{"id":"https://openalex.org/W1968253107","doi":"https://doi.org/10.2165/00044011-200424100-00002","title":"A Randomised, Controlled Comparison of Low-Dose Polyethylene Glycol 3350 plus Electrolytes with Ispaghula Husk in???the Treatment of Adults with Chronic???Functional Constipation","display_name":"A Randomised, Controlled Comparison of Low-Dose Polyethylene Glycol 3350 plus Electrolytes with Ispaghula Husk in???the Treatment of Adults with Chronic???Functional Constipation","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W1968253107","doi":"https://doi.org/10.2165/00044011-200424100-00002","mag":"1968253107","pmid":"https://pubmed.ncbi.nlm.nih.gov/17523718"},"language":"en","primary_location":{"id":"doi:10.2165/00044011-200424100-00002","doi":"https://doi.org/10.2165/00044011-200424100-00002","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00044011-200424100-00002","pdf_url":null,"source":{"id":"https://openalex.org/S138241747","display_name":"Clinical Drug Investigation","issn_l":"0114-2402","issn":["0114-2402","1173-2563","1179-1918","2196-4920"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Drug Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015467850","display_name":"Huiji Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui-Ji Wang","raw_affiliation_strings":["Beijing Friendship Hospital, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Friendship Hospital, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085832630","display_name":"Xiaomei Liang","orcid":"https://orcid.org/0000-0002-9320-8593","observed_orcids":["https://orcid.org/0000-0002-9320-8593","https://orcid.org/0000-0001-5335-0213"]},"institutions":[{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Mei Liang","raw_affiliation_strings":["Beijing Friendship Hospital, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Friendship Hospital, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113748083","display_name":"Zhonglin Yu","orcid":"https://orcid.org/0009-0006-0787-3121","observed_orcids":["https://orcid.org/0009-0006-0787-3121"]},"institutions":[{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhong-Lin Yu","raw_affiliation_strings":["Beijing Friendship Hospital, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Friendship Hospital, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031613982","display_name":"Liya Zhou","orcid":"https://orcid.org/0000-0002-2064-5522","observed_orcids":["https://orcid.org/0000-0002-2064-5522"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Ya Zhou","raw_affiliation_strings":["The Third Hospital of Peking University, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Hospital of Peking University, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102361081","display_name":"Sanren Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"San-Ren Lin","raw_affiliation_strings":["The Third Hospital of Peking University, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Hospital of Peking University, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009924202","display_name":"Mike Geraint","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141803","display_name":"Norgine (United Kingdom)","ror":"https://ror.org/046zgtw08","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210136628","https://openalex.org/I4210141803"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Mike Geraint","raw_affiliation_strings":["Norgine Ltd, Harefield, Moorhall Road, Middlesex, UB9 6NS, UK","Norgine Ltd, Harefield, Middlesex, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Norgine Ltd, Harefield, Moorhall Road, Middlesex, UB9 6NS, UK","institution_ids":["https://openalex.org/I4210141803"]},{"raw_affiliation_string":"Norgine Ltd, Harefield, Middlesex, UK","institution_ids":["https://openalex.org/I4210141803"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5009924202"],"corresponding_institution_ids":["https://openalex.org/I4210141803"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":0.4806,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.69151037,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"24","issue":"10","first_page":"569","last_page":"576"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10418","display_name":"Pelvic floor disorders treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12020","display_name":"Enhanced Recovery After Surgery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-functional-constipation","display_name":"chronic functional constipation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/polyethylene-glycol-3350","display_name":"polyethylene glycol 3350","score":0.9679999947547913},{"id":"https://openalex.org/keywords/ispaghula-husk","display_name":"ispaghula husk","score":0.8809999823570251},{"id":"https://openalex.org/keywords/psyllium","display_name":"psyllium","score":0.9879999756813049},{"id":"https://openalex.org/keywords/laxatives","display_name":"laxatives","score":0.6589999794960022},{"id":"https://openalex.org/keywords/fecal-consistency","display_name":"stool consistency","score":0.9620000123977661},{"id":"https://openalex.org/keywords/bristol-stool-form-scale","display_name":"Bristol Stool Form Scale","score":0.7360000014305115},{"id":"https://openalex.org/keywords/laxative-efficacy","display_name":"laxative efficacy","score":0.6060000061988831},{"id":"https://openalex.org/keywords/laxative-safety","display_name":"laxative safety","score":0.9309999942779541},{"id":"https://openalex.org/keywords/adults","display_name":"adults","score":0.5339999794960022},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.6859999895095825},{"id":"https://openalex.org/keywords/electrolytes","display_name":"electrolytes","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8491559028625488},{"id":"https://openalex.org/C54400483","wikidata":"https://www.wikidata.org/wiki/Q1793202","display_name":"PEG ratio","level":2,"score":0.6947858333587646},{"id":"https://openalex.org/C2781112942","wikidata":"https://www.wikidata.org/wiki/Q178436","display_name":"Constipation","level":2,"score":0.5792137384414673},{"id":"https://openalex.org/C2779642851","wikidata":"https://www.wikidata.org/wiki/Q5508805","display_name":"Functional constipation","level":3,"score":0.5646670460700989},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.527725338935852},{"id":"https://openalex.org/C2780661987","wikidata":"https://www.wikidata.org/wiki/Q217972","display_name":"Laxative","level":3,"score":0.5223763585090637},{"id":"https://openalex.org/C2779372120","wikidata":"https://www.wikidata.org/wiki/Q430675","display_name":"Psyllium","level":3,"score":0.521294116973877},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5154303312301636},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.44895872473716736},{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.4429927468299866},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3345852196216583},{"id":"https://openalex.org/C2992741425","wikidata":"https://www.wikidata.org/wiki/Q215210","display_name":"Dietary fiber","level":2,"score":0.0613846480846405},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.05427676439285278},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2165/00044011-200424100-00002","doi":"https://doi.org/10.2165/00044011-200424100-00002","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00044011-200424100-00002","pdf_url":null,"source":{"id":"https://openalex.org/S138241747","display_name":"Clinical Drug Investigation","issn_l":"0114-2402","issn":["0114-2402","1173-2563","1179-1918","2196-4920"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Drug Investigation","raw_type":"journal-article"},{"id":"pmid:17523718","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17523718","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical drug investigation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W2024469473","https://openalex.org/W2046549547","https://openalex.org/W2065735588","https://openalex.org/W2165844124","https://openalex.org/W2166386674","https://openalex.org/W4247718302","https://openalex.org/W4250245083"],"related_works":["https://openalex.org/W1994006062","https://openalex.org/W2352982618","https://openalex.org/W4380148832","https://openalex.org/W2416065502","https://openalex.org/W2123514148","https://openalex.org/W1996604120","https://openalex.org/W2165844124","https://openalex.org/W2076779392","https://openalex.org/W7098615935","https://openalex.org/W2085025198"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}