{"id":"https://openalex.org/W1968294582","doi":"https://doi.org/10.1097/00008480-199606000-00010","title":"Diagnosis and management of opioid- and benzodiazepine-induced comatose overdose in children","display_name":"Diagnosis and management of opioid- and benzodiazepine-induced comatose overdose in children","publication_year":1996,"publication_date":"1996-06-01","ids":{"openalex":"https://openalex.org/W1968294582","doi":"https://doi.org/10.1097/00008480-199606000-00010","mag":"1968294582","pmid":"https://pubmed.ncbi.nlm.nih.gov/8814402"},"language":"en","primary_location":{"id":"doi:10.1097/00008480-199606000-00010","doi":"https://doi.org/10.1097/00008480-199606000-00010","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00008480-199606000-00010","pdf_url":null,"source":{"id":"https://openalex.org/S204673346","display_name":"Current Opinion in Pediatrics","issn_l":"1040-8703","issn":["1040-8703","1080-8116","1531-698X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109177642","display_name":"Holly Elizabeth Perry","orcid":"https://orcid.org/0009-0004-1371-7745","observed_orcids":["https://orcid.org/0009-0004-1371-7745"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holly E. Perry","raw_affiliation_strings":["Division of Emergency Medicine, Children's Hospital, Boston, MA 02115, USA","Division of Emergency Medicine, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Emergency Medicine, Children's Hospital, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Division of Emergency Medicine, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110019639","display_name":"Michael Wayne Shannon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael W. Shannon","raw_affiliation_strings":["Division of Emergency Medicine, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Emergency Medicine, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1288882113"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1288882113"],"apc_list":null,"apc_paid":null,"fwci":2.6244,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.88380556,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"8","issue":"3","first_page":"243","last_page":"247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opioid-overdose","display_name":"opioid overdose","score":0.9789999723434448},{"id":"https://openalex.org/keywords/benzodiazepine-overdose","display_name":"benzodiazepine overdose","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pediatric-poisoning","display_name":"pediatric poisoning","score":0.7239999771118164},{"id":"https://openalex.org/keywords/naloxone","display_name":"naloxone","score":0.9160000085830688},{"id":"https://openalex.org/keywords/flumazenil","display_name":"flumazenil","score":1.0},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.5559999942779541},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.6980000138282776},{"id":"https://openalex.org/keywords/emergency-department-management","display_name":"emergency department management","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C2778409475","wikidata":"https://www.wikidata.org/wiki/Q421920","display_name":"Flumazenil","level":4,"score":0.9321994781494141},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9268288612365723},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.8103891015052795},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.6764817237854004},{"id":"https://openalex.org/C2780724011","wikidata":"https://www.wikidata.org/wiki/Q1295316","display_name":"Emergency department","level":2,"score":0.5110489130020142},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.48427265882492065},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4651167690753937},{"id":"https://openalex.org/C100136789","wikidata":"https://www.wikidata.org/wiki/Q1772448","display_name":"Coma (optics)","level":2,"score":0.4339430630207062},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.420773446559906},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.14916539192199707},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14664477109909058},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000931","descriptor_name":"Antidotes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000931","descriptor_name":"Antidotes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003128","descriptor_name":"Coma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003128","descriptor_name":"Coma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005442","descriptor_name":"Flumazenil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005442","descriptor_name":"Flumazenil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009294","descriptor_name":"Narcotics","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D009294","descriptor_name":"Narcotics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D062787","descriptor_name":"Drug Overdose","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D062787","descriptor_name":"Drug Overdose","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00008480-199606000-00010","doi":"https://doi.org/10.1097/00008480-199606000-00010","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00008480-199606000-00010","pdf_url":null,"source":{"id":"https://openalex.org/S204673346","display_name":"Current Opinion in Pediatrics","issn_l":"1040-8703","issn":["1040-8703","1080-8116","1531-698X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Pediatrics","raw_type":"journal-article"},{"id":"pmid:8814402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8814402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in pediatrics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4285346773","https://openalex.org/W2354750740","https://openalex.org/W2133468945","https://openalex.org/W2086946805","https://openalex.org/W7217495550","https://openalex.org/W4292117471","https://openalex.org/W134411259","https://openalex.org/W2081122351","https://openalex.org/W1919879941","https://openalex.org/W2464272793"],"abstract_inverted_index":{"Opioids":[0],"and":[1,26,45,72,77,85,122],"benzodiazepines":[2],"are":[3,36],"two":[4,33],"of":[5,20,65,68,75,83,102,119],"the":[6,66,80,88,95,103],"most":[7],"common":[8],"exposures":[9],"that":[10,35],"cause":[11],"depressed":[12],"mental":[13],"status":[14],"in":[15,57,87],"children.":[16,109],"Establishing":[17],"a":[18,62],"diagnosis":[19],"these":[21,32,58],"intoxications":[22],"may":[23],"be":[24,48],"difficult":[25],"is":[27,98,111],"complicated":[28],"by":[29,39],"drugs":[30],"from":[31],"classes":[34],"not":[37,106],"detectable":[38],"routine":[40],"toxicologic":[41],"screening":[42],"techniques.":[43],"Naloxone":[44],"flumazenil":[46,86],"can":[47],"used":[49],"as":[50,52,54],"diagnostic":[51],"well":[53],"therapeutic":[55],"medications":[56],"ingestions.":[59],"We":[60],"present":[61],"brief":[63],"review":[64],"mechanism":[67],"action,":[69],"administration":[70,118],"recommendations,":[71],"adverse":[73],"effects":[74],"naloxone":[76,84,121],"flumazenil.":[78,123],"Although":[79],"empiric":[81,117],"use":[82],"comatose":[89],"adult":[90],"patient":[91],"who":[92],"presents":[93],"to":[94,108],"emergency":[96],"department":[97],"being":[99],"reexamined,":[100],"many":[101],"concerns":[104],"do":[105],"apply":[107],"There":[110],"still":[112],"an":[113],"important":[114],"role":[115],"for":[116],"both":[120]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}