{"id":"https://openalex.org/W1968301214","doi":"https://doi.org/10.1007/s11010-012-1423-7","title":"Hexavalent chromium induces energy metabolism disturbance and p53-dependent cell cycle arrest via reactive oxygen species in L-02 hepatocytes","display_name":"Hexavalent chromium induces energy metabolism disturbance and p53-dependent cell cycle arrest via reactive oxygen species in L-02 hepatocytes","publication_year":2012,"publication_date":"2012-08-10","ids":{"openalex":"https://openalex.org/W1968301214","doi":"https://doi.org/10.1007/s11010-012-1423-7","mag":"1968301214","pmid":"https://pubmed.ncbi.nlm.nih.gov/22886373"},"language":"en","primary_location":{"id":"doi:10.1007/s11010-012-1423-7","doi":"https://doi.org/10.1007/s11010-012-1423-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11010-012-1423-7","pdf_url":null,"source":{"id":"https://openalex.org/S11742566","display_name":"Molecular and Cellular Biochemistry","issn_l":"0300-8177","issn":["0300-8177","1573-4919"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058837840","display_name":"Fang Xiao","orcid":"https://orcid.org/0000-0002-6814-1227","observed_orcids":["https://orcid.org/0000-0002-6814-1227"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Xiao","raw_affiliation_strings":["Department of Health Toxicology, School of Public Health, Central South University, Changsha 410078, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Toxicology, School of Public Health, Central South University, Changsha 410078, People's Republic of China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112840095","display_name":"Xiaotao Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113348","display_name":"Guangxi University of Chinese Medicine","ror":"https://ror.org/024v0gx67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113348"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaotao Feng","raw_affiliation_strings":["Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, 530001, People\u2019s Republic of China","Guangxi University of Chinese Medicine;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, 530001, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210113348"]},{"raw_affiliation_string":"Guangxi University of Chinese Medicine;","institution_ids":["https://openalex.org/I4210113348"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012698759","display_name":"Ming Zeng","orcid":"https://orcid.org/0000-0002-6150-8591","observed_orcids":["https://orcid.org/0000-0002-6150-8591","https://orcid.org/0009-0000-8566-4508"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Zeng","raw_affiliation_strings":["Department of Health Toxicology, School of Public Health, Central South University, Changsha, 410078, People\u2019s Republic of China","central south university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Toxicology, School of Public Health, Central South University, Changsha, 410078, People\u2019s Republic of China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"central south university","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100566747","display_name":"Lan Guan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lan Guan","raw_affiliation_strings":["Department of Health Toxicology, School of Public Health, Central South University, Changsha, 410078, People\u2019s Republic of China","central south university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Toxicology, School of Public Health, Central South University, Changsha, 410078, People\u2019s Republic of China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"central south university","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052445737","display_name":"Qingqing Hu","orcid":"https://orcid.org/0000-0003-2820-9490","observed_orcids":["https://orcid.org/0000-0003-2820-9490"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qingqing Hu","raw_affiliation_strings":["Department of Health Promotion and Education, University of Utah, Salt Lake City, UT, 84112, USA","University of Utah,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Promotion and Education, University of Utah, Salt Lake City, UT, 84112, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"University of Utah,","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043209240","display_name":"Caigao Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Caigao Zhong","raw_affiliation_strings":["Department of Health Toxicology, School of Public Health, Central South University, Changsha, 410078, People\u2019s Republic of China","central south university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Toxicology, School of Public Health, Central South University, Changsha, 410078, People\u2019s Republic of China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"central south university","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5043209240"],"corresponding_institution_ids":["https://openalex.org/I139660479"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":2.407,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.85835506,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"371","issue":"1-2","first_page":"65","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11972","display_name":"Chromium effects and bioremediation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11972","display_name":"Chromium effects and bioremediation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hexavalent-chromium","display_name":"hexavalent chromium","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cr-vi-toxicity","display_name":"Cr(VI) toxicity","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9190000295639038},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9800000190734863},{"id":"https://openalex.org/keywords/p53-activation","display_name":"p53 activation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.7310000061988831},{"id":"https://openalex.org/keywords/cd206","display_name":"CD206","score":0.6570000052452087},{"id":"https://openalex.org/keywords/bubr1","display_name":"BubR1","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cdc25","display_name":"Cdc25","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cdk2","display_name":"CDK2","score":0.8600000143051147},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8870000243186951},{"id":"https://openalex.org/keywords/pifithrin-alpha","display_name":"pifithrin-alpha","score":0.800000011920929},{"id":"https://openalex.org/keywords/l02-hepatocytes","display_name":"L02 hepatocytes","score":0.8519999980926514}],"concepts":[{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.7501856088638306},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.7318753004074097},{"id":"https://openalex.org/C2781468121","wikidata":"https://www.wikidata.org/wiki/Q2660666","display_name":"Hexavalent chromium","level":3,"score":0.6929413676261902},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5104607343673706},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4775836765766144},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42282554507255554},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.4181874990463257},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38270995020866394},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35334059596061707},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27925997972488403},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2667335271835327},{"id":"https://openalex.org/C511782168","wikidata":"https://www.wikidata.org/wiki/Q725","display_name":"Chromium","level":2,"score":0.14563646912574768},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002274","descriptor_name":"Carcinogens, Environmental","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002857","descriptor_name":"Chromium","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004785","descriptor_name":"Environmental Pollutants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014050","descriptor_name":"Toluene","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014050","descriptor_name":"Toluene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051357","descriptor_name":"Cyclin-Dependent Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11010-012-1423-7","doi":"https://doi.org/10.1007/s11010-012-1423-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11010-012-1423-7","pdf_url":null,"source":{"id":"https://openalex.org/S11742566","display_name":"Molecular and Cellular Biochemistry","issn_l":"0300-8177","issn":["0300-8177","1573-4919"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:22886373","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22886373","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1494766755","https://openalex.org/W1562225087","https://openalex.org/W1923133867","https://openalex.org/W1964374342","https://openalex.org/W1964779874","https://openalex.org/W1965895804","https://openalex.org/W1965951402","https://openalex.org/W1972353515","https://openalex.org/W1974599587","https://openalex.org/W1985665319","https://openalex.org/W1986529290","https://openalex.org/W2004247480","https://openalex.org/W2008117638","https://openalex.org/W2011925577","https://openalex.org/W2012976406","https://openalex.org/W2017357811","https://openalex.org/W2025776438","https://openalex.org/W2026525843","https://openalex.org/W2033950216","https://openalex.org/W2036127346","https://openalex.org/W2042000503","https://openalex.org/W2043509649","https://openalex.org/W2044261960","https://openalex.org/W2052406949","https://openalex.org/W2056035305","https://openalex.org/W2056642013","https://openalex.org/W2060363769","https://openalex.org/W2060674443","https://openalex.org/W2062674518","https://openalex.org/W2064474659","https://openalex.org/W2068445412","https://openalex.org/W2071222224","https://openalex.org/W2073180738","https://openalex.org/W2073655872","https://openalex.org/W2075733006","https://openalex.org/W2078144055","https://openalex.org/W2080911031","https://openalex.org/W2085951179","https://openalex.org/W2086795875","https://openalex.org/W2087121509","https://openalex.org/W2087561593","https://openalex.org/W2089218510","https://openalex.org/W2091485610","https://openalex.org/W2092895723","https://openalex.org/W2098303916","https://openalex.org/W2109458089","https://openalex.org/W2117561017","https://openalex.org/W2119671429","https://openalex.org/W2124352629","https://openalex.org/W2128635872","https://openalex.org/W2133643927","https://openalex.org/W2134435289","https://openalex.org/W2135706825","https://openalex.org/W2155455929","https://openalex.org/W2158304473","https://openalex.org/W2236824038","https://openalex.org/W2271272206","https://openalex.org/W2415671846","https://openalex.org/W2498594918","https://openalex.org/W4230909167"],"related_works":["https://openalex.org/W2597088488","https://openalex.org/W2019108427","https://openalex.org/W1980280918","https://openalex.org/W2373420015","https://openalex.org/W3037311076","https://openalex.org/W2529792485","https://openalex.org/W2013595664","https://openalex.org/W1966126720","https://openalex.org/W2379720153","https://openalex.org/W195338222"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}