{"id":"https://openalex.org/W1968330659","doi":"https://doi.org/10.1158/1538-7445.am10-2960","title":"Abstract 2960: TRIM29 is a novel biomarker for basal-like breast cancer","display_name":"Abstract 2960: TRIM29 is a novel biomarker for basal-like breast cancer","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W1968330659","doi":"https://doi.org/10.1158/1538-7445.am10-2960","mag":"1968330659"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am10-2960","doi":"https://doi.org/10.1158/1538-7445.am10-2960","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-2960","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100327034","display_name":"Jin Liu","orcid":"https://orcid.org/0000-0002-0557-026X","observed_orcids":["https://orcid.org/0000-0002-0557-026X"]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin Liu","raw_affiliation_strings":["1Huntsman Cancer Institute, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Huntsman Cancer Institute, Salt Lake City, UT","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022854192","display_name":"Philip Seth Bernard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Bernard","raw_affiliation_strings":["1Huntsman Cancer Institute, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Huntsman Cancer Institute, Salt Lake City, UT","institution_ids":["https://openalex.org/I2801159745"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801159745"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"8_Supplement","first_page":"2960","last_page":"2960"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/basal-like-breast-cancer","display_name":"basal-like breast cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.871999979019165},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7570000290870667},{"id":"https://openalex.org/keywords/sfpq","display_name":"SFPQ","score":0.9330000281333923},{"id":"https://openalex.org/keywords/fus","display_name":"FUS","score":0.7770000100135803},{"id":"https://openalex.org/keywords/taf15","display_name":"TAF15","score":0.9890000224113464},{"id":"https://openalex.org/keywords/akap13","display_name":"AKAP13","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mda-mb-468-cells","display_name":"MDA-MB-468","score":0.8500000238418579},{"id":"https://openalex.org/keywords/nuclear-localization","display_name":"nuclear localization","score":0.47200000286102295},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.5879999995231628},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.744882345199585},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.6348433494567871},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.560084879398346},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5395862460136414},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.46541905403137207},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4488829970359802},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3704233169555664},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.352912962436676},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2688518166542053},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17040523886680603},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.07179975509643555}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am10-2960","doi":"https://doi.org/10.1158/1538-7445.am10-2960","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-2960","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7799999713897705,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7044002524","https://openalex.org/W4220935105","https://openalex.org/W6982355848","https://openalex.org/W3009805634","https://openalex.org/W2259415825","https://openalex.org/W2127613358","https://openalex.org/W1974635099","https://openalex.org/W2590139302","https://openalex.org/W2071220701","https://openalex.org/W4391936852"],"abstract_inverted_index":{"Abstract":[0],"Basal-like":[1,57,130],"breast":[2,58,131,157,368],"cancer":[3,158,171,209],"is":[4,41,62],"a":[5,42,97,109,144,155,198,261,345],"subtype":[6],"of":[7,44,122,129,147,173,182,202,298,311,330,389,394],"tumors":[8,59],"associated":[9],"with":[10,176,197,237,246,254],"aggressive":[11,22],"clinical":[12],"behavior":[13],"and":[14,29,50,60,75,127,137,223,269,277,280,320,328,370],"poor":[15],"prognosis.":[16],"The":[17],"genes":[18,210],"responsible":[19],"for":[20,34,366,398],"their":[21],"phenotype":[23],"have":[24,362],"not":[25],"been":[26],"well":[27],"characterized":[28],"may":[30,106,349],"provide":[31],"an":[32,177,287],"opportunity":[33],"targeted":[35,377],"therapies.":[36,380],"Tripartite":[37],"motif-containing":[38],"29":[39],"(TRIM29)":[40],"member":[43],"the":[45,87,120,125,170,193,299,333,390,395],"TRIM":[46],"protein":[47,266,284,289,292,358],"family.":[48],"Microarray":[49],"RT-qPCR":[51],"analyses":[52],"shows":[53],"TRIM29":[54,83,105,123,166,187,194,215,247,255,315,331,348],"overexpressed":[55],"in":[56,89,94,101,114,124,148,152,169,192,211,248,291,314,332,352],"it":[61],"highly":[63],"correlated":[64],"to":[65,86,96,118,142,214,227,241,325],"other":[66],"basal":[67,90],"tumor":[68,91],"markers":[69],"such":[70],"as":[71,108,344],"CK5/6,":[72],"CK17,":[73],"EGFR,":[74,222],"FOXC1.":[76,224],"We":[77,204],"recently":[78],"observed":[79],"using":[80,323],"immunohistochemistry":[81],"that":[82,244,252,341,373],"predominantly":[84],"localizes":[85],"nucleus":[88],"epithelial":[92],"cells,":[93,154],"contrast":[95],"cytoplasmic":[98],"localization":[99],"seen":[100],"ER-positive":[102],"tumors.":[103],"Thus,":[104],"act":[107],"transcriptional":[110,262,278],"regulatory":[111],"factor":[112,258],"involved":[113,290],"carcinogenesis.":[115],"In":[116,225],"order":[117],"investigate":[119],"role":[121],"initiation":[126],"progression":[128],"cancer,":[132],"we":[133,232],"employed":[134],"chromatin":[135],"immunoprecipitation":[136],"massively":[138],"parallel":[139],"sequencing":[140],"(ChIP-seq)":[141],"create":[143],"genome-wide":[145],"profile":[146],"vivo":[149],"TRIM29-binding":[150],"sites":[151],"MDA-MB-468":[153,174,249],"human":[156],"cell":[159],"line.":[160],"ChIP-seq":[161],"analysis":[162],"revealed":[163,371],"94":[164],"putative":[165],"binding":[167,188,195,216,230,265,312],"regions":[168,196],"genome":[172],"cells":[175],"estimated":[178],"false":[179],"discovery":[180],"rate":[181],"less":[183],"than":[184],"5%.":[185],"One":[186],"motif":[189],"was":[190,303],"found":[191],"core":[199],"consensus":[200],"sequence":[201],"CTGTCTCC.":[203],"also":[205,350],"identified":[206,363],"some":[207],"known":[208],"close":[212],"proximity":[213],"sites,":[217,231],"including":[218,309],"JUND,":[219],"FBXO31,":[220],"CCND3,":[221],"addition":[226],"mapping":[228],"TRIM29-DNA":[229],"used":[233],"co-immunoprecipitation":[234],"(co-IP)":[235],"coupled":[236],"tandem":[238],"mass":[239],"spectrometry":[240],"identify":[242],"proteins":[243,327],"interact":[245],"cells.":[250],"Proteins":[251],"co-precipitated":[253],"included":[256],"splicing":[257],"proline/glutamine-rich":[259],"(SFPQ,":[260],"co-repressor),":[263],"poly(A)":[264],"(PABPC4);":[267],"FUS":[268],"TAF15":[270],"RNA":[271],"polymerase":[272],"II":[273],"(both":[274],"are":[275],"proto-oncoproteins":[276],"activators),":[279],"A":[281,294],"kinase":[282,293],"anchor":[283],"13":[285],"(AKAP13,":[286],"adaptor":[288],"signaling":[295],"pathway).":[296],"Confirmation":[297],"initial":[300],"co-IP":[301,322],"results":[302,336],"achieved":[304],"through":[305],"several":[306],"independent":[307],"techniques,":[308],"detection":[310,329],"partners":[313],"precipitates":[316],"by":[317,356,378],"Western":[318],"blot":[319],"reciprocal":[321],"antibodies":[324],"partner":[326],"precipitates.":[334],"Overall,":[335],"from":[337],"our":[338],"studies":[339,361],"indicated":[340],"besides":[342],"functioning":[343],"transcription":[346],"factor,":[347],"participate":[351],"signal":[353],"transduction":[354],"pathways":[355],"forming":[357],"complexes.":[359],"Our":[360],"new":[364],"biomarkers":[365],"basal-like":[367],"cancers":[369],"kinases":[372],"could":[374],"potentially":[375],"be":[376],"biologic":[379],"Citation":[381],"Format:":[382],"{Authors}.":[383],"{Abstract":[384],"title}":[385],"[abstract].":[386],"In:":[387],"Proceedings":[388],"101st":[391],"Annual":[392],"Meeting":[393],"American":[396],"Association":[397],"Cancer":[399,409],"Research;":[400],"2010":[401],"Apr":[402],"17-21;":[403],"Washington,":[404],"DC.":[405],"Philadelphia":[406],"(PA):":[407],"AACR;":[408],"Res":[410],"2010;70(8":[411],"Suppl):Abstract":[412],"nr":[413],"2960.":[414]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}