{"id":"https://openalex.org/W1968300358","doi":"https://doi.org/10.7326/0003-4819-153-1-201007060-00019","title":"Menopausal Hormone Therapy and Risk for Cardiovascular Disease in the WHI Trial","display_name":"Menopausal Hormone Therapy and Risk for Cardiovascular Disease in the WHI Trial","publication_year":2010,"publication_date":"2010-07-06","ids":{"openalex":"https://openalex.org/W1968300358","doi":"https://doi.org/10.7326/0003-4819-153-1-201007060-00019","mag":"1968300358","pmid":"https://pubmed.ncbi.nlm.nih.gov/20621909"},"language":"en","primary_location":{"id":"doi:10.7326/0003-4819-153-1-201007060-00019","doi":"https://doi.org/10.7326/0003-4819-153-1-201007060-00019","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-153-1-201007060-00019","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"letter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079428284","display_name":"Sherman Mitchell Harman","orcid":"https://orcid.org/0000-0002-8806-8178","observed_orcids":["https://orcid.org/0000-0002-8806-8178"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210144491","display_name":"Kronos Longevity Research Institute","ror":"https://ror.org/04anb9w92","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210144491"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Mitchell Harman","raw_affiliation_strings":["From Kronos Longevity Research Institute, Phoenix, AZ 85016; University of Utah School of Medicine, Salt Lake City, UT 84108; New York University School of Medicine, New York, NY 10016; University of Washington School of Medicine, Seattle, WA 98195; University of California at San Francisco, San Francisco, CA 94115; Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461; and University of Colorado at Denver, Aurora, CO 80045","Kronos Longevity Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Kronos Longevity Research Institute, Phoenix, AZ 85016; University of Utah School of Medicine, Salt Lake City, UT 84108; New York University School of Medicine, New York, NY 10016; University of Washington School of Medicine, Seattle, WA 98195; University of California at San Francisco, San Francisco, CA 94115; Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461; and University of Colorado at Denver, Aurora, CO 80045","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I180670191","https://openalex.org/I201448701","https://openalex.org/I223532165","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Kronos Longevity Research Institute","institution_ids":["https://openalex.org/I4210144491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020230532","display_name":"Eliot A. Brinton","orcid":"https://orcid.org/0000-0002-9807-4010","observed_orcids":["https://orcid.org/0000-0002-9807-4010"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eliot A. Brinton","raw_affiliation_strings":["From Kronos Longevity Research Institute, Phoenix, AZ 85016; University of Utah School of Medicine, Salt Lake City, UT 84108; New York University School of Medicine, New York, NY 10016; University of Washington School of Medicine, Seattle, WA 98195; University of California at San Francisco, San Francisco, CA 94115; Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461; and University of Colorado at Denver, Aurora, CO 80045","University of Utah,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Kronos Longevity Research Institute, Phoenix, AZ 85016; University of Utah School of Medicine, Salt Lake City, UT 84108; New York University School of Medicine, New York, NY 10016; University of Washington School of Medicine, Seattle, WA 98195; University of California at San Francisco, San Francisco, CA 94115; Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461; and University of Colorado at Denver, Aurora, CO 80045","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I180670191","https://openalex.org/I201448701","https://openalex.org/I223532165","https://openalex.org/I57206974"]},{"raw_affiliation_string":"University of Utah,","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030184373","display_name":"Frederick Nicholas Naftolin","orcid":"https://orcid.org/0000-0002-9447-6266","observed_orcids":["https://orcid.org/0000-0002-9447-6266"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick Naftolin","raw_affiliation_strings":["From Kronos Longevity Research Institute, Phoenix, AZ 85016; University of Utah School of Medicine, Salt Lake City, UT 84108; New York University School of Medicine, New York, NY 10016; University of Washington School of Medicine, Seattle, WA 98195; University of California at San Francisco, San Francisco, CA 94115; Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461; and University of Colorado at Denver, Aurora, CO 80045","New York University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Kronos Longevity Research Institute, Phoenix, AZ 85016; University of Utah School of Medicine, Salt Lake City, UT 84108; New York University School of Medicine, New York, NY 10016; University of Washington School of Medicine, Seattle, WA 98195; University of California at San Francisco, San Francisco, CA 94115; Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461; and University of Colorado at Denver, Aurora, CO 80045","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I180670191","https://openalex.org/I201448701","https://openalex.org/I223532165","https://openalex.org/I57206974"]},{"raw_affiliation_string":"New York University","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108385429","display_name":"George R. Merriam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George R. Merriam","raw_affiliation_strings":["From Kronos Longevity Research Institute, Phoenix, AZ 85016; University of Utah School of Medicine, Salt Lake City, UT 84108; New York University School of Medicine, New York, NY 10016; University of Washington School of Medicine, Seattle, WA 98195; University of California at San Francisco, San Francisco, CA 94115; Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461; and University of Colorado at Denver, Aurora, CO 80045","University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Kronos Longevity Research Institute, Phoenix, AZ 85016; University of Utah School of Medicine, Salt Lake City, UT 84108; New York University School of Medicine, New York, NY 10016; University of Washington School of Medicine, Seattle, WA 98195; University of California at San Francisco, San Francisco, CA 94115; Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461; and University of Colorado at Denver, Aurora, CO 80045","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I180670191","https://openalex.org/I201448701","https://openalex.org/I223532165","https://openalex.org/I57206974"]},{"raw_affiliation_string":"University of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074289517","display_name":"Marcelle Ivonne Cedars","orcid":"https://orcid.org/0000-0003-3682-6907","observed_orcids":["https://orcid.org/0000-0003-3682-6907"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcelle I. Cedars","raw_affiliation_strings":["From Kronos Longevity Research Institute, Phoenix, AZ 85016; University of Utah School of Medicine, Salt Lake City, UT 84108; New York University School of Medicine, New York, NY 10016; University of Washington School of Medicine, Seattle, WA 98195; University of California at San Francisco, San Francisco, CA 94115; Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461; and University of Colorado at Denver, Aurora, CO 80045","University of California at San Francisco,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Kronos Longevity Research Institute, Phoenix, AZ 85016; University of Utah School of Medicine, Salt Lake City, UT 84108; New York University School of Medicine, New York, NY 10016; University of Washington School of Medicine, Seattle, WA 98195; University of California at San Francisco, San Francisco, CA 94115; Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461; and University of Colorado at Denver, Aurora, CO 80045","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I180670191","https://openalex.org/I201448701","https://openalex.org/I223532165","https://openalex.org/I57206974"]},{"raw_affiliation_string":"University of California at San Francisco,","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104036243","display_name":"Ruth G. Freeman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth G. Freeman","raw_affiliation_strings":["From Kronos Longevity Research Institute, Phoenix, AZ 85016; University of Utah School of Medicine, Salt Lake City, UT 84108; New York University School of Medicine, New York, NY 10016; University of Washington School of Medicine, Seattle, WA 98195; University of California at San Francisco, San Francisco, CA 94115; Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461; and University of Colorado at Denver, Aurora, CO 80045","Obstetrics & Gynecology and Women's Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Kronos Longevity Research Institute, Phoenix, AZ 85016; University of Utah School of Medicine, Salt Lake City, UT 84108; New York University School of Medicine, New York, NY 10016; University of Washington School of Medicine, Seattle, WA 98195; University of California at San Francisco, San Francisco, CA 94115; Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461; and University of Colorado at Denver, Aurora, CO 80045","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I180670191","https://openalex.org/I201448701","https://openalex.org/I223532165","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Obstetrics & Gynecology and Women's Health","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038096153","display_name":"Nanette Santoro","orcid":"https://orcid.org/0000-0001-9096-7490","observed_orcids":["https://orcid.org/0000-0001-9096-7490"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nanette Santoro","raw_affiliation_strings":["From Kronos Longevity Research Institute, Phoenix, AZ 85016; University of Utah School of Medicine, Salt Lake City, UT 84108; New York University School of Medicine, New York, NY 10016; University of Washington School of Medicine, Seattle, WA 98195; University of California at San Francisco, San Francisco, CA 94115; Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461; and University of Colorado at Denver, Aurora, CO 80045","University of Colorado Anschutz Medical Campus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Kronos Longevity Research Institute, Phoenix, AZ 85016; University of Utah School of Medicine, Salt Lake City, UT 84108; New York University School of Medicine, New York, NY 10016; University of Washington School of Medicine, Seattle, WA 98195; University of California at San Francisco, San Francisco, CA 94115; Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461; and University of Colorado at Denver, Aurora, CO 80045","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I180670191","https://openalex.org/I201448701","https://openalex.org/I223532165","https://openalex.org/I57206974"]},{"raw_affiliation_string":"University of Colorado Anschutz Medical Campus","institution_ids":["https://openalex.org/I51713134"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"153","issue":"1","first_page":"60","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hormone-replacement-therapy","display_name":"hormone replacement therapy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.8980000019073486},{"id":"https://openalex.org/keywords/women-s-health-initiative","display_name":"Women's Health Initiative","score":0.9340000152587891},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.4480000138282776},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.7559999823570251},{"id":"https://openalex.org/keywords/cardiovascular-events","display_name":"cardiovascular events","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9545637369155884},{"id":"https://openalex.org/C2780275930","wikidata":"https://www.wikidata.org/wiki/Q1628266","display_name":"Hormone therapy","level":4,"score":0.6478168964385986},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.49598798155784607},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.4716452956199646},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4475935101509094},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44640517234802246},{"id":"https://openalex.org/C2780159708","wikidata":"https://www.wikidata.org/wiki/Q17003363","display_name":"Hormone replacement therapy (female-to-male)","level":3,"score":0.4429882764816284},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3660411834716797},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.17711621522903442},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.12589031457901},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.11843293905258179}],"mesh":[{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004966","descriptor_name":"Estrogens, Conjugated (USP)","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015914","descriptor_name":"Estrogen Replacement Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D017258","descriptor_name":"Medroxyprogesterone Acetate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.7326/0003-4819-153-1-201007060-00019","doi":"https://doi.org/10.7326/0003-4819-153-1-201007060-00019","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-153-1-201007060-00019","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:20621909","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20621909","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of internal medicine","raw_type":"Comment"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1589956668","https://openalex.org/W1593442063","https://openalex.org/W1981922048","https://openalex.org/W1990817648","https://openalex.org/W2004937659","https://openalex.org/W2031745594","https://openalex.org/W2049381808","https://openalex.org/W2060218189","https://openalex.org/W2078878902","https://openalex.org/W2109376303","https://openalex.org/W2159587574"],"related_works":["https://openalex.org/W2148227989","https://openalex.org/W3098835207","https://openalex.org/W2015301494","https://openalex.org/W2007554131","https://openalex.org/W2789410737","https://openalex.org/W4412805139","https://openalex.org/W2047459323","https://openalex.org/W2903024567","https://openalex.org/W2107675294","https://openalex.org/W2002043245"],"abstract_inverted_index":{"Letters6":[0],"July":[1,1127,1141,1146],"2010Menopausal":[2],"Hormone":[3,1000,1063,1080,1095],"Therapy":[4,1064,1081,1096],"and":[5,38,98,105,176,183,254,261,332,339,410,417,488,495,510,566,573,589,605,635,649,670,747,785,832,879,897,953,960,1002,1024,1058,1065,1076,1082,1097,1113,1120,1136],"Risk":[6,1042,1066,1083,1098],"for":[7,114,192,270,348,426,504,582,608,825,1067,1084,1099],"Cardiovascular":[8,1068,1085,1100,1124],"Disease":[9,1030,1069,1086,1101,1125],"in":[10,617,679,713,753,796,838,992,1008,1031,1070,1087,1102,1123],"the":[11,612,618,625,645,650,662,674,680,722,754,797,826,845,880,1009,1040,1071,1088,1103],"WHI":[12,1072,1089,1104],"TrialS.":[13],"Mitchell":[14,42],"Harman,":[15,43],"MD,":[16,21,24,29,33,37,44,200],"PhD,":[17,25],"Eliot":[18,120],"A.":[19,121,1060,1115],"Brinton,":[20,122],"Frederick":[22,198],"Naftolin,":[23,199],"George":[26,276],"R.":[27,277],"Merriam,":[28,278],"Marcelle":[30,354],"I.":[31,355],"Cedars,":[32,356],"Ruth":[34,432],"G.":[35,433],"Freeman,":[36,434],"Nanette":[39,511],"Santoro,":[40,512],"MDS.":[41],"PhDFrom":[45,201],"Kronos":[46,124,202,280,358,436,514,901],"Longevity":[47,125,203,281,359,437,515,902],"Research":[48,126,204,282,360,438,516,903],"Institute,":[49,127,205,283,361,439,517,904],"Phoenix,":[50,128,206,284,362,440,518,905],"AZ":[51,129,207,285,363,441,519,906],"85016;":[52,130,208,286,364,442,520,907],"University":[53,66,74,83,106,131,144,152,161,184,209,222,230,239,262,287,300,308,317,340,365,378,386,395,418,443,456,464,473,496,521,534,542,551,574,908,921,929,938,961],"of":[54,57,68,75,78,84,96,107,132,135,146,153,156,162,174,185,210,213,224,231,234,240,252,263,288,291,302,309,312,318,330,341,366,369,380,387,390,396,408,419,444,447,458,465,468,474,486,497,522,525,536,543,546,552,564,575,615,620,647,652,661,684,696,716,750,787,794,834,882,909,912,923,930,933,939,951,962,974,983,986,1005,1034,1154],"Utah":[55,133,211,289,367,445,523,910],"School":[56,67,77,134,145,155,212,223,233,290,301,311,368,379,389,446,457,467,524,535,545,911,922,932],"Medicine,":[58,69,79,136,147,157,214,225,235,292,303,313,370,381,391,448,459,469,526,537,547,913,924,934],"Salt":[59,137,215,293,371,449,527,914],"Lake":[60,138,216,294,372,450,528,915],"City,":[61,139,217,295,373,451,529,916],"UT":[62,140,218,296,374,452,530,917],"84108;":[63,141,219,297,375,453,531,918],"New":[64,70,142,148,220,226,298,304,376,382,454,460,532,538,919,925],"York":[65,143,221,299,377,455,533,920],"York,":[71,149,227,305,383,461,539,926],"NY":[72,103,150,181,228,259,306,337,384,415,462,493,540,571,927,958],"10016;":[73,151,229,307,385,463,541,928],"Washington":[76,154,232,310,388,466,544,931],"Seattle,":[80,158,236,314,392,470,548,935],"WA":[81,159,237,315,393,471,549,936],"98195;":[82,160,238,316,394,472,550,937],"California":[85,163,241,319,397,475,553,940],"at":[86,109,164,187,242,265,320,343,398,421,476,499,554,577,941,964],"San":[87,89,165,167,243,245,321,323,399,401,477,479,555,557,942,944],"Francisco,":[88,90,166,168,244,246,322,324,400,402,478,480,556,558,943,945],"CA":[91,169,247,325,403,481,559,946],"94115;":[92,170,248,326,404,482,560,947],"Albert":[93,171,249,327,405,483,561,948],"Einstein":[94,172,250,328,406,484,562,949],"College":[95,173,251,329,407,485,563,950,1153],"Medicine":[97,175,253,331,409,487,565,952],"Montefiore":[99,177,255,333,411,489,567,954],"Medical":[100,178,256,334,412,490,568,955],"Center,":[101,179,257,335,413,491,569,956],"Bronx,":[102,180,258,336,414,492,570,957],"10461;":[104,182,260,338,416,494,572,959],"Colorado":[108,186,264,342,420,498,576,963],"Denver,":[110,188,266,344,422,500,578,965],"Aurora,":[111,189,267,345,423,501,579,966],"CO":[112,190,268,346,424,502,580,967],"80045.Search":[113,191,269,347,425,503,581],"more":[115,193,271,349,427,505,583,694],"papers":[116,194,272,350,428,506,584],"by":[117,195,273,351,429,507,585,668,1151],"this":[118,196,274,352,430,508,586],"author,":[119,197,275,353,431,509],"MDFrom":[123,279,357,435,513],"authorAuthor,":[587],"Article,":[588,896],"Disclosure":[590,898],"Informationhttps://doi.org/10.7326/0003-4819-153-1-201007060-00019":[591],"SectionsAboutFull":[592],"TextPDF":[593],"ToolsAdd":[594],"to":[595,687],"favoritesDownload":[596],"CitationsTrack":[597],"CitationsPermissions":[598],"ShareFacebookTwitterLinkedInRedditEmail":[599],"TO":[600],"THE":[601],"EDITOR:We":[602],"applaud":[603],"Toh":[604,669,700,1046,1107],"colleagues":[606,671],"(1)":[607],"delving":[609],"deeper":[610],"into":[611],"still-controversial":[613],"issue":[614],"inconsistencies":[616],"outcomes":[619],"cardiovascular":[621,984],"disease":[622,712],"(CVD)":[623],"between":[624],"Women's":[626,827,846,872],"Health":[627,756,828,847,873,1011],"Initiative":[628,829,848,874],"(WHI)":[629],"estrogen":[630,717,835],"plus":[631,718,836,877],"progestin":[632,719,837,878],"hormone":[633,654,745,782,990],"trial":[634],"previous":[636],"large":[637],"observational":[638,760],"studies.":[639],"Current":[640],"evidence":[641],"suggests":[642],"that":[643,673],"both":[644],"timing":[646],"initiation":[648],"duration":[651],"menopausal":[653,781,994],"therapy":[655,784],"(2,":[656],"3)":[657],"are":[658,971],"important":[659],"determinants":[660],"risk\u2013benefit":[663],"ratio.":[664],"The":[665],"data":[666],"presented":[667],"suggest":[672],"slightly":[675],"higher":[676],"CVD":[677],"risk":[678,690,724,786,881],"first":[681],"2":[682],"years":[683,695],"treatment":[685,991],"leads":[686],"a":[688],"lower":[689],"after":[691],"6":[692,1126,1140,1145],"or":[693],"use":[697,746],"only":[698],"...References1.":[699],"S,":[701,703],"Hern\u00e1ndez-D\u00edaz":[702,1049],"Logan":[704,778,1052],"R,":[705],"Rossouw":[706,809,864,1056,1111],"JE,":[707,741,810,859,865],"Hern\u00e1n":[708,1061,1116],"MA.":[709],"Coronary":[710,1006,1028],"heart":[711,884],"postmenopausal":[714,840],"recipients":[715],"therapy:":[720],"does":[721],"increased":[723],"ever":[725],"disappear?":[726],"A":[727,758,1013],"randomized":[728,849],"trial.":[729,851],"Ann":[730,762],"Intern":[731,763],"Med.":[732,764,889],"2010;152:211-7.":[733],"[PMID:":[734,766,805,854,891],"20157135]":[735],"LinkGoogle":[736,768],"Scholar2.":[737],"Grodstein":[738,1018],"F,":[739],"Manson":[740,858,1022],"Stampfer":[742,1027],"MJ.":[743],"Postmenopausal":[744,1032],"secondary":[748],"prevention":[749],"coronary":[751,883],"events":[752],"Nurses'":[755,1010],"Study.":[757],"prospective,":[759],"study.":[761],"2001;135:1-8.":[765],"11434726]":[767],"Scholar3.":[769],"Chilvers":[770],"CE,":[771],"Knibb":[772],"RC,":[773],"Armstrong":[774],"SJ,":[775],"Woods":[776],"KL,":[777],"RF.":[779],"Post":[780],"replacement":[783],"acute":[788],"myocardial":[789],"infarction\u2014a":[790],"case":[791],"control":[792],"study":[793],"women":[795],"East":[798],"Midlands,":[799],"UK.":[800],"Eur":[801],"Heart":[802,1029],"J.":[803,1026],"2003;24:2197-205.":[804],"14659771]":[806],"CrossrefMedlineGoogle":[807,856,893],"Scholar4.":[808],"Anderson":[811],"GL,":[812],"Prentice":[813],"RL,":[814],"LaCroix":[815],"AZ,":[816],"Kooperberg":[817],"C,":[818],"Stefanick":[819],"ML,":[820],"et":[821,870],"al;":[822,871],"Writing":[823],"Group":[824],"Investigators.":[830,875],"Risks":[831],"benefits":[833],"healthy":[839],"women:":[841],"principal":[842],"results":[843],"From":[844,900],"controlled":[850],"JAMA.":[852],"2002;288:321-33.":[853],"12117397]":[855],"Scholar5.":[857],"Hsia":[860],"J,":[861],"Johnson":[862],"KC,":[863],"Assaf":[866],"AR,":[867],"Lasser":[868],"NL,":[869],"Estrogen":[876,978,1035],"disease.":[885],"N":[886],"Engl":[887],"J":[888],"2003;349:523-34.":[890],"12904517]":[892],"Scholar":[894],"Author,":[895],"InformationAffiliations:":[899],"80045.Disclosures:":[968],"All":[969,1156],"authors":[970],"co-principal":[972],"investigators":[973],"KEEPS":[975],"(Kronos":[976],"Early":[977],"Prevention":[979,1004],"Study),":[980],"an":[981],"investigation":[982],"effects":[985],"oral":[987],"versus":[988],"transdermal":[989],"recently":[993],"women.":[995],"PreviousarticleNextarticle":[996],"Advertisement":[997],"FiguresReferencesRelatedDetailsSee":[998],"AlsoPostmenopausal":[999],"Use":[1001],"Secondary":[1003],"Events":[1007],"Study:":[1012],"Prospective,":[1014],"Observational":[1015],"Study":[1016],"Francine":[1017],",":[1019,1023,1047,1050,1053,1057,1108,1112],"JoAnn":[1020],"E.":[1021,1055,1110],"Meir":[1025],"Recipients":[1033],"Plus":[1036],"Progestin":[1037],"Therapy:":[1038],"Does":[1039],"Increased":[1041],"Ever":[1043],"Disappear?":[1044],"Sengwee":[1045,1106],"Sonia":[1048],"Roger":[1051],"Jacques":[1054,1109],"Miguel":[1059,1114],"Menopausal":[1062,1079,1094],"Trial":[1073,1090,1105],"Amos":[1074],"Pines":[1075],"David":[1077],"Sturdee":[1078],"Jerome":[1091],"L.":[1092],"Sullivan":[1093],"Metrics":[1117],"Cited":[1118],"BySex":[1119],"Gender":[1121],"Differences":[1122],"2010Volume":[1128],"153,":[1129],"Issue":[1130,1143],"1Page:":[1131],"60-61KeywordsCardiovascular":[1132],"diseasesEstrogensForecastingHormonal":[1133],"therapyHormonesMenopauseObservational":[1134],"studiesObstetrics":[1135],"gynecologyRisk":[1137],"management":[1138],"ePublished:":[1139],"2010":[1142,1147,1150],"Published:":[1144],"CopyrightCopyright":[1148],"\u00a9":[1149],"American":[1152],"Physicians.":[1155],"Rights":[1157],"Reserved.PDF":[1158],"DownloadLoading":[1159],"...":[1160]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}