{"id":"https://openalex.org/W1968275388","doi":"https://doi.org/10.1016/0006-291x(78)90593-4","title":"The enzyme activity of bovine adrenocortical cytochrome P-450 producing pregnenolone from cholesterol: Kinetic and electrophoretic studies on the reactivity of hydroxycholesterol intermediates","display_name":"The enzyme activity of bovine adrenocortical cytochrome P-450 producing pregnenolone from cholesterol: Kinetic and electrophoretic studies on the reactivity of hydroxycholesterol intermediates","publication_year":1978,"publication_date":"1978-05-01","ids":{"openalex":"https://openalex.org/W1968275388","doi":"https://doi.org/10.1016/0006-291x(78)90593-4","mag":"1968275388","pmid":"https://pubmed.ncbi.nlm.nih.gov/666833"},"language":"en","primary_location":{"id":"doi:10.1016/0006-291x(78)90593-4","doi":"https://doi.org/10.1016/0006-291x(78)90593-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-291x(78)90593-4","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083592312","display_name":"Carmenza Duque","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I4387155384","display_name":"National Institute of Radiological Sciences","ror":"https://ror.org/05szqz470","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4387155384"]},{"id":"https://openalex.org/I4405287617","display_name":"Institute for Radiological Science","ror":"https://ror.org/05pbkxj36","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217","https://openalex.org/I4405287617"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Carmenza Duque","raw_affiliation_strings":["Laboratory of Chemistry for Natural Products, Tokyo Institute of Technology, 4259 Nagatsuta-machi, Midori-ku, Yokohama-shi 227 Japan","National Institute of Radiological Sciences, Anagawa, Chiba-shi 280 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemistry for Natural Products, Tokyo Institute of Technology, 4259 Nagatsuta-machi, Midori-ku, Yokohama-shi 227 Japan","institution_ids":["https://openalex.org/I114531698"]},{"raw_affiliation_string":"National Institute of Radiological Sciences, Anagawa, Chiba-shi 280 Japan","institution_ids":["https://openalex.org/I4387155384","https://openalex.org/I4405287617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110130357","display_name":"Masuo Morisaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I4387155384","display_name":"National Institute of Radiological Sciences","ror":"https://ror.org/05szqz470","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4387155384"]},{"id":"https://openalex.org/I4405287617","display_name":"Institute for Radiological Science","ror":"https://ror.org/05pbkxj36","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217","https://openalex.org/I4405287617"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masuo Morisaki","raw_affiliation_strings":["Laboratory of Chemistry for Natural Products, Tokyo Institute of Technology, 4259 Nagatsuta-machi, Midori-ku, Yokohama-shi 227 Japan","National Institute of Radiological Sciences, Anagawa, Chiba-shi 280 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemistry for Natural Products, Tokyo Institute of Technology, 4259 Nagatsuta-machi, Midori-ku, Yokohama-shi 227 Japan","institution_ids":["https://openalex.org/I114531698"]},{"raw_affiliation_string":"National Institute of Radiological Sciences, Anagawa, Chiba-shi 280 Japan","institution_ids":["https://openalex.org/I4387155384","https://openalex.org/I4405287617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111690337","display_name":"Nobuo Ikekawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I4387155384","display_name":"National Institute of Radiological Sciences","ror":"https://ror.org/05szqz470","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4387155384"]},{"id":"https://openalex.org/I4405287617","display_name":"Institute for Radiological Science","ror":"https://ror.org/05pbkxj36","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217","https://openalex.org/I4405287617"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuo Ikekawa","raw_affiliation_strings":["Laboratory of Chemistry for Natural Products, Tokyo Institute of Technology, 4259 Nagatsuta-machi, Midori-ku, Yokohama-shi 227 Japan","National Institute of Radiological Sciences, Anagawa, Chiba-shi 280 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemistry for Natural Products, Tokyo Institute of Technology, 4259 Nagatsuta-machi, Midori-ku, Yokohama-shi 227 Japan","institution_ids":["https://openalex.org/I114531698"]},{"raw_affiliation_string":"National Institute of Radiological Sciences, Anagawa, Chiba-shi 280 Japan","institution_ids":["https://openalex.org/I4387155384","https://openalex.org/I4405287617"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048985067","display_name":"Mikio Shikita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114531698","display_name":"Tokyo Institute of Technology","ror":"https://ror.org/0112mx960","country_code":"JP","type":"education","lineage":["https://openalex.org/I114531698","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I4387155384","display_name":"National Institute of Radiological Sciences","ror":"https://ror.org/05szqz470","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4387155384"]},{"id":"https://openalex.org/I4405287617","display_name":"Institute for Radiological Science","ror":"https://ror.org/05pbkxj36","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217","https://openalex.org/I4405287617"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mikio Shikita","raw_affiliation_strings":["Laboratory of Chemistry for Natural Products, Tokyo Institute of Technology, 4259 Nagatsuta-machi, Midori-ku, Yokohama-shi 227 Japan","National Institute of Radiological Sciences, Anagawa, Chiba-shi 280 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemistry for Natural Products, Tokyo Institute of Technology, 4259 Nagatsuta-machi, Midori-ku, Yokohama-shi 227 Japan","institution_ids":["https://openalex.org/I114531698"]},{"raw_affiliation_string":"National Institute of Radiological Sciences, Anagawa, Chiba-shi 280 Japan","institution_ids":["https://openalex.org/I4387155384","https://openalex.org/I4405287617"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":4.6967,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.94969756,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"82","issue":"1","first_page":"179","last_page":"187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-p450scc","display_name":"cytochrome P450scc","score":0.8930000066757202},{"id":"https://openalex.org/keywords/pregnenolone-biosynthesis","display_name":"pregnenolone biosynthesis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/cholesterol-side-chain-cleavage","display_name":"cholesterol side-chain cleavage","score":0.8550000190734863},{"id":"https://openalex.org/keywords/22-hydroxycholesterol","display_name":"22-hydroxycholesterol","score":1.0},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.7160000205039978},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.7229999899864197},{"id":"https://openalex.org/keywords/adrenal-steroidogenesis","display_name":"adrenal steroidogenesis","score":0.7300000190734863},{"id":"https://openalex.org/keywords/isoelectric-focusing","display_name":"isoelectric focusing","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C2780193516","wikidata":"https://www.wikidata.org/wiki/Q412158","display_name":"Pregnenolone","level":4,"score":0.9434777498245239},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7949239015579224},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.7174704670906067},{"id":"https://openalex.org/C80446465","wikidata":"https://www.wikidata.org/wiki/Q412483","display_name":"Cholesterol side-chain cleavage enzyme","level":4,"score":0.7027952671051025},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.6574851274490356},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.6087312698364258},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5288853645324707},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.5095239281654358},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4786188006401062},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.36420297622680664},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35703951120376587},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.32136327028274536},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.27698418498039246},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09862110018730164},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006888","descriptor_name":"Hydroxycholesterols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011284","descriptor_name":"Pregnenolone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0006-291x(78)90593-4","doi":"https://doi.org/10.1016/0006-291x(78)90593-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-291x(78)90593-4","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:666833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/666833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1509707135","https://openalex.org/W1519888646","https://openalex.org/W1567805507","https://openalex.org/W1998745328","https://openalex.org/W2004946640","https://openalex.org/W2030224141","https://openalex.org/W2063507722","https://openalex.org/W2069146173","https://openalex.org/W2117778669","https://openalex.org/W2132501195","https://openalex.org/W2419433543"],"related_works":["https://openalex.org/W2094459468","https://openalex.org/W2076564102","https://openalex.org/W2056394711","https://openalex.org/W2004031738","https://openalex.org/W2063507722","https://openalex.org/W2061376611","https://openalex.org/W2005789182","https://openalex.org/W1567805507","https://openalex.org/W2092591620","https://openalex.org/W2411172204"],"abstract_inverted_index":null,"counts_by_year":[{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
