{"id":"https://openalex.org/W196831092","doi":null,"title":"Clinical evaluation of serum antimitochondrial antibody-negative primary biliary cirrhosis.","display_name":"Clinical evaluation of serum antimitochondrial antibody-negative primary biliary cirrhosis.","publication_year":2004,"publication_date":"2004-05-01","ids":{"openalex":"https://openalex.org/W196831092","mag":"196831092","pmid":"https://pubmed.ncbi.nlm.nih.gov/15138128"},"language":"en","primary_location":{"id":"pmid:15138128","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15138128","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatobiliary & pancreatic diseases international : HBPD INT","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022888340","display_name":"Fu-Kui Zhang","orcid":"https://orcid.org/0000-0002-2766-2034","observed_orcids":["https://orcid.org/0000-0002-2766-2034"]},"institutions":[{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fu-Kui Zhang","raw_affiliation_strings":["Liver Research Center, Beijing Friendship Hospital, Capital University of Medical Sciences, Beijing 100050, China. frankliver@yahoo.com.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Research Center, Beijing Friendship Hospital, Capital University of Medical Sciences, Beijing 100050, China. frankliver@yahoo.com.cn","institution_ids":["https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042547974","display_name":"Jidong Jia","orcid":"https://orcid.org/0000-0002-9407-8890","observed_orcids":["https://orcid.org/0000-0002-9407-8890"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ji-Dong Jia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109094366","display_name":"Bao-en Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bao-En Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1966,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.60616803,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"3","issue":"2","first_page":"288","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11576","display_name":"IgG4-Related and Inflammatory Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-biliary-cholangitis","display_name":"primary biliary cirrhosis","score":1.0},{"id":"https://openalex.org/keywords/antimitochondrial-antibodies","display_name":"antimitochondrial antibodies","score":0.9549999833106995},{"id":"https://openalex.org/keywords/ama-m2","display_name":"AMA-M2","score":0.7889999747276306},{"id":"https://openalex.org/keywords/serum-immunoglobulin-m","display_name":"serum immunoglobulin M","score":0.8479999899864197},{"id":"https://openalex.org/keywords/antinuclear-antibodies","display_name":"antinuclear antibodies","score":0.9869999885559082},{"id":"https://openalex.org/keywords/smooth-muscle-antibodies","display_name":"smooth muscle antibodies","score":0.9990000128746033},{"id":"https://openalex.org/keywords/autoantibody-profile","display_name":"autoantibody profile","score":0.7059999704360962},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.7239999771118164},{"id":"https://openalex.org/keywords/clinical-characteristics","display_name":"clinical features","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9135619401931763},{"id":"https://openalex.org/C2780366471","wikidata":"https://www.wikidata.org/wiki/Q1072420","display_name":"Primary biliary cirrhosis","level":2,"score":0.8519178032875061},{"id":"https://openalex.org/C149443304","wikidata":"https://www.wikidata.org/wiki/Q185390","display_name":"Anti-nuclear antibody","level":4,"score":0.662726104259491},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.5613174438476562},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5481517314910889},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.540968656539917},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5343192219734192},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4799549877643585},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.4132075309753418},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.36310791969299316},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2889639437198639}],"mesh":[{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008105","descriptor_name":"Liver Cirrhosis, Biliary","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008105","descriptor_name":"Liver Cirrhosis, Biliary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:15138128","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15138128","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatobiliary & pancreatic diseases international : HBPD INT","raw_type":"Journal Article"},{"id":"mag:196831092","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15138128","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2390600347","https://openalex.org/W1994218082","https://openalex.org/W2408007194","https://openalex.org/W2396234598","https://openalex.org/W2373016863","https://openalex.org/W2021284716","https://openalex.org/W1964789582","https://openalex.org/W2348146853","https://openalex.org/W2104861780","https://openalex.org/W3032264619"],"abstract_inverted_index":{"BACKGROUND:":[0],"Primary":[1],"biliary":[2],"cirrhosis":[3],"(PBC)":[4],"is":[5,34],"characterized":[6,208],"by":[7,209],"frequent":[8],"presence":[9,29,77],"of":[10,18,30,49,78,87,93,112,140,153,213,220,237],"antimitochondrial":[11],"antibodies":[12,178,183],"(AMAs).":[13],"The":[14,150],"sensitivity":[15],"and":[16,54,84,105,116,133,147,216,223,234],"specificity":[17],"AMA":[19,31,79],"for":[20,59,68],"PBC":[21,101,163,168,192,205],"are":[22,57,64,207,224],"both":[23],"greater":[24],"than":[25,165,194],"90%-95%,":[26],"so":[27],"the":[28,35,51,76,81,88,129,190,196,231,238],"in":[32,38,47,110,138,161,166,189,195,230],"serum":[33,125,154,214,221],"major":[36],"hallmark":[37],"PBC.":[39],"However,":[40],"it":[41],"has":[42],"long":[43],"been":[44],"recognized":[45],"that":[46],"5%-10%":[48],"patients":[50,95,107,123,135,164,169,193,198,206],"clinical,":[52,82,113],"biochemical":[53,233],"histological":[55,85,117,148,235],"features":[56,86],"diagnostic":[58],"PBC,":[60],"but":[61],"their":[62],"sera":[63],"consistently":[65],"tested":[66],"negative":[67],"AMA/AMA-M2.":[69],"This":[70],"study":[71],"aimed":[72],"to":[73],"evaluate":[74],"whether":[75],"alters":[80],"serological":[83],"disease.":[89,239],"METHODS:":[90],"Clinical":[91],"data":[92],"70":[94],"clinically":[96],"and/or":[97,180],"histologically":[98],"diagnosed":[99],"with":[100,227],"were":[102,108,124,136,185],"reviewed.":[103],"AMA-negative":[104,132,162,191,204],"AMA-positive":[106,134,167,197],"compared":[109],"terms":[111,139],"biochemical,":[114],"immunological":[115],"features.":[118],"RESULTS:":[119],"At":[120,128],"presentation,":[121],"11":[122],"AMA/AMA-M2":[126],"negative.":[127],"initial":[130],"visit,":[131],"similar":[137],"age,":[141],"sex,":[142],"clinical":[143,232],"manifestations,":[144],"liver":[145],"biochemistries":[146],"findings.":[149],"mean":[151],"level":[152],"immunoglobulin":[155],"M":[156],"(IgM)":[157],"was":[158],"significantly":[159],"lower":[160,211],"(2851+/-1418":[170],"mg/L":[171],"vs":[172,200],"6361+/-4928":[173],"mg/L,":[174],"P=0.033).":[175],"Serum":[176],"antinuclear":[177],"(ANA)":[179],"smooth":[181],"muscle":[182],"(SMA)":[184],"more":[186],"frequently":[187],"positive":[188],"(81.8%":[199],"40.7%,":[201],"P=0.031).":[202],"CONCLUSION:":[203],"relatively":[210],"levels":[212],"IgM":[215],"a":[217],"higher":[218],"prevalence":[219],"ANA/SMA":[222],"not":[225],"associated":[226],"substantial":[228],"differences":[229],"spectrum":[236]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}