{"id":"https://openalex.org/W1968270886","doi":"https://doi.org/10.1089/10799900050151076","title":"Interferon Coordinately Inhibits the Disruption of PML-Positive ND10 and Immediate-Early Gene Expression by Herpes Simplex Virus","display_name":"Interferon Coordinately Inhibits the Disruption of PML-Positive ND10 and Immediate-Early Gene Expression by Herpes Simplex Virus","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W1968270886","doi":"https://doi.org/10.1089/10799900050151076","mag":"1968270886","pmid":"https://pubmed.ncbi.nlm.nih.gov/11032400"},"language":"en","primary_location":{"id":"doi:10.1089/10799900050151076","doi":"https://doi.org/10.1089/10799900050151076","is_oa":false,"landing_page_url":"https://doi.org/10.1089/10799900050151076","pdf_url":null,"source":{"id":"https://openalex.org/S109620152","display_name":"Journal of Interferon & Cytokine Research","issn_l":"1079-9907","issn":["1079-9907","1557-7465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interferon & Cytokine Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109954847","display_name":"Jerry Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry L. Taylor","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics & Ophthalmology, Medical College of Wisconsin, Milwaukee, WI 53226"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics & Ophthalmology, Medical College of Wisconsin, Milwaukee, WI 53226","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011472806","display_name":"Dina Unverrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dina Unverrich","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":null,"display_name":"William J. O'Brien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J. O'Brien","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics & Ophthalmology, Medical College of Wisconsin, Milwaukee, WI 53226"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics & Ophthalmology, Medical College of Wisconsin, Milwaukee, WI 53226","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020670808","display_name":"Kent W. Wilcox","orcid":"https://orcid.org/0000-0002-5440-0793","observed_orcids":["https://orcid.org/0000-0002-5440-0793"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kent W. Wilcox","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204308271"],"apc_list":null,"apc_paid":null,"fwci":0.7072,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.67802503,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"20","issue":"9","first_page":"805","last_page":"815"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.09719999879598618,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.9509999752044678},{"id":"https://openalex.org/keywords/herpes-simplex-virus","display_name":"herpes simplex virus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pml","display_name":"PML","score":0.5649999976158142},{"id":"https://openalex.org/keywords/nd10","display_name":"ND10","score":0.9190000295639038},{"id":"https://openalex.org/keywords/icp4","display_name":"ICP4","score":0.9470000267028809},{"id":"https://openalex.org/keywords/immediate-early-gene-expression","display_name":"immediate early gene expression","score":0.9819999933242798},{"id":"https://openalex.org/keywords/viral-transcription","display_name":"viral transcription","score":0.699999988079071},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.628000020980835},{"id":"https://openalex.org/keywords/multiplicity-of-infection","display_name":"multiplicity of infection","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.7618463039398193},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7067896127700806},{"id":"https://openalex.org/C111441629","wikidata":"https://www.wikidata.org/wiki/Q18030615","display_name":"Promyelocytic leukemia protein","level":5,"score":0.6381295323371887},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5292595624923706},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5198448300361633},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49956417083740234},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.49043652415275574},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4774661362171173},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.45173180103302},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4485064744949341},{"id":"https://openalex.org/C2779555244","wikidata":"https://www.wikidata.org/wiki/Q409638","display_name":"Immediate early gene","level":4,"score":0.4303804337978363},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.42826610803604126},{"id":"https://openalex.org/C203233990","wikidata":"https://www.wikidata.org/wiki/Q1511135","display_name":"Multiplicity of infection","level":3,"score":0.4261434078216553},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4223129153251648},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.4176367521286011},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4071018099784851},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2614896595478058},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.2512280344963074},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09530317783355713},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071156","descriptor_name":"Promyelocytic Leukemia Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081","descriptor_name":"Acetamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000882","descriptor_name":"Haplorhini","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017781","descriptor_name":"Genes, Immediate-Early","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/10799900050151076","doi":"https://doi.org/10.1089/10799900050151076","is_oa":false,"landing_page_url":"https://doi.org/10.1089/10799900050151076","pdf_url":null,"source":{"id":"https://openalex.org/S109620152","display_name":"Journal of Interferon & Cytokine Research","issn_l":"1079-9907","issn":["1079-9907","1557-7465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interferon & Cytokine Research","raw_type":"journal-article"},{"id":"pmid:11032400","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11032400","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3626115345","display_name":"INTERFERON'S ROLE IN ANTIVIRAL ACTIVITIES","funder_award_id":"5r01ey006990-12","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G409595788","display_name":null,"funder_award_id":"R 01-EY 06990","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G5985780757","display_name":null,"funder_award_id":"P01-EY01931","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G6763994594","display_name":null,"funder_award_id":"R01-AI 17246","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8747218207","display_name":"REGULATION OF GENE EXPRESSION IN HSV INFECTED CELLS","funder_award_id":"5r01ai017246-19","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":93,"referenced_works":["https://openalex.org/W204188251","https://openalex.org/W1490731141","https://openalex.org/W1497604752","https://openalex.org/W1516008369","https://openalex.org/W1526130707","https://openalex.org/W1586627611","https://openalex.org/W1602186443","https://openalex.org/W1605241030","https://openalex.org/W1656209509","https://openalex.org/W1666232456","https://openalex.org/W1742513880","https://openalex.org/W1779679253","https://openalex.org/W1802370618","https://openalex.org/W1854068525","https://openalex.org/W1886515277","https://openalex.org/W1895304651","https://openalex.org/W1898584802","https://openalex.org/W1921267352","https://openalex.org/W1931385722","https://openalex.org/W1966729098","https://openalex.org/W1967020705","https://openalex.org/W1969078573","https://openalex.org/W1970042886","https://openalex.org/W1971660413","https://openalex.org/W1978728124","https://openalex.org/W1978917718","https://openalex.org/W1981400752","https://openalex.org/W1985537838","https://openalex.org/W1988154113","https://openalex.org/W1989142628","https://openalex.org/W1998475589","https://openalex.org/W2000110844","https://openalex.org/W2000527254","https://openalex.org/W2002896353","https://openalex.org/W2006551110","https://openalex.org/W2012100191","https://openalex.org/W2012234391","https://openalex.org/W2012482167","https://openalex.org/W2020034373","https://openalex.org/W2020894304","https://openalex.org/W2022116983","https://openalex.org/W2027361460","https://openalex.org/W2032040954","https://openalex.org/W2040114529","https://openalex.org/W2043852307","https://openalex.org/W2051530525","https://openalex.org/W2051864256","https://openalex.org/W2053972916","https://openalex.org/W2059823369","https://openalex.org/W2060865001","https://openalex.org/W2062097395","https://openalex.org/W2065572781","https://openalex.org/W2071228459","https://openalex.org/W2073535549","https://openalex.org/W2075413744","https://openalex.org/W2086117977","https://openalex.org/W2088874438","https://openalex.org/W2090317877","https://openalex.org/W2092009940","https://openalex.org/W2093877605","https://openalex.org/W2096546138","https://openalex.org/W2098409847","https://openalex.org/W2098504102","https://openalex.org/W2099338303","https://openalex.org/W2103552572","https://openalex.org/W2103565638","https://openalex.org/W2104404172","https://openalex.org/W2107761373","https://openalex.org/W2115418322","https://openalex.org/W2116445024","https://openalex.org/W2117568376","https://openalex.org/W2127217324","https://openalex.org/W2129737437","https://openalex.org/W2130273663","https://openalex.org/W2131517280","https://openalex.org/W2132050737","https://openalex.org/W2133376634","https://openalex.org/W2134321753","https://openalex.org/W2135002148","https://openalex.org/W2138630631","https://openalex.org/W2141897889","https://openalex.org/W2146870828","https://openalex.org/W2148547711","https://openalex.org/W2160902316","https://openalex.org/W2161737006","https://openalex.org/W2163535407","https://openalex.org/W2163620766","https://openalex.org/W2187131173","https://openalex.org/W2295163900","https://openalex.org/W2326128035","https://openalex.org/W2417675333","https://openalex.org/W3015436948","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2130273663","https://openalex.org/W2125000624","https://openalex.org/W2142756909","https://openalex.org/W7095135097","https://openalex.org/W2065572781","https://openalex.org/W2062097395","https://openalex.org/W2142732844","https://openalex.org/W1505592466","https://openalex.org/W2023170691","https://openalex.org/W7099500898"],"abstract_inverted_index":{"Interferons":[0],"(IFNs)":[1],"are":[2],"important":[3],"components":[4],"of":[5,23,33,46,65,80,119,128,186,194,196],"the":[6,26,76,92,117,123,132,137,148,153,160,166,187,192,201],"innate":[7],"immune":[8],"response,":[9],"limiting":[10],"herpes":[11],"simplex":[12],"virus":[13],"(HSV)":[14],"infection.":[15],"In":[16,97],"recombinant":[17,105],"HSV-infected":[18],"cells,":[19],"IFN":[20,38,40,49,69,173],"inhibited":[21,50],"expression":[22,62,179],"beta-galactosidase":[24],"from":[25],"immediate-early":[27,149],"gene,":[28],"ICP4,":[29],"promoter.":[30],"The":[31,67],"extent":[32],"inhibition":[34,143],"was":[35,144,151,157,162],"dependent":[36],"on":[37],"dose,":[39],"type,":[41,43],"cell":[42],"and":[44,78,183],"multiplicity":[45],"infection":[47],"(moi).":[48],"gene":[51,61,178,205],"transcription,":[52],"leading":[53],"to":[54],"a":[55,104,110],"complete":[56,146],"block":[57,176,202],"in":[58,63,72,75,122,131,136,152,180,203],"ICP4":[59,108],"promoter-driven":[60],"90%":[64],"cells.":[66,141],"same":[68,133],"treatments":[70],"resulted":[71],"an":[73],"increase":[74],"size":[77],"number":[79],"nuclear":[81],"domain":[82],"10":[83],"(ND10)":[84],"structures":[85],"that":[86,172,184],"stained":[87],"positive":[88],"by":[89],"immunofluorescence":[90],"for":[91],"promyelocytic":[93],"leukemia":[94],"(PML)":[95],"protein.":[96],"cultures":[98],"infected":[99,181],"at":[100],"low":[101],"moi":[102],"with":[103,113,126,200],"HSV":[106,197],"producing":[107],"as":[109],"fusion":[111],"protein":[112],"green":[114,120],"fluorescence":[115,121],"protein,":[116],"appearance":[118],"nucleus":[124],"coincided":[125],"loss":[127],"PML-positive":[129],"ND10":[130,188],"nucleus,":[134],"even":[135],"rare":[138],"ICP4-expressing":[139],"IFN-treated":[140],"IFN-dependent":[142],"nearly":[145],"when":[147,159],"promoter":[150,161],"viral":[154,177,204],"genome":[155],"but":[156],"minimal":[158],"stably":[163],"integrated":[164],"into":[165],"cellular":[167],"genome.":[168],"These":[169],"data":[170],"reveal":[171],"can":[174],"completely":[175],"cells":[182],"enhancement":[185],"structure,":[189],"which":[190],"is":[191],"site":[193],"initiation":[195],"replication,":[198],"correlates":[199],"expression.":[206]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}