{"id":"https://openalex.org/W1968283974","doi":"https://doi.org/10.1067/mlc.2000.105180","title":"Hemoglobin stimulates the release of proinflammatory cytokines from leukocytes in whole blood","display_name":"Hemoglobin stimulates the release of proinflammatory cytokines from leukocytes in whole blood","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W1968283974","doi":"https://doi.org/10.1067/mlc.2000.105180","mag":"1968283974","pmid":"https://pubmed.ncbi.nlm.nih.gov/10711865"},"language":"en","primary_location":{"id":"doi:10.1067/mlc.2000.105180","doi":"https://doi.org/10.1067/mlc.2000.105180","is_oa":false,"landing_page_url":"https://doi.org/10.1067/mlc.2000.105180","pdf_url":null,"source":{"id":"https://openalex.org/S26537864","display_name":"Journal of Laboratory and Clinical Medicine","issn_l":"0022-2143","issn":["0022-2143","1532-6543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Laboratory and Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111675053","display_name":"Steve J. McFaul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800363604","display_name":"Walter Reed National Military Medical Center","ror":"https://ror.org/025cem651","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330347796","https://openalex.org/I2800250139","https://openalex.org/I2800363604","https://openalex.org/I2800386880"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve J. McFaul","raw_affiliation_strings":["WRAIR Blood Research, Walter Reed Army Medical Center, Washington, DC 20307-5100, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WRAIR Blood Research, Walter Reed Army Medical Center, Washington, DC 20307-5100, USA","institution_ids":["https://openalex.org/I2800363604","https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110102619","display_name":"Phillip D. Bowman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phil D. Bowman","raw_affiliation_strings":["Washington, District of Columbia, and San Antonio, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington, District of Columbia, and San Antonio, Texas","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110510881","display_name":"Vilmar Villa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vilmar M. Villa","raw_affiliation_strings":["Washington, District of Columbia, and San Antonio, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington, District of Columbia, and San Antonio, Texas","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2574,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.75737327,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"135","issue":"3","first_page":"263","last_page":"269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemoglobin","display_name":"hemoglobin","score":0.8259999752044678},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8619999885559082},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8740000128746033},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":1.0},{"id":"https://openalex.org/keywords/leukocytes","display_name":"leukocytes","score":0.6710000038146973},{"id":"https://openalex.org/keywords/whole-blood","display_name":"whole blood","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.9079999923706055},{"id":"https://openalex.org/keywords/endothelial-cell-adhesion","display_name":"endothelial cell adhesion","score":0.6669999957084656},{"id":"https://openalex.org/keywords/neutrophil-chemotaxis","display_name":"neutrophil chemotaxis","score":0.875},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.93207848072052},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.6412023305892944},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5452908873558044},{"id":"https://openalex.org/C1621761","wikidata":"https://www.wikidata.org/wiki/Q7997549","display_name":"Whole blood","level":2,"score":0.4639686346054077},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3960433006286621},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.39528417587280273},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36641550064086914},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24578019976615906}],"mesh":[{"descriptor_ui":"D001802","descriptor_name":"Blood Substitutes","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001802","descriptor_name":"Blood Substitutes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006441","descriptor_name":"Hemoglobin A","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006441","descriptor_name":"Hemoglobin A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1067/mlc.2000.105180","doi":"https://doi.org/10.1067/mlc.2000.105180","is_oa":false,"landing_page_url":"https://doi.org/10.1067/mlc.2000.105180","pdf_url":null,"source":{"id":"https://openalex.org/S26537864","display_name":"Journal of Laboratory and Clinical Medicine","issn_l":"0022-2143","issn":["0022-2143","1532-6543"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Laboratory and Clinical Medicine","raw_type":"journal-article"},{"id":"pmid:10711865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10711865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W60734750","https://openalex.org/W78931606","https://openalex.org/W380953071","https://openalex.org/W625407427","https://openalex.org/W953750962","https://openalex.org/W1494977501","https://openalex.org/W1514294337","https://openalex.org/W1546629881","https://openalex.org/W1561653939","https://openalex.org/W1670842080","https://openalex.org/W1816680223","https://openalex.org/W1827857596","https://openalex.org/W1866771879","https://openalex.org/W1899881065","https://openalex.org/W1934000172","https://openalex.org/W1974993576","https://openalex.org/W1977358316","https://openalex.org/W1984362947","https://openalex.org/W1989197621","https://openalex.org/W1991062723","https://openalex.org/W1992458520","https://openalex.org/W1994543341","https://openalex.org/W2005828038","https://openalex.org/W2008947167","https://openalex.org/W2011587215","https://openalex.org/W2012977460","https://openalex.org/W2018446366","https://openalex.org/W2019758748","https://openalex.org/W2021266075","https://openalex.org/W2028468567","https://openalex.org/W2028808290","https://openalex.org/W2030148186","https://openalex.org/W2030509492","https://openalex.org/W2037899846","https://openalex.org/W2049599679","https://openalex.org/W2051673284","https://openalex.org/W2060084728","https://openalex.org/W2061215861","https://openalex.org/W2068005545","https://openalex.org/W2072654554","https://openalex.org/W2081274939","https://openalex.org/W2082994356","https://openalex.org/W2084827879","https://openalex.org/W2091515190","https://openalex.org/W2091791088","https://openalex.org/W2099869893","https://openalex.org/W2109505564","https://openalex.org/W2114810470","https://openalex.org/W2118593308","https://openalex.org/W2123592366","https://openalex.org/W2127516794","https://openalex.org/W2149994976","https://openalex.org/W2152993036","https://openalex.org/W2160892616","https://openalex.org/W2164194120","https://openalex.org/W2229645819","https://openalex.org/W2409201598","https://openalex.org/W2409594038","https://openalex.org/W2411952082","https://openalex.org/W2413691447","https://openalex.org/W2414012323","https://openalex.org/W2414395251","https://openalex.org/W2414991540","https://openalex.org/W2419167666","https://openalex.org/W2426691155","https://openalex.org/W2433117739","https://openalex.org/W6658036411","https://openalex.org/W6683460505","https://openalex.org/W6717256635"],"related_works":["https://openalex.org/W2409594038","https://openalex.org/W2002047489","https://openalex.org/W2300028231","https://openalex.org/W2125361730","https://openalex.org/W258210870","https://openalex.org/W2044163016","https://openalex.org/W2027222698","https://openalex.org/W1977028102","https://openalex.org/W1984564407","https://openalex.org/W4416412914"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
