128593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056887464","display_name":"Marco Wachtel","orcid":"https://orcid.org/0000-0002-6077-3692","observed_orcids":["https://orcid.org/0000-0002-6077-3692"]},"institutions":[{"id":"https://openalex.org/I4210128593","display_name":"University Children's Hospital Zurich","ror":"https://ror.org/035vb3h42","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210128593"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marco Wachtel","raw_affiliation_strings":["1Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210128593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075958485","display_name":"Peter K. Bode","orcid":"https://orcid.org/0000-0002-9633-4042","observed_orcids":["https://orcid.org/0000-0002-9633-4042"]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Peter Bode","raw_affiliation_strings":["2Department of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047903403","display_name":"Paolo Nanni","orcid":"https://orcid.org/0000-0001-8429-3557","observed_orcids":["https://orcid.org/0000-0001-8429-3557"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4405257037","display_name":"Functional Genomics Center Zurich","ror":"https://ror.org/04tgr1802","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405257037"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Paolo Nanni","raw_affiliation_strings":["3Functional Genomics Center Zurich, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Functional Genomics Center Zurich, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4405257037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074367227","display_name":"Bernd Blank","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113917","display_name":"Olgahospital","ror":"https://ror.org/01xet8208","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]},{"id":"https://openalex.org/I4210161485","display_name":"Klinikum Stuttgart","ror":"https://ror.org/059jfth35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210161485"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernd Blank","raw_affiliation_strings":["4Department of Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082438382","display_name":"Ewa Ko\u015bcielniak","orcid":"https://orcid.org/0000-0002-1519-7569","observed_orcids":["https://orcid.org/0000-0002-1519-7569"]},"institutions":[{"id":"https://openalex.org/I4210113917","display_name":"Olgahospital","ror":"https://ror.org/01xet8208","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]},{"id":"https://openalex.org/I4210161485","display_name":"Klinikum Stuttgart","ror":"https://ror.org/059jfth35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210161485"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ewa Koscielniak","raw_affiliation_strings":["4Department of Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Oncology/Hematology/Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043116632","display_name":"Beat W. Sch\u00e4fer","orcid":"https://orcid.org/0000-0001-5988-2915","observed_orcids":["https://orcid.org/0000-0001-5988-2915"]},"institutions":[{"id":"https://openalex.org/I4210128593","display_name":"University Children's Hospital Zurich","ror":"https://ror.org/035vb3h42","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210128593"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Beat W. Sch\u00e4fer","raw_affiliation_strings":["1Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210128593"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5043116632"],"corresponding_institution_ids":["https://openalex.org/I4210128593"],"apc_list":null,"apc_paid":null,"fwci":2.2934,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.88675941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"75","issue":"1","first_page":"98","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.049300000071525574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plk1","display_name":"PLK1","score":0.8550000190734863},{"id":"https://openalex.org/keywords/pax3-foxo1","display_name":"PAX3-FOXO1 fusion","score":0.9520000219345093},{"id":"https://openalex.org/keywords/alveolar-rhabdomyosarcoma","display_name":"alveolar rhabdomyosarcoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/kinase-phosphorylation","display_name":"kinase phosphorylation","score":0.6340000033378601},{"id":"https://openalex.org/keywords/protein-stabilization","display_name":"protein stabilization","score":0.8730000257492065},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.9240000247955322},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/plk1-inhibition","display_name":"PLK1 inhibition","score":0.7319999933242798},{"id":"https://openalex.org/keywords/bi-2536","display_name":"BI2536","score":0.9959999918937683},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.777999997138977},{"id":"https://openalex.org/keywords/pediatric-soft-tissue-sarcoma","display_name":"pediatric soft tissue sarcoma","score":0.7440000176429749},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C2776522094","wikidata":"https://www.wikidata.org/wiki/Q4737958","display_name":"Alveolar rhabdomyosarcoma","level":4,"score":0.9463545083999634},{"id":"https://openalex.org/C140149449","wikidata":"https://www.wikidata.org/wiki/Q17928793","display_name":"FOXO1","level":4,"score":0.6357002854347229},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5014724731445312},{"id":"https://openalex.org/C2780844630","wikidata":"https://www.wikidata.org/wiki/Q1898141","display_name":"Rhabdomyosarcoma","level":3,"score":0.4940688908100128},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37732017040252686},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3401221036911011},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3271319568157196},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.309221088886261},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17404457926750183},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.14803913235664368},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12123605608940125},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.06286433339118958}],"mesh":[{"descriptor_ui":"D000097869","descriptor_name":"Polo-Like Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018232","descriptor_name":"Rhabdomyosarcoma, Alveolar","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018232","descriptor_name":"Rhabdomyosarcoma, Alveolar","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018232","descriptor_name":"Rhabdomyosarcoma, Alveolar","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051761","descriptor_name":"Paired Box Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064593","descriptor_name":"Heterografts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1158/0008-5472.can-14-1246","doi":"https://doi.org/10.1158/0008-5472.can-14-1246","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-14-1246","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:25398439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25398439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:www.zora.uzh.ch:101251","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/101251/7/PLK1_rev2_merged.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/101251/7/PLK1_rev2_merged.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Thalhammer, Verena; Lopez-Garcia, Laura A; Herrero Mart\u00edn, David; Hecker, Regina; Laubscher, Dominik; Gierisch, Maria E; Wachtel, Marco; Bode, Peter; Nanni, Paolo; Blank, Bernd; Koscielniak, Ewa; Sch\u00e4fer, Beat W (2015). PLK1 phosphorylates PAX3-FOXO1 the inhibition of which triggers regression of alveolar rhabdomyosarcoma. Cancer Research, 75(1):98-110.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/80342","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/80342","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Thalhammer, V., Lopez-Garcia, L. A., Herrero Mart\u00edn, D., Hecker, R., Laubscher, D., Gierisch, M. E., Wachtel, M., Bode, P., Nanni, P., Blank, B., Koscielniak, E., & Sch\u00e4fer, B. W. (2015). PLK1 phosphorylates PAX3-FOXO1 the inhibition of which triggers regression of alveolar rhabdomyosarcoma. Cancer Research, 75, 98\u2013110. https://doi.org/10.1158/0008-5472.CAN-14-1246","raw_type":"Journal Article"},{"id":"doi:10.5167/uzh-101251","doi":"https://doi.org/10.5167/uzh-101251","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-101251","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:www.zora.uzh.ch:101251","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/101251/7/PLK1_rev2_merged.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/101251/7/PLK1_rev2_merged.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Thalhammer, Verena; Lopez-Garcia, Laura A; Herrero Mart\u00edn, David; Hecker, Regina; Laubscher, Dominik; Gierisch, Maria E; Wachtel, Marco; Bode, Peter; Nanni, Paolo; Blank, Bernd; Koscielniak, Ewa; Sch\u00e4fer, Beat W (2015). PLK1 phosphorylates PAX3-FOXO1 the inhibition of which triggers regression of alveolar rhabdomyosarcoma. Cancer Research, 75(1):98-110.","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1487327361","https://openalex.org/W1566606307","https://openalex.org/W1910933204","https://openalex.org/W1975776530","https://openalex.org/W1990736019","https://openalex.org/W1993191575","https://openalex.org/W1994925922","https://openalex.org/W1998510221","https://openalex.org/W1999025078","https://openalex.org/W2004610844","https://openalex.org/W2006061944","https://openalex.org/W2029108033","https://openalex.org/W2036837630","https://openalex.org/W2043406338","https://openalex.org/W2044433401","https://openalex.org/W2048172259","https://openalex.org/W2053738387","https://openalex.org/W2058727957","https://openalex.org/W2059381746","https://openalex.org/W2060512760","https://openalex.org/W2061622036","https://openalex.org/W2062972691","https://openalex.org/W2063951341","https://openalex.org/W2064465439","https://openalex.org/W2076819367","https://openalex.org/W2076994758","https://openalex.org/W2081261283","https://openalex.org/W2083833418","https://openalex.org/W2090675060","https://openalex.org/W2096048988","https://openalex.org/W2100555004","https://openalex.org/W2102352112","https://openalex.org/W2102563614","https://openalex.org/W2103077999","https://openalex.org/W2104398480","https://openalex.org/W2108810565","https://openalex.org/W2118464763","https://openalex.org/W2121425239","https://openalex.org/W2124636729","https://openalex.org/W2127736279","https://openalex.org/W2134694638","https://openalex.org/W2137480884","https://openalex.org/W2138077682","https://openalex.org/W2145444933","https://openalex.org/W2152324247","https://openalex.org/W2156768359","https://openalex.org/W2160417212","https://openalex.org/W2164893149","https://openalex.org/W2165014022","https://openalex.org/W2167831982","https://openalex.org/W2170840111","https://openalex.org/W2171879013","https://openalex.org/W2913844769","https://openalex.org/W6639969120"],"related_works":["https://openalex.org/W1580743813","https://openalex.org/W2317827779","https://openalex.org/W2020233730","https://openalex.org/W2104398480","https://openalex.org/W243674610","https://openalex.org/W2791564799","https://openalex.org/W2108103623","https://openalex.org/W3123306281","https://openalex.org/W2554544711","https://openalex.org/W4285086494"],"abstract_inverted_index":{"Pediatric":[0],"tumors":[1],"harbor":[2],"very":[3],"low":[4],"numbers":[5],"of":[6,69,109,123,133,151],"somatic":[7],"mutations":[8],"and":[9,72,86,105,145,168],"therefore":[10],"offer":[11,161],"few":[12],"targets":[13],"to":[14,44,95,102,160,184],"improve":[15],"therapeutic":[16],"management":[17],"with":[18,28,85],"targeted":[19],"drugs.":[20],"In":[21,46],"particular,":[22],"outcomes":[23],"remain":[24],"dismal":[25],"for":[26,58,164],"patients":[27],"metastatic":[29],"alveolar":[30],"rhabdomyosarcoma":[31],"(aRMS),":[32],"where":[33,135],"the":[34,64,90,110,136,177],"chimeric":[35,112],"transcription":[36],"factor":[37],"PAX3/7-FOXO1":[38,65],"has":[39],"been":[40],"implicated":[41],"but":[42],"problematic":[43],"target.":[45],"this":[47,51,115],"report,":[48],"we":[49,75,117],"addressed":[50],"challenge":[52],"by":[53],"developing":[54],"a":[55,120,126,129,181],"two-armed":[56],"screen":[57],"druggable":[59],"upstream":[60],"regulatory":[61],"kinases":[62],"in":[63,128],"pathway.":[66],"Screening":[67],"libraries":[68],"kinome":[70],"siRNA":[71],"small":[73],"molecules,":[74],"defined":[76],"PLK1":[77,83,99,124,137,158],"as":[78,125,180],"an":[79],"upstream-acting":[80],"regulator.":[81],"Mechanistically,":[82],"interacted":[84],"phosphorylated":[87],"PAX3-FOXO1":[88,111],"at":[89],"novel":[91],"site":[92],"S503,":[93],"leading":[94],"protein":[96],"stabilization.":[97],"Notably,":[98],"inhibition":[100],"led":[101],"elevated":[103],"ubiquitination":[104],"rapid":[106],"proteasomal":[107],"degradation":[108],"oncoprotein.":[113],"On":[114],"basis,":[116],"embarked":[118],"on":[119],"preclinical":[121,174],"validation":[122],"target":[127,183],"xenograft":[130],"mouse":[131],"model":[132],"aRMS,":[134],"inhibitor":[138],"BI":[139],"2536":[140],"reduced":[141],"PAX3-FOXO1-mediated":[142],"gene":[143],"expression":[144,159],"elicited":[146],"tumor":[147,154],"regression.":[148],"Clinically,":[149],"analysis":[150],"human":[152],"aRMS":[153],"biopsies":[155],"documented":[156],"high":[157],"prognostic":[162],"significance":[163],"both":[165],"event-free":[166],"survival":[167],"overall":[169],"survival.":[170],"Taken":[171],"together,":[172],"these":[173],"studies":[175],"validate":[176],"PLK1-PAX3-FOXO1":[178],"axis":[179],"rational":[182],"treat":[185],"aRMS.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}