{"id":"https://openalex.org/W1968308121","doi":"https://doi.org/10.3892/etm.2012.651","title":"Relationship between expression and prognostic ability of PTEN, STAT3 and VEGF-C in colorectal cancer","display_name":"Relationship between expression and prognostic ability of PTEN, STAT3 and VEGF-C in colorectal cancer","publication_year":2012,"publication_date":"2012-07-31","ids":{"openalex":"https://openalex.org/W1968308121","doi":"https://doi.org/10.3892/etm.2012.651","mag":"1968308121","pmid":"https://pubmed.ncbi.nlm.nih.gov/23170117","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3501400"},"language":"en","primary_location":{"id":"doi:10.3892/etm.2012.651","doi":"https://doi.org/10.3892/etm.2012.651","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2012.651","pdf_url":"https://www.spandidos-publications.com/10.3892/etm.2012.651/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.spandidos-publications.com/10.3892/etm.2012.651/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076500388","display_name":"Canhui Jin","orcid":"https://orcid.org/0000-0002-2844-1081","observed_orcids":["https://orcid.org/0000-0002-2844-1081"]},"institutions":[{"id":"https://openalex.org/I4210134906","display_name":"First Affiliated Hospital of Henan University of Science and Technology","ror":"https://ror.org/035zbbv42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134906"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"CANHUI JIN","raw_affiliation_strings":["The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003,  P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003,  P.R. China","institution_ids":["https://openalex.org/I4210134906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101902302","display_name":"Aihong Wang","orcid":"https://orcid.org/0000-0003-1110-9928","observed_orcids":["https://orcid.org/0000-0003-1110-9928"]},"institutions":[{"id":"https://openalex.org/I4210134906","display_name":"First Affiliated Hospital of Henan University of Science and Technology","ror":"https://ror.org/035zbbv42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134906"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"AIHONG WANG","raw_affiliation_strings":["The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China","institution_ids":["https://openalex.org/I4210134906"]}]},{"author_position":"middle","author":{"id":null,"display_name":"JIANMIN CHEN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134906","display_name":"First Affiliated Hospital of Henan University of Science and Technology","ror":"https://ror.org/035zbbv42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134906"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"JIANMIN CHEN","raw_affiliation_strings":["The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China","institution_ids":["https://openalex.org/I4210134906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100768232","display_name":"Xiao-Min Liu","orcid":"https://orcid.org/0000-0003-3212-123X","observed_orcids":["https://orcid.org/0000-0003-3212-123X"]},"institutions":[{"id":"https://openalex.org/I4210134906","display_name":"First Affiliated Hospital of Henan University of Science and Technology","ror":"https://ror.org/035zbbv42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134906"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XIAOMIN LIU","raw_affiliation_strings":["The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China","institution_ids":["https://openalex.org/I4210134906"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037863148","display_name":"Gongping Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134906","display_name":"First Affiliated Hospital of Henan University of Science and Technology","ror":"https://ror.org/035zbbv42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134906"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"GONGPING WANG","raw_affiliation_strings":["The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China","institution_ids":["https://openalex.org/I4210134906"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210134906"],"apc_list":null,"apc_paid":null,"fwci":2.4544,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.88957775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"4","issue":"4","first_page":"633","last_page":"639"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.06069999933242798,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.02810000069439411,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9959999918937683},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vegf-c","display_name":"VEGF-C","score":1.0},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9539999961853027},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.41600000858306885},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.9020000100135803},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.640999972820282},{"id":"https://openalex.org/keywords/gene-expression-correlation","display_name":"gene expression correlation","score":0.6380000114440918},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6179999709129333},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.8479999899864197},{"id":"https://openalex.org/keywords/clinicopathological-features","display_name":"clinicopathological features","score":0.6110000014305115},{"id":"https://openalex.org/keywords/prognostic-value-of-gene-expression","display_name":"prognostic value of gene expression","score":0.36000001430511475},{"id":"https://openalex.org/keywords/prognostic-value","display_name":"prognostic value","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.8561580777168274},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.826073408126831},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.7313545346260071},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6513689160346985},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6394832730293274},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.578073263168335},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5534972548484802},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.5433796644210815},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5328671932220459},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.453241765499115},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43480485677719116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3957415521144867},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.28279969096183777},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.12230551242828369},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08111357688903809}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3892/etm.2012.651","doi":"https://doi.org/10.3892/etm.2012.651","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2012.651","pdf_url":"https://www.spandidos-publications.com/10.3892/etm.2012.651/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2775924","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3501400","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3501400","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3501400","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Ther Med","raw_type":"Text"},{"id":"pmid:23170117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23170117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and therapeutic medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/etm.2012.651","doi":"https://doi.org/10.3892/etm.2012.651","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2012.651","pdf_url":"https://www.spandidos-publications.com/10.3892/etm.2012.651/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321760","display_name":"Henan University of Science and Technology","ror":"https://ror.org/05d80kz58"},{"id":"https://openalex.org/F4320322878","display_name":"Henan University","ror":"https://ror.org/003xyzq10"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968308121.pdf","grobid_xml":"https://content.openalex.org/works/W1968308121.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W804190794","https://openalex.org/W1489873347","https://openalex.org/W1589477690","https://openalex.org/W1855056902","https://openalex.org/W1981282881","https://openalex.org/W2002106645","https://openalex.org/W2004349741","https://openalex.org/W2020830322","https://openalex.org/W2027949644","https://openalex.org/W2048935448","https://openalex.org/W2049489582","https://openalex.org/W2063221603","https://openalex.org/W2065676042","https://openalex.org/W2068272071","https://openalex.org/W2080864928","https://openalex.org/W2108811145","https://openalex.org/W2110223708","https://openalex.org/W2120434825","https://openalex.org/W2120521583","https://openalex.org/W2126156135","https://openalex.org/W2131116203","https://openalex.org/W2133930874","https://openalex.org/W2144470771","https://openalex.org/W2153672941","https://openalex.org/W2165174685","https://openalex.org/W2168478794","https://openalex.org/W2389551440","https://openalex.org/W2406628940","https://openalex.org/W2419050713","https://openalex.org/W4230897222","https://openalex.org/W4285719527","https://openalex.org/W6651482280","https://openalex.org/W6713820648","https://openalex.org/W7073604552"],"related_works":["https://openalex.org/W3030341850","https://openalex.org/W2355217597","https://openalex.org/W2366258937","https://openalex.org/W3032843966","https://openalex.org/W3031672452","https://openalex.org/W2350779345","https://openalex.org/W2387214733","https://openalex.org/W2360268737","https://openalex.org/W1984597758","https://openalex.org/W2369226492"],"abstract_inverted_index":{"Expression":[0,126],"of":[1,15,40,72,81,127,156,169,184,195,209,222,265,271],"phosphatase":[2],"and":[3,13,18,24,30,51,62,70,76,79,87,129,141,152,161,174,180,187,199,205,213,226,251,267],"tensin":[4],"homolog":[5],"deleted":[6],"on":[7],"chromosome":[8],"10":[9],"(PTEN),":[10],"signal":[11],"transducer":[12],"activator":[14],"transcription-3":[16],"(STAT3)":[17],"vascular":[19],"endothelial":[20],"growth":[21],"factor-C":[22],"(VEGF-C)":[23],"their":[25],"relationship":[26],"with":[27,43,91,99,111,118,134,147],"clinico-pathological":[28],"features":[29],"prognostic":[31,53,241,256],"ability":[32],"was":[33,49,55,65,109,131,144,238],"determined":[34,56],"using":[35,57],"immunohistochemistry":[36],"in":[37,67,261],"68":[38],"cases":[39,75],"colorectal":[41,73,272],"cancer":[42,273],"follow-up":[44],"data.":[45],"Kaplan-Meier":[46],"survival":[47,154,182,207],"analysis":[48,233],"performed":[50],"the":[52,220,262],"value":[54],"univariate":[58],"analysis.":[59],"PTEN,":[60,249],"STAT3":[61,88,128,140,250],"VEGF-C":[63,108,130,142,236,252],"expression":[64,143,237,253],"detected":[66],"32.4,":[68],"60.3":[69],"63.2%":[71],"carcinoma":[74],"90.0,":[77],"0":[78],"0%":[80],"normal":[82],"colon":[83],"samples,":[84],"respectively.":[85],"PTEN":[86,135,148,157,170],"were":[89,164,190,216],"correlated":[90,110,133,146],"pathological":[92,121],"grade":[93,122],"(p=0.011,":[94],"p=0.001,":[95],"respectively),":[96,138],"but":[97,116],"not":[98,117],"tumor":[100,119],"size,":[101,120],"lymph":[102,112],"node":[103,113],"metastasis":[104,114],"or":[105,123],"clinical":[106,124,269],"stage.":[107,125],"(p=0.002),":[115],"negatively":[132],"(r=-0.402,":[136],"r=-0.320,":[137],"whereas":[139],"positively":[145],"(r=0.254).":[149],"The":[150,178,203],"3-":[151,179,204],"5-year":[153,181,206],"rates":[155,183,208,221],"protein-positive":[158],"patients":[159,172,197,211,224],"(68.1":[160],"50.0%,":[162],"respectively)":[163,189,215],"significantly":[165,191,217],"higher":[166],"than":[167,193,219],"those":[168,194],"protein-negative":[171],"(32.6":[173],"19.6%,":[175],"respectively;":[176,201,228],"p=0.008).":[177],"STAT3-positive":[185],"(29.3":[186,212],"17.1%,":[188,214],"lower":[192,218],"STAT3-negative":[196],"(66.7":[198,225],"48.1%,":[200,227],"p=0.005).":[202],"VEGF-C-positive":[210],"VEGF-C-negative":[223],"p=0.003,":[229],"p=0.004,":[230],"respectively).":[231],"Multivariate":[232],"revealed":[234],"that":[235,248],"an":[239],"independent":[240],"factor.":[242],"In":[243],"conclusion,":[244],"this":[245],"study":[246],"indicates":[247],"are":[254],"beneficial":[255],"factors,":[257],"which":[258],"may":[259],"aid":[260],"accurate":[263],"assessment":[264],"prognosis":[266],"guide":[268],"treatment":[270],"patients.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}